In the study of "Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in Singapore" by Koh WP, Van Den Berg D, Jin A, Wang R, Yuan JM, Yu MC., posted in US National Library of Medicine National Institutes of Health, researchers found that support experimental data implicating combined effects of MDM2 protein and the p53-mediated pathway in breast carcinogenesis, and suggest that soy isoflavones may exert protective effect via down-regulation of the MDM2 protein.
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