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Wednesday, July 14, 2021

Brassica Food plants in the Prevention and Treatment of Cardiac Hypertrophy

Hypertrophy is a process or condition that increases and growth of muscle cells by increasing the muscular size achieved through exercise.

Lifting weights are the most common way to increase hypertrophy.

In other words, hypertrophy is the enlargement of an organ or tissue from the increase in the size of its cells by increasing the number of contractile proteins in each muscle fiber.

There are two types of muscular hypertrophy including the growth of muscle contraction parts or myofibrillar and the increased muscle glycogen storage or sarcoplasmic.

Myofibrillar training improves strength and speed, compared to sarcoplasmic growth that sustains more energy in endurance athletic events.

Cardiac hypertrophy is a medical condition associated with the abnormal enlargement, or thickening, of the heart muscle.

The most common causes of cardiac hypertrophy are the results of hypertension or valvular disease.


The condition can also be caused by athletic hypertrophy (a condition related to exercise), valve disease, hypertrophic cardiomyopathy (HOCM), and congenital heart disease.


The most common symptoms are shortness of breath, chest pain, and palpitation, especially during exercise.

On finding a potential compound that attenuates cardiac H9c2 cell hypertrophy, researchers examined the effects of 3,3'-Diindolylmethane (DIM) is the major product of the acid-catalyzed condensation of indole-3-carbinol (I3C), a component of extracts of Brassica food plants.


The study was conducted using an in vitro model with 1 µM angiotensin II (Ang II) in cultured rat cardiac H9c2 cells, to observe the effects of DIM on cardiac hypertrophy.

According to the tested analysis, the optimal concentration of DIM for 6, 12, and 24 h. showed a significant effect on the atrial natriuretic peptide, brain natriuretic peptide, and myosin heavy chain β mRNA expression induced by Ang II in H9c2 cells.



In other words, DIM lowers the blood pressure, promotes diuresis, natriuresis, vasodilation of the systemic and pulmonary vasculature, and reduction of circulating levels of endothelin and aldosterone and cardiac muscle contraction induced by Ang II in H9c2 cells.

Furthermore, H9c2 cells treated with DIM for 0, 15, 30, and 60 min induced by Ang II also improve the function of 5'-AMP-activated protein kinase catalytic subunit alpha-1 that regulates the activities of a number of key metabolic enzymes in protecting the cardiac cells from stresses in response to hypertrophic stimuli.

Based on the findings, Brassica food plants consist of DIM that may be used for the prevention of cardiac hypertrophy, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase-α by Zong J1, Wu QQ1, Zhou H1, Zhang JY1, Yuan Y1, Bian ZY1, Deng W1, Dai J1, Li FF1, Xu M1, Fang Y1, Tang QZ. (PubMed)

Friday, July 9, 2021

Whole Food Tomato Protects the Tissues of Stomach Against Gastric Injury

Gastrointestinal injury is an injury associated with the stomach, small bowel, colon, or rectum.

In other words, any damage to the organs of the digestive system caused by blunt or penetrating trauma is considered a gastrointestinal injury.

Gastrointestinal injury caused by blunt trauma in children is uncommon, accounting for less than 1% of all gastrointestinal injuries.

Believe it or not, in children, most common causes of gastrointestinal injury are caused by a discrete point of energy transfer such as a seatbelt (19%), a handlebar (13%), or a blow from abuse (19%), or other blows and is unique to this population, according to the Children's Hospital.


Depending on the organs damage, patients may experience different symptoms.

In small intestinal injury, patients may have symptoms of pain closed to the injured bowel segment, abdominal distension, and diarrhea, ileus, diffuse abdominal pain, nausea, and vomiting.

In large intestinal injury, patients may have symptoms of persistent focal pain in a trocar site with abdominal distention, diarrhea, and leukopenia.

In gastric/stomach injury, patients may first experience symptoms of nausea, vomiting, blood in the urine, and fever, following by abdominal pain, tenderness, distension, or rigidity.

In rectal injury, patients may have symptoms of rectal itching, pain, and rectal bleeding.


Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On findings a potential ingredient for the prevention and treatment of gastrointestinal injury, researchers investigated the transgenic mini-tomato and protection against alcohol-induced gastrointestinal injury.

By examining the function of the epidermal growth factor (EGF) in maintaining the physiological function of the mucosa of the digestive tract, and to promote the healing of the gastric and duodenal ulcers, researchers chemically synthesized a tomato codon preference hEGF gene by Agrobacterium-mediated transformation.

Where Epidermal growth factor (EGF) has been found to play an essential role in wound healing by stimulating epidermal and dermal regeneration.

According to the radioimmunoassay (RIA),15 days of intragastric gavage (ig) administration of the rhEGF-containing juice of the transgenic tomato could significantly protect mice against alcohol-induced ulceration.

The Ulcer index expressed as a degree of the stomach lesion, also decreased from 42.20 +/- 18.13 to 16.25 +/- 9.57.

In other words, the transgenic tomato protects the integrity of the stomach cell against the insults of excessive alcohol consumption that damage the stomach lining tissues and speeds up ulcer healing


Taken altogether, tomato with rhEGF may be considered a dietary supplements for the prevention and treatment of gastrointestinal injury, pending a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Transgenic mini-tomato and protection against alcohol-induced gastric injury by Zhi Q1, Wang S, Chai M, Zhang F, Li Q, Li S, Sun M. (PubMed)
(2) Injuries of the gastrointestinal tract from blunt trauma in children: a 12-year experience at a designated pediatric trauma center by Canty TG Sr1, Canty TG Jr, Brown C. (PubMed)