Honey Protects Our Skin Pigment Against the Onset of Melanoma Skin Cancer

Scientists may have found a natural whole food for the prevention and treatment of skin melanoma cancer, according to some studies.

Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare case, melanoma can also occur in the mouth, intestines, or eye.

The 4 most common types of skin melanoma include
1. Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.

2. Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.

3. Lentigo maligna melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.

4. Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.


According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.

The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin. Why some people are susceptible to the onset of the disease while others do not even share similar health conditions, family history, and ethnicity.

However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV rays are the most common associated with the increased risk of melanoma skin cancer.

In fact, people who inherited the BRAF oncogene have a substantial risk to develop melanoma skin cancer and the most common genes which have been primarily linked to familial melanoma, are CDKN2A and CDK4.

Dr. Miriam Potrony, the lead author in the study "Update in genetic susceptibility in melanoma" suggested that 10% of melanoma skin cancer are genetically related and cyclin-dependent kinase inhibitor 2A (CDKN2A), identified as the first melanoma susceptibility gene more than 20 years ago, is the main high-risk gene for melanoma.


Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the finding a natural ingredient for the reduction of risk and treatment of melanoma skin cancer, researchers launched an investigation to determine the effect of chrysin, a flavonoid present in honey, propolis, against human uveal melanoma cell lines (M17 and SP6.5)


Injection of chrysin reduced the viability of cultured human melanoma cells in a dose-dependent manner (0, 10, 30 and 100 µM) with IC50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively.


Chrysin at 30-100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of nearby healthy cells.

Chrysin inhibited the melanoma skin cancer cells through the proteins associated with cancer cell death and degradation.

These results indicated chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway in the increased mitochondrial permeability.

In the finding the scientist evidence for Manuka honey effect in the treatment of cancer, researchers at the UAE University conducted an investigation to examine the anti-cancer effect on three different cancer cell lines, murine melanoma (B16.F1) and colorectal carcinoma (CT26) as well as human breast cancer (MCF-7) cells in vitro.

Manuka honey has a potent anti-proliferative effect on all three cancer cell lines in a time- and dose-dependent manner, at the concentrations as low as 0.6% (w/v).

The efficacy of Manuka honey in the inhibitory melanoma skin cancer was attributed to the increased expression of pro-apoptotic and cell death programming activity.


Treatment with manuka honey alone resulted in about 33% inhibition of tumor growth, which correlated with a histologically observable increase in tumor apoptosis without inducing any side effects.

Dr. Fernandez-Cabezudo MJ, the lead author said, "Although better control of tumor growth was observed in animals treated with paclitaxel alone or in combination with manuka honey (61% inhibition), a dramatic improvement in host survival was seen in the co-treatment group".

In support of the above differentiation, a joint study led by Nazarbayev University also suggested that honey processed the anti-carcinogenic effects in vitro and in a murine model of melanoma.

Taken altogether, honey may be considered a functional food for the prevention of melanoma skin cancer and a secondary therapy combined with primary medicine for the treatment of melanoma skin cancer.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.





Sources
(1) Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis by Xue C1, Chen Y2, Hu DN3, Iacob C4, Lu C5, Huang Z. (PubMed)
(2) Honey: A Therapeutic Agent for Disorders of the Skin by McLoone P1, Oluwadun A2, Warnock M3, Fyfe L. (PubMed)
(3) Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model by Fernandez-Cabezudo MJ1, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK. (PubMed)
(4) Update in genetic susceptibility in melanoma by Miriam Potrony,1 Celia Badenas,2,3 Paula Aguilera,1,2 Joan Anton Puig-Butille,2,3Cristina Carrera,1,2 Josep Malvehy,1,2 and Susana Puig. (PMC)