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Saturday, October 26, 2019

Black beans, The Legume in the Prevention and Treatment of Benign Prostatic Hyperplasia (Enlarged Prostate)

Black bean, a glossy black shell legume may have a potential effect in protecting the prostate gland against the onset of prostatic hyperplasia, scientists found.

Prostatic hyperplasia is a medical condition associated with the enlarged prostate that impedes the urinary flow.

The prostate is a gland that surrounds part of your urethra, the tube with a function to carry urine and semen out of men's penis.

The condition is found mostly in aging men, as a result of free testosterone converting to the hormone dihydrotestosterone (DHT). Overabundant DHT in the men body is a major cause of an enlarged prostate.

Truly, DHT has been found to plays a beneficial role in the developing prostate but it can be detrimental in the adult prostate in facilitating pathologic prostate growth, including the enlarged prostate.

The role of DHT in other adult tissues is uncertain. DHT has not been shown to perform beneficial functions unique from testosterone in the adult male, and it is believed that its fundamental effect may amplify testosterone's weaker hormonal signal.

The 5alpha-reductase inhibitors play an important role in the protection of the prostate gland by blocking the process of prostate diseases, by reducing the prostate volume, and reduce the risk of acute urinary retention and enlarged prostate.

5alpha-reductase inhibitors have been found in the low levels in aging males with prostate diseases.

Some researchers suggested that by targeting the conversion of testosterone to DHT, the enlarged prostate can be preventable.

Men who follow an unhealthy diet and lifestyle of the Western diet with a lot of saturated and trans fat, red meat, process and less in fruits and vegetable and whole-grain are associated with a substantial risk of the early onset of LUTS (lower urinary tract symptoms) in describing the symptoms related to problems of the lower urinary tract (bladder, prostate, and urethra), including enlarged prostate.

Dr. Pao-Hwa Lin, the lead author in the study "Lifestyle and LUTS: what is the correlation in men?" reconfirm these statements said, "1) Epidemiological data repeatedly show a favorable relationship between healthy eating habits and regular physical activity level and a lower risk for LUTS or progression of LUTS, 2) certain specific nutrients or dietary factors may contribute to the link between diet and LUTS due to their anti-inflammatory potential, and 3) very little research has been conducted to test the epidemiological findings in randomized controlled trials".

"A healthy lifestyle with a good quality diet and regular physical activity is beneficial not only for potentially improving or reducing LUTS but also for cardiovascular and overall health".

In other words, an enlarged prostate can be preventable in the aging male, if they follow a healthy diet and lifestyle with moderate exercise.

Black bean is a small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The legume can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Chemical constituents of black bean include
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

In the examination to reconfirm the effect of black soybeans on benign prostatic hyperplasia (BPH), researchers launched an investigation to evaluate the anti benign prostatic hyperplasia (BPH) anthocyanin extracted from the legume on rat induced enlarged prostate.

The study included a total of male rats who were divided into five experimental groups: a control group, a BPH-induced group, and three BPH-induced groups that received oral doses of anthocyanin (40, 80, and 160 mg/kg).

Prostate hyperplasia was induced by the administration of testosterone propionate for 4 weeks.

Anthocyanin-treated groups received the compound for 4 weeks after the induction of enlarged prostate.

The mean prostate weights for the rats receiving 40, 80, and 160 mg/kg anthocyanin were 323.00, 324.00, and 617.50 mg, respectively.

This assessment indicated the preferred dose of anthocyanin in the prevention of enlarged prostate is 40 mg.

In groups comparison, the average prostate weight in the BPH-induced group was significantly higher than in the control group (p < 0.05), whereas the prostate weights in the anthocyanin-administered groups were significantly lower than in the BPH-induced group (p < 0.05).

Furthermore, the anthocyanin administration helped to prevent the change of prostate weight caused by injecting testosterone to induce prostatic hyperplasia.

Moreover, apoptotic body counts were significantly higher in groups receiving anthocyanin than in the BPH-induced group.

These results suggested that anthocyanin may be effective in decreasing the volume and suppressing the proliferation of the prostate, through inhibiting the conversion of testosterone to the hormone dihydrotestosterone (DHT).

Additionally, in the testing to examine whether Seoritae extract (SE) form the black soybeans have beneficial effects on the reduction of prostate weight in a rat model of benign prostatic hyperplasia (BPH), researchers at the joint study led by the The Catholic University of Korea College of Medicine conducted an experiment with BPH induced by intramuscular injections of testosterone enanthate once a week for 5 weeks in Sprague-Dawley rats, then rats were treated with or without daily oral doses of SE during BPH induction.

After 5 weeks, the SE treatment group showed a significant decrease in prostate weight, oxidative stress, apoptosis, and 5alpha-reductase activity compared to the nontreated BPH group.

These results coincidently showed that SE is effective in decreasing the weight and proliferation of the prostate similar to those of the above study

Dr. Hoon Jang, the lead scientists suggest that SE may be an effective treatment for BPH.

Taken all together, black beans containing the abundant major bioactive compound anthocyanin may
be considered a functional food for the prevention and treatment of the early phase of enlarged prostate with no side effects, depending on the further the human studies.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia by Hoon Jang,1 Woong-Jin Bae,1 Seung-Mo Yuk,1 Dong-Seok Han,1 U-Syn Ha,1 Seong-Yeon Hwang,2 Shin-Hee Yoon,3 Sae-Woong Kim,1 and Chang-Hee Han. (Hinwadi)
(3) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model. by Jang H, Ha US, Kim SJ, Yoon BI, Han DS, Yuk SM, Kim SW. (PubMed)
(4) Lifestyle and LUTS: what is the correlation in men? by Pao-Hwa Lin, PhD1 and Stephen J. Freedland, MD. (PMC)

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