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Tuesday, October 22, 2019

Honey Prevents and Relieves Hangover, Scientists Reveal

The traditional medicine suggested that intake of one spoonful honey before and after a drinking party may prevent a hangover.

According to Dr. Zhou, the scientist in the field of TCM, honey processed a cooling, hydrating and revitalizing properties and has been used in traditional Chinese medicine for purifying stimulant and a tonic against dizziness and hangover-upset stomachs.

A hangover is unpleasant physiological and psychological effects caused by the (over) consumption of alcohol, according to studies.

Most common symptoms of a hangover include headache, drowsiness, concentration problems, dizziness, fatigue, and gastrointestinal discomforts.

The exact causes of hangover are unknown. The most common factor associated with a hangover is the accumulation of acetaldehyde, a highly toxic substance.

The conversion of acetaldehyde is a chemical process as a result of enzyme alcohol dehydrogenase (ADH) which metabolizes the alcohol intake to acetaldehyde.

Depending on the individual variations in alcohol metabolism, some people may experience worse hangover symptoms than others.


Hangover symptoms are affected by alcohol tolerance which is measured by the bodily responses to the functional effects of ethanol in alcoholic beverages.

CYP2E1, one of the genes has been linked with alcohol tolerance. However, people with high alcohol tolerance are also more likely to develop alcoholism.


Dr. Claire Heit,, the lead scientist in the evaluation of the role of CYP2E1 in alcohol metabolism wrote, "Acetaldehyde (the direct metabolite of ethanol oxidation) contributes to many aspects of the behavioral effects of ethanol. Given acetaldehyde cannot pass through the blood-brain barrier, its concentration in the CNS is primarily determined by local production from ethanol".


And, "Catalase and cytochrome P450 2E1(CYP2E1) represent the major enzymes in the CNS that catalyze ethanol oxidation. CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions".


Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on finding a natural and potential compound for hangover relief examined the traditional medicine use of honey for preventing drunkenness and relieving hangover symptoms.


Intoxicated male mice selected to the study were assigned randomly either to low or high doses of lychee flower honey (2.19 or 4.39 g/kg body weight, respectively) that were single orally administrated 30 min before the ethanol intoxication of mice, followed by recording the locomotor activity by autonomic activity instrument and observing the climbing ability after alcohol or 2.19 g/kg honey that was single orally administrated 5 min after the ethanol intoxication of mice, followed by determining the ethanol concentration in mice blood.

Both doses of honey increased the autonomic activity of alcoholized mice.

Futhermore, intoxicated mice treated with 2.19 g/kg honey showed a decrease significantly of the blood ethanol concentration.

Additional differentiation suggested that The anti-intoxication activity of honey is attributed to the effect of the fructose contained in the honey.

Interestingly, honey inhibited hangover symptoms without affecting the levels of oxidative stress and antioxidant enzymes produced by the host.

The results showed that honey processed a direct anti-hangover activity in a dose time-dependent manner.

Taken altogether, honey may be considered a functional remedy to relieve hangover symptoms caused by alcoholic intoxication, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Honey reduces blood alcohol concentration but not affects the level of serum MDA and GSH-Px activity in intoxicated male mice models by Shi P1,2, Chen B3, Chen C1, Xu J3, Shen Z1, Miao X4,5, Yao H. (PubMed)
(2) The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System
Claire Heit, Hongbin Dong,b Ying Chen, David C. Thompson,c Richard A. Deitrich,d and Vasilis Vasiliou. (PMC)
(3) Curing hangovers the Chinese way by Timeout

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