Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
In the evaluation of Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats, posted in PubMed, indicated that Oral administration of biochanin A (10mg/kg body weight) or glibenclamide (600 μg/kg body weight)
in 0.5% dimethyl sulfoxide, for 45 days, prevented the above changes
and improved towards normality. In addition, protection against body weight loss
of diabetic animals by biochanin A was also observed. No significant
effect was observed in normal rats treated with biochanin A (10mg/kg
bodyweight). These results showed that biochanin A has potential
antihyperglycemic activity at a dose of 10mg/kg bodyweight in
streptozotocin induced diabetic rats.
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