Coagulation is the process to form a blood clot. Coagulation is also used by the immune system to cover the wound or cut to prevent additional blood loss and protect the body against the invasion of foreign microorganisms.
More precisely, in the acute phase of infection, the immune system activated the fibrins together with small blood cell fragments called platelets, to form the clot. The clots are removed after healing.
However, excessive blood clotting associated with certain diseases and conditions, genetic mutations and medicines, particularly in the aging population has been found to increase the risk of cardiovascular disease.
Excessive blood clotting can be classified into acquired and genetic excessive blood clotting
* Risk factors associated with acquired excessive blood clotting are smoking, overweight, and obesity, pregnancy, use of birth control pills or hormone replacement therapy,...
* The genetic preposition of clotting occurs in the mutation of proteins associated with blood clotting including mutated proteins that cause delay or dissolve blood clots such as Factor V Leiden and
Prothrombin gene mutation.
Most common diseases associated with excessive blood clotting include venous thromboembolism or DVT that involve in the deep veins in the legs and arterial thrombosis that involves the arteries of the heart.
Conventionally, most cases of excessive blood clotting are treated by anticoagulants. In life-threatening blood clots, thrombolytics can dissolve clots that are already formed.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of blood coagulation, researchers examined the bromelain coagulation-inhibiting effects.
In an animal model, bromelain enhanced the activity of serum fibrinolysis by inhibiting the fibrinogen synthesis involving in hepatocytes in the final stages of the blood coagulation process.
Additionally, the anti-blood coagulative activity also exhibits the direct degradation of fibrin and fibrinogen associated with the clotting of blood.
Furthermore, bromelain lowers kininogen and bradykinin serum that involve in the contact activation of the blood coagulation process.
Additionally, bromelain also influenced on prostaglandin synthesis that serves the physiological function of preventing needless clot formation.
Moreover, these effects of bromelain are also dose-dependent.
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of blood coagulation, pending to the confirmation of the larger sample size and multicenter human study.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
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