Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health
The prevalence of childbearing age obesity is wide spreading in US,
approximately, 50% of them are either overweight [body mass index (BMI)
25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Body weight at age 20 years and breast cancer risk
Many studies have investigated the association between BMI at age 20 years (BMI20y) and breast cancer
risk with consideration to estrogen/progesterone receptor status
(ER/PR). In the study to investigate the the association between BMI20y
and ER/PR-defined breast cancer risk among 41,594 women in the population-based Japan Public Health Center, posted in PubMed, showed that BMI and subsequent BMI gain were not associated with increased risk
among premenopausal women, but were substantially associated with
increased risk among postmenopausal women [corresponding RR(recent
BMI)=1.31 (95%CI=1.07-1.59); RR(subsequent BMI gain)=1.32
(95%CI=1.09-1.60)]. In subanalyses by receptor status (∼50% of cases),
the observed inverse association of BMI20y with risk was consistent with
the result for ER-PR- [0.49 (95%CI=0.27-0.88)], while the observed
positive associations of BMI gain with postmenopausal breast cancer
risk appeared to be confined to ER+PR+ tumors [corresponding RR(for
subsequent BMI gain)=2.24 (95%CI=1.50-3.34)]. Low BMI at age 20 years
was substantially associated with an increased risk of breast cancer.
In contrast, high recent BMI and subsequent BMI gain from age 20 were
associated with increased risk of postmenopausal ER+PR+ tumors.
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