Herbal Ashwagandha, the Potent Anti Cancer Activity in Vitro and Vivo

Cancer is a class of diseases associated with abnormal cell growth in a specific tissue of an organ, due to the alternation of DNA.

A primary tumor or original tumor is a tumor that is at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance of the body and alter the metabolic pathways, leading to disordered and violent cellular behavior.

Most cases of cancer begin in the cells on the surface of the inner lining of tissue. At the early stage, due to the small size of the tumor, most patients are asymptomatic.

However, at the advanced stage, the oversize tumor can press on the nearby nerve cells and blood vessels, leading to bleeding and localized pain and symptoms accompanied by the general symptoms shared by other types of cancer, such as unintended weight loss.

Furthermore, at this stage, cancer cells can also travel a distance away from the originated site to infect other healthy cells and tissue, leading to secondary metastasis.

Localized symptoms are totally depending on the types of cancer.

In the cell cycle division perspective, under normal circumstances, cell growth is a natural process. Every day millions of cells grow to replace millions of dead cells and keep our bodies in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells is back to a normal rate again.

However, if the DNA of a cell is altered, it can multiply indefinitely comapred to limit cell cycle division in a normal cell.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to discover a natural compound for the treatment of cancer, researchers examined the anticancer activity in the water extract of Ashwagandha leaves (ASH-WEX) in vitro and in vivo.

According to the results from the tested analysis, ASH-WEX not only demonstrated a cytotoxic effect on cancer cells selectively, and also induced tumor suppression in vivo.


Triethylene glycol (TEG), an active compound found in the extract processed the strongest anti-cancer property compared to other chemical constituents.

Additionally, ASH-WEX activated the genes associated with tumor suppression in cancer cells.

Furthermore, the extract induced the increase of protein that regulates mitosis and decrease of proteins associated with cell cycle division without causing harm to normal cells.


Moreover, ASH-WEX also inhibited the matrixes involved in cancer metastasis, without affecting the normal cells.

Based on the findings, researchers wrote in the final report, "ASH-WEX and TEG have selective cancer cell growth arrest activity and hence may offer natural and economic resources for anticancer medicine".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cancer, pending to larger example size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action by Wadhwa R1, Singh R, Gao R, Shah N, Widodo N, Nakamoto T, Ishida Y, Terao K, Kaul SC. (PubMed)
(2) Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action by Wadhwa R1, Singh R, Gao R, Shah N, Widodo N, Nakamoto T, Ishida Y, Terao K, Kaul SC. (PubMed)