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Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Thursday, October 31, 2019

Cucumber's Bioactive Compound Cucurbitacin B (CuB) Exerts Anti-Hyperglycemic Effect in Diabetics

Hypoglycemia is abnormally high blood glucose levels in the bloodstream in diabetes.

Most cases of hyperglycemia are associated with poor management of blood sugar levels as a result of poor diet and poor practice of medicine intake and insulin injection.

Hyperglycemia is a hallmark of diabetes caused by the inability of the body to convert glucose to energy or make the hormone insulin.

Most common and early signs of hyperglycemia are increased thirst and/or hunger, frequent urination, sugar in your urine, fatigue.

In severe cases, patients with hyperglycemia may also experience symptoms of headache and blurred vision.

Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, ner, es and heart.


In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.

Women who are nondiabetics before pregnancy and experience gestation hyperglycemia are likely to develop diabetes in the latter days.

Believe it or not, hyperglycemia can also occur in people without diabetes due to stress. According to the study, people who are nondiabetics and experience abnormally high blood glucose are most likely to develop diabetes later in life.

According to the statistics, In 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes.

Some researchers suggested that by changing lifestyle with moderate exercise, hyperglycemia can be manageable in type II diabetes.

Dr. Salwa W. Rizkalla wrote, " Only 4 weeks of a (low GI diet) LGI diet was able to improve glycemic control, glucose utilization, some lipid profiles, and the capacity for fibrinolysis in type 2 diabetes. Even if changes in glycemic control were modest during the 4-week period, the use of an LGI diet in a longer-term manner might play an important role in the treatment and prevention of diabetes and related disorders"

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural ingredient for the prevention of hyperglycemia in patients with diabetes, researchers examined the effect of Cucurbitacin B (CuB) isolated from cucumber induced hypoglycemic effect in an animal model.

On mice, induced diabetes, administration of Cucurbitacin B (CuB) composed of triterpenoid structure stimulated AMP-activated protein kinase (AMPK) pathway which has been found to contribute to the correction of insulin resistance overexpression in hyperglycemia.

CuB also ameliorated hyperglycemia not only by activating intestinal AMPK levels and also by inducing production of plasma GLP-1 associated with the improvement of insulin-releasing by pancreatic β-cells.

However, GLP-1 mimetic medicines although exerted a similar effect compared to that of natural GLP-1, it induced clinical side effects, such as autoimmune hepatitis, acute kidney injury, pancreatitis, and pancreatic cancer.

Interestingly, the efficacy of hypoglycemic activity of CuB decreased significantly in dorsomorphin- (a selective inhibitor of the BMP pathway involved in the expression of cytokines) injected mice and α-gustducin null mice.

In differentiated NCI-H716 cell line, CuB inhibited hyperglycemia involved in activation of AMPK through α-gustducin and Gβγ-signaling of taste receptors in signaling secretion of incretin hormones such as glucagon-like peptide-1 (GLP-1).

Where taste receptors are found in several organs including tongue to colon and have the diverse functions dependent on specific cell types.

In enteroendocrine L cells, stimulated taste receptor signaling plays a critical role in inducing incretin hormones, including GLP-1.

Based on the findings, researchers said, "CuB represents novel hypoglycemic agents by activation of AMPK and stimulation of GLP-1 in differentiated enteroendocrine L-cells".

Taken altogether, cucumber processed high levels of CuB may be used for the treatment of hyperglycemia in diabetics, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(2) Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men by
Salwa W. Rizkalla, MD, PHD12,
Laika Taghrid, MD1,
Muriel Laromiguiere, PharmD, PHD3,
Dorothée Huet, MD1,
Josette Boillot, PHD1,
Aude Rigoir, RN1,
Fabienne Elgrably, MD1 and
Gerard Slama, MD. (the American Diabetes Association)

Localized Honey, the Best for the Treatment of Allergies with No Side Effects, According to Studies

Scientists may have found a natural alternative for the treatment of allergies, according to studies.

Allergies are a faulty reaction of the immune system responses against harmful substances that enter the body.


Symptoms and diseases associated with allergies include sinus swelling, seasonal and returning allergies, hay fever and nasal allergies.


Believe or not, Penicillin, antibiotic medicine is the most common allergy trigger in drug allergies. 10 percent of people are allergic after using the medicine.

According to the statistics, in the US, approximately, more than 50 million Americans have experienced various types of allergies each year and 15 million Americans have food allergies, including 5.9 million children under age 18.

In other words, 1 in 13 children suffers from a food allergy. About 30 percent of children with food allergies are allergic to more than one food.


The findings strongly suggested that foods are the most common and major cause of allergic onset.

Dr. Ruchi S. Gupta and colleagues in the allergic team in examining the food allergies in children wrote, "Overall, estimated current FA prevalence was 7.6%,.The most prevalent allergens were peanut (2.2%), milk (1.9%), shellfish (1.3%), and tree nut (1.2%)".


And, "Among food-allergic children, 42.3% reported ≥1 severe FA and 39.9% reported multiple FA. Furthermore, 19.0% reported ≥1 FA-related emergency department visit in the previous year and 42.0% reported ≥a 1-lifetime FA-related emergency department visit, whereas 40.7% had a current epinephrine autoinjector prescription.


Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural compound for the treatment of allergies examined the honey effects in the treatment of allergic rhinitis (AR).

The prospective randomized placebo-controlled study included 40 AR patients divided equally into a case group and a control group. All the subjects received a daily dose of 10 mg of loratadine for 4 weeks.

The case group then ingested 1 g/kg body weight of honey daily in separate doses for the 4-week period. The control group ingested the same dose of honey-flavored corn syrup as a placebo.


According to the AR symptoms scored at the start, week 4, and week 8 of the study, at week 4, both groups showed progressive improvement in the symptoms, however, at week 8, only the case group showed continuous improvement in the symptom score.


The ingested honey group showed a significant improvement in individual AR symptoms after week 8 and the efficacy in reducing the symptoms persisted for a month after the cessation of the honey treatment.

The results suggested that honey processed certain chemical compounds that were not found in the corn syrup for the treatment of AR.

Some researchers suggested that long-term intake of raw honey can help to ameliorate allergy symptoms by regularly exposing to pollen, similarly to the allergy injection in desensitizing pollen-program.


If this result is true then only local honey can process the anti-AR symptoms compared to honey unlocalized pollen.

Taken altogether, honey may be considered a functional remedy for the prevention and treatment of AR symptoms, regardless of the types of honey, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East coast of Peninsular Malaysia by Asha'ari ZA1, Ahmad MZ, Jihan WS, Che CM, Leman I. (PubMed)
(2) Will honey relieve my seasonal allergies? by Allergists
(3) The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States by Ruchi S. Gupta, Christopher M. Warren, Bridget M. Smith, Jesse A. Blumenstock, Jialing Jiang, Matthew M. Davis, Kari C. Nadeau. (APP News and Journals)

Dried Peas, the Potent Weight Loss Functional Food, Studies Discovered

Dried pea may have a profound effect on the promotion of healthy weight loss naturally without inducing any side effects, some studies found.

Obesity is a medical condition caused by excessive body fat accumulation over time, while overweight is a condition of excess body weight relative to the height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

A healthy weight loss is important to adults in Americans. According to the statistic, 68% of the American population is either overweight or obese. Researchers found that overweight and obesity are 2 of the most prevalent risk factors that cause substantially the early onset of numbers of chronic health conditions.

The Tufts University School of Medicine, in the examination of a total of 16884 adults, 25 years and older, classified as overweight and obese (body mass index [BMI] > or =25 kg/m2) based on National Institutes of Health recommended guidelines using the data from the Third National Health and Nutrition Examination Survey (NHANES III), which was conducted in 2 phases from 1988 to 1994, found that diseases associated with overweight and obesity in the US are type 2 diabetes mellitus, gallbladder disease, coronary heart disease, high blood cholesterol level, high blood pressure, or osteoarthritis.

Dr. Must A, the lead author said, "more than half of all US adults are considered overweight or obese. The prevalence of obesity-related comorbidities emphasizes the need for concerted efforts to prevent and treat obesity rather than just its associated comorbidities".

The complications caused by unmanaged overweight and obesity also elevated the financial burden in the health care system.

According to the study by the University of Florida, "The elderly men who were overweight or obese at age 65 had 6–13 percent more lifetime health care expenditures than the same age cohort within normal weight range at age 65" and


"Elderly women who were overweight or obese at age 65 spent 11–17 percent more than those in a normal weight range. Both elderly men and women who were overweight or obese at age 65 had worse health outcomes than the normal weight cohorts".


Therefore, actively engaged weight loss may be the only solution to maintain good health that not only reduces the risks of chronic diseases individually but also releases the pressure from the health care system, particularly in the elderly.

Dried pea is a small but nutritionally mighty member of the legume family, the genus Pisum belonging to the family Fabaceae.

The tiny bean processes healthy sources of protein, fibers, vitamins, and minerals that are good for everyone's diet.

In the concerns of the prevalence of obesity has reached epidemic proportions, making finding effective solutions to reduce obesity a public health priority, the Department of Foods and Nutrition conducted an experiment on the effects of nonoilseed pulses (dry beans, peas, chickpeas, and lentils) through searching the database of some medical literature.

Application of pulse was found to benefit weight control, including slowly digestible carbohydrates, high fiber and protein contents, and moderate energy density.

Observational studies consistently showed an inverse relationship between pulse consumption and BMI or risk for obesity, but many do not control for potentially confounding dietary and other lifestyle factors.

In a short-term study, pulse consumption increases satiety over 2-4 h, suggesting that at least part of the effect of pulses on satiety is mediated by available carbohydrate amount or composition.

Randomized controlled trials generally supported a beneficial effect of pulses on weight loss when pulse consumption is coupled with energy restriction, but not without energy restriction.

Additionally, the inclusion of peas (Pisum sativum L.) as the source of protein in the diet of growing rats brought about a reduction in growth rate as well as the impairment in the liver, muscle and spleen weights, compared with casein-fed controls.

Application of dried peas produced a fall in plasma glucose, triglycerides, and protein, observed in the legume fed animals, with no changes in cholesterol levels.


The rats fed on the diet containing peas showed lower levels of plasma insulin, corticosterone, insulin-like growth factor IGF-I and thyroid (T)4 in mediating restraint-induced weight gain, compared to the case in controls.

Liver and muscle total protein (mg) and total DNA (mg) were markedly decreased in the legume fed animals, an indication of weight loss.


Further analysis of the liver and muscle fractional synthesis rates researchers discovered that the whole-body protein synthesis is lower in the legume fed animals due to differences in body weights compared to the casein controls.


In the comparison with other legume group, animals fed on a diet containing peas (Pisum sativum L.) as the only source of protein showed less adverse effects than those found with other legumes probably due to protein quality, antinutritional factors, and nutrient availability.


Taken altogether, dried Peas may be considered a functional food for the promotion of weight loss without inducing any side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pulse consumption, satiety, and weight management by McCrory MA, Hamaker BR, Lovejoy JC, Eichelsdoerfer PE. (PubMed)
(2) Growth, hormonal status and protein turnover in rats fed on a diet containing peas (Pisum sativum L.) as the source of protein by Martinez JA, Marcos R, Macarulla MT, Larralde J.(PubMed)
(3) The disease burden associated with overweight and obesity by Must A1, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. (PubMed)
(4) The Financial Burden of Overweight and Obesity among Elderly Americans: The Dynamics of Weight, Longevity, and Health Care Cost by Zhou Yang and Allyson G Hall. (PMC)

Lentils (Legume) Ameliorated Risk of Hyperlipidemia

Hyperlipidemia.is a medical condition characterized by abnormally high blood cholesterol in the bloodstream.



The evaluation of the effect of lentils in the risk of high blood cholesterol was found to associate with certain mechanisms through a number of aspects.

According to the study of the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the metabolic syndrome in two groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults, at week 8, after a 75 g oral glucose load, measurement of HDL increased by 4·5 in the pulse group, in compared to decreased of 0·8 in energy group


Furthermore, the treatment of pulse diet also expressed a significant improvement in restriction of energy intake to promote weight loss and reduced weight circumference which have been considered as some risk factors in facilitated abnormal blood cholesterol in overweight and obese subjects.


According to general belief, weight loss in obese and overweight adults plays an important role in reduced risk of having high LDL (low-density lipoprotein) bad cholesterol and triglyceride levels, and low HDL (high-density lipoprotein) good cholesterol.


Additionally, in the investigation of hydroalcoholic extract isolated from lentils to examine the hypocholesterolemic action in diet-induced hypercholesterolemic animal model for 70 days, by studying the plasma cholesterol level and the concentration of bile acids in the feces, researchers found that at day 71, injection of hydroalcoholic extract demonstrated a strong effect in decreased cholesterol level of rats by 16.8%, in compared to non treatment group.

Further analysis also suggested that the extract also increased the level of bile acids, metabolic regulators of lipid, in the feces of rats which is an indication of decreased LDL-cholesterol concentration, and increased HDL-cholesterol concentration.

Dr, Färkkilä M, the lead author in the study of lipid metabolism in bile acid malabsorption said,
"Enhanced cholesterol and bile acid synthesis in ileal dysfunction are reflected by raised concentrations of plasma cholesterol precursors, especially lathosterols, which can be used as an indicator of increased bile acid loss to feces".


More interestingly, the measured and compared the metabolic variables, weight loss and inflammatory marker concentrations of 30 obese subjects (17 M/13F; BMI: 32.5 ± 4.5 kg/m(2); 36 ± 8 years) randomly assigned to either (4 weeks): Calorie-restricted legume-free diet (Control: C-diet) or calorie-restricted legume-based diet (L-diet, different cooked-servings (160-235 g) of lentils, chickpeas, peas or beans) conducted by the University of Navarra indicated that group treated with L-diet displayed a significant effect in induction of weight loss, reduced both total and LDL cholesterol levels in compared to Calorie-restricted legume-free diet control group.


The weight loss in the treatment group also demonstrated a decrease concentration levels of CRP and C3 which may be an indication of the lower inflammatory process in facilitated lipid deposits in the inner wall of arteries induced by oxidative stress through stimulation by reactive oxygen species (ROS).

Dr. Hermsdorff HH, the lead author at the University of Navarra said, " the reduction (%) in CRP concentrations was positively associated with decreases (%) in systolic BP and total cholesterol concentration specifically in the L-diet group, independent from weight loss (p < 0.05)". t

Taken together, lentils and other species of legume may be considered as functional foods in reduced risks of hyperlipidemia, through lowering levels of low density lipoprotein(LDL), increasing levels of high density lipoprotein(HDL) and improving ratio of high-density lipoprotein (HDL/total cholesterol number, particularly in inducing weight loss in overweight and obese population.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Evaluation of the hypocholesterolemic effect and prebiotic activity of a lentil (Lens culinaris Medik) extract by Micioni Di Bonaventura MV1, Cecchini C2,3, Vila-Donat P4, Caprioli G4, Cifani C1, Coman MM2,3, Cresci A2,3, Fiorini D5, Ricciutelli M4, Silvi S2,3, Vittori S4, Sagratini G4.(PubMed)
(2) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(3) A legume-based hypocaloric diet reduces proinflammatory status and improves metabolicfeatures in overweight/obese subjects by Hermsdorff HH1, Zulet MÁ, Abete I, Martínez JA.(PubMed)
(4) Lipid metabolism in bile acid malabsorption by Färkkilä M1, Miettinen TA.(PubMed)

Kidney bean, the Anti Hyperlipidemia Natural and Functional Food

Intake of kidney bean may lower risk and treatment of hyperlipidemia, a study by respectable institution suggested

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish-brown in nature used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Hyperlipidemia is a condition of abnormally high levels of cholesterol in the bloodstream.

According to the Universidade Federal de Viçosa, in the study of the effectiveness of kidney bean against high blood cholesterol of five groups of 8 male rats, Wistar strain, initial body weight of 200 g were kept at 25 degrees in a light-dark cycle of 12 h, for 28 days, group received red (RB) beans, showed a 12% reduction of blood cholesterol in comparison to other groups.

Dr. Rosa CO, the lead author said, "the reduction of cholesterol in the blood is followed by its( lipid deposition) retention in the rat livers".


Additionally, in a randomly assigned to one of the four experimental groups of hypercholesterolaemic pigs fed on a Western-type diet and 300 g baked beans/kg , group fed with baked beans showed a significant reduction of blood cholesterol in compared with the control (without baked beans).

The study also expressed a significantly reduced level of low-density-lipoprotein-cholesterol by 48% without affecting high-density-lipoprotein-cholesterol and triacylglycerol contents.

More importantly, researchers in the study also wrote, "supplements of 200 and 300 g baked beans/kg promoted a significant (P < 0.05) reduction of about 50% in cholesterol deposition in the liver, compared with the control".


In fact, the study on steroid metabolism of hypercholesterolaemic pigs also showed support of the efficacy of bake bean in lower blood cholesterol through inhibition of hepatic cholesterol synthesis and reduced plasma cholesterol.

With all the above information, there is no doubt that kidney bean and baked kidney bean can be used as a functional food for reduced high blood cholesterol, but human trials are necessary to confirm the validation.




Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) [The cholesterol-lowering effect of black, carioquinha and red beans (Phaseolus vulgaris, L.) in hypercholesterolemic rats].[Article in Portuguese]by Rosa CO1, Costa NM, Nunes RM, Leal PF.(PubMed)
(2) The effect of graded inclusion of baked beans (Phaseolus vulgaris) on plasma and liver lipids in hypercholesterolaemic pigs given a Western-type diet by Costa NM1, Walker AF, Low AG.(PubMed)
(3) Effect of baked beans (Phaseolus vulgaris) on steroid metabolism and non-starch polysaccharide output of hypercholesterolaemic pigs with or without an ileo-rectal anastomosis by Costa NM1, Low AG, Walker AF, Owen RW, Englyst HN.(PubMed)

Wednesday, October 30, 2019

Phytochemical Alliin Protects The Heart Against the Risk Heart Attack (Myocardial Infarction)

Myocardial infarction or heart attack is a medical emergency caused by a reduced and stopped blood flow to the heart.

Most common symptoms of heart attacks are chest pain or discomfort that affects the shoulder, arm, back, neck, or jaw accompanied by shortness of breath, dizziness, faintness, or nausea.


Epidemiologically, episodes of angina are considered an early warning sign that a heart attack may be coming.

In angina, blood flow is stopped than restored, pain recedes within minutes, and the heart is not permanently damaged. However, in some cases, angina may cause some heart muscles to damage without affecting the heart functioning.

Unfortunately, heart attacks without any early warning signs were found in proximately 25% of the patients.

According to statistics, in the US, every year, approximately 790,000 Americans have a heart attack, inclduing 580,000 cases of a first heart attack and 210,000 cases of a recurrent heart attack.

Dr. Fatemeh Kiani, the lead scientist in the examination of the risk factors involved in myocardial infarction said, "Results showed that 70% of patients were women and only 30% were men. 48% of them were illiterate and the patient's mean age was 58.3".

And, "17% of patients (coronary artery diseases history), 25.5% (hypertension history), 26% (diabetes history), 15.5% (cholesterol history), 13% (smoking) and 3% have reported CABG history. The majority of people who referred had inferior MI (40.4%). 67.1% normal rhythm, 2.8% atrial fibrillation and 16% had ventricular tachycardia".


In other words, gender, aging, smoking and medical conditions associated with increased risk of heart disease are some of the most common risk factors found in patients with myocardial infarction.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a potential compound for the prevention of heart attack, researchers examined S-allyl cysteine sulfoxide (SACS, alliin) preventive effect in isoproterenol (ISO)-induced myocardial ischemia in an animal model.

The study included male Wistar rats pretreated with SACS (40 and 80 mg kg(-1)) orally for 5 weeks followed by ISO (150 mg kg(-1)) administered subcutaneously at an interval of 24 h for 2 days.

The activities of beta-D-N-acetyl-glucosaminidase, beta-galactosidase, beta-glucosidase, and acid phosphatase in serum and the heart of ISO-induced rats.associated with mitochondrial dysfunction in the heart were increased substantially.

Furthermore, the declined of Na(+)K(+)-ATPase and increased Ca(2+)- and Mg(2+)-ATPases activity significantly (p < 0.05) associated with association of the risk of myocardial infarction were also found ISO-induced rats.

However, pretreatment of alliin 40 and 80 mg kg(-1)) showed a significant (p < 0.05) effect in all the aforementioned biochemical parameters.

In other words, alliin inhibited all risk factors involved in the onset of a heart attack.

In order to reveal more information about alliin anti hear attack activity, researchers investigated the preventive role of SACS on some biochemical parameters, glycoproteins, and hematology in experimentally induced myocardial infarction in rats.

Treatment of alliin followed by myocardial infarction induced in rats by subcutaneous injection of isoproterenol (ISO) (150 mg kg(-1)) at an interval of 24 h for 2 days, not only inhibited all parameters aforementioned study but also inhibited the levels/concentrations of glycoproteins in the heart.

Moreover, levels of pro-inflammation associated with immune response caused by ISO associated with the risk heart attacks were also significantly reduced by pretreatment of alliin.

Based on the results, Dr. Sangeetha T, the lead scientist said, "Oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days showed a positive effect on all the biochemical parameters studied in ISO-induced rats".

Taken altogether, alliin may be considered supplements for the prevention and treatment of myocardial infarction,, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preventive effect of S-allyl cysteine sulfoxide (alliin) on lysosomal hydrolases and membrane-bound ATPases in isoproterenol-induced myocardial infarction in Wistar rats by Sangeetha T1, Darlin Quine S. (PubMed)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) Assessment of Risk Factors in Patients With Myocardial Infarction by Fatemeh Kiani,1 Nasrin Hesabi,1 and Azizollah Arbabisarjou. (PMC)

Healthy Food Turmeric, a Natural Prevention and Treatment of Endometriosis, According to Studies

Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus.

More precisely, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood on the last stage of the menstrual cycle, some of the endometriosis tissues grow somewhere else in the body.

Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.

According to the statistics, 20% of reproductive-age women with endometriosis present without symptoms, 55% of women who have developed the new onset of severe menstrual cramps.

Additonally, endometriosis also induce sub-fertility (less fertile than a normal couple) in 25% of women.

There are a number of theories that hypotheses the onset of endometriosis, including
* Retrograde menstruation
The retrograde menstruation theory suggests that during menstruation the blood flows backward instead of outward, causing menstrual blood to go through the fallopian tubes to the pelvic and abdominal cavity


* Weakened immune system
Normally, the immune will destroy endometrial cells which are located outside the uterus. If the immune system is weakened, it will allow the endometrial cells that shed to attach and grow elsewhere in the body.

* Stress and emotion
During stress and emotion, the adrenal glands produce cortisol which affects the function of the body to cleanse toxins resulting in stimulating the growth of endometriosis.

* Embryonic theory
This theory suggests during the embryonic stage, some endometrial cells which normally grow in the womb instead develop in the abdomen.

* Hormone imbalance
Any imbalance of hormones during the menstrual cycle causes conversion of estrogen into bad estrogen and over-production of prostaglandin, leading to the cervix to contract in facilitating the onset of endometriosis. Nutritional deficiency is also one of the causes of hormone imbalance.

* Hereditary
Endometriosis may be genetics passing through from generation to generation or it may result from genetic errors, causing some women to become more likely than others to develop the condition.

* Toxic environment
Study shows that exposing our body to toxins found in pesticides and some harmful waste products may cause hormonal imbalance induced endometriosis developing.

* Xenoestrogen
Interaction of our body with certain chemicals causes a disruption of the body's hormones leading to over-production of estrogen converting to xenoestrogen that stimulates the growth of endometriosis.


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of endometriosis, researchers examined the effect of curcumin, antioxidant, anti-inflammatory and antiproliferative activities.


In mice induced endometriosis by peritoneal implantation of uterine fragments, researchers showed that* Curcumin administered either post- or pre-endometriosis exerted a significantly arrested endometriosis in a dose-dependent manner.

* Injection of curcumin inhibited both MMP-9 activity and its expression at the level of secretion to initiate cytokines and chemokines that regulate tissue remodeling, during regression of the endometriotic lesion.

* Furthermore, curcumin attenuated the activity of MMP-9 was associated with decreased expression of tumor necrosis factor-alpha (TNF-alpha) involved in cell apoptosis during healing, In other words, curcumin induced anti-inflammatory activity against the production of pro-inflammatory cytokines of TNF-alpha

* Most importantly, curcumin pretreatment prevented lipid peroxidation and protein oxidation in normal endometriotic tissue.

Based on the findings, researchers said, "... the anti-endometriotic property of curcumin via MMP-9 dependent pathway (that) may lead to a new therapeutic intervention".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of endometriosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and endometriosis: Review on potential roles and molecular mechanisms by Arablou T1, Kolahdouz-Mohammadi R. (PubMed)
(2) Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity by Swarnakar S1, Paul S. (PubMed)
(3) The Causes of Endometriosis by Kyle J. Norton

Garbanzo bean(Chickpea), The Best antioxidant for free radical scavenging and inhibited cancer cell cycle progression

Whole food(herbal medicine), linking health benefits in the prevention, management, and treatment of diseases has played an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over the world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and pattern right to producers.

Garbanzo bean also is known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.

With Nutrients of
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Vitamin E
14. Vitamin K
15. Iron
16. Magnesium
17. Phosphorus
18. Potassium
19. Zinc
20. Etc.


Chickpea with abundant bioactive phenolic compounds along with the relevant antioxidant capacities may be considered as a functional ingredient of antioxidants for their beneficial health effects, according to the study of the Universidad Autónoma de Madrid (UAM)(1).

Gallic acid, one of the major ingredient of Phenolic profile and a phytochemical found abundantly in tea, mango, strawberries, rhubarb, soy, etc. has found to process bioactive phenolic compounds in radical scavenging effects against DPPH, nitric oxide (NO) and superoxide (SO) radicals as well as inhibiting certain types of cancers(2).

Ferulic acid, another Phenolic profile found abundantly in chickpea, cinnamon, aloe, flaxseed hull, etc. has also found to consist strong antioxidant effect and may be used as potential sources of functional food ingredients(3).

Other in ingredients of the Phenolic profile such as Quercetin(9)(10), Catechin(6)(7), Resveratrol(8)(9),.... also found to process strong antioxidant effects in free radical scavenging as well as protection against the development of many types of cancer.

In fact, sodium selenite and germination on the sprouting of chickpeas (Cicer arietinum L.) may increase the antioxidant capacities of high Se content (2.14 μg/g dry weight) and a moderate-high content of isoflavones (601.56 μg biochanin A/g dry weight and 578.11 μg formononetin/g dry weight). According to the Taishan Medical University, Se-enriched chickpea sprouts may serve as a convenient dietary source of Se and of isoflavones, including formononetin and biochanin A(4).
In support of the above, in a study of sodium metavanadate and germination on the sprouting of chickpeas, researchers at the same university said, " The addition of sodium metavanadate significantly increased V content in CS in a dose-dependent manner. The highest V content (1.52 mg/g) in CS was observed when germination was carried out in the NaVO(3) solution with 1,200 mg/L NaVO(3) concentration. Chickpea seeds germinated in 50 ∼200 mg/L NaVO(3) solutions for 6 days at 28 °C showed a higher germination rate (>99%%) and a higher content of isoflavones including formononetin and biochanin A than those obtained in NaVO(3) solutions with other concentration in the same germination conditions."(5).

Taking all together, intake of one portion of chickpea may reduce the risk of free radical causes of diseases, such as chronic inflammatory diseases, cancers..... For more information, please visit antioxidant research and studies at https://kylejnorton.blogspot.ca/p/blog-page_24.html


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.



Sources
(1) Phenolic profile and antioxidant capacity of chickpeas (Cicer arietinum L.) as affected by a dehydration process by Aguilera Y1, Dueñas M, Estrella I, Hernández T, Benitez V, Esteban RM, Martín-Cabrejas MA.(PubMed)
(2) Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactivecompounds by Harput US1, Genc Y, Saracoglu I.(PubMed)
(3) Qualitative and quantitative analysis of the major phenolic compounds as antioxidants in barley and flaxseed hulls using HPLC/MS/MS by Hao M1, Beta T.(PubMed)
(4) Effects of sodium selenite and germination on the sprouting of chickpeas (Cicer arietinum L.) and its content of selenium, formononetin and biochanin A in the sprouts by Zhang L1, Li Q, Yang X, Xia Z.(PubMed)
(5) Effects of sodium metavanadate and germination on the sprouting of chickpeas and its content of vanadium, formononetin and biochanin A in the sprouts by Zhang L1, Mao X, Xia Z.(PubMed)
(6) Phenolic profile of edible honeysuckle berries (genus lonicera) and their biological effects by Jurikova T1, Rop O, Mlcek J, Sochor J, Balla S, Szekeres L, Hegedusova A, Hubalek J, Adam V, Kizek R.(PubMed)
(7) Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis by Rathore K1, Choudhary S, Odoi A, Wang HC.(PubMed)
(8) Fighting cancer with red wine? Molecular mechanisms of resveratrol.by Kraft TE1, Parisotto D, Schempp C, Efferth T.(PubMed)
(9) Effect of antioxidants resveratrol and quercetin on in vitro evaluation of frozen ram sperm by Silva EC1, Cajueiro JF, Silva SV, Soares PC, Guerra MM.(PubMed)
(10) Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression byJeong JH1, An JY, Kwon YT, Rhee JG, Lee YJ.(PubMed)

Navy Bean Normalizes Postprandial Glycemic Response

Diabetes is a chronic disease associated with insufficient insulin entering the bloodstream to regulate the glucose caused by either the cells in pancreas died-off or receptor sites clogged-up by fat and cholesterol.
Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.

Glycemic response is a change in blood glucose after consuming a carbohydrate-containing food compared to Glycemic Index (GI) that ranks carbohydrate-containing foods according to their effect on blood glucose levels.

In other words, the glycemic response is the change of blood glucose after the intake of a food or meal.

Postprandial blood glucose is the levels taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.

According to the 2015 statistics by the American Diabetes Association, in the U.S. over 30.3 million Americans or 9.4% of the population are living with diabetes. Sadly, out of 30.3 million adults with diabetes, 23.1 million were diagnosed, and 7.2 million were undiagnosed.

Believe it or not, in 2015, 84.1 million Americans age 18 and older had prediabetes.

Most people who are not prediabetes or diabetes have normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.

According to the epidemiological studies, by controlling the glycaemic response with the healthy range, the glycaemic response can reduce the risk of type 2 diabetes. Some researchers suggested including additional fibers into a meal or food can reduce the levels of glucose shortly after intake.


By managing postprandial blood glucose effectively, diabetics can decrease the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).


The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find a potential compound for the improvement of postprandial glycaemic response, researchers examined the effect of dietary intake of pulses, including navy bean.

The study included healthy young men received commercially prepared pulse powders and BG response was recorded before and after a subsequent meal.

More precisely, participants were randomly divided into a whole, puréed and powdered pulses (navy beans in Expt 1; lentils in Expt 2; chickpeas in Expt 3) and whole-wheat flour as the control.

After a fixed-energy pizza meal (50·2 kJ/kg body weight) was provided at 120 min, the BG concentration was measured before (0-120 min) and after (140-200 min) the pizza meal, researchers found that
* Compared with the whole-wheat flour control, navy bean treatments lowered peak BG concentrations but not the mean BG concentration over 120 min.

* Compared to nay bean, all lentil and chickpea lower the mean BG concentration over 120 min after treatments

* Moreover, processing pulses to powdered form does not eliminate the benefits of whole pulses on BG response.

Based on the finding, researchers said, "the use of pulse powders as value-added food ingredients to moderate postprandial glycaemic response".

Taken altogether, Navy bean used alone or combined with conventional medicine may be considered a remedy for the improvement of postprandial glycaemic response, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The acute effect of commercially available pulse powders on postprandial glycaemic response in healthy young men by Anderson GH1, Liu Y1, Smith CE1, Liu TT1, Nunez MF1, Mollard RC1, Luhovyy BL. (PubMed)
(2) First and second meal effects of pulses on blood glucose, appetite, and food intake at a later meal by Mollard RC1, Wong CL, Luhovyy BL, Anderson GH. (PubMed)

Lentils (Legumes) in Reducing the Risk, Progression and Treatment of Metabolic Syndrome



Daily and regularly intake of lentils may have a potential and therapeutic effect in reduced risk and treatment of metabolic syndrome, some researchers suggested.

Lentil, a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens pf the Fabaceae family, native to the Middle East.

Metabolic syndrome is a set of conditions characterized by increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels which are considered as risk factors of cardiovascular disease and diabetes.

Investigation of lentils' effect on the risk of metabolic syndrome was depending on numbers of the mechanism through several aspects.

The testing of low-GLoad foods effect in metabolic syndrome occurrence with 131 male Nile rats aged 3 weeks to 15 months randomly assigned to 15 dietary exposures of varied Glycemic Index (GI, 36-88), GLoad (102-305/2000 kcal), and cumulative GLoad (Cum GLoad=days×GLoad, 181-537g total glucose), indicated that lentil diets with low GLoads (102, 202) displayed a significant effect in reduced onset and treatment of metabolic syndrome in compared to other food with higher glycemic index.

More specifically, the benefit from lentils exceeded dietary factors of combined macronutrient composition (%Energy from carbohydrate:fat: protein, between 70:10:20 to 40:40:20), total fiber (0-24%), or dietary caloric density (2.9-4.7 kcal/g) found in the legume.

Additionally, the experiment also found that the lentil diet even reversed the progression in metabolic syndrome and diabetes expression in the tested Nile rats.

According to the randomized assays, intake of lentils over 15 dietary exposures decreased factors of insulin resistance, lower blood sugars, particular in fasting glucose levels as well as improving levels of blood lipid and the ratio of cholesterol= high-density choleaterol#/ total cholesterol#.

Inspection of total food intake of tested rats also demonstrated a strong correlation between the cumulative GLoad (Cum GLoad=days×GLoad, 181-537g total glucose) and parameters of MetS and T2DM.


In another word, longer-term intake of lower Gload intake is correlated linearly to lesser prevalence risk of cardiovascular disease and diabetes.

More profoundly, according to the University of Toronto, in the experiment to investigate the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the MetSyn of two groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults, measurement of body weight, waist circumference, blood pressure, fasting blood parameters and 24 h food intakes at weeks 1, 4 and 8 and blood glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and ghrelin were measured after a 75 g oral glucose load at weeks 1 and 8 indicated that frequent consumption (five cups/week over 8 weeks) of pulses displayed a significant and positive effect in reduced energy intake in ubction of weight loss, waist circumference, systolic blood pressure, glycosylated Hb (HbA1c), and glucose AUC and homeostasis model of insulin resistance (HOMA-IR) following the glucose load (P < 0·05) similar to those in energy group.

Glycosylated Hb (HbA1c), a measurement of a three-month average plasma glucose concentration is used to determine the risk of diabetes in a suspected subject. There is a suggestion of a lower HbA1c level by 1% associated to lower 19% risk of diabetes onset.



The homeostatic model is a test with an aim to assess the function of β-cell and insulin resistance (IR) from basal (fasting) glucose and insulin or C-peptide, proinsulin molecule concentrations.


Further analysis also found that frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils also increased HDL levels and fasting C-peptide and insulin Area under the curve (AUC) responses in compared to energy group. In deed, the influence of the above parameters was associated with linearly and directly to types of diet intake..


More precisely, pulse treatment group showed HDL and C-peptide increased by 4·5 and 12·3 %, respectively, compared to decreased by 0·8 and 7·6 %, respectively, in the energy-restricted group.
Insulin AUC decreased in both females and males on the energy-restricted diet by 24·2 and 4·8 %, respectively, but on the pulse diet, it decreased by 13·9 % in females and increased by 27·3 % in males (P < 0·05).


Taken together, there is no doubt that frequent intake of lentils or legume products may have a substantial and direct influence on reduced risk, progression, and treatment of the metabolic syndrome.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Low glycemic load diets protect against metabolic syndrome and Type 2 diabetes mellitus in the male Nile rat by Bolsinger J1, Landstrom M2, Pronczuk A3, Auerbach A4, Hayes KC5.(PubMed)
(2) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(3) A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects by Hermsdorff HH1, Zulet MÁ, Abete I, Martínez JA(PubMed)

Tuesday, October 29, 2019

Green Peas (Pisum Sativum) Reduces the Risk of Inflammatory Bowel Disease

An inflammatory bowel (IBD) disease is a group of chronic inflammatory diseases associated with the gastrointestinal tract, including ulcerative colitis and Crohn's disease.

Ulcerative colitis has been found to induce chronic inflammation and ulcers in the inner lining of the large intestine (colon) and rectum, causing diarrhea, often with blood or pus, abdominal pain, and cramping, rectal pain, and bleeding and urgency to defecate.

Crohn's disease is a type of IBD associated with the inflammation of the lining of the digestive tract, leading to symptoms of frequent, recurring diarrhea, rectal bleeding, unexplained weight loss, fever.
and abdominal pain and cramping.

According to the statistics, provided by the CDC in the US, IBD affects over 1.3% or 3 million US adults including Crohn's disease or ulcerative colitis in 2015.

Most common symptoms of IBD include diarrhea, fever, and fatigue, abdominal pain and cramping, loss of appetite and unintended weight loss and blood in the stool.

Conventionally, most cases of IBD are treated with anti-inflammatory medicine, immune suppressor or antibiotics, and drugs that reduce symptoms, depending on the severity of the conditions.

Most cases of IBD has been found in older adults in the age of 45 years or older.

Dr. Danielle Nimmons and Jimmy K Limdi said, "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing globally. Coupled with an aging population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences".

And, "In addition, age-specific concerns such as co-morbidity; loco-motor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximizing benefit and minimizing harm".

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of inflammatory bowel disease, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis.



The study included 6-week-old C57BL/6J female mice fed a 45% HFD or HFD supplemented with 10% GP. for 7-week before colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.

Based on the tested analysis, BP supplement showed a significant effect in ameliorating the disease index score in HFD-fed mice during the recovery stage by reducing neutrophil infiltration and chemokine associated with a pro-inflammatory response.

Furthermore, pro-inflammatory markers in the tested mice such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ) were also inhibited by the administration of GP supplement.

Moreover, the mucin 2 content and goblet cell differentiation markers associated with the protection of digestive functioning were significantly increased by the GP supplement.


Additionally, the endoplasmic reticulum (ER) stress induced by the 2.5% DSS that cause digestive cell dysfunction was inhibited by the GP application.

Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".

Taken altogether, green peas may be considered a functional food for the prevention of inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)

Honey, the Heart Friendly Natural Remedy

Scientists may have found a natural alternative for the treatment of heart disease, according to studies.

Heart diseases are a medical condition associated with any disruption of blood vessels and heart function.

There are 5 types of heart diseases, including
* Heart disease affected by the arteries to the heart, such as coronary artery heart disease
* heart disease affected by heart valves function in regulating blood flow such as valvular heart disease
* heart disease affected electrical conduction such as arrhythmias
* Heart disease affected by heart muscles such as cardiomyopathy
and * Congenital heart disease caused by heart defect at birth

According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year.

Coronary heart disease (CHD) kills over 370,000 people annually.

Most common heart disease in North America is CHD, the type of heart disease caused by plaque buildup on artery walls, leading to narrow, thickens and stiffens arteries. Some researchers suggested that the causes of plaque build-up on the arterial wall were the results of several factors including an unhealthy diet, lack of exercise, being overweight and smoking.

Dr. Sonia S. Anand and colleagues in examing the risk of heart disease associated with poor diet wrote, "Based on the current evidence, the optimal dietary pattern to reduce CVD is one that emphasizes whole grains, fruits and vegetables, legumes, nuts, fish, poultry, and moderate dairy and heart-healthy vegetable oil intake; this pattern will likely reduce the CVD risk by about a third".


And, "This healthy dietary pattern needs also to be low in refined grains, added sugars, trans-fats, SSBs, and red and processed meats. The traditional Mediterranean-type diet provides a well-tested prototype for this healthy dietary pattern".

Researchers not only mentioned that the Western diet pattern associated with the risk of CVD indirectly but also suggested that the diet pattern including the intake of whole grains, fruits and vegetables, legumes, nuts, fish, poultry, and moderate dairy and heart-healthy vegetable oil in reducing the risk of CVD.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural compound for the treatment of heart disease investigated the
honey and its polyphenols cardioprotective activity.

According to the epidemiological studies, regular intake of phenolic compounds is associated with reducing the risk of heart diseases.
Honey exerted coronary heart disease protective effects by the expression of phenolic compounds through several mechanisms, including mainly antithrombotic, anti-ischemic, anti-oxidant, and vasorelaxant effects.

Furthermore, the effect of flavonoids found in honey decreased the risk of coronary heart disease by improving coronary vasodilatation, decreasing the ability of platelets in the blood to clot, and preventing low-density lipoproteins (LDLs) from oxidization.

The results clearly suggested the preventive role of polyphenols of honey against the onset of cardiovascular diseases (CVD).


In order to reveal more information about the honey cardioprotective activity, researchers examined the honey effects on blood sugar, body weight, lipid profile, C-reactive protein, nitric oxide, pro-inflammatory prostaglandins, and homocysteine.


By examing the growing evidence and scientific data, researchers found honey not only demonstrates in the treatment of diabetes, HTN, dyslipidemia, obesity but also has a potential effect against CVD.


Taken altogether, honey may be considered a functioning remedy for the prevention and treatment of heart disease, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) The Potential Role of Honey and its Polyphenols in Preventing Heart Diseases: A Review by M I Khalil and S A Sulaiman. (PubMed)
(2) Honey and cardiovascular risk factors, in normal individuals and in patients with diabetes mellitus or dyslipidemia by Al-Waili N1, Salom K, Al-Ghamdi A, Ansari MJ, Al-Waili A, Al-Waili T. (PubMed)
(3) Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation by Sonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)

Kidney beans( Phaseolus), The Best Anti-Inflammatory Functional Foods

Intake of kidney bean in different varieties may reduce risk and enhance treatment of inflammatory diseases, including colitis, a recent study suggested.

Kidney beans with kidney shape, strong flavor, and color of reddish-brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the University of Guelph, mice fed with red and white kidney bean display significantly anti-inflammatory effects in colitis induced by dextran sodium sulfate (DSS) exposure.

The result of anti colitis activity is attributed to the potency in reduced colon tissue protein levels through ameliorated disease severity and proinflammatory mediator expression, protected further colonic damage,.....

In biochemical approaches including reporter gene assays, immunoprecipitation, kinase assays, and immunoblot analyses, ethanol extract (Pa-EE) of Phaseolus angularis was found to exert anti-inflammatory effects by suppressing the release of Prostaglandin E2 (PGE(2)) and NO in Lipopolysaccharide,..........in the activation of infection and inflammation.



Furthermore, the phaseolus angularis ethanol extract (Pa-EE) strongly reduced the function of lipopolysaccharide in induced the mRNA expression of the formation of enzymes in response to cytokines and in the production of prostaglandins involved activation of the infectious and inflammatory immune response.

Orally administered Pa-EE clearly decreases the ratio of ethanol/hydrogen chloride(EtOH/HCl)-induced gastritis in mice, through the protection of gastric surface tissues against further damage.


In fact, the study in differentiating the efficacy of bean hull antioxidant and anti-inflammatory activities, insisted, "Anti-inflammatory activity of bean hulls was dependent on their phenolic content and antioxidant activity that was significantly affected by cultivar and extracting solvent".


Taking together, Kidney beans (Phaseolus) and their family may be used as therapeutic functional foods in improved immunomodulatory activity against inflammatory diseases.


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Sources
(1) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA6.(PubMed)
(2) Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans by Yu T1, Ahn HM, Shen T, Yoon K, Jang HJ, Lee YJ, Yang HM, Kim JH, Kim C, Han MH, Cha SH, Kim TW, Kim SY, Lee J, Cho JY.(PubMed)
(3) Antioxidant and anti-inflammatory activities of bean ( Phaseolus vulgaris L.) hulls by Oomah BD1, Corbé A, Balasubramanian P.(PubMed)

Lentils and Whole Food Lectin, A Treatment and Biomarker and Therapeutic Targets for treatment of Cervical cancer

Protein binding lectin (including lectin isolated from lentils) may have a positive and profound effect on treatment of cancers and used as a new type of potential biomarkers and therapeutic targets in the treatment of cervical cancer, some scientists suggested.


Lentil a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens in the Fabaceae family, native to the Middle East.

Lectins are carbohydrate-binding proteins with function to specifically interact with other carbohydrate moieties.



The investigation of the effect of protein binding lectin for the treatment of cancers and as potential biomarkers and therapeutic targets in the treatment of cervical cancer was depending on the expression of certain mechanisms in some aspects.

In the study of the effect of Frutalin, α-D-galactose-binding lectin, isolated from Pichia pastoris and native frutalin on cervical cancer cell line HeLa measured by confocal microscopy, researchers found that Frutalin expressed a significant magnitude in the induction of cytotoxicity on cell growth and cell apoptosis in tested HeLa cell line through targeting HeLa cell's nucleus.

Additionally, in other study to evaluate the association of specific mbl-2 alleles(mannose-binding lectin (MBL)) and susceptibility to HPV infection of 150 patients with HPV and 277 control subjects with no HPV, scientists suggested that there is potential linking of expression of mannose-binding lectin (MBL) in high-risk HPV in induction of cervical cancer, but patients with the mbl-2 alternative phenotypes gene represented a least significant risk for the group with HPV, even though, the frequency of high-producer mbl-2 genotypes was found higher in patients with HPV than in control.


Mannose-binding lectin (MBL), is a serum lectin with function in signaling innate immunity in mediated phagocytosis via the lectin pathway.

Furthermore, the study to find a new type of potential biomarkers and therapeutic targets for treatment of cervical cancer by evaluating Galectin-1, -3 and -9, the proteins bind β-galactoside sugars via lectin pathway indicated that galectin expression was found to associate to tumor cells, tumor epithelium infiltrating immune cells and stromal cells in squamous cervical cancer.

Indeed, tested tumor cells, fibroblasts, macrophages, and T cells all expressed the presence of galectins in different scores.

Galectin-1 and -9 were both expressed by tumor cells in 11% of samples, while 84% expressed galectin-3.


Moreover, the Strong galectin-1 expression by tumor cells as an independent predictor was found to associate to poor survival and correlated with increased tumor invasion in compared to weak and positive tumor cell galectin-3 expression is correlated with increased and decreased tumor invasion and tumor cell expression of galectin-9 showed a trend toward improved survival.
The in-depth evaluation also found that tumor CD163+ macrophages associated with progression and prognostication of cervical cancers was predominant immune cell type found in expressing galectin-1, -3 and -9. More precisely, Galectin-1 and -3 were expressed by a minor population of T cells and Galectin-1 was mainly expressed by fibroblasts in the tumor stroma.



After taking into account other confounder, researchers concluded that Galectin-1 expression might be used as a marker to target more aggressive Anti-cervical cancer treatment.


Taken together, protein binding lectins may have a potential effect in the induction of cells apoptosis and proliferation on cervical cancer


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer by Punt S1, Thijssen VL2, Vrolijk J3, de Kroon CD4, Gorter A1, Jordanova ES5.(PubMed)
(2) Mannose-binding lectin in high-risk human papillomavirus infection by Tsai CC1, Lin TM, You HL, Eng HL.(PubMed)
(3) Cytotoxic Effects of Native and Recombinant Frutalin, a Plant Galactose-Binding Lectin, on HeLa Cervical Cancer Cells by Carla Oliveira, Ana Nicolau, José A. Teixeira, and Lucília Domingues(PMC)

Navy Bean Promotes the Healthy Gut Bacterial Metabolism

Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.

Normally, the ratio of good and bad microbes in the gut are balanced. However, people who have a psychological condition such as anxiety, and depression, and are under constant stress and long-term use of antibiotics, particularly your diet may have a negative impact on the ratio.

In other words, the risk factors that alter the ratio of the microbes in the gut may lead to inflammation, oxidative stress, and blood sugar imbalances.

The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.

Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. In other words, imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.

Some researchers suggested that we can optimize our health by manipulating the gut microbiota through diet by increasing the intake of prebiotic and probiotic foods.

However, the benefits may totally depend on their effect on the resident community which is different individually.

Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".

And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.


On finding a natural compound for the improvement of gut microbiota, researchers examined the effects of heat-stabilized rice bran (SRB) and cooked navy bean powder (NBP) phytochemicals on colonic microbiota and intestinal health.

The experiment included a total of 29 overweight/obese volunteers with a prior history of colorectal cancer consumed a study-provided meal and snack daily including eating SRB (30 g/day) or cooked navy bean powder (35 g/day) on gut microbiota and metabolites for 28 days.

Based on the tested assays,* SRB or NBP showed increased gut bacterial diversity and altered gut microbial composition at 28 days compared to baseline in favor of the "good" bacterias.
* Supplementation with SRB or NBP increased total dietary fiber intake similarly, compared to the decrease of rice bran intake.

* More precisely, the Firmicutes: Bacteroidetes ratio is increased and SCFA (propionate and acetate) associated with chronic inflammatory disease in the stool is decreased after 14 days but not at 28 days.


The results strongly suggested that the efficacy of cooked navy bean in the re-balanced the gut microbiomes in favor of the good bacterias may be attributed to fiber contents in the interaction with
phytochemicals in the bean.


Dr. Sheflin AM, the lead scientist said, " modulation of gut microbiota and fermentation byproducts by SRB and suggest that foods with similar ability to increase dietary fiber intake may not have equal effects on gut microbiota and microbial metabolism".


Taken altogether, the cooked-navy bean may be considered a remedy for the improvement of gut microbiota, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors by Sheflin AM1, Borresen EC2, Kirkwood JS3, Boot CM4, Whitney AK1, Lu S1, Brown RJ5, Broeckling CD3, Ryan EP2, Weir TL. (PubMed)
(2) Microbial Metabolism in the Mammalian Gut: Molecular Mechanisms and Clinical Implications.
Hall A, and Versalovic J. (PubMed)

Monday, October 28, 2019

Dried Pea, The Legume Which May Process Anti Colon Cancer Potency

Dried peas with high fiber may have a potential effect in the prevention and treatment of colon cancer.

Colon cancer is a chronic and medical condition characterized by cells growth uncontrollably and disorderly that start on the surface of the inner lining of colon tissue.

At the advanced stage, the cancerous cell can travel a distance away from the original site to affect other healthy tissue and organ through the circulation of blood and fluids.

The exact causes of colon cancer are unknown. However, researchers do know that unhealthy diet and lifestyle with physical inactivity are associated with a substantially increased risk of colon cancer.

Epidemiological studies agreed that the Western diet is associated with the increased risk and recurrent risk of colon cancer.

Ms. Marilisa Racco at the National Online Journalist, Smart Living Global News wrote "There’s more bad news for lovers of red meat and refined grains — also known as a Western diet — from cancer researchers. A new study has found that a pro-inflammatory diet that’s heavy in processed red and organ meat, refined grains, and sugary drinks, will significantly increase the risk of developing colorectal cancer in both men and women".

Furthermore, a higher intake of a Western dietary pattern after cancer diagnosis was also associated with recurrence and death in colon cancer patients.

Publish on the Public Medical Literature, the study includes a total of 1009 patients with stage III colon cancer.

Researchers said, "During a median follow-up of 5.3 years for the overall cohort, 324 patients had a cancer recurrence, 223 patients died with cancer recurrence, and 28 died without documented cancer recurrence".

These result suggested that genetic preposition and an unhealthy diet and lifestyle the major risk factors that associate to the onset of colon cancer and recurrent colon cancer.


Dried peas are the small but nutritionally mighty member of the legume family, the genus Pisum belonging to the family Fabaceae.

The bean has a healthy source of protein, fibers, vitamins, and minerals that are good for everyone's diet.

Besides its main component of the polyphenolic compound, dried bean also contains saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside, etc.

In the study to reaffirm the polyphenolics and saponins effect in the stimulation of antioxidant enzymes in the host and anticarcinogenic activity, researchers launched an investigation to examine the naturally occurring plant protease inhibitors which have potential health-promoting properties within the mammalian gastrointestinal tract against the risk of colon cancer.
Bowman-Birk inhibitors (BBI) isolated from peas exerts anti-carcinogenic and anti-inflammatory properties in the large intestine by surviving from both acidic conditions and the action of proteolytic enzymes in the stomach and small intestine,

A recombinant form of TI1B (rTI1B), representing a major BBI isoinhibitor from pea also inhibited the growth of human colorectal HT29 cells in vitro.

The proliferation of HT29 colon cancer cells was significantly affected by the injection of rTI1B in a dose-dependent manner (IC50 = 31 (sd 7) μm), compared to the novel engineered mutant.

Interestingly, the application of rTI1B induced HT29 colon cancer cells apoptosis without affecting the nearby healthy cells.

Furthermore, the rTI1B proved to be active against trypsin and chymotrypsin in facilitating the colorectal carcinogenesis and promotes proliferation, invasion, and metastasis.

Proteases inhibitor isolated from the peas may process a potential chemopreventive effect during the early stages of colorectal carcinogenesis.

Adding 1 or 2 portions of dried peas into a daily diet in high colon cancer risk patients may reduce the incidence of colon cancer.

Taken all together, dried peas may be considered a function legume in the prevention and adjunct therapy for the treatment of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the dried peas or its bioactive compounds during the course of the disease will be necessary to complete the picture of its anti-colon cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Review of the health benefits of peas (Pisum sativum L. by Dahl WJ, Foster LM, Tyler RT. (PubMed)
(2) The anti-proliferative effect of TI1B, a major Bowman-Birk isoinhibitor from pea (Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition by Clemente A, Carmen Marín-Manzano M, Jiménez E, Carmen Arques M, Domoney C.(PubMed)
(3) Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer by Meyerhardt JA1, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS. (PubMed)