The Root Veggie That Inhibits Immune-Mediated, Cardiovascular, Infectious,....and Systemic Inflammatory Diseases Caused By Thrombosis

Carrots may have a profound and positive effect in reduced risk and complications of thrombosis some scientists suggested.

The results of the analysis were reported in the online literature conducted by numbers of universities including Kobe Gakuin University.

You can view the abstract from the studies by clicking any link at the resources data.

Thrombosis is a medical condition characterized by the formation of a blood clot inside a blood vessel, obstructing the flow of blood in the circulatory system.

Thrombosis is considered as a common cause of atherosclerosis.

The 2 major types of thrombosis are
* If the blood clot blocks a vein, it is classified as venous thrombosis.
Veins are blood vessels that carry blood from the body back into the heart.
* If the blood clot blocks an artery, it is arterial thrombosis.
Arteries are the blood vessels that carry oxygen-rich blood away from the heart to the body.

The actual causes of thrombosis are debatable. However, some researchers suggested that diseases or conditions of the leg veins, immobility due to physical incapability, bone fracture, obesity,... and genetic mutation of certain genes are associated to the causes and risks of thrombosis.


Importantly, certain medications such as Apixaban, Dabigatran, Edoxaban, Heparin. Rivaroxaban ..... and Warfarin and birth control pills containing the hormones desogestrel, gestodene, drospirenone, and cyproterone are also considered as risk factors of thrombosis.

Risks of deep vein thrombosis (DVT) and pulmonary embolism (PE), are increased substantially in pregnant women, especially in women who have an inherited clotting disorder.

Diseases associated to include immune-mediated disease, systemic inflammatory, cardiac,.......and infectious diseases.


Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation to find a daily diet with proven antithrombotic effects in reduced risk of acute thrombotic events, researchers at the Kobe Gakuin University launched a study to examine vegetables and fruits for antithrombotic activity.

The vegetables included 15 different varieties of carrot using shear-induced in vitro platelet reactivity/thrombolysis method, Global Thrombosis Test, formerly Gorog Thrombosis Test.


According to the differentiation of the antiplatelet and thrombolytic activities, researchers showed that
* Different carrot varieties demonstrate a variable effect on thrombosis in vitro and in vivo.

* In laser-induced thrombosis model in mice, heat treatment of carrot variety
exerts an antithrombotic effect independent from heat treatment of the filtrate at 100 degrees C for 10 min.

* In oral intake, the particular heat-resistant variety (SAKATA-0421) shows an antithrombotic effect in vivo possibly due to antiplatelet reactivity and/or spontaneous thrombolytic activity.


Interestingly, the expression of antithrombotic activity showed no significant correlation between antithrombotic activity and the levels of polyphenolics and any other biochemical parameter, including antioxidant activity, alpha-carotene and beta-carotene, alpha-tocopherol and ascorbic acid


These results suggested that carrot demonstrated strong impacts in reduced blood clot accumulation regardless of the effect of individual ingredients.


Dr. Yamamoto J, the lead author said, "An inappropriate diet is known to enhance the risk for acute thrombotic events and a regular diet with proven antithrombotic effects( including carrots) might be a beneficial way to prevent disease" and "the present study added a new variety to the list of antithrombotic fruits and vegetables".

Further analysis of the tissue linked to the development of cardiovascular disease due to endothelial activation in the induction of thrombosis of blood vessels, researchers at the Comanche County Memorial Hospital launched an investigation to evaluate the effect of diet-derived antioxidants in suppressed and/or delayed progression of cardiovascular disease.

The suggestions of water-dispersible forms of various carotenoids (beta-carotene, lutein, and lycopene) from natural sources in microemulsion were recommended to study the effects of carotenoids on tissue factor activity in human endothelial cells.

According to the differentiation, all carotenoids suppressed tissue factor activity (P<.01) and gene expression in human endothelial cells which may have a strong effect in the contribution of the development of blood clot in the vessels.


Endothelial cells in the endothelium have an essential effect in regulating vascular tone, cellular adhesion, smooth muscle cell proliferation, and vessel wall inflammation.

Moreover, application of carotenoids also enhanced phosphorylation of Akt activity in human endothelial cells on tissue factor activity in regulation of thrombosis of blood vessels.


After taking into account of other co and confounders, Dr. Lee DK, the lead scientist said, "diet-derived antioxidants might suppress and/or delay progression of cardiovascular disease (through regulating endothelial activation in the expression of thrombosis of blood vessels)".


The findings suggested that carrot and its bioactive carotenoids may be considered as functional food in reduced formation of blood clot in the vessels in the induction of cardiovascular diseases.

However, intake of supplementation should be taken with extreme care as acute liver toxicity was reported in numbers of the case in the medical literature.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The antithrombotic effects of carrot filtrates in rats and mice by Yamamoto J1, Naemura A, Ijiri Y, Ogawa K, Suzuki T, Shimada Y, Giddings JC(PubMed)
(2) Carotenoids enhance phosphorylation of Akt and suppress tissue factor activity in human endothelial cells by Lee DK1, Grantham RN, Mannion JD, Trachte AL(PubMed)

Cat's claw, The Herb That Cures Type I Diabetes In Vivo and Vitro, Scientists Found

Scientists who work for the big pharmaceutical companies have tried mimicked and replace the effectiveness of herbal phytochemical single ingredient by their synthetic version, which can be patent for commercial profits.

Even they know exactly the discovery in the treatment of certain diseases may induce serious side effect.

Therefore, if you are taking any conventional medicine, please discuss the adverse effects with your doctor.

A recent study suggested that Cat's Claw may be effective to cure of type 1 diabetes induced by Th1/Th2 (T cell) cytokine production.

Unlike type 2 diabetes which is caused by Insulin resistance due to an unhealthy diet, genetics,.... and lifestyle, type 1 diabetes is a chronic disease characterized by an inability of the pancreas in produced insulin. a hormone with function in normalized the level of glucose caused by the immune system mistakenly attacks and destroys the beta cells in the pancreas.

Researchers do not know why the immune system produces autoantibodies.to attack the pancreas beta cells?

Patients with type 1 diabetes are associated with classical symptoms of frequent urination, increased thirst, increased hunger,..... and weight loss.

Some scientists in the differentiation of the difference of type 1 and type 2 diabetes found that the symptoms of type 2 diabetes are developed over the long period of time in compared to the short period of time in type 1 patients.

According to the statistic in 2015, over 30 million Americans, or 9.4% of the population, had diabetes, including 125 million children and adults who had developed type 1 diabetes.


Patient with type 1 diabetes must inject insulin for survival, however, a healthy diet and lifestyle are also the must to improve quality of life and reduce the risk of diabetic complications.
If Untreated or poor management, type 1 diabetes can cause long-term complications of heart disease, stroke, kidney failure, foot ulcers,...... and eyes damage

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In vivo, immunotoxicity testing, BALB/c male mice treated once a day with 125, 500 or 1250 mg/kg of U. tomentosa extract for 28 days, increased the number of T helper lymphocytes and B lymphocytes.

The whole herb medicine also significantly exerted a large stimulatory effect on lymphocyte(a form of small white blood cell) viability.

Other study involved C57BL/6 male mice injected with MLDS (40 mg/kg) orally treated with UT at 10-400mg/kg during 21 days, showed to express a significant protection against the loss of insulin-secreting presented β-cells, through modulated the production of two helper T cell classes, known as Th1 and Th2, with increased levels of type-2 T helper cells and mast cells, known as IL-5 and the protein regulated activities of white blood cells known as IL-2.

Further linking Interleukin-2 effected on type I diabetes, the study of Interleukin-2 and type 1 diabetes and several autoimmune diseases suggested that depended on interleukin-2 (IL-2) in proliferating and controlling the T effector cells (Teff) reaction, low dose IL-2 treatment at the initial time of diabetes can rescue insulin secretion by restoring proteins expression.

Dr. Rosenzwajg M, the lead author said, " Regulatory T cells (Tregs) play a major role in controlling effector T cells (Teffs) responding to self-antigens, which cause autoimmune diseases.,....and expanding/activating Tregs with low-dose interleukin-2 (IL-2) could provide immunoregulation without immunosuppression"

Cat's Claw may be effective in protein regulated activities of white blood cells, known as IL-2 through improvement of immune function in induced immunosuppression cause of Type I diabetes, but the quantity intake should only be prescribed by professional herbalist to prevent toxicity.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antitype 1 diabetes possibilities.


And intake of Cat's claw supplement and phytochemical should be taken with care, as acute liver toxicity caused by overdoses had been reported in the numbers of the case.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? by Domingues A1, Sartori A, Golim MA, Valente LM, da Rosa LC, Ishikawa LL, Siani AC, Viero RM. (PubMed)
(2) Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile by Domingues A1, Sartori A, Valente LM, Golim MA, Siani AC, Viero RM. (PubMed)
(3) Interleukin-2 and type 1 diabetes: new therapeutic perspectives by Hartemann A1, Bourron O.(PubMed)
(4) Interleukin 2 in the pathogenesis and therapy of type 1 diabetes by Rosenzwajg M1, Churlaud G, Hartemann A, Klatzmann D.(PubMed)

Herbal Chamomile Enhances Immune System Integrity and Immune Cells Viability

Herbalism or phytotherapy a traditional medicine used botany and plants as medical treatment, linking health benefits in the prevention, management, and treatment of diseases has drawn many interests in today respectable scientists.

But herbal qualities, because geographic differences, time of grown,..... and harvest, are still raised some concerns of conventional researchers.

How many conscientious scientists do believe that some days phytotherapy will replace conventional single-ingredient medicine for treatment of diseases without inducing serious side effects.

Would the big pharmaceutical companies whose bottom line is nothing but profits and more profits allowed that to happen?

The immunomodulatory effect is a function that stimulates T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCcs),.... and nitric oxide (NO) production.

In other words, improving immune function of modulation of a gene or neurohormonal system may exert a strong efficacy in protected our body against harmful agents, including microorganisms,......and immunotoxins.



Immune dysfunction can be expressed in several different ways, depending to whether the immune system is overactive or underactive.


In long-term overactive immune function, the patient may be experiencing some symptoms of chronic inflammation caused by the overproduction of pro-inflammatory cytokines. Diseases associated with these syndromes include asthma, rheumatoid arthritis (RA), type 1 diabetes...... and Inflammatory bowel disease



Long-term of the underactive immune system can reduce immune function in fighting against various pathogens or toxins, leading to the development of diseases. Diseases associated underactive immune function include Human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS),...



The causes of immune dysfunction, in joint investigation of " Immune Dysfunction as a Cause and Consequence of Malnutrition" lead by the Queen Mary University of London, suggested "Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect." and " Defects emerge before birth via modifications in the immunoepigenome of malnourished parents"(3).


Patients with chronic immune dysfunction are associated to increase the risk of morbidity and mortality(4)(5).


Chamomile is also known as camomile, the common name of many species daisy-like plants, belonging to the family Asteraceae, a native of the Old World.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.


Chamomile (Matricaria chamomilla), in a recent study conducted by some institutions, restored the resistance against lethal infection with the predominately granulocyte-dependant Candida albicans in immunosuppressed mice.

Administration of the chamomile extract in five doses enhanced the total white blood cells count (up to 1.2 × 10(4) cells/mm(3)) and increased significantly bone marrow cellularity.

Some researchers suggested, "Changes in bone marrow cellularity can be an indicator of systemic toxicity and, therefore, bone marrow should be included in the battery of tissues examined for enhanced histopathology of the immune system"(6).

In other words, increased numbers of bone marrow cellularity have a strong effect in enhanced immune function.

Heteropolysaccharides found in Matricaria chamomilla L. also showed to normalize the developing of the immune response upon air cooling as a result of initiated immunostimulating properties of enlargement of red blood cells and activation of immunoregulation cells.

Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".

There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in protection of our body against various diseases, but intake of large quantity should be taken with care to avoid toxicity.

However, further data collection with larger example size and multi-centers performed on human consumption over a long-term and during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.

Additionally, while addressing the possible advantages of chamomile's immunomodulatory activities, researchers must also take into account of potential, risk such as quality controls, dosages, and dosage induced the adverse effect of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Evaluation of immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA.(PubMed)
(3) Immune Dysfunction as a Cause and Consequence of Malnutrition by Claire D. Bourke,1,⁎ James A. Berkley,2,3 and Andrew J. Prendergast(PMC)
(4) Extrahepatic morbidity and mortality of chronic hepatitis C by Negro F1, Forton D2, Craxì A3, Sulkowski MS4, Feld JJ5, Manns MP(PubMed)
(5) [Morbidity and mortality in HIV infection].[Article in German] by Stöckle M1, Elzi L, Rockstroh JK, Battegay M(PubMed)
(6) Enhanced Histopathology of the Bone Marrow by SUSAN A. ELMORE, the Society of Toxicologic Pathology

The Root Veggie That Inhibits Bladder Cancer Cells

Intake of function food beetroot regularly not only lowers the early occurrence but also provides a natural treatment of bladder cancer without inducing adverse effects.

Bladder cancer is a medical condition characterized by irregular cell growth and multiplied disorderly and uncontrollably in bladder tissues.

According to statistic, men are 4 times like to get bladder cancer in compared to women. The condition is the 9th common cancer worldwide.

Every year, approximately 400, 000 new cases are diagnosed. The 5 years of survival rate included all stage of bladder cancer is about 77% in compared to 70% and 65% of 10 years and 15 years respectively.

The survival rate of early diagnosed with bladder cancer is at 98%.

The causes of the bladder are unknown. However, some researchers suggested that smoking and tobacco used is one major cause of bladder cancer.

Long-term exposure to chemicals and irritation of the lining of the bladder due to infection are associated with risk factors of the disease.


Most common symptoms of bladder cancer are blood in urine accompanied by painful urination,... and pelvic pain. You should check with your doctor right the way, you experience some of these symptoms.


Dr. Martin C. S. Wong the lead scientist at the joint study conducted by The Chinese University of Hong Kong and other institutes said, "Many European countries experienced incidence rise. A substantial mortality reduction was observed in most countries, yet increases in mortality rates were observed in the Philippines and Iceland. These findings identified countries where more preventive actions are required"(4).


Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the University of Urbino 'Carlo Bo', betaxanthins and betacyanins, isolated from beetroot exerted a significant anti-cancer effect in testing bladder cancer cell lines, through the expression of antioxidant and proapoptotic activities.

The anti cancer property of beet root also displayed a strong anti-angiogenesis by blocking the cancer cell in established new blood vessel signaling.


When used combination with Vitexin-2-O-xyloside, an apigenin flavone glucoside, betaxanthins and betacyanins also exerted a strong antiproliferative activity in bladder cancer cell lines, intrinsically and extrinsically in the expression of apoptosis.

The study also indicated that this combination when used conjunction in conventional chemotherapy not only enhance the effectiveness of treatment in bladder cancer but also overcome the adverse effect of toxicity and multidrug resistance of cancer cells.

Furthermore, in other study conducted by the same university, Betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) tested, alone or in combination with vitexin-2-O-xyloside (XVX) also isolated from the same vegetable enhanced the ability to reduce the proliferation rate in T24 bladder cancer cells, synergistically by inhibition of protein or gene in promoted cell survival and enhanced cancer apoptosis.

Taking together, a diet enriched with these bioactive molecules of beetroot could be used as functional food in the prevention and treatment of human bladder cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P1.(PubMed)
(3) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(4) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projectio by Martin C. S. Wong,1,2 Franklin D. H. Fung,1 Colette Leung,1 Wilson W. L. Cheung,1William B. Goggins,3 and C. F. Ng(PMC)

Herbal Chamomile Enhances Immune System Integrity and Immune Cells Viability

Herbalism or phytotherapy a traditional medicine used botany and plants as medical treatment, linking health benefits in the prevention, management, and treatment of diseases has drawn many interests in today respectable scientists.

But herbal qualities, because geographic differences, time of grown,..... and harvest, are still raised some concerns of conventional researchers.

How many conscientious scientists do believe that some days phytotherapy will replace conventional single-ingredient medicine for treatment of diseases without inducing serious side effects.

Would the big pharmaceutical companies whose bottom line is nothing but profits and more profits allowed that to happen?

The immunomodulatory effect is a function that stimulates T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCcs),.... and nitric oxide (NO) production.

In other words, improving immune function of modulation of a gene or neurohormonal system may exert a strong efficacy in protected our body against harmful agents, including microorganisms,......and immunotoxins.

Immune dysfunction can be expressed in several different ways, depending on whether the immune system is overactive or underactive.

In long-term overactive immune function, the patient may be experiencing some symptoms of chronic inflammation caused by the overproduction of pro-inflammatory cytokines. Diseases associated with these syndromes include asthma, rheumatoid arthritis (RA), type 1 diabetes...... and Inflammatory bowel disease



Long-term of the underactive immune system can reduce immune function in fighting against various pathogens or toxins, leading to the development of diseases. Diseases associated underactive immune function include Human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS),...



The causes of immune dysfunction, in joint investigation of " Immune Dysfunction as a Cause and Consequence of Malnutrition" lead by the Queen Mary University of London, suggested "Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect." and " Defects emerge before birth via modifications in the immunoepigenome of malnourished parents"(3).


Patients with chronic immune dysfunction are associated to increase the risk of morbidity and mortality(4)(5).


Chamomile is also known as camomile, the common name of many species daisy-like plants, belonging to the family Asteraceae, a native of the Old World.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.


Chamomile (Matricaria chamomilla), in a recent study conducted by some institutions, restored the resistance against lethal infection with the predominately granulocyte-dependant Candida albicans in immunosuppressed mice.

Administration of the chamomile extract in five doses enhanced the total white blood cells count (up to 1.2 × 10(4) cells/mm(3)) and increased significantly bone marrow cellularity.

Some researchers suggested, "Changes in bone marrow cellularity can be an indicator of systemic toxicity and, therefore, bone marrow should be included in the battery of tissues examined for enhanced histopathology of the immune system"(6).

In other words, increased numbers of bone marrow cellularity have a strong effect in enhanced immune function.

Heteropolysaccharides found in Matricaria chamomilla L. also showed to normalize the developing of the immune response upon air cooling as a result of initiated immunostimulating properties of enlargement of red blood cells and activation of immunoregulation cells.

Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".

There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in protection of our body against various diseases, but intake of large quantity should be taken with care to avoid toxicity.

However, further data collection with larger example size and multi-centers performed on human consumption over a long-term and during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.

Additionally, while addressing the possible advantages of chamomile's immunomodulatory activities, researchers must also take into account of potential, risk such as quality controls, dosages, and dosage induced the adverse effect of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA. (PubMed)
(3) Immune Dysfunction as a Cause and Consequence of Malnutrition by Claire D. Bourke,1,⁎ James A. Berkley,2,3 and Andrew J. Prendergast(PMC)
(4) Extrahepatic morbidity and mortality of chronic hepatitis C by Negro F1, Forton D2, Craxì A3, Sulkowski MS4, Feld JJ5, Manns MP(PubMed)
(5) [Morbidity and mortality in HIV infection].[Article in German] by Stöckle M1, Elzi L, Rockstroh JK, Battegay M(PubMed)
(6) Enhanced Histopathology of the Bone Marrow by SUSAN A. ELMORE, the Society of Toxicologic Pathology

Losing Weight By Restricting Fat and Glucose Absorption of GI, Scientists Say

Green tea may have a therapeutic and positive effect in the induction of weight loss through reduced GI absorption of glucose and lipid, some scientists suggested.

The absorption of too much sugar too quickly may depress the pancreas in produced extra insulin to neutralize glucose transport in the body.

A prolonged period of too much sugar in the bloodstream not only increases the risk of diabetes but also puts pressure of liver in converted triglycerides to fat to tissue


Blocking fat absorption also plays an important role in weight loss and weight management. According to Dr. Ying Sun and Dr. Jiande Chen, reducing fat absorption may be a therapeutic potential for obesity"(4).


The GI tract plays an essential role in our body well being and lifelong health.

Some researchers suggested that a poor functioning of GI may induce occurrence of many chronic health problems.

There are many causes of digestive dysfunction. It can be the digestive system itself due to bacterial infection, viral infection, inflammation, lactase deficiency, difficulty digesting certain foods, poor circulation to the intestines or symptoms of the wider systemic disease, such perforated organs, muscle dysfunction, gallstones, stress, and anxiety.

Dysfunction GI if untreated may interfere with daily activities and induce poor quality of life.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

According to the Agriculture and Agri-Food Canada, native catechins found in green tea were not absorbed by the digestive system after intake.

The polyphenol catechins were accumulated in the intestinal lumen inside space of a tubular structure where they exhibited a significant activity in ameliorated cellular glucose and cholesterol uptake that reduced risk in overexpression of fasting glucose and lipid accumulation entering the bloodstream in the induction of syndromes of abnormally high blood sugar and cholesterol.

The pervaded catechins found approximately, 2-15% in the intestinal levels significantly bound to 37% to plasma HDLs through inhibiting the key enzymes involved in lipid biosynthesis and reduced intestinal lipid absorption, thus improving blood lipid profile.action of cholesterol metabolism.

Further analysis of the unstable condition of polyphenols in intestinal environment, also found that transition from the gastric phase to the intestinal phase of green tea extract shows a 50% decrease in the antioxidant activity due to the degradation of polyphenols but the deceased extract still exerts a strong effect in the gastrointestinal environment.

However, intake of whole food milk and cheese in the definition of dairy matrices displayed a significant improvement of polyphenol stability in the intestinal phase and increase of the antioxidant activity by 29% (cheese) to 42% (milk) in compared to nongreen tea injection control.


Additionally, administration of green tea also demonstrated a strong activity in decreased expression of stomach secretes pepsinogen, in breaking down milk and cheese protein and fat intake in degraded into their component polypeptide or amino acid and glycerol and fatty acids, respectively in the gastric phase but had no effect in the intestinal phase, thus reducing glucose and fat being absorbed and presented in the bloodstream.

The findings showed that green tea polyphenols intake after certain times of intake of dairy products improved antioxidant activity and enhanced the integrity of polyphenols in the intestinal phase of digestion, but have a serious effect in the stomach if it is taken together with milk.


Interestingly, in the evaluated rats fed with selenium-containing green tea (Se-GTE, 1.44 mg selenium/kg dry leaves) and China green tea(CH-GTE, 0.13 mg selenium/kg leaves) and China green tea(CH-GTE) effect in the intestinal micro bacterial activity, researchers indicated that oral administration of rat group fed with Se-GTE extract for 6 days
* Exerts a significant increase in caecal counts of lactobacilli and bifidobacteria while significantly reducing the caecal counts of Bacteroides and clostridial bacteria in compared to

* CH-GTE rat group. exerts insignificant increase in the numbers of caecal lactobacilli and bifidobacteria but decreased significantly the numbers of bacteroides (p < 0.05) and clostridia.


Moreover, rats fed with CH-GTE and Se-GTE showed a 17.2% and 21.3% reduction in the activity of the bacterial enzyme β-glucuronidase, which has been found in the contribution of biliary sludge, stone formation and increased risk for colorectal cancer, respectively.

More promisingly, treatment of both CH-GTE and Se-GTE also resulted in 19% and 25.5% increments in the activity of β-glucosidase, an enzyme presented in cellulase with function in completed the final step in converting cellobiose (a reducing sugar) to glucose.

Taken all together, green tea with abundantly major bioactive polyphenols may be considered a functional food in weight loss and weight management by reduced absorption of glucose and lipid in the induction of abnormal high fasting blood sugar and cholesterol levels through binding to fat and protein in the gastric phase of digestion.

However, further data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of digestion will be necessary to complete the picture of green tea effects in gastrointestinal phases in the absorption of glucose and lipid possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Interaction of green tea polyphenols with dairy matrices in a simulated gastrointestinal environment by Lamothe S1, Azimy N, Bazinet L, Couillard C, Britten M.(PubMed)
(2) Simulated gastrointestinal digestion, intestinal permeation and plasma protein interaction of white, green, and black tea polyphenols by Tenore GC1, Campiglia P2, Giannetti D3, Novellino E3.(PubMed)
(3) The ability of green tea to positively modulate key markers of gastrointestinal function in rats by Molan AL1, Liu Z, Tiwari R.(PubMed)
(4) Intestinal Electric Stimulation Decreases Fat Absorption in Rats: Therapeutic Potential for Obesity by Ying Sun and Jiande Chen(PMC)

The Herb That Cure Type I Diabetes In Vivo and Vitro, Scientists Found

Scientists who work for the big pharmaceutical companies have tried mimicked and replace the effectiveness of herbal phytochemical single ingredient by their synthetic version, which can be patent for commercial profits.

Even they know exactly the discovery in the treatment of certain diseases may induce serious side effect.

Therefore, if you are taking any conventional medicine, please discuss the adverse effects with your doctor.

A recent study suggested that Cat's Claw may be effective to cure of type 1 diabetes induced by Th1/Th2 (T cell) cytokine production.

Unlike type 2 diabetes which is caused by Insulin resistance due to an unhealthy diet, genetics,.... and lifestyle, type 1 diabetes is a chronic disease characterized by an inability of the pancreas in produced insulin. a hormone with function in normalized the level of glucose caused by the immune system mistakenly attacks and destroys the beta cells in the pancreas.


Researchers do not know why the immune system produces autoantibodies.to attack the pancreas beta cells?


Patients with type 1 diabetes are associated with classical symptoms of frequent urination, increased thirst, increased hunger,..... and weight loss.


Some scientists in the differentiation of the difference of type 1 and type 2 diabetes found that the symptoms of type 2 diabetes are developed over the long period of time in compared to the short period of time in type 1 patients.


According to the statistic in 2015, over 30 million Americans, or 9.4% of the population, had diabetes, including 125 million children and adults who had developed type 1 diabetes.


Patient with type 1 diabetes must inject insulin for survival, however, a healthy diet and lifestyle are also the must to improve quality of life and reduce the risk of diabetic complications.
If Untreated or poor management, type 1 diabetes can cause long-term complications of heart disease, stroke, kidney failure, foot ulcers,...... and eyes damage

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In vivo, immunotoxicity testing, BALB/c male mice treated once a day with 125, 500 or 1250 mg/kg of U. tomentosa extract for 28 days, increased the number of T helper lymphocytes and B lymphocytes.

The whole herb medicine also significantly exerted a large stimulatory effect on lymphocyte(a form of small white blood cell) viability.

Other study involved C57BL/6 male mice injected with MLDS (40 mg/kg) orally treated with UT at 10-400mg/kg during 21 days, showed to express a significant protection against the loss of insulin-secreting presented β-cells, through modulated the production of two helper T cell classes, known as Th1 and Th2, with increased levels of type-2 T helper cells and mast cells, known as IL-5 and the protein regulated activities of white blood cells known as IL-2.

Further linking Interleukin-2 effected on type I diabetes, the study of Interleukin-2 and type 1 diabetes and several autoimmune diseases suggested that depended on interleukin-2 (IL-2) in proliferating and controlling the T effector cells (Teff) reaction, low dose IL-2 treatment at the initial time of diabetes can rescue insulin secretion by restoring proteins expression.

Dr. Rosenzwajg M, the lead author said, " Regulatory T cells (Tregs) play a major role in controlling effector T cells (Teffs) responding to self-antigens, which cause autoimmune diseases.,....and expanding/activating Tregs with low-dose interleukin-2 (IL-2) could provide immunoregulation without immunosuppression"

Cat's Claw may be effective in protein regulated activities of white blood cells, known as IL-2 through improvement of immune function in induced immunosuppression cause of Type I diabetes, but the quantity intake should only be prescribed by professional herbalist to prevent toxicity.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its anti type 1 diabetes possibilities.


And intake of Cat's claw supplement and phytochemical should be taken with care, as acute liver toxicity caused by overdoses had been reported in numbers of the case.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? by Domingues A1, Sartori A, Golim MA, Valente LM, da Rosa LC, Ishikawa LL, Siani AC, Viero RM.(PubMed)
(2) Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile by Domingues A1, Sartori A, Valente LM, Golim MA, Siani AC, Viero RM.(PubMed)
(3) Interleukin-2 and type 1 diabetes: new therapeutic perspectives by Hartemann A1, Bourron O.(PubMed)
(4) Interleukin 2 in the pathogenesis and therapy of type 1 diabetes by Rosenzwajg M1, Churlaud G, Hartemann A, Klatzmann D.(PubMed)

The Natural Remedies That Inhibit Over Growth of Candida, Scientists Say

Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.

Herbal medicine or phytotherapy is a traditional practice used botany and plants for treatment of a variety of diseases.

Today, due to serious side effects caused by intake of conventional single ingredient medication, some scientists once again have looked into herbal whole food plant with an aim to find the replacements with similar effect without inducing the adverse effect.

These journeys have encountered many problems, as the discovery of such plants will provide no commercial benefit and patent right to producers. Particularly, if such plants are found, they will exert a major blow in cutting into sizable benefits of big pharmaceutical companies

Truly, between 25 to 50% of current pharmaceuticals derived from plants, none are used as antimicrobials(b).


Some researchers suggested that duplicated herbal successes of Western drugs with the synthetic version for the patent right without using the whole herb ingredients for commercial profits may eventually contribute to overexpression of serious adverse effects(b).

Imbalance of ratio of ROS species and antioxidant enzymes in the host tissue have played an essential role in the initiated expression of healthy cell cytotoxicity that can alternate DNA transcription in facilitating the development of chronic ailments such as overgrowth of candida.

In free radical over expression cause of over growth candida, certain natural alternatives exerted a strong antioxidant effect that target Candida.

According to Dr. Seneviratne CJ at the University of Hong Kong, in the study of "Potent anti-traditional Chinese herbal plant contains significant and potent antifungal activities, such as Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis(a).


The Anti Over Growth of Candida Natural Alternatives
1. Manuka Honey
Manuka honey has been known to benefit humans in healing wounds and injuries(309) without inducing damage to cells. The product also contains hydrogen peroxide claimed to have antimicrobial property(310), including Candida albicans(311).


2. Undecylenic acid
Undecylenic acid is the common name of the 10-undecenoic acid, an organic unsaturated fatty acid derived from castor oil, It is a natural antimicrobial property(312)against fungal skin infections(313)(314) and Candida albicans(315).


3. Caprylic acid
Caprylic acid is the common name for the eight-carbon saturated fatty acid found naturally in coconuts and breast milk, used in treatments for a variety of conditions, including Candida(316)(317).


4. Echinacea angustifolia
Echinacea angustifolia is a herbaceous plant species Echinacea angustifolia, belongings to the family Asteraceae native to Northern America. Echinacea angustifolia besides enhances the immune system function(318)(319) against the invasion of bacteria and viral through its antioxidant effects, it also used to treat bacterial infections(320) and candida(318) in herb medicine.


5. Horopeit
Horopeit is a genus Pseudowintera, part of family Winteraceae. The herb contains a compound polygodial, a chemical compound used to suppress the growth of candida(321)(322) by damaging the permeable cell membrane of yeast(322).


6. Oregano
Oregano is a genus of the mint family Lamiaceae, native to southwestern Eurasia and the Mediterranean region. The herb not only promotes digestive health(323), clear skin and healthy immune system(324) but also dehydrates candida(325) by reacting with the water in the bloodstream, through its phytochemicals Carvacrol and Thymol(326).


7. Aloe vera
Aloe vera is a genus Aloe belongings to the family Asphodelaceae, originated in Sudan. Beside containing significant amounts of amino acids, enzymes, vitamins, minerals and antioxidants which help to enhance the immune function(327) in fighting against virus and bacterial infection and inflammation(328), it also maintains a proper PH levels that inhibit the growth of candida(329) and repairs and seals the intestinal wall, which stops Candida from actually penetrating through and into your bloodstream(330).


8. Tea tree oil
Tea tree oil is a pale yellow color to nearly clear essential oil extracted from the leaves of the Narrow-leaved Tea-tree, native to the northeast coast of New South Wales, Australia. In Fluconazole-resistant candida Albicans strains, dose-depend manner, tea tree oil strongly exhibited fluconazole activity against fluconazole-resistant C. albicans strains, through its antifungal activity(331).


Terpinen-4-ol, the main bioactive component found in teat tree oil, also showed to accelerate clearance of all Candida strains from the vagina, including the azole-resistant forms in rat vaginal infection model(332)


9. Tannate plant extracts
Tannate is the salt or ester of tannic acid. Tannate plant extract is a powerful antifungal agent(333)(334) by destroying candida selectively without harming the good flora in the body(335). It is said that tannate plant extract is effective in treating bacteria, viruses, fungal infections due to its antifungal(333)(334), anti-inflammatory properties(336).


10. Biotin
Biotin or vitamin B7, a coenzyme in the metabolism of fatty acids and leucine, plays an important role in gluconeogenesis(337). According to Università degli Studi di Torino, patients with biotin deficiency are at high risk of candida albicans overgrowth(338).

Biotin prevents yeast to change into its fungal form(339), thus reducing the risk of candida albicans overgrowth.


11. Probiotics (friendly bacteria)
Probiotic is live microorganisms which benefit the host. Intake of probiotics enhances the production of hydrogen peroxide(340) that plays an important role in preventing candida overgrowth and through self-multiple mechanisms(341).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(a) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP.(PubMed)
(b) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)
(310) Effect of hydrogen peroxide on antibacterial activities of Canadian honeysby Brudzynski K1.(PubMed)
(311) Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective propertiesby Stankovic N1, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J.(PubMed)
(312) Antimicrobial polyurethane thermosets based on undecylenic acid: synthesis and evaluation.by Lluch C1, Esteve-Zarzoso B, Bordons A, Lligadas G, Ronda JC, Galià M, Cádiz V.(PubMed)
(313) Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution by Anguita JL1, Escutia B, Marí JI, Rodríguez M, De La Cuadra J, Aliaga A.(PubMed)
(314) Undecylenic acid and fungous infections by Landau JW.(PubMed)
(315) Undecylenic acid inhibits morphogenesis of Candida albicansby McLain N1, Ascanio R, Baker C, Strohaver RA, Dolan JW.(PubMed)
(316) [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis].[Article in Japanese]by Takahashi M1, Inoue S, Hayama K, Ninomiya K, Abe S.(PubMed)
(317) [Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinen-4-ol and a middle-chain fatty acid, capric acid].[Article in Japanese]by Ninomiya K1, Hayama K, Ishijima S, Takahashi M, Kurihara J, Abe S.(PubMed)
(318) In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea) by Morazzoni P1, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T.(PubMed)
(319) Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function by Kim HR, Oh SK, Lim W, Lee HK, Moon BI, Seoh JY.(PubMed)
(320) Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. by Hudson JB1.(PubMed)
(321) Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agentby Fujita K1, Fujita T, Kubo I.(PubMed)
(322) Polygodial, an antifungal potentiator by Kubo I1, Taniguchi M.(PubMed)
(323) Enterococci from piglets--probiotic properties and responsiveness to natural antibacterial substances by Strompfová V1, Lauková A.(PubMed)
(324) Dietary supplementation with two Lamiaceae herbs-(oregano and sage) modulates innate immunity parameters in Lumbricus terrestris by Vattem DA1, Lester C, Deleon R, Jamison B, Maitin V.(PubMed)
(325) Oregano Oil for Candida(New health guide)(326) In vitro activity of origanum vulgare essential oil against candidaspecies by Cleff MB1, Meinerz AR, Xavier M, Schuch LF, Schuch LF, Araújo Meireles MC, Alves Rodrigues MR, de Mello JR.(PubMed)
(327) Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. by Halder S1, Mehta AK, Mediratta PK.(PubMed)
(328) Antimicrobial activity of preparation Bioaron C by Gawron-Gzella A, Michalak A, Kędzia A.(PubMed)
(329) Antimicrobial activity of plant extracts on Candida albicans: an in vitro study by Doddanna SJ1, Patel S, Sundarrao MA, Veerabhadrappa RS.(PubMed)
(330) Antifungals: Aloe Vera(The candida diets)
(331) The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains by Mertas A1, Garbusińska A1, Szliszka E1, Jureczko A1, Kowalska M1, Król W1.(PubMed)
(332) In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species by Mondello F1, De Bernardis F, Girolamo A, Cassone A, Salvatore G.(PubMed)
(333) [The effect of tannic acid on colonization of Candida in tissue conditioning material].
[Article in Japanese]by Kubota K.(PubMed)(334) [The effect of tannic acid on attachment of Candida albicans to plate denture lining material].
[Article in Japanese]by Tanaka T.(PubMed)
(335) Who Gets Yeast Infections?(Things for ladies)(336) Evaluation of Phytochemical Screening and Anti Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild by Banerjee S1, Chanda A1, Adhikari A2, Das A2, Biswas S3.(PubMed)
(337) The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes. Increased sensitivity to inhibition as a result of biotindeficiency by Bannister DW, O'Neill IE.(PubMed)
(338) Growth of Candida albicans in a minimal synthetic medium without biotin. by Vidotto V1, Pugliese A, Gioannini P.(PubMed)
(339) Candida Infestation and BiotinWritten by Sean Brookwood Published on September 22, 2013
(340) Improved growth and viability of lactobacilli in the presence of Bacillus subtilis (natto), catalase, or subtilisin by Hosoi T1, Ametani A, Kiuchi K, Kaminogawa S.(PubMed)
(Oxidative stress responses in the human fungal pathogen, Candidaalbicans by Dantas Ada S1, Day A2, Ikeh M3, Kos I4, Achan B5, Quinn J6.(PubMed)
(341) Candida Diets: Part II: Hydrogen Peroxide Written by Jeff McCombs(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)

A Common and Kitchen Spice that Inhibits Diabetes Naturally

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Type 1 diabetes is a congenital condition caused by the die-off of pancreas cells which are responsible for producing insulin, a hormone with a function to control the level of blood glucose.


A regular injection of insulin or insulin therapy is required daily in a patient who was born with the disease.

In contrast to type II diabetes, types 1 diabetes are not associated with dietary intake or unhealthy lifestyle that can cause an increase in glucose levels in the blood.


According to Diabetes Canada, patients with type 1 diabetes should aware of the number of insulin injections that are needed per day; the timing of insulin injections and the dose of insulin that are needed with each injection


The cause of type 1 diabetes is debatable, but some researchers found that most patients with type 1 diabetes are linked to abnormal body’s immune system overreaction to the cells that make insulin.



On the other hand, type 2 diabetes is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol due to unhealthy dietary and lifestyle selections.


In some cases, the disease is also caused by allergic reactions of cells in the immune system.

If you experience some of the physical symptoms of frequent urination, excessive thirst, unexplained weight loss, nonrefractive visual impairment, and appetite problems, together with gastrointestinal symptoms such as stomach pain, heartburn, diarrhea, constipation, nausea and vomiting and mental symptoms of depression, emotion stress, sleeping difficulties,..... and suicidal ideation, you may have type 2 diabetes. Please check with your doctor as soon as possible(4).

According to the 2011 statistic from National Diabetes Information Clearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, have diabetes in 2010.

About 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010.

And approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

For my years of practice and research, I do believe that intake of 1/4 tablespoon of Vietnamese cinnamon powder in the morning and evening have significant effects in keeping blood sugar in check.

In prediabetes with the morning reading of 6.9 mmol/L of a lady whom I know for 10 years, intake of the volume of cinnamon suggested above has managed to maintain her's the morning blood glucose at 5.3 mmol/L since.

Cinnamon, a kitchen spice used in many cultures, may have gained many believers, including medical professions because of its antidiabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.

According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse side effects.

The herb has been used in herbal and traditional medicine as anti-fungal and bacteria activities and improves reproductive organ, prevents flatulence and intestinal cramping, treats indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, researchers found that oral administration of cinnamon reduced significantly of blood triglyceride levels even in the low-dose group, after 3 months. (2).

Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering the insulin secretion may be attributed to its effects in lowering triglyceride and increasing liver glycogen content and improving insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that “the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4).

Peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARγ, and PPARβ/δ are receptors that reduce triglyceride level and regulate energy homeostasis.
In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomum cassia) displayed a significant improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes, according to a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, even though consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but high degree of heterogeneity including quality and content may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5).

Moreover, a randomized clinical trial in which 70 Patients with type II diabetes were assigned randomly into two groups (35 in cinnamon and 35 in placebo group) for the testing of the effect of cinnamon on the glucose level in blood, at the end of the experiment researchers found that there is an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

Taken altogether, although there are some discrepancies involving cinnamon efficacy, I do believe that cinnamon in low dose is effective to control and manage the level of blood glucose in a patient with diabetes without altering the insulin level.

However, according to Dr. Georgakopoulou EA(7), oral intake of cinnamon may cause Stomatitis, and burning sensation in the mouth if it is taken in large amounts.

The traditional Chinese medicine also indicated that overdoses of cinnamon can be toxic and damage the liver(1).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(8) Diabetes – The Symptoms by Kyle J. Norton

Beet, The Root Veggie That Inhibits Bladder Cancer Cells

Intake of function food beetroot regularly not only lowers the early occurrence but also provides a natural treatment of bladder cancer without inducing adverse effects.

Bladder cancer is a medical condition characterized by irregular cell growth and multiplied disorderly and uncontrollably in bladder tissues.

According to statistic, men are 4 times like to get bladder cancer in compared to women. The condition is the 9th common cancer worldwide.

Every year, approximately 400, 000 new cases are diagnosed. The 5 years of survival rate included all stage of bladder cancer is about 77% in compared to 70% and 65% of 10 years and 15 years respectively.

The survival rate of early diagnosed with bladder cancer is at 98%.


The causes of the bladder are unknown. However, some researchers suggested that smoking and tobacco used is one major cause of bladder cancer.

Long-term exposure to chemicals and irritation of the lining of the bladder due to infection are associated with risk factors of the disease.


Most common symptoms of bladder cancer are blood in urine accompanied by painful urination,... and pelvic pain. You should check with your doctor right the way, you experience some of these symptoms.


Dr. Martin C. S. Wong the lead scientist at the joint study conducted by The Chinese University of Hong Kong and other institutes said, "Many European countries experienced incidence rise. A substantial mortality reduction was observed in most countries, yet increases in mortality rates were observed in the Philippines and Iceland. These findings identified countries where more preventive actions are required"(4).


Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the University of Urbino 'Carlo Bo', betaxanthins and betacyanins, isolated from beetroot exerted a significant anti-cancer effect in testing bladder cancer cell lines, through the expression of antioxidant and proapoptotic activities.

The anticancer property of beetroot also displayed a strong anti-angiogenesis by blocking the cancer cell in established new blood vessel signaling.


When used combination with Vitexin-2-O-xyloside, an apigenin flavone glucoside, betaxanthins and betacyanins also exerted a strong antiproliferative activity in bladder cancer cell lines, intrinsically and extrinsically in the expression of apoptosis.

The study also indicated that this combination when used conjunction in conventional chemotherapy not only enhance the effectiveness of treatment in bladder cancer but also overcome the adverse effect of toxicity and multidrug resistance of cancer cells.

Furthermore, in other study conducted by the same university, Betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) tested, alone or in combination with vitexin-2-O-xyloside (XVX) also isolated from the same vegetable enhanced the ability to reduce the proliferation rate in T24 bladder cancer cells, synergistically,. by inhibition of protein of gene in promoted cell survival and enhanced cancer apoptosis.

Taking together, a diet enriched with these bioactive molecules of beetroot could be used as functional food in the prevention and treatment of human bladder cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P1.(PubMed)
(3) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(4) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projectio by Martin C. S. Wong,1,2 Franklin D. H. Fung,1 Colette Leung,1 Wilson W. L. Cheung,1William B. Goggins,3 and C. F. Ng(PMC)

How to Alleviate Pain Caused by Muscles and Blood Vessels Constriction Naturally

Anise may have potential and substantial relaxant effects in reduced overexpression of vessel and muscle constrictions in precipitation of pain, some scientists suggested.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...


Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

According to the evaluation of Anise 3 hidroalcoholic extracts claimed to have a substantial effect in tracheal and ileal smooth muscles in 3 different concentration of doses at 40% (HA(40%)), 60% (HA(60%)) or 80% (HA(80%)) researchers found that

* Application of all extracts at half maximum effect,50 microg/mL EC(50) inhibited acetylcholine-induced contraction.

* However, the extract HA(60%) at 5-50 microg/mL(EC(5-50)) concentration-dependently relaxed acetylcholine-pre-contracted tissues and HA(40%) and HA(80%) did not exert relaxant action in any volume out of indicated range.

These results suggested that the substantial effect in tracheal and ileal smooth muscles of Anise was associated with a dose-dependent manner.

In other words, only certain concentrations of Anise hydroalcoholic extract are effective in reduced muscles and vessels constriction in the induction of pain.

Injection of muscle constriction substances such as N(G)-nitro-L-arginine methyl ester (L-NAME, 100 microM), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 3 microM) and oxyhemoglobin (10 microM) were also inhibited by HA(60%) in doses concentration-dependent manner through the influence of muscle relaxation.

This inhibition suggested that Anise not only ameliorates the tracheal and ileal smooth muscles pain caused by natural spasmodic activities but also pain caused by the injection of muscle and vessel contraction substances.

Moreover, an additional treatment of nitric oxide synthase(L-NAME) in induced production of vascular smooth muscle cells and enhanced the maximal contraction induced by acetylcholine, administration of HA(60%) expressed a strong activity in modulated NO contractile response, stimulated by primary transmitter released by inhibitory nerves through cyclic GMP-dependent which is found to have a implication in the regulation of smooth muscle relaxation and other independent mechanisms

Further observation also indicated that injection of HA 60% showed an insignificant effect in calcium chloride(CaCl(2))-induced muscle contraction.

Dr. Tirapelli CR, the lead author at the Escola de Enfermagem de Ribeirão Preto. said, "The relaxant action displayed by Pimpinella anisum justifies its use in the folk medicine as an antispasmodic agent".

In isolated tracheal chains of the guinea pig induced by 10 microM methacholine in non-incubated tissues (group 1) and incubated tissues with 1 microM propranolol and 1 microM chlorpheniramine (group 2), to investigate the relaxant effect of Pimpinella anisum aqueous and ethanol extracts and essential oil, researchers showed that injections Anise aqueous and ethanol extracts, essential oil and theophylline, a conventional medicine used to relax bronchial smooth muscle in COPD and asthma patients display a substantial activity in exhibited relaxant effects in compared to those of controls.

There was no significant difference between both Pimpinella anisum aqueous and ethanol extracts in promoted muscle relaxation but both exerted lower efficacy in compared to those of theophylline.

Interestingly, the applications of essential oil and 10 nM atropine, a muscle relaxant medicine, used as nerve anticholinergic agent, blocked the neurotransmitter acetylcholine in the central and the peripheral nervous system is responsible for the involuntary movement of smooth muscles and reduced the muscle contraction caused by methacholine, a substance used to tighten the lung muscle and airway for test of asthma.

These results indicated a potential activity of bronchodilatory and anticholinergic effects of essential oil, aqueous, and ethanol extracts from Anise.

However, researchers also found that application of all doses expressed insignificant effects in inhibited histamine (H(1)), smooth muscles, vascular endothelial cells, the heart, and the central nervous system or stimulated beta(2)-adrenergic receptor in binding to epinephrine.

Dr. Boskabady MH, after taking into account of other co-founders, said, "....showed that the relaxant effect of this plant is not due to an inhibitory effect of histamine (H(1)) or stimulatory effect of beta(2)-adrenergic receptors, but due to inhibitory effects on muscarinic receptors".


Collectively, the efficacy of Anise in elevated muscle and blood vessel pain was associated with numbers of mechanism, not invoked the constriction caused by allergens or stimulants.

Taken together, Anise aqueous and ethanol extracts and essential oil may be used as adjunct herbal medicine in reduced risk of diseases associated to spasmodic muscle contraction in the induction of muscle cramp accompanied by a sudden burst of pain caused by abnormal nerve stimulation or by abnormal activity of the muscles and vessels.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinellaanisum (Apiaceae) on rat anococcygeus smooth muscle by Tirapelli CR1, de Andrade CR, Cassano AO, De Souza FA, Ambrosio SR, da Costa FB, de Oliveira AM. (PubMed)
(2) Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s) by Boskabady MH1, Ramazani-Assari M.(PubMed)