Dietary phytoestrogens and intestinal bacteria

Posted by Chantel M. research contributed  US National Library of Medicine National Institutes of Health   

The indigenous intestinal microflora are involved in a variety of processes within the human body, and are important for maintaining host health. suggest that Daidzein, an isoflavone phytoestrogen found in soy, is metabolized to equol and O-desmethylangolensin (O-DMA) by intestinal bacteria. The specific bacterium/bacteria responsible for equol and O-DMA production in humans have yet to be identified definitively, but in vitro and animal studies have suggested that equol and O-DMA are more biologically active than their precursor daidzein. Interestingly, substantial interindividual differences in daidzein metabolism exist; following soy or daidzein consumption, approximately 30%-50% of the human population produce equol, and approximately 80%-90% produce O-DMA. posted in PubMed,

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