Soy isoflavones on estrogen and phytoestrogen metabolism

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the abstract of Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women, posted in PubMed, indicated that Compared with the control diet, increased isoflavone consumption decreased urinary excretion of estradiol, estrone, estriol, and total estrogens, as well as excretion of the hypothesized genotoxic estrogen metabolites, 16alpha-hydroxyestrone, 4-hydroxyestrone, and 4-hydroxyestradiol. Of importance are the observations of a significant increase in the 2-hydroxyestrone/16alpha-hydroxyestrone ratio and a decrease in the genotoxic/total estrogens ratio. These data suggest that soy isoflavone consumption may exert cancer-preventive effects by decreasing estrogen synthesis and altering metabolism away from genotoxic metabolites toward inactive metabolites.

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