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Ovarian Cyst Miracle
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Saturday, June 25, 2016

Women Health: The Effects of Hormone Estrogen(2)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Estrogen is a female sex hormone defined as a group of compounds for its function in regulating in the estrous cycle of women after puberty.

A. Maintenance of vessels and skin
It is easy to understand that estrogen maintain the healthy and vessels and skin for pre-menopause women, as ageing is considered as a progressive reduction in function and reserve capacity of skin and vessel tissue. According to the study of "The effect of menopause on the skin and other connective tissues", by Calleja-Agius J, Brincat M., posted in PubMed, researchers wrote that oestrogen has profound effects on connective tissue turnover, no matter the site. It has been shown that menopause has similar effects on the connective tissue of the carotid artery media, intervertebral discs and bones.

B. Protein synthesis
Protein is also known as polypeptides, they are are organic compounds made of amino acids and can be found in meat, beans, milk, eggs or any source of food which provides our body the raw materials to build its own protein. Since our body can not store protein, we require to take them regularly. Researchers found that intake of plant base protein is more healthy than animal base protein, because it helps to prevent high blood pressure, reduce cholesterol, heart diseases and strokes, if taking together with complex carbohydrate.


Protein synthesis is defined as a complicate process of cells building or manufacturing proteins. You can view the step of protein synthesis from this link. According to the study of "Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pathway" by Akama KT, McEwen BS., posted in PubMed, researchers found that These results demonstrate an essential role for Akt in estrogen-stimulated dendritic spine protein expression, describe for the first time a signal transduction pathway in PSD-95 expression, and delineate a novel, molecular mechanism by which ovarian hormones might translationally regulate synaptogenesis via activating protein synthesis for dendritic function.


C. Coagulation
Coagulation is defined as a complicate process of forming blood clots to reduce the risk of bleeding that can cause blood vessels damage and health of the patient. In a study of in 27 postmenopausal women at baseline and after 2 and 12 weeks of treatment. Oral and transdermal estradiol induced similar increases in serum free estradiol concentrations in measuring the measures of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins, conducted by University of Helsinki, Finland, posted in PubMed, researchers found that oral estradiol increased markers of fibrinolytic activity, decreased serum soluble E-selectin levels and induced potentially antiatherogenic changes in lipids and lipoproteins. In contrast to these beneficial effects, oral estradiol changed markers of coagulation towards hypercoagulability, and increased serum CRP concentrations.

D. Lipid
Lipid is defined as fat in the blood, including HDL(high density lipoproteins), triglyceride, LDL(low density lipoproteins), etc. levels of estrogen really affect the levels of fat in the blood as one can easily see through the levels of estrogen and lipid in a woman menstrual cycle. According to the study of "Variations in lipid levels according to menstrual cycle phase: clinical implications. Mumford SL, Dasharathy S, Pollack AZ, Schisterman EF., posted in PubMed, researchers wrote that Overall, lipoprotein cholesterol levels were observed to vary in response to changing estrogen levels. Taken together, the evidence suggests that total cholesterol and LDL-C tend to be highest during the follicular phase and to decline during the luteal phase, with HDL C highest around ovulation. Based on these findings, the menstrual cycle phase should be taken into account when evaluating lipoprotein cholesterol levels among reproductive-aged women. Measuring cholesterol levels during menses is recommended for consistent comparisons as this phase can be more reliably identified than other phases, although women within National Cholesterol Education Program acceptable ranges, but near the boundaries when tested during menses, should undergo additional tests.

E. Fluid balancing
Estrogen plays an important role in balancing the fluid in the body. According to the study of "Estrogen and the central control of body fluid balance" by Curtis KS., posted in PubMed, researchers indicated that Taken together, the body of evidence amassed from more than 40 years of investigations suggests that the central actions of estrogen influence body fluid regulation and, more specifically, compensatory responses to perturbations of osmotic or volume balance in two interrelated ways.

F. Estrogen and Cortisol
Cortisol is a glucocorticoid produced by the adrenal gland. It is one the hormone that work together with melatonin to regulate the pattern of sleep and awake. Estrogenhas a very close relationshion ship with the increase of levels of cortisol in the reproductive years. According to the stdy of "Cortisol, Estradiol-17{beta} and Progesterone Secretion within the First Hour after Awakening in Women with Regular Menstrual Cycles" by Ahn RS, Choi JH, Choi BC, Kim JH, Lee SH, Sung SS., posted in PubMed, researchers found that The areas under curves showing the E2 and P4 levels from the time immediately after awakening to 60 min after awakening (i.e., E2auc and P4auc) in women with regular menstrual cycles were greater than those in postmenopausal women.

G. Estrogen and Sex Hormone Binding Globulin
SHBG is a glycoprotein, produced by the liver to bind to sex hormones testosterone and estradiol. In an abstract of the study of "The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase of SHBG gene, protein expression and intracellular levels in MCF-7 cells line" by Gregoraszczuk EL, Ptak A, Wrobel A., posted in PubMed, researchers filed the result that 4-OH-E2 in high doses and 2-OH-E2 in the highest dose, while 17β-estradiol in all doses used increased intracellular but not extracellular SHBG levels. Both metabolites increased SHBG mRNA expression, the rank order of potency being E2 > 4-OH-E2 > 2-OH-E2. Both E2 and its metabolites increased SHBG protein expression.

H. Gastrointestinal tract
Gastrointestinal tract forms a part of digestive system and refers to the stomach and intestine or digestive system of all the structures from the mouth to the anus. According to the researcher of the study of "Estrogen, progesterone and the gastrointestinal tract" by Eliakim R, Abulafia O, Sherer DM., posted in PubMed, researchers indicated that This review provides an abundance of data supporting that estrogen and progesterone have both beneficial and detrimental effects on the esophagus, stomach, gallbladder, and small and large intestine.

I. Melanin
Melanin is a is a pigment that gives the human skin and hair color. It is easlily to understand the relattionship of estrogen and melanin, as thw women age, the reduction of levels of estrogen cause the hair color to turn gray. According to the study of Estrogen increases hair pigmentation in female recessive yellow mice" by Hirobe T, Kiuchi M, Wakamatsu K, Ito S., posted in PubMed, researchers concluded that suggest that estrogen is the main factor in determining the higher content of eumelanin and pheomelanin in female hair of Mc1r(e)/Mc1r(e) mice.

J. Estrogen and the Lung
Believe it or not, estrogen plays an important role in protect the women lung against diseases. According to the study of Estrogen Rescues Pre-existing Severe Pulmonary Hypertension in Rats" by Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der Laarse A, Eghbali M., posted in PubMed, researchers concluded that estrogen rescues pre-existing severe PH in rats by restoring lungand RV structure and function that is maintained even after removal of estrogen.Estrogen-induced rescue of PH is associated with stimulation of cardiopulmonary neoangiogenesis, suppression of inflammation, fibrosis and RV-hypertrophy. Furthermore, estrogen-rescue is likely mediated through estrogen receptor-b.

K. Estrogen and Fetal development
Believe or not, estrogen Estrogen turns play a central role in maintaining pregnancy and fetal development In the abstract of the study of "Estrogenregulation of placental angiogenesis and fetal ovarian development during primate pregnancy" by Albrecht ED, Pepe GJ., posted in PubMed, researchers wrote that this review will describe the developmental processes required for placental vascularization and fetal follicular maturation and recent studies which show thatestrogen has an important role in regulating these events.

L. Etc.
Pregnancy Miracle
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Friday, June 24, 2016

Women Health: The Effect of Hormone Estrogen on female reproductive system(1)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Estrogen is a female sex hormone defined as a group of compounds for its function in regulating in the estrous cycle of women after puberty.

1. Promote female reproductive system
Estrogen promotes female reproductive system beginning in the puberty by increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity, leading to the growth of breasts and other female characteristics. In a study of "Inducing puberty" by Delemarre EM, Felius B, Delemarre-van de Waal HA., posted in PubMed, researchers indicated that sex steroids will induce development of the secondary sex characteristics alone, while combined administration of gonadotropins and GnRH may induce gonadal development including fertility.

2. Accelerate metabolism
Estrogen enhances metabolism to allow the body of the women to grow, reproduce, maintain the structures and survival of the human species, adapt to the change of environments to sustain living, etc.. According to the study of "Differential roles of estrogen receptors α and β in control of B-cell maturation and selection" by Hill L, Jeganathan V, Chinnasamy P, Grimaldi C, Diamond B., posted in PubMed, researchers found that engagement of either estrogen receptor α or β can alter B-cell maturation, but only engagement of estrogen receptor α is a trigger for autoimmunity. Thus, maturation and selection are regulated differentially byestrogen. These observations have therapeutic implications.

3. Muscle mass, Abnormal fat distribution
According to the study of 64-week prospective cohort trial evaluated the effects of 20-mg oestradiol implants, replaced every 4 months, in healthy postmenopausal women aged 45-65 years. Of 20 implant and 14 control subjects who remained in the trial at 32 weeks, 13 implant and seven controls continued to 64 weeks, conducted by University of Sydney Royal North Shore Hospital, posted inPubMed, researchers concluded that The abdominal fat-to-lean soft tissue ratio decreased by 18% in implant subjects ( p<0.001), but did not change in controls ( p<0.05 implants versus controls). Neither group displayed significant changes inweight, fat or appendicular skeletal muscle mass. The 32-week data were consistent with these results. Hence, oestradiol implant therapy can reduceabdominal adiposity and could lower the risk of obesity-related metabolic disorders.

4. Increase bone density
Deficiency or reduced estrogen levels in post menopause women can lead to bone density loss.
According to the study of "A protective effect of Curcuma comosa Roxb. on boneloss in estrogen deficient mice" by Weerachayaphorn J, Chuncharunee A, Mahagita C, Lewchalermwongse B, Suksamrarn A, Piyachaturawat P., posted inPubMed, researchers suugested that suggest that C. comosa prevents bone loss induced by estrogen deficiency. Therefore, C. comosa would be a potential alternative treatment for prevention of postmenopausal osteoporosis.

5. Endometrial growthWomen's endomyrium undergoes certain change after puberty to adapt to the estrous cycle and pregnancy. According to the study conducted by Research laboratory at Kansai Medical University of 16 patients undergoing hysterectomy for benign reasons, in vitro, posted in PubMed, researchers found that the E(2) or OHT stimulates VEGF production and concurrently attenuates sVEGFR-1 production in ESCs. This consequential increase in VEGF:sVEGFR-1 ratio might enhance the biological effects of VEGF on the angiogenic environment in human endometrium.

6. Uterine growth
In the stage of estrous cycle, women uterus undergoes marked morphological, physiological and functional changes as a result of the levels of estrogen produced by the body. According to the study of "Characterisation of mouse interferon-induced transmembrane protein-1 gene expression in the mouse uterus during the oestrous cycle and pregnancy" by Park HJ, Kuk IS, Kim JH, Kim JH, Song SJ, Choi BC, Kim B, Kim NH, Song H., posted in PubMed, researchers concluded that Expression of Ifitm1 mRNA was higher in response to PMSG than other hormones investigated. These results suggest that Ifitm1 may be involved in uteri physiology, although the mechanisms involved in the regulation of this gene expression and function in the uterus remain unknown.


7. Vaginal lubrication
Vaginal lubrication is one of characteristic of hormone estrogen for women in per-manopause stage to moistens the vagina and to protect it especial during sexual intercourse. Insufficient lubrication or vaginal dryness in women can cause painful sexual intercourse disorder. According to the sudy of "Treatment options for female sexual arousal disorder: part II" by Feldhaus-Dahir M., posted in PubMed, researcher wrote that Female sexual arousal disorder (FSAD) occurs when a woman experiences distress due to the inability to attain or maintain adequatevaginal lubrication. Many treatments are still under investigation, and at this time, there are no FDA-approved medications available for the treatment of FSAD. Treatment options include "off-label" medications, vaginal estrogen, compounded preparations, and over-the-counter products.

8. Thicken the vaginal wall
As a result of level of estrogen, the vaginal wall is thickened to provide favorable condition for conception by moisturizing the vaginal and protecting the vaginal during sexual intercourse, In a study of The study included 89 patients undergoingvaginal surgery for urogynecological conditions, conducted by Mainz University Hospital, Dept. of Obstetrics and Gynecology,posted in PubMed, researchers found that menopausal women showed a higher amount of PR expression invaginal tissue than premenopausal women. Women with no endocrine treatment showed a lower amount of ER β expression in vaginal tissue.

9. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine



Thursday, June 23, 2016

The Smoothie of Green tea, Orange and Apple for Reduced Risk and Treatment of Cirrhosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of Cirrhosis
Yield: 2 servings (about 8 ounces each)
1  cup tomato
1/2 cup grape
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of Cirrhosis considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine . Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Cirrhosis is a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(1). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.

According to the studies reported by some respectable institutions, Green tea may process the anti Cirrhosis effects through expression antixiodant effects. Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.        . 

According to the study lead by Dr. Safer AM, Green Tea Extract (GTE) encapsulated into Chitosan Nanoparticles (CS-NPs) removed all the extracellular collagen caused by CCl4, a ligand for the primary human immunodeficiency virus type 1 (HIV-1) in the hepatic fibrosis rat liver(2).
In animal model, Chitosan Nano-Encapsulated Green Tea expressed the healing ratio of heals nearly 25% of the sub-cellular area infected with hepatic fibrosis(3),
In the study of liver disease with green tea consumption, by searching the data bases of PubMed, CNKI, Wanfang and Weipu, Zhujiang Hospital of Southern Medical University Guangzhou firmly suggested the effectiveness of green tea in reduced risk of liver disease. However, more long term randomized clinical trials are needed to comprehensively evaluate the health benefits(4).

Naringenin, an phytochemical found in Citrus fruits, including orange attenuated the expression of liver fibrosis by exhibiting antioxidant and anti-inflammatory activities(5).
According to the Annamalai University, application of naringenin promoted the expression of therapeutic potential in the abatement of ethanol-induced hepatotoxicity by reduced the toxic levels, including serum aspartate and alanine transaminases, gamma-glutamyl transpeptidase, tissue thiobarbituric acid reactive substances(6).
Furthermore, According to dr. Hermenean A and research team at the Vasile Goldis Western University of Arad, the flavonoid naringenin (NGN), exerted antioxidant and hepatoprotective effects  against injuries induced by CCl4, a natural ligand for the primary human immunodeficiency virus type 1 (HIV-1)(7).

Flavonoids, a group of plant phytochemicals found abundantly in apple may consist a numbers of health benefit through its effects in cell signalling pathways and antioxidant activity. According to the Chinese study, flavonoids, attenuate the risk of thioacetamide-induced hepatic fibrosis through mechanism  related to the down-regulation of the protein expressions of TGF-β1 in controlling the expression of proliferation, differentiation, and Caspase-3 in cell apoptosis(8).
The phytochemical , flavonoids found in the the extracts of pomegranate peels (EPP) and seeds (EPS) also exerted the protective effects against liver fibrosis induced by CCl4, through restored the decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and inhibited the formation of lipid peroxidized products(9).
Dr. Yuan LP and colleagues at the College of Pharmacy, Anhui Medical University said,"(the) total flavonoids of Bidens bipinnata L.b was able to ameliorate liver injury and protect rats from CCl4-induced liver fibrosisby suppressing oxidative stress" through " inhibiting the induction of NF-kappaB (proinflammatory signaling pathway) on hepatic stellate cell activation and the expression of TGF-beta1 in controlling cells proliferation, differentiation"(10).

The combined ingredient found in green tea, orange and apple may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of Cirrhosis .
People who are at increased risk of Cirrhosis due to family history, genetic mutation,... should drink at least one serving daily and people with Cirrhosis should drink as much as they can, depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References
(1) Center for Diseases control and Prevention(CDC)
(2) Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic Fibrosis Collagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model by Safer AM, Hanafy NA, Bharali DJ, Cui H, Mousa SA.(PubMed)
(3) Quantification of the Healing Effect in Hepatic Fibrosis Induced by Chitosan Nano-Encapsulated Green Tea in Rat Model by Safer AM, Sen A, Hanafy NA, Mousa SA.(PubMed)
(4) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)
(5) Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation by Karuppagounder V1, Arumugam S1, Thandavarayan RA2, Pitchaimani V1, Sreedhar R1, Afrin R1, Harima M1, Suzuki H1, Suzuki K3, Nakamura M4, Ueno K5,Watanabe K6.(PubMed)
(6) Potential beneficial effect of naringenin on lipid peroxidation and antioxidant status in rats with ethanol-induced hepatotoxicity by Jayaraman J1, Veerappan M, Namasivayam N.(PubMed)
(7) Antioxidant and hepatoprotective effects of naringenin and its β-cyclodextrin formulation in mice intoxicated with carbon tetrachloride: a comparative study by Hermenean A1, Ardelean A, Stan M, Hadaruga N, Mihali CV, Costache M, Dinischiotu A.(PubMed)
(8) [Inhibitory effect of flavonoids from Glycyrrhiza uralensis on expressions of TGF-β1 and Caspase-3 in thioacetamide-induced hepatic fibrosis in rats].[Article in Chinese] by Jing J, Zhao JY, Hua B, Xue MQ, Zhu YF, Liu G, Wang YH, Peng XD.(PubMed)
(9) Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats by Wei XL1,2, Fang RT3, Yang YH4, Bi XY1, Ren GX2, Luo AL2, Zhao M5, Zang WJ6.(PubMed)
(10) Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats by Yuan LP1, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ.(PubMed)

Wednesday, June 22, 2016

The Tasty smoothie of Olive, Tomato and Artichoke in Reduced Risk and Treatment of Hay Fever

Kyle J. Norton(Scholar, master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for Reduced risk and Treatment of Hay fever
Yield: 2 servings (about 8 ounces each)
1/4 cup olive
1 cup tomato
1/4 cup artichoke
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of infectious skin diseases, such as  Impetigo, without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard because of not achieving the same potent results in human trials.

Hay fever is also known as allergic rhinitis, is a collections of many signs and symptoms similar to a cold with sneezing, watery, as a result of allergic effect, including dust, dander, insect venom, pollen, etc.

Scientist community may have found the smoothie(combined ingredients of olive, tomato and artichoke ) with potential and therapeutic value for reduced risk and treatment of Hay fever without adverse effects.

Omega 3 fatty acids, found abundantly in olive may process the magic in reduced risk allergic disease inducing Hay fever, according to the The University of Adelaide(1).
Dr. Hageman JH and colleagues at the Wageningen University, although epidemiological studies linking intake of Omega fatty acids in reduced risk of allergic disease with conflict results, Three well known randomized controlled trials showed that providing LCPUFA during infancy or childhood reduced allergy and/or respiratory illness while one found no effect(2).
In support of above validation, the Lebanese University study suggested, maternal diet during pregnancy and a childhood diet rich in antioxidants and omega-3 fatty acids are considered as healthy diets that could be protective for allergic diseases in childhood(3).

Silymarin, a powerful phytochemical found in Artichokes may be another ingredient used for treatment of Hay Fever. According to the Mashhad University of Medical Sciences, intake of silymarin alleviated the severity of allergic rhinitis symptoms through regulating the serum IgE, and interleukin (IL-4, IL-5, interferon-γ) levels(4).

Carotenoid found abundantly in tomato may also be potential in reduced risk and treatment of Hay fever. According to the Institute of Epidemiology,in adulthood, high concentration of plasma of crotentoid level is associated to a protective effect on allergic rhinitis(5)(6).
In the Bingöl State Hospital study, imbalance of vitamins A and E measured as enzymatic and non-enzymatic antioxidants and oxidative stress played an essential role in the etiopathogenesis of allergic rhinitis(7).

The Smoothie of Olive, Tomato and Artichoke  may hold a key for further studies in production of
a curable natural remedy for prevention and treatment of  Hay Fever
People who are at  increased risk of  Hay Fever due to family history,weaken immunity,....should drink at least one cup or more daily. People with hay fever may drink as much as they can, depending to the digestive toleration.

References
(1) Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood by Gunaratne AW1, Makrides M, Collins CT.(PubMed)
(2) The impact of dietary long-chain polyunsaturated fatty acids on respiratory illness in infants and children by Hageman JH1, Hooyenga P, Diersen-Schade DA, Scalabrin DM, Wichers HJ, Birch EE.(PubMed)
(3) Diet and allergic diseases among population aged 0 to 18 years: myth or reality? by Saadeh D1, Salameh P, Baldi I, Raherison C.(PubMed)
(4) Effect of silymarin in the treatment of allergic rhinitis by Bakhshaee M1, Jabbari F, Hoseini S, Farid R, Sadeghian MH, Rajati M, Mohamadpoor AH, Movahhed R, Zamani MA.(PubMed)
(5) Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisation in adults by Kompauer I1, Heinrich J, Wolfram G, Linseisen J.(PubMed)
(6) Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries by Olmedilla B1, Granado F, Southon S, Wright AJ, Blanco I, Gil-Martinez E, Berg H, Corridan B, Roussel AM, Chopra M, Thurnham DI.(PubMed)
(7) [Oxidative stress and antioxidant factors in pathophysiology of allergic rhinitis].[Article in Turkish] by Akbay E1, Arbağ H, Uyar Y, Oztürk K.(PubMed)

Tuesday, June 21, 2016

The Smoothie of Green Tea, Peanut and Grape for Reduced Risk and Treatment of Malarial nephropathy and Malaria induced by Malaria Parasite

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Malarial nephropathy
Yield: 2 servings (about 8 ounces each)
1/ 2 cup peanut
1 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Malarial nephropathy  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Malarial nephropathy is a condition of renal and renal-related disorders commonly occur in infection with Plasmodium falciparum and P. malariae.  Falciparum malaria causes fluid and electrolyte disorders, affecting mostly people in tropics. The disease may cause chronic glomerulopathy, leading to end stage of renal failure. Most case of Malarial nephropathy is a result of Plasmodium falciparum cause of kidney infection(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study led by the Chiang Mai University, green tea extract (GTE) used conjunction with 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) inhibited the growth of malaria parasite Plasmodium falciparum(2).
Dr.Patil PR and colleagues at the University of Siena, said, "the anti-adhesive property of (+)-EGCG against a new panel of ICAM-1-binding patient isolates of P. falciparumshowed that this inhibitor, identified as potential mimic of the L43 loop of human ICAM-1, was effective at blocking cytoadherence"(3).
Furthermore, EGCG also inhibited the formation of MSP2 fibrils, one of the most abundant proteins on the surface of Plasmodium falciparum merozoites(4).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in peanuts and grape, may also exhibited anti Antimalarial activity against parasites, according to the Wonkwang University Sanbon Medical Center(5).
The The Walter and Eliza Hall Institute of Medical Research study also suggested that resveratrol may inhibit MSP2 fibrillogenesis, a glycosylphosphatidylinositol (GPI)-anchored protein expressed abundantly on the surface of Plasmodium falciparum merozoites(6).
furthermore, resveratrol isolated from the leaves of Parthenocissus tricuspidata (Vitaceae) expressed significant antiplasmodial activity(7).

The combination of Green Tea, Peanut and Grape smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Malarial nephropathy and Malaria induced by Malaria Parasite  without inducing adverse effects.

People who are at increased risk of Malarial nephropathy and Malaria induced by Malaria Parasite  due to weaken immunity, family history .....should drink at least one cup daily and people with Malarial nephropathy and Malaria induced by Malaria Parasite  should drink the juices at least 4 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

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References
(1) A female patient with malarial nephropathy by Kanda E1, Kida Y, Suzuki H, Ando M, Negishi M, Sasaki S, Saito H.(PubMed)
(2) Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) andgreen tea extract on growth of Plasmodium falciparum by Thipubon P1, Uthaipibull C2, Kamchonwongpaisan S3, Tipsuwan W4, Srichairatanakool S5.(PubMed)
(3) Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate by Patil PR1, Gemma S, Campiani G, Craig AG.(PubMed)
(4) EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2 by Chandrashekaran IR1, Adda CG, Macraild CA, Anders RF, Norton RS.(PubMed)
(5) Antimalarial activity in mice of resveratrol derivative from Pleuropterus ciliinervis by Moon HI1, Sim J.(PubMed)
(6) Inhibition by flavonoids of amyloid-like fibril formation by Plasmodium falciparum merozoite surface protein 2 by Chandrashekaran IR1, Adda CG, MacRaild CA, Anders RF, Norton RS.(PubMed)
(7) Antiplasmodial activity of novel stilbene derivatives isolated from Parthenocissus tricuspidata from South Korea by Son IH1, Chung IM, Lee SJ, Moon HI.(PubMed)

Monday, June 20, 2016

The Smoothie of Cooked Tomato, Peanut and Olive for reduced risk and Treatment of Juvenile nephronophthisis(polycystic kidney disease (Renal cystic disease)


 Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of  Juvenile nephronophthisis
Yield: 2 servings (about 8 ounces each)
3/4 cup carrot
1/2 dulse
1 cup avocado drink

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Juvenile nephronophthisis is an inherited autosomal recessive disease, inducing multiple cysts at the corticomedullary junction and medulla in Juvenile around age of 13. According to Dr. Wolf MT, Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the most common genetic disorders causing end-stage renal disease (ESRD) in children and adolescents(*).Therefore, smoothie with ingredients of Cooked Tomato, Peanut and Olive showed effectively in treatment of polycystic kidney disease, through clinical trials and studies, may also induce significant effect for treatment of Juvenile nephronophthisis.


The smoothie for prevention and treatment of  Juvenile nephronophthisis(polycystic kidney disease (Renal cystic disease))
Yield: 2 servings (about 8 ounces each)
3/4 cup cooked tomato
1/2 cup peanut
1/4 cup olive
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Polycystic kidney disease (Renal cystic disease) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Polycystic Kidney Disease is an inherited diseases with fluid-filled cysts developed on the kidney. According to the University of Kansas Medical Center, the disease is associated to risk factors of aging, in older persons with multiple cysts probably induced by potassium deficiency, congenital disorders, metabolic diseases, and toxic renal injury(1).

Recent studies back by well known institutions proposed, Cooked Tomato, Peanut and Olive may be the next generation of natural ingredients for reduced complications and treatment of Polycystic kidney disease.

Vitamin B3 , also known as niacin, is a water-soluble vitamin.Vitamin B3 found abundantly in peanut may benefit patient with polycystic kidney disease(2). According to C.J. Janovy, administration of Vitamin B3 to a neonate, toddler or adolescent will effectively prevent or delay cyst formation and can be used for a lifetime(2).
Dr. Al Adlouni A and Dr. Hertig A. Said, "Vitamin B3 exhibited anti  autosomal dominant effect  involed the develop of polycystic kidney disease"(3).

Omaga 3 fatty acids found abundantly in flax seed also attenuated the progression of polycystic kidney disease, through alternation of multiple steps in PKD pathogenesis(4). According to the University of Guelph, mice fed with an n-3 fatty acid-enriched diet (MaxEPA) for 60 days, showed a marked decrease in the proportion of kidney area occupied by cysts in male but not in female rat(5).
Dr. Yamaguchi T and colleagues in the study led by the University of Manitoba, said,"Dietary flax oil may therefore reduce disease progression via mitigation of oxylipin abnormalities"(6) in patients with renal diseases.

Retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) with function as of vitamin A suppressed the activation of the poly cystic kidney disease-1 (PKD1) promoter in's attenuated the diseases' progression(7). 
 Dr.Yamane A and professors at the Gunma University Graduate School of Medicine, said," A 63-year-old APL patient, complicated by Child-Pugh class A liver cirrhosis and polycystic kidney (creatinine 3.2 mg/dL), was successfully treated with 45 mg/m(2)/day of all-trans retinoic acid (ATRA)"(8).

The effectiveness of  Cooked Tomato, Peanut and Olive may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of polycystic kidney disease (Renal cystic disease) with little or no adverse effects.

 Juvenile who are at high risk of nephronophthisis (polycystic kidney disease (Renal cystic disease)) due to aging, weaken renal function... should drink at least one serving daily and  Juvenile with nephronophthisis (polycystic kidney disease (Renal cystic disease)) should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.



Refeneces
(* ) Nephronophthisis and related syndromes by Wolf MT1.(PubMed)
(1) Polycystic kidney disease: etiology, pathogenesis, and treatment by Martinez JR1, Grantham JJ.(PubMed)
(2) Vitamin B3 holds promise for treating polycystic kidney disease, research suggests, June 17, 2013
By C.J. Janovy
(3) [Vitamin B3 to prevent autosomal dominant polycystic kidney disease].[Article in French] by Al Adlouni A1, Hertig A2.(PubMed)
(4) Evidence for a role of proteins, lipids, and phytochemicals in the prevention of polycystic kidney disease progression and severity by Maditz KH1, Gigliotti JC, Tou JC.(PubMed)
(5) Effects of dietary supplementation with n-3 fatty acids on kidney morphology and the fatty acid composition of phospholipids and triglycerides from mice with polycystic kidney disease by Yamaguchi T1, Valli VE, Philbrick D, Holub B, Yoshida K, Takahashi H.(PubMed)
(6) Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis by Yamaguchi T1, Devassy JG1, Gabbs M2, Ravandi A3, Nagao S4, Aukema HM5.(PubMed)
(7) Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter by Islam MR1, Puri S, Rodova M, Magenheimer BS, Maser RL, Calvet JP.(PubMed)
(8) Successful treatment by all-trans retinoic acid in a patient with acute promyelocytic leukemia complicated by liver cirrhosis and polycystic kidney by Yamane A1, Tsukamoto N, Saitoh T, Uchiumi H, Handa H, Karasawa M, Nojima Y, Murakami H.(PubMed)

Sunday, June 19, 2016

The Smoothie and Green tea and Artichoke for Prevention and Treatment of Vitiligo

Kyle J. Norton (Scholar, and Master of nutrients) All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Imaging of long term intake of delicious smoothies loved by many with the power of reduced risk and treatment of chronic illness with no one mentions about.  Epidemiological studies with strong evidences suggested that blueberry oral administration hold a potential with therapeutic values for reduced risk of women who carry the mutation gene and treatment of breast cancer(*).

The curable smoothies are collection of recipes produced from natural sources, including organic fruits and vegetables, and some herbs which have been proven effectively for reduced risk and treatment for diseases and syndromes by scientific research of clinical trials and/or studies.

The finding of foods from natural sources has been a dream of scientists and scholars since ancient time. Socrates Said," Let foods be your medicine and let medicine be your foods". Let all of us all exercise the values of the past wisdom to build a letter living and living health while enjoining these delicious drinks.

The smoothie for Prevention of the Early Onset and Treatment of vitiligo

Yield: 2 serving (about 8 ounce each)
1/2 cup cooked artichoke
2 cups green tea drink (Make from 8 grams(4 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Recent studies by some renowned institutions suggested that green tea(1) and artichoke may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of psoriasis.

Vitiligo is a condition with the loss of skin color in blotches caused the death of melanocytes or or melanocytes has stop producing melanin.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study lead by the The Third People's Hospital of Hangzhou, EGCG administration was significantly associated with a decreased risk of vitiligo, through its effects on proinflammatory cytokines and inflammatory mediators(1).
In support to the effectiveness, the University of Freiburg study insisted, green tea, one of many plant containing antioxidant polyphenolic compounds may process the therapeutic values for prevention and treatment of Vitiligo(3).

Additionally, Dr. Ning W abd colleadues in the investigation of the effect of EGCG, suggested, green tea inhibited Vitiligo through directly inhibited the kinase activity of Janus kinase 2 (JAK2) in cell division by attenuated interferon (IFN)-γ, the immune mediator of inflammation(2).

Silymarin, a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes,  according to the Dr. Sehgal VN. may have a potential value for established therapeutic ingredient for
progressive vitiligo in children(4), when it is used conjunction with topical Tacrolimus.
In reinforcement of the effect of Silymarin, Feily A, Namazi MR. suggested that silymarin may be as a potential novel addition to the limited anti-vitiligo weaponry(5).

Taking altogether, The combination of green tea and artichoke may offer the potential effect not only in prevention of the onset and but also in treatment of Vitiligo.
 People with increased risk of vitiligo are wise to drink at least one serving daily. People with vitiligo, should drink the juice as much as they can, depending to the toleration of digestive system.


References
(1) The therapeutic effects of EGCG on vitiligo by Zhu Y1, Wang S1, Lin F1, Li Q2, Xu A3.(PubMed)
(2) Epigallocatechin-3-gallate (EGCG) Suppresses the Trafficking of Lymphocytes to Epidermal Melanocytes via Inhibition of JAK2: Its Implication for Vitiligo Treatment by Ning W1, Wang S, Dong X, Liu D, Fu L, Jin R, Xu A.(PubMed)
(3) Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications.[Article in English, German] by Reuter J1, Wölfle U, Korting HC, Schempp C.(PubMed)
(4) Role of tacrolimus (FK506) 0.1% ointment WW in vitiligo in children and imperatives of combine therapy with Trioxsalen and Silymarin suspension in progressive vitiligo by Sehgal VN.(PubMed)
(5) Silymarin as a potential novel addition to the limited anti-vitiligo weaponry: an untested hypothesis by Feily A, Namazi MR.(PubMed)