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Tuesday, December 10, 2019

Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Progression of Atherosclerosis

Recent study suggested that patients with atherosclerosis may be benefits from adding aged garlic extract with supplement into their diet.

According to the UCLA-School of Medicine, Los Angeles, the effectiveness of garlic in reduced homocysteine and progression of Atherosclerosis is the result of the changing white (wEAT) and brown (bEAT) epicardial adipose tissue(a form of visceral fat deposited around the heart) in plaque stabilization.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.


Atherosclerosis is a disease in which plaque builds up inside the arteries affecting the levels of oxygen in the blood as well as increased risks of heart attacks, strokes, and peripheral vascular disease.

In a placebo-controlled, double-blind, randomized trial (conducted 2005-2007), with 65 intermediate-risk patients (age 60+/-9 years, 79% male), patients treated with a capsule containing aged garlic extract (250 mg) plus Vitamin B12 (100 microg), folic acid (300 microg), Vitamin B6 (12.5 mg) and l-arginine (100 mg) daily for a 1 year are found to associate with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.

(AGE) has shown to retard the progression of coronary calcification in patients with coronary artery disease in vitro and vivo,


Dr. Morihara N, the lead author at the joint study said, " Antiatherosclerotic activity of AGE is at least partly due to the suppression of inflammation and lipid deposition in the vessels during the early stage of atherosclerotic development".

In a total of 157 healthy postmenopausal women (age 65 ± 6) randomized study, 500 mg isoflavonoid-rich herbal preparation, including garlic powder, showed to reduce risk of cardiovascular disease and atherosclerosis progression through lowering high blood cholesterol.

Although garlic prevents the development of cholesterol-induced experimental atherosclerosis and possesses direct anti-atherogenic activity, the intake of garlic supplements should be taken with care to patients with an ulcer.


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Sources
(1) Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis by Ahmadi N1, Nabavi V, Hajsadeghi F, Zeb I, Flores F, Ebrahimi R, Budoff M.(PubMed)
(2) Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial by Budoff MJ1, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S.(PubMed)
(3) Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice by Morihara N1, Hino A2, Yamaguchi T3, Suzuki J3.(PubMed)
(4)
(5) Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits by Sobenin IA1, Andrianova IV2, Lakunin KY3, Karagodin VP4, Bobryshev YV5, Orekhov AN6.(PubMed)

Green beans, the Anti-Hyperglycemic Remedy

Hyperglycemia is a condition of abnormally high blood sugar in the bloodstream, inducing diabetic complications in patients with type 2 diabetes.

In order words, hyperglycemia is a result of the body which does not properly use or make the hormone insulin.

The condition is also considered a hallmark of patients with type 2 diabetes. Another hallmark is insulin resistance.

Hyperglycemia occurs mostly due to poor control and management in patients with diabetes such as
a poor diet, physical inactivity choices, symptoms of medicines intake.

Some patients with diabetes also experience symptoms of hyperglycemia due to skipping or not taking enough glucose-lowering medication.

The most common symptoms of hyperglycemia are frequent urination, increased thirst, blurred vision, persistent fatigue, and headache.

According to the epidemiological studies, untreated or long term persistently hyperglycemia in patients with diabetes has been found to induce serious symptoms such as shortness of breath, and confusion.

In serious cases, untreated hyperglycemia also induces long-term complications of cardiovascular disease, nerve damage associated with skin infections, and ulcerations.

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belonging to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. The veggie can be classified into two major groups, bush beans, and pole beans.

On finding a potent veggie for the prevention of hyperglycemia, researchers examiend the effects of bean extract on overexpression of free radicals and higher reactive oxidative species (ROS) production induced high blood glucose.

The randomized controlled trial (RCT) study included mice (Micetus norvegicus) of Wistar strains randomized in five groups: P1-negative control, positive P2-control, P-3 ethanol extract group of 200mg / kg BW, P4-group 400mg / kg BW, P5- group 600 mg / kg BW.

According to the differences in blood sugar levels and superoxide enzyme levels of intergroup dismutase, ethanol extract of green beans 600 mg/kg BW from day 14 to day 28 (p <0.05) showed a statistically significant decrease in blood glucose levels.

However, ethanol extract of green beans 200 mg/kg BW and 400 mg / kg GB from day 7 until day 28 (p> 0.05) did not have any effect on the decreasing blood glucose in the tested rats.

The tested ethanol extract of green beans showed no effect on the levels of activity of the superoxide dismutase enzyme (p = 0.830).

In other words, green bean extract inhibited the expression of hyperglycemia without affecting the levels of antioxidant enzymes produced by the host at a dose depending manner.

Based on the findings, researchers said, "Giving ethanol extract of green beans 600 mg/kg BW effectively decrease blood sugar in male Wistar mice (Micetus norvegicus) from day 14 to day 28".


Taken altogether, green beans may be used as an adjunct therapy for the prevention of diabetes by inhibiting the expression of hyperglycemia, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Bean Ethanol Extract (Phaseolus Vulgaris L.) on Superoxide Dismutase Activity in Wistar Mice (Micetus Norvegicus) Hyperglycemia by Ade Putra Fratama Sinaga1), Syafruddin Ilyas2), Dwi Rita Anggraini.

Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period

Fennel may have a potential and therapeutic effects in improved milk secretion, some scientists suggested.

Galactogenisis is a function in promoted lactation in milk insufficient feeding baby's women.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In the finding, the natural sources for answer of the question of produced enough milk in women who face challenges in their efforts to breast-feed their infants, researchers at the CANADIAN JOURNAL OF MIDWIFERY RESEARCH AND PRACTICE conducted a study of a total of 23 women at one to four months postpartum to share their experiences with childbirth and postpartum self-care, suggested that out of 23 women interviewed, 4 women reported insufficient milk supply and 11 women showed an improvement of lactation by using galactagogue substances, including herbal medicine fennel.

According to the survey returned from these participants, four women used fennel seed or oil, and all considered herbal products was effective as a galactagogue. One learned about it from a friend, two from their midwives, and one from her mother who used it herself while breastfeeding.



These results suggested that herbal medicine including fennel may process a significant benefit in increased milk production but Dr. Rachel Emma Westfall, Ph.D. suggested that further investigation is necessary to validate this viability.

Although the mechanism in enhanced lactation effects of fennel seeds acting as galactagogues are little known, some scientists postulated that the result of fennel in increased milk secretion was attributed to the phytochemical anethole in the expression of estrogenic property.



Anethole, the main constituent of the essential oils of fennel and anise, has been considered as an active estrogenic agent by the actual pharmacologically active investigation.

Truly, according to the Cochrane Pregnancy and Childbirth Group, in the evaluation of the fennel effect in increased milk production breastfeeding mothers suggested that anethole, the major bioactive compound isolated from fennel is considered weakly estrogenic agent and may increase breast milk production or assist with the ‘let-down’ reflex, through enhanced function of hormone oxytocin.


These results suggested that fennel as galactagogues may improve milk production by working, either directly or indirectly, on the hormonal pathways that control lactation.



In other words, the application of fennel restored the function of hormone prolactin in the induction of milk formation and hormone oxytocin produced by the pituitary gland with function to contract special muscle cells around the alveoli in the breast to ensure the expulsion of milk.


To ensure these processes continued without interruption, the application of fennel seed also rebalance the hormone secretion by preventing the overproduction of estrogen and progesterone in reduced expression of the hormone prolactin in inhibited milk production. according to the results in animal models.


By blocking serum of estrogen and progesterone in blood circulation, fennel seed ensured that the pituitary gland continuously releases of prolactin in stimulated mammary gland cells in the secretion of milk.

Some researchers suggested the function of fennel in facilitated milk formation and secretion may also be as a result of increasing numbers of milk-secreting cells during the lactation state caused by sucking of the young by enhancing the growth of mammary alveolar growth, prolactin, or both.
Today, even with extensive researchers, there is little known about the mechanisms of fennel seeds in the enhanced production of milk during the lactation period. Some researchers concerned that overdoses of fennel seeds may cause potential adverse effects since dosages for galactagogues are mostly unquestioned and untested.


Taken together, fennel seeds may have a potential effect as galactogenic herbal medicine in increased milk formation and production. However, further study with a large sample size conducted by multi centers is necessary to re-confirm its viability scientifically.


For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Galactagogue Herbs: A Qualitative Study and Review by Rachel Emma Westfall, PhD(Journal of Midwifary) file:///C:/Users/hhh/Downloads/v2n2_westfall_galactagogue-herbs.pdf
(2) Oral galactagogues for increasing breast-milk production in mothers of non-hospitalised term infants by Siew Cheng Foong, May Loong Tan, Lisa A Marasco, Jacqueline J Ho, Wai Cheng Foong(Cochrance Library)

Ginger, the Kitchen Spice Which Suppresses the Onset and Progression of Rheumatoid Arthritis

Ginger may have a potential effect in the prevention and treatment of rheumatoid arthritis, some scientists suggested.

Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with immune system mistakenly attacks the joint tissue.

According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.

As of today, researchers do not know what trigger the immune system makes antibodies that attack the joint tissue. Why people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.

However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.

In fact, lifestyle is some preventable risk factors which have been found to elevate the risk RA in the Western world.

Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.

The Doctor team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".

And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.

These results indicated a significant change of RA risk just by quitting cigarette smoking.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.

Application of Z. officinale extract at the doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.

Continued administration for 26 days Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.

The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critic role in facilitating the onset of low-grade inflammation.

The extract also reduced the immune system in the production of an antibody against the joint tissue.

Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.

Dr. Fouda AM, at the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".

In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.

Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.

Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.


Further analysis suggested that the protective effects of GTaq are attributed to increasing food intake and decreasing the systemic inflammation and antioxidant activity in the inhibition of oxidative stress.

The finding supported the use of ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)

Monday, December 9, 2019

Green Beans Induce Weight Loss and Reduces Risk of CVD in Obese

Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 is considered overweight and a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, and over 650 million were obese worldwide.

The most common causes of obesity are associated with an increased intake of energy-dense foods that are high in saturated and trans fat, processed foods and red meat and physical inactivity.

The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".

Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition and use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants or some seizure medications, also increases the risk of overweight and obesity.

Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.

According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015, compared to women.

Believe it or not, more than 63),000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.

On another hand, stroke is a medical condition caused by poor blood flow to the brain, leading to brain cell death in the affected region.

Dr. Luma Akil, the lead scientist in the investigation of the risk of CVD in obese wrote, "Obesity is among the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. In the present study, the associations between the increase in body mass index (BMI) and the increasing rates of CVD and high blood pressure (HBP)".

And, " Data from Behavioral Risk Factor Surveillance System were obtained and analyzed for obesity rates, percent of myocardial infarction, stroke, and HBP from 2005–2009".

In other words, if you are obese, your risk CVD are substantially higher compared to non-obese individuals

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent whole food which process anti-anti-obesity activity, researchers examined the effect of edible dry bean consumption (Phaseolus vulgaris L. including green beans) modulates diet-induced obesity in rats and mice.

Sprague-Dawley rats and a diet-induced obesity model in C57Bl/6 mice included in the Vivo suggested, cooked dry bean showed a positive modulation of plasma lipids and hepatic proteins that involves in lipid biosynthesis.

In both animal species, short-term feeding of a bean-containing diet demonstrated a reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG associated with the target of cholesterol catabolism and excretion.


More importantly, bean-fed obese mice displayed a significant weight loss within a 12 d time frame.

In other words, dry beans injection in a short-term of 7-14 day ) not only had a strong effect on weight regulatory effects but also exerted a cardioprotective against CVD obese mice.

Taken altogether, green beans or other dried beans may be used as an adjunct therapy for the prevention of cardiovascular disease, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ. (PubMed)
(2) Relationships between Obesity and Cardiovascular Diseases in Four Southern States and Colorado by Luma Akil, PhD-C, Candidate and H. Anwar Ahmad, Ph.D., MBA, MCIS. (PMC)

Eggplant, the Potential Anti Diabetes Functional Food

Eggplant may be considered a functional food for the prevention and treatment of type 2 diabetes, some scientists suggested.

Diabetes is a chronic and medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Insulin resistance, a hallmark for the early onset of the diseases is caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

People with insulin resistance, the pancreas has to work overtime to deploy greater amounts of the hormone to keep cells energized and blood glucose levels under control. However, al longterm overworked pancreas can lead to reduced function of pancreatic beta cells in making insulin. These results eventually cause damage to the pancreas impaired function that no longer produces enough insulin to overcome the cells' resistance.

Cholesterol may be necessary for the body to function properly, however, the impaired ratio of lower density and high-density lipoprotein only cause cholesterol plague built upon the walls of arteries but also can clog up the insulin receptor sites, leading to the spike of blood glucose.


People who follow the Western diet with high on saturated and trans fat, red meat, processed food and less in fruits and vegetables and whole grains are associated with increased risk of type 2 diabetes caused by clogging up on the insulin receptors.


Please make sure that you maintain a healthy total blood cholesterol ratio of 4 (low-density lipoprotein, LDL) to 1 (high-density lipoprotein, HDL).


In other words, insulin produced by the pancreas still binds to the receptor normally, but the signal is not sent into the cell, the cells do not take up glucose and the resulting high blood glucose levels cause organ damage over time.

In some cases, acute high blood glucose can also be caused by an allergic reaction of the cells in the immune system.

Some researchers suggested that these may be a result associated with the use of OTC or prescription nasal spray, containing steroids. People with diabetes should be aware that steroids can stimulate the liver to make more glucose.

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in season.

In the reaffirming of the National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association recommendation that eggplant-based diet as a choice for the management of type 2 diabetes, researchers launched an investigation to examine the phenolic-linked antioxidant activity and alpha-glucosidase inhibitory potential of eggplant which could reduce hyperglycemia-induced pathogenesis.
At the end of the experiment, researchers found that

* Phenolic-enriched extracts of eggplant process a moderate free radical scavenging-linked antioxidant activity and high angiotensin I-converting enzyme (ACE) inhibitory activity that plays an essential role not only prevent high blood pressure but also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.


* The extracts also had a high alpha-glucosidase inhibitory activity which prevents the digestion of carbohydrates

The inhibition of these enzymes provides a strong biochemical basis for the management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively.
Dr. the lead author wrote, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".

Additionally, in the examine the anti-diabetes effect of chlorogenic acids (CGAs) received considerable attention for their wide distribution and part of the human diet with potential biological effects, researchers launched an investigation to examine CGAs found in eggplant.

At the end of the experiment, researchers found that

* Coffee is among the highest found in plants, ranging from 4 to 14%.of chlorogenic acids (CGAs) compared to eggplant
* CGA besides processes strong antioxidant and anti-inflammatory effects, it also plays an important role in glucose and lipid metabolism regulation and on the related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.

Dr. the lead author after taking into account ac and confounders said, " The wide range of potential health benefits of CGA, including its anti-diabetic, anti-carcinogenic, anti-inflammatory and anti-obesity impacts, may provide a non-pharmacological and non-invasive approach for treatment or prevention of some chronic diseases".

Taken altogether, eggplant may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of diabetes without inducing adverse effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the eggplant or its bioactive compounds during the course of the disease will be necessary to complete the picture of eggplant anti-diabetes possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.




References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ. (PubMed)
(3) The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature by Tajik N1, Tajik M2, Mack I1, Enck P. (PubMed)

The Testosterone Booster Whole Food Medicine?

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure, cholesterol, natural antibiotic, etc.

Garlic may be the next generation of natural testosterone reducer or inducer? High level of testosterone may alter the balance between ROS production and antioxidant defenses of that induce testicular antioxidants and free radicals, including glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) and ameliorate the reduction in testosterone levels.


Dr. Prasad S lead research at the Industrial Toxicology Research Centre, diallyl sulfide (DAS), a constituent of garlic, exerted antioxidant activities against testosterone-induced oxidative stress in male Swiss albino mice, by significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation.


The effects of garlic supplementation on protein metabolism also suggested that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high protein diet.

Overproduction of testosterone may associate to increase the risk of prostate cancer, caused by an imbalance of free radicals and antioxidants.

According to the Tunis El Manar University, intake of garlic impacted on the male reproductive system by the increased number of tubules deprived of spermatozoa. In addition, garlic fractions induced apoptosis of testicular gem cells.

In fact, like all-natural phytochemicals, garlic is both a testosterone booster and testosterone reducer, depending on the levels of testosterone in the body and amount of garlic intake.


Conflicting results have been found between total testosterone and subsequent prostate cancer, probably due to conflicting study designs, definitions, and methodologies. Therefore, the use of garlic in increasing sexual desire should be taken with care.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis by El-Akabawy G1, El-Sherif NM2.(PubMed)
(2) Effects of garlic fractions consumption on male reproductive functions by Hammami I1, Nahdi A, Atig F, Kouidhi W, Amri M, Mokni M, May AE, May ME.(PubMed)
(3) Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action by Hammami I1, Amara S, Benahmed M, El May MV, Mauduit C.(PubMed)
(4) The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding by Hammami I1, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV.(PubMed)
(5) Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice by Prasad S1, Kalra N, Shukla Y.(PubMed)
(6) Testosterone and oxidative stress: the oxidation handicap hypothesi by Carlos Alonso-Alvarez,1,* Sophie Bertrand,1 Bruno Faivre,2 Olivier Chastel,3and Gabriele Sorci1,2(The Royal Society Publicizing)
(7) https://www.stronghealthtips.com/garlic

Fennel, A Potent Functional Food for Treatment of Infantile Colic



Fennel may have a profound and positive effect on the reduced risk of infantile colic, some scientists suggest.

Infantile colic is a reaction of the infant if episodes of crying for more than three hours a day, for more than three days a week, for three weeks in an otherwise healthy child. The condition has a strong impacted on psychological, emotional, and physical burden to parents.


Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)


In a randomized, double-blind, placebo-controlled trial to investigate the effectiveness and side effects of phytotherapeutic agent with Matricariae recutita, Foeniculum vulgare and Melissa officinalis in treatment of infantile colic in a total of the 93 breastfed colicky infants conducted by the John Wiley & Sons, Ltd, after a 3 day observation period, the infants randomly assigned to groups treated with phytotherapeutic agent (PA) and group received placebo twice a day for 1 week, researchers found that crying time in group received PA was reduced substantially in 85.4% of subjects in compared to 48.9% subjects in placebo group against baseline.


PA treatment group exerted no side effects during the period of the experiment.

Base on the result, researchers suggested that PA demonstrated a significant activity within one week of application in infantile colic.



Furthermore, the St. Petersburg Medical Academy of Postdoctoral Education in the concerns of the side effects of 5% of infants treated with dicyclomine hydrochloride, the only pharmacological treatment for infantile colic, with substantial side effects, including death, conducted a randomized placebo-controlled trial of 125 infants, 2 to 12 weeks of age from 2 large multi-specialty clinics by assigned them to either group treated with fennel or placebo, indicated that fennel treatment group improves the crying time episodes and frequency significantly in compared to the placebo group.



According to the Wessel assay, infantile colic was reduced by 65% (40/62) in the treatment group in compared to only 23.7% (14/59) in placebo.


Further analysis also found that the application of fennel induced a risk reduction of 41% in compared to placebo without causing any side effects.


Although the causes of infantile colic are unknown, some researchers suggested that the results of fennel in the treatment of infantile colic may be attributed to its efficacy in the hypothetical conditions catalyzed by
*Abnormal gastrointestinal function caused by imbalanced of the bacterial ratio

According to the literature reported by Swansea University, the application of fennel essential oil has a sustainable effect in inhibited E. coli growth, observed by disc diffusion assays and in liquid culture.

These results were illustrated by the effect of an aqueous extract of the aerial part and aqueous extract of seed samples of fennel.

Fennel inhibited overgrowth of Agrobacterium radiobacter pv. tumefaciens, Erwinia carotovora, Pseudomonas fluorescens, andPseudomonas glycinea, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomona aeruginosa, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Bacillus cereus in maintenance integrity of digestive function.

Further differentiation also suggested that fennel has a strong impact in protected gastric damage through significantly increased nitrite, nitrate, ascorbic acid, retinol, and beta-carotene levels.



Dr. Shamkant B. Badgujar, the lead author, in the differentiation of fennel, in regard to the gastrointestinal effect, said, "Foeniculum vulgare is indicated in the treatment of spastic gastrointestinal disturbances, in some forms of chronic colitis (which resist other treatments), in dyspepsias from gastrointestinal atony, in dyspepsias with the sensation of heaviness in the stomach, and so forth. The addition of fennel to preparations containing anthraquinone components reduces the occurrence of abdominal pain often associated with this type of laxative"


* In Psychological aspect of mother such as mother’s depression, anxiety, and distress during pregnancy in induction of infantile colic, although there is no direct literature to confirm the efficacy of fennel in treating syndromes of these group of women, but in the study of psychological symptoms in women with premenstrual syndrome, application of fennel seed was associated in decreased depression and anxiety.

Also, in stress-induced maternal anxiety and depression, application of fennel extract (50, 100 and 200 mg/kg body weight) showed a significant improvement of urinary levels of vanillyl mandelic acid(VMA) and ascorbic acid excretion levels in measurement of potentially psychological stress in fennel treatment group in compared to the normal group.

These results indicated that the extract of the entire plant of F. vulgare pay has a potential effect by acting as an anti-stress agent in reduced depression and anxiety in maternity.


* In food allergic aspect, although there are no direct study in the expression of fennel improved immune response against food allergy,.

Some researchers postulated that anethole, a bioactive compound from fennel inhibited food allergy probably through enhancing immune system food hypersensitivity response by modulating the expression of Foxp3+ in regulated the development and function T cells and inhibition of Th2 cytokines in promoted antibodies production of immunoglobulin E (IgE), thus reducing immune system overreacts to an allergen.


Taken together, the findings suggested that fennel may be considered as a functional food for the treatment of infantile colic, however, a large sample size and study by multi centers are necessary to reconfirm the viability.



Reprint of this article is welcome with the name of the author and link back to sources intact https://kylejnorton.blogspot.ca/2018/02/herbal-therapy-fennel-potent-functional.html

For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants by Savino F1, Cresi F, Castagno E, Silvestro L, Oggero R.(PubMed)
(2) The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study by Alexandrovich I1, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S.(PubMed)
(3) Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung,1 Seung-Hyung Kim,2 Dong-Seon Kim,3 Ji-eun Lee,2 and Ho Kyoung Kim1(Hidawi)
(4) Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome by Thompson A1, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE.(PubMed)
(5) Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome by Masoumeh Delaram,1,* Soleiman Kheiri,2 and Mohammad Reza Hodjati(PMC)

Cucumbers (Cucumis sativus) Bioactive Compound Cucurbitacin B (CuB) Kills Melanoma in Vitro

Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.

The melanin is a pigment that gives skin, hair, and eyes their color.

Malignant melanin cells (melanocytes) lead to the formation of moles on the skin with usually brown or pink color.

Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver failure.

Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light color skin, personal and family history of skin cancer are associated with the onset melanoma.

However, most people with some of the aforementioned risk factors have not developed melanoma.

Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.

Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, has been identified as a risk factor for the development of melanoma".

And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".



The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cell.

According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration and invasion potential of the melanoma cells.

In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to control.

Furthermore, the injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.

Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved in the formation of microfilaments.

Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".

Additionally, CuB inhibited the proliferation of the cell line was found to be in a dose-dependent manner, involving the induction of autophagy and exhibited the function of a protein associated with anti-apoptosis.

Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitive to the tested melanoma cells.

In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine side effects.

Taken altogether, cucumber processed a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending to the confirmation of larger sample size and multicenter human study


Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)

Sunday, December 8, 2019

Garlic, The Best anti cancers Whole food medicine

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu, blood pressure cholesterol levels, natural antibiotics, etc. but Garlic appears to be generally safe although allergic reactions may occur.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues. Sometimes cancer cells spread to other organs in the body via lymph or blood and results may be in death.

A recent study led by author Dr. Oommen S, indicated that allicin, the main ingredient found in garlic induced the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells, causing cell death.

Researchers in the study of ingredient allicin also showed that the phytochemical was capable of inducing an increase of the rate of apoptosis with affecting the expression of the cell cycle division and negation of pro-inflammation.

In cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway by GSH depletion and by changes in the intracellular redox status.

In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.


Other compounds found in garlic such as organosulfur, its extract and phytocompounds also suppress cancer cell proliferation and induced cell cycle arrest.

Therefore, people with or without cancers may consider adding a portion of garlic whole food into their diet for prevention, management, and treatment of the disease.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC.(PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3.(PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)

Cucurbitacins (CuB) Isolated from Cucumber Processes Both Antioxidant and Cytotoxic Activity

Antioxidants are atoms that inhibit oxidation.

Cytotoxicity is an action that kills cancer cells by inducing toxin to the cells.

Antioxidant activity is an action in which the stable atoms inhibit the expression of free radicals including antioxidants with free radical scavenging properties.

In other words, an antioxidant produced by the host or from dietary source balances the levels of free radicals produced by the cellular metabolism and from outside of our body.


In a healthy individual, antioxidant enzymes produced by the body are good enough to counter the expression of free radicals. However, in people with a weakened immune system such as elderly, intake of antioxidant supplements may be necessary.

Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.

Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.

Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cells and lipid damage, leading to alteration of cell DNA.

Diseases associated with oxidative stress include atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation,... and stroke.


Risk of oxidative stress can be reduced by lifestyle change and moderate exercise.


Dr. Tameko Kihira, the lead scientist in the correlation of lifestyle and oxidative stress in patients with amyotrophic lateral sclerosis (ALS) wrote, "Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles was associated with high contents of transition metals, such as Mn, Al, and V, in the scalp hair".


The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural and potential ingredient for the treatment of disease associated with oxidative stress, researchers investigated the effect of Cucurbitacins (CuB), a major bioactive compound found in cucumber.

According to the antioxidative analysis, Cucurbitacins (CuB), not only showed significant scavenging free-radicals activity such as hydroxyl radical, superoxide anions and singlet oxygen but also inhibited the lipid peroxidation and oxidation.

In other words, CuB protected cells integrity by inhibiting the free radical expression before they can induce a chain of reaction to cause oxidative stress to the tissues and organs.

Furthermore, Cub also processes anti-inflammatory and analgesic properties by modulating the immune response against the production of proinflammatory cytokines in facilitating the cellular and lipid damage and DNA alternation.

In the growth of four NSCLC cells (H1299, A549, HCC-827, and H661) Cucurbitacin B (CuB) inhibited cancer cell proliferation by altered the actin cytoskeletal assembly in the cell by cell cycle arrest and mitochondrial apoptosis.

Cucurbitacin B (CuB) inhibited the antioxidant activity produced by the cancer cells by significantly decreasing levels of protein thiols and GSH/GSSG ratio.

In other words, CuB causes the cancer cell apoptosis by inducing cytotoxicity through disrupting the cancer cellular redox balance.

The results strongly suggested that on one hand, CuB killed cancer cells through its cytotoxic by inducing overexpression of free radicals and on the other hand CuB protected the healthy cells against cytotoxic damage through its antioxidant property.

Taken altogether, cucumber processed abundantly bioactive compound CuB may be used for the treatment of diseases associated with oxidative stress and cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Search for a novel antioxidant, anti- inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba, and Olayinka Oridupa. (Research Gate)
(2) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(3) Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan by Tameko Kihira,1 Kazushi Okamoto,2 Iori Sakurai,1 Yuya Arakawa,1 Ikuro Wakayama,1Koichi Takamiya,3 Ryo Okumura,3 Yuhto Iinuma,3 Keiko Iwai,4 Yasumasa Kokubo,5 andSohei Yoshida. (PMC)

How to Maintain A Healthy Skin, Naturally and Permanently, PubMed Studies Find

Tomatoes may have a profound and positive effect on improved skin health, some scientists suggested.

The results of the analysis were carried out by several universities and research companies, including IUF - Leibniz Research Institute for Environmental Medicine and published on numbers of online literature.

Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purpose
and often in the greenhouse.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A
6. Vitamin B1
7. Vitamin B2
8. Vitamin B3
9. Vitamin B5
10. Vitamin B6
11. Folate
12. Vitamin C
13. Vitamin E
14. Molybdenum
15. Magnesium
16. Manganese
17. Copper
18. Potassium
19. Chromium

In the aim to reaffirm tomatoes effect in reduced negative impact against ultraviolet (UV)A/B and UVA1 radiation at a molecular level, scientists at the IUF - Leibniz Research Institute for Environmental Medicine launched a study of the tomato bioactive compounds lutein and lycopene photoprotective effect on human skin health.


The purpose of the study was to assess the two active treatments containing either lycopene (TNC) or lutein to test for their capacity in decreased expression of UVA1 the radiation-inducible genes HO1, ICAM1 and MMP1

Gene heme oxygenase 1 (HO1) is an enzyme with function to protect cells from oxidative damage, in this case, it was the UVA1

Gene intercellular adhesion molecule 1 (ICAM1) also known as CD54 (Cluster of Differentiation 54) is a protein with function in adhesion phenomena involved in the immune response.


Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme with a function to break down collagens located in the ECM.


The placebo-controlled, double-blinded, randomized, crossover study included 65 healthy volunteers allocated to four treatment groups and subjected to a 2-week washout phase, followed by two 12-week treatment phases separated by another 2 weeks of washout.

Volunteers started either with active treatment and were then switched to placebo, or vice versa.

24 hours after the irradiation phase skin, biopsies were taken from untreated, UVA/B- and UVA1-irradiated skin for subsequent reverse transcriptase-polymerase chain reaction analysis of gene expression.


Interestingly, after taking into account of other co and confounders, researchers found that lycopene isolated from tomato exerts a strong activities in completely inhibited UVA1- and UVA/B-induced upregulation of heme-oxygenase 1, intercellular adhesion molecule 1 and matrix metallopeptidase 1, through restricting the transformation of mRNA in initiated cell changes.

Blood samples taken from the lycopene treatment group showed a clinically relative protective effect of skin cells through its inhibition of levels of oxidative stress induced by UVA1- and UVA/B exposure in compared to other groups.

In compared to lycopene active group, the group treated with lutein injection provided complete protection taken in the first period but showed insignificant effects in the second sequence.

These results suggested that there must be some unknown mechanisms to cause reduced levels of
lutein in the second sequence in compared to TNC.


Dr. Grether-Beck S, the lead author said, " the role of these genes as indicators of oxidative stress, photodermatoses and photoaging" and " these results might indicate that TNC and lutein could protect against solar radiation-induced health damage".


Furthermore, in re-evaluating the effect of Carotenoids in skin photoprotection against UV radiation through analysis of the collection of dermal biopsies of healthy humans (N=27) and blood samples, researchers reconfirmed that lycopene and beta-carotene made up the majority of carotenoids in both skin and plasma followed by beta-cryptoxanthin.

These expressions suggested that lycopene and beta-carotene may play an important role in improved skin health through its antioxidant activity compared to other members of carotenoids such as
dihydroxycarotenoids, lutein, and zeaxanthin.


In other words, the skin of humans is relatively enriched in lycopene and beta-carotene, compared to lutein and zeaxanthin, possibly reflecting a specific function of hydrocarbon carotenoids in humans skin photoprotection.

Additionally, in the examine the skin collected from 74 men and women with diverse skin pigmentation using the Resonance Raman spectroscopy (RRS) to measure of the palm, inner arm, and outer arm were obtained at baseline, 1 wk, 2 wk, 1 mo, 3 mo, and 6 mo (to maximize seasonal variation), researchers with no surprise found that total carotenoids across time are 0.97 (palm), 0.95 (inner arm), and 0.93 (outer arm).

Similarly, the assessment of lycopene by RRS was significantly correlated with lycopene assessed by HPLC of dermal biopsies (r = 0.74, P < 0.0001).

These findings once again indicated the protective effect of tomato and bioactive ingredient lycopene in skin health compared to other compounds.

Taken together, there is no doubt that tomato with its major bioactive phytochemicals may be considered as a functional food in improved skin health against skin damage caused by numbers of negative implications including oxidative stress, photodermatoses, and photo aging


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Molecular evidence that oral supplementation with lycopene or lutein protects human skinagainst ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study by Grether-Beck S1, Marini A1, Jaenicke T1, Stahl W2, Krutmann J1(PubMed)
(2) Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults by Scarmo S1, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST(PubMed)
(3) Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake by Mayne ST1, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W.(PubMed)

Ginger, The Alternative Painkiller With No Side Effect

Ginger is one of the natural whole food recommended by many scientists for the treatment of muscle pain and soreness.

Muscle pain is a common condition can arise by a number of factors including injury or overexertion, infections of soft tissues, or inflammation.
Another factor such as the flu may also cause muscle pain.


Medication used for the treatment of cholesterol such as statins, fibromyalgia and underactive thyroidism is also associated with the onset of muscle pain.

Swelling, redness, or fever are also the most common symptoms accompanied by muscle pain.

Acute pain triggered by the nervous system, alerting you to possible injury.


Chronic muscle pain is a pain that lasts more than 3 months. Most cases of chronic muscle are caused by a syndrome of chronic myofascial pain (CMP), a painful condition that affects the muscles and the sheath of the tissue that surrounds the muscles.

The syndrome processes the most highly sensitive and notable symptom associated with the areas within the muscles that can also stimulate the pain in the other area of the body.

In contrast to the chronic myofascial pain (CMP), fibromyalgia syndrome (FMS) also cause chronic muscle pain due to brain disorder in processing pain signalings

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In the reaffirming ginger root pain-relief properties, researchers at the Old Dominion University launched a randomized, double-blind, placebo-controlled trial to determine whether ginger root supplementation reduces muscle soreness and dysfunction from downhill running.

Thirty-two runners (10 women, 22 men) included in the trial were pair-matched and randomized to 1.425 g/day of ginger root or placebo for 5 days.

Ang a 40-minute downhill (-7.5%) run was completed on day 3. Before supplementation and at various points throughout a 5-day protocol, muscle soreness, pain-pressure threshold, vertical jump, and 1.5-mile run performance.

Soreness while jogging likely increased to a lesser degree with ginger root from baseline. Ginger root had a possible small benefit on the vertical jump from baseline to day 5 but no meaningful impact on 1.5-mile run performance.

No significant differences in adverse events were observed during the experiment between treatments.

The results suggested that ginger root possibly has moderate beneficial effects on running-induced soreness but irrelevant effects on recovery of physical performance.

Dr. Wilson PB, said, "Ginger represents one option for runners looking to temporarily reduce pain".


Furthermore, in the findings, a natural ingredient for the treatment of inflammation and pain induced by delayed onset muscle soreness (DOMS), a joint study led by the Shiraz University, was launched to examine the effect of ginger extract on the biochemical and functional symptom of delayed onset muscle soreness.

36 healthy female subjects included in the study were recruited by intra dormitory calls and randomly divided into 3 groups, including ginger intake 1 hour before exercise (GIBE), ginger intake immediately after exercise (GIAE) and placebo group (PL).

Participants consumed capsules contain 60 mg of ginger extract (the equivalent of 2 g dried ginger powder) or a placebo before and after exercise. The exercise protocol consisted of a 20-minute step test using a 46cm step at a rate of 15 steps per minute.


Ginger intake immediately after exercise (GIAE) showed a significant reduction of pain compared to GIAE after 24 and 48h of EE and GIAE compared to PL.

The inflammatory cytokine IL-6 changed significantly in GIBE compared to PL (p<0.05) after 1, 24, and 48h after EE.

These results indicated that 2 grams of ginger may have anti-inflammation and analgesic effect on DOMS.

Taken altogether, ginger root may be considered a functional painkiller kitchen spice for the deduction of muscle pain and soreness if it is intake 1 hour before exercise.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners.
Wilson PB. (PubMed)

(2) Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness by Hoseinzadeh K1, Daryanoosh F2, Baghdasar PJ3, Alizadeh H. (PubMed)

Green Beans, Reduce the Risk of Cardiovascular Diseases (CVD)

Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.

Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or stroke caused by reducing oxygen supply to the brain cells.

Heart disease is a class of conditions associated with blood vessels and heart muscle that affect heart functioning, including coronary artery disease; heart rhythm problems (arrhythmias); and heart defects.

Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.

Stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain functioning.

Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.

According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.

Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.

There are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes.


Some researchers suggested overconsumption of carbohydrates over the long-term may be one major condition that causes the onset of CVD.

Dr. Norman J. Temple in the examination of the effect of fat, sugar, whole grains in the risk of heart disease wrote, " The evidence linking carbohydrate-rich foods with CHD has been steadily strengthening. Refined carbohydrates, especially sugar-sweetened beverages, increase the risk of CHD. Conversely, whole grains and cereal fiber are protective. An extra one or 2 servings per day of these foods increases or decreases risk by approximately 10% to 20%.".

In other words, the intake of a high amount of carbohydrates is associated with an increased risk of CVD.

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a portent compound or the prevention of cardiovascular disease, researchers compared
the antithrombotic activity in participants in central Chile.


The study included extracts samples of 19 fruits and 26 vegetables of the local diet.prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction.

According to the results of differentiation, green beans and tomato extracts inhibited the platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner.

However, green beans and tomato extracts showed a lesser effect compared to the methanolic extracts of grapes on prolonged the prothrombin time (PT), diluted prothrombin time (dPT).

Moreover, extracts of raspberry are more effective in prolonged the activated partial thromboplastin time (APTT), and fibrinolytic activity compared to the green beans extracts.

Taken altogether, green beans used combined with tomato may be considered a remedy for the prevention of cardiovascular diseases, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion by Norman J. Temple (PMC)

Saturday, December 7, 2019

Garlic, The Pungent Spice Which Kills Bowel Cancer Cells, Researcher Find

Studies suggested that garlic may have the potential in killing bowel cancer cells before they can spread to form colonization.

Bowel cancer also known as colorectal cancer, is a chronic and medical condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.

Bowel cancer is relatively very common and slowly growing cancer. The progression of cancer and is predictable.

The exact causes of bowel cancer are unknown. researchers as of today do not know why people in the same health condition and age in the same family and similar dietary pattern, some are susceptible to the onset of bowel cancer, while others do not.

However, researchers do know that certain risk factors are associated with the development of the disease, including age, family history

Some researchers suggested that the mutated gene inherited from the parents, certain medical conditions such as inflammatory bowel disease, polyps, obesity are also some of the bowel cancer prevalent risk factors.

A recent study also showed people who smoke and consume high volumes of red meat are also in elevated risk of the onset of the disease.

Truly, following a healthy diet and active lifestyle can decrease the risk of bowel cancer by 10 folds. Dr. IAIN ROBERTSON, the lead author at the Monash University, in the study "Colorectal cancer, diet and lifestyle factors: opportunities for prevention" wrote " The potential for colorectal cancer risk reduction by decreasing consumption of animal fats, red meat, alcohol, and cigarettes, by increasing physical activity levels, and by increasing intake of fruits, vegetables and dietary fibre".

If you are experiencing symptoms of a change of bowel habits that last longer than one month, persistent rectal bleeding, abdominal pain that does not stop,.and blood in the stool, please check with your doctor to rule out the possibility of bowel cancer.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.

The pungent spice has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Allicin (diallyl thiosulfinate), is the best-known biologically active component in freshly crushed garlic, found to reduce the risk of bowel cancer through inhibiting bowel cancer cell lines HCT-116, LS174T, HT-29, and Caco-2, via the activity of Nrf2, according to The Hebrew University of Jerusalem.

Nrf2 is a protein that regulates the expression of antioxidant proteins to protect the cells against damage and injury caused by oxidative stress triggered by inflammation.

However, in the colon cancer cell lines, overexpression of Nsf2 can initiate cancer cells apoptosis.

The Chungbuk National University study that uses colon cancer cell (SW620 and HCT116) to investigate whether sulfur compounds thiacremonone isolated from garlic could modulate NF-kappaB activity and thereby induce apoptotic cell death of colon cancer cells, suggested, application of different concentrations ranged from 30 - 150 microg/ml of thiacremonone for the periods from 0 to 48 hour inhibited colon cancer cell (SW620 and HCT116) growth followed by induction of apoptosis in a dose-dependent manner.


Further analysis showed that the efficacy of the novel sulfur compound against colon cancer cell growth and induction of apoptotic cell death was attributed to the compound's function in modulating NF-kappaB, a protein that controls transcription of DNA, cytokine production and cell survival.

In vitro, intake of garlic and its lipid-based extracts, induced cell cycle arrest, through a fourfold increase in caspase activity (apoptosis) in PC-3 cells when treated at a dose of 0.5 or 1 μg/m and may be considered a potential as promising anticancer agents, including colon cancer.

Dr. Baena R and Dr, Salinas P said, " Dietary factors and lifestyle may contribute to the increasing colorectal cancer (CRC) incidence... Fish consumption may decrease CRC risk by 12% whereas garlic intake is not significantly associated with reduced CRC risk".

In fact, diet represents 30-35% of risk factors that contribute to the onset of cancer, adding garlic in your diet together with the reduction of meat intake can reduce the risk of various cancers, including colorectal cancer

However, in the order to confirm garlic isolated compounds anti bowel cancer efficacy, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W1, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfur compound isolated from garlic in human colon cancer cells by Ban JO1, Yuk DY, Woo KS, Kim TM, Lee US, Jeong HS, Kim DJ, Chung YB, Hwang BY, Oh KW, Hong JT. (PubMed)
(3) Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro by Bagul M1, Kakumanu S1, Wilson TA1,2. (PubMed)
(4) Diet and colorectal cancer by Baena R1, Salinas P2(PubMed)
(5) Diet and cancer: risk factors and epidemiological evidence by Baena Ruiz R1, Salinas Hernández P2.(PubMed)
(6) Colorectal cancer, diet and lifestyle factors: opportunities for prevention by IAIN ROBERTSON, RONA BOUND and LEONIE SEGAL, (Monash University)