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".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Sunday, March 31, 2019

Phytochemical Sinigrin, Inhibits the Risk and Progress of Aberrant Crypt Foci Against Colon Cancer, Researchers Find

The bioactive compound Sinigrin may be used for the prevention and treatment of aberrant crypt foci (ACF) in the lining of the colon and rectum, according to studies.

Aberrant crypt foci is a condition of clusters of abnormal tube-like glands in the lining of the colon and rectum. The condition can be subclassified into dysplastic, nondysplastic or mixed type.

Crypt cells of the colon renew the lining of the intestine and produce mucus.


Epidemiological studies suggested that aberrant crypt foci have been found to form before colorectal polyps, the main cause of colon cancer.

According to the high magnification chromoendoscopy, aberrant cryptic foci are stained darker than normal crypts.

And, dysplastic ACF is found in 25- 30% of all patients with colon cancer due to genetic preposition of mutation of KRAS.


Where KRAS protein is associated with the regulation of cell proliferation under normal condition.

Dr. Takayama T and colleagues in the investigation of aberrant crypt foci in gene abnormalities and risk of colon cancer, wrote, "ACF, particularly dysplastic ACF, are precursor lesions of the adenoma-carcinoma sequence in humans. In most sporadic ACF, K-ras mutations were positive, but APC mutations were negative irrespective of nondysplastic or dysplastic features".


And, "In most sporadic ACF, K-ras mutations were positive, but APC mutations were negative irrespective of nondysplastic or dysplastic features. Conversely, in most ACF from familial adenomatous polyposis patients, APC mutations were positive but K-ras mutations were negative".

The results strongly support the genetic mutation of gene KRAS involved in the initiation of dysplastic crypt foci.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Scientists on finding a bioactive compound for the protection of colonic mucosal crypts against the aberrant crypt foci investigated the effect of oral administration of the isolated glucosinolate sinigrin in the suppression of aberrant crypt foci in the colonic mucosa of rats treated with 1,2-dimethylhydrazine (DMH).

During the experiment, glucosinolate sinigrin found in Brussels sprout modulated crypt cell apoptosis and mitosis, and the frequency of aberrant crypt foci in the colon.

Oral administration of uncooked Brussels sprouts, whether as a juice or as a freeze-dried powder, was associated with significantly enhanced levels of apoptosis and reduced mitosis in the colonic crypts.

The findings strongly suggested that the inhibition of colonic mucosal crypts was attributed to other chemical compounds found in freeze-dried raw, microwave-cooked Brussels sprouts and sprout juice.

In-depth analysis of the activity, researchers found that the efficacy was attributed to the glucosinolate breakdown products derived from Brassica vegetables on the balance of colorectal cell proliferation and death in an animal model of precancerous colon polyp.

Additionally, in order to reveal more information about the sinigrin effects on the colonic mucosal crypts, researchers examined the sinigrin on the intestinal mucosa of rats treated with dimethylhydrazine (DMH).

Sinigrin showed to inhibit the aberrant crypt foci at 18, 24, 38, 48 and 72 h after injection, compared to control groups were given DMH only, or a sham injection.

Before injection of sinigrin, tested rats showed higher numbers of aberrant crypt foci in colonic tissue from both groups of DMH-treated rats and the controls.

Moreover, the experiment of rats given sinigrin (400 microg/g diet) 22 h after the second of two injections of DMH, showed that sinigrin reduced numbers of ACF by increasing the levels of apoptosis compared to those of higher in DMH-and controls.

The findings clearly support the use of sinigrin for the protection of colonic mucosal crypts.

Taken altogether, sinigrin in forms of glucosinolates, the sulfur compounds may be considered a supplement for the prevention and treatment of aberrant crypt foci, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo by Smith TK1, Mithen R, Johnson IT. (PubMed)
(2) Inhibition of dimethylhydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin by Smith TK1, Lund EK, Johnson IT. (PubMed)
(3) Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness by Takayama T1, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y. (PubMed)

Phytochemical Allicin, the Potent Anti Osteosarcoma Bioactive Supplement

Phytochemical allicin isolated from garlic may be used for the prevention and treatment of osteosarcoma with no side effects, some scientists suggested.

Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, the disease is the result of the conditions associated with inherited mutated genes from the parent.

However, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation also use play a major role in many adult cancers.

According to the statistic, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are reported each year. and children and teens younger than 20 accounts for half of the numbers.

Dr. James J. Morrow, the lead scientist in the study of genetic risk of osteosarcoma wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life"


And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)"


These results strongly suggested that young teenagers with genetic syndrome are more likely to be infected by the disease, compared to others.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find a natural ingredient for the treatment of osteosarcoma with no side effects, researchers at the Wenling City Chinese Medicine Hospital looked into the anti osteosarcoma activity of the main biologically active compound derived from garlic.

The combined treatment significantly suppressed the invasion, motility and colony formation ability and activated the protein associated with a pro-apoptotic activity, compared to the lone treatment group.

Furthermore, in vivo.artesunate and allicin also inhibited the tumor growth and cell proliferation

Dr.Jiang W, the lead scientist said, "artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis".

Moreover, in the examined the effects of diallyl sulfide (DAS) derived from allicin in vitro and vivo on the proliferation of human osteosarcoma MG-63 cells, researchers found that in vivo, the nude mice MG-63 cells tumor-bearing model after twenty-one days treatment with DAS inhibit proliferation of MG-63 cells in a time- and concentration-dependent manner.

DSA groups (different concentrations) showed a significantly reduced the expression levels of VEGF mRNA, associated with stimulating the formation of blood vessels. compared with those in the control group.


At the dose of 20 and 40 μg/mL, cells migration was significantly lower in the DAS groups (91.4±8.3 and 81.8±7.4, respectively) compared to the control group (150.4±14.7, both).

Also at the dose of 20 and 40 μg/mL, DAS also decreased the microvessel density (MVD) of MG-63 tumor-bearing tissue.

Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of osteosarcoma.

However, intake of allicin as a form of supplement should be taken with extreme care to prevent overdose toxicity



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)(3) Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies by James J. Morrowa and Chand Khannab. (PMC)

Saturday, March 30, 2019

Honey Promotes Drainage of Bile and Pancreatic Duct Against Obstructive Jaundice



On seeking natural therapy with no side effects, scientists may have a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.

Obstructive jaundice is a condition caused by the obstruction of bile or pancreatic duct, that interferes with the drainage of bile from the bloodstream into the intestines.

On the other hand, jaundice is a result of overexpression of bilirubin, a yellowish pigment found in hemoglobin in the blood.

Increased expression of bilirubin in the blood in some cases is caused by liver injury.

Some researchers suggested that gallstones, pancreatic disease, including cancer and cysts, developed on or nearby the tube connecting the pancreas to the intestines.


In other words, any diseases associated with the narrowing and blocking of the normal function of the drainage of bile from the blood may be considered the causes of obstruction jaundice.


According to the statistics, obstructive jaundice is a very common symptom found in approximately 10-15% of patients with Gallstones. Sadly, most cases of obstructive jaundice were a result of cancers with a 2-year mortality rate of 95%.


Dr. D. PHILIP MACGUIRE, M.D. in the article of obstructive jaundice suggested that in the differentiation of obstructive jaundice, physicians should also take into consideration the biochemical analyses of icterus index, bile acids, blood sedimentation test, cholesterol, nonprotein nitrogen, urea and amino nitrogen, uric acid of the blood, and urobilin excretion in the urine.


The doctor continued, " there is also a distinctive change in the chemical composition of the blood in obstructive jaundice as shown by an increase of cholesterol which is present in two forms: (a) free alcohol and (b) combined with acid as esters".


The statement is clearly suggested that a surgeon should also know the extent of liver impairment in patients with obstructive jaundice before the surgery.


Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural and therapeutic compound for the treatment of obstructive jaundice (OJ), a serious, life-threatening condition that can lead to death, researchers examined the anti-obstruction jaundice of honey and immunonutrients.

The study included forty 24-week-old male Sprague Dawley rats, randomly placed into five groups, each group consisted of eight rats. The sham group underwent only common bile duct (CBD) dissection and no ligation was performed. CBD ligation was applied to the other groups and after the operation, one CBD group was fed with rat chow only, the others were fed with rat chow supplemented with honey, or immunonutrients, or honey plus immunonutrients.


On the final day of the experiment, researchers found that honey and immunonutrient reduced the markers of oxidative stress observed by the levels of alanine aminotransferase (ALT) compared to the other groups.


Bacterial translocation (BT) rates also significantly reduced in the honey and immunonutrient treatment group according to the liver and spleen samples.

Futhermore, the mean mucosal thickness of ileum samples also improved notably in the BDL+HI group compared to the other groups.

Dr. Oguz S after taking into account co and confounders wrote, "Immunonutrition applied with honey had immunostimulant effects, decreased BT due to an additive effect, and had positive effects on intestinal mucosa".

Additionally, in order to reveal more information about honey anti-OJ property, researchers once again investigated the possible effects of honey supplementation on anastomotic wound healing in obstructive jaundice (OJ) model.

The study included 80 Wistar-albino rats divided into four groups as control, OJ, O plus artificial honey and OJ plus honey.

Selected rats were fed with standard rat chow (SRC) in group-I&II, SRC plus 10 mg/kg/day honey in group-4 and SRC plus artificial honey including the same caloric amount with honey in group-3. Colon anastomoses were performed in all groups.

Also, common bile duct ligation was performed in group-1, group-2, and group-3.

Honey treatment significantly lowers the levels of jaundice in the animal by inhibiting the levels of hydroxyproline compared with the controls and those given honey or artificial honey.

According to the anastomotic bursting pressure assay, the use of honey significantly increased the bursting pressure compared with that of the bile duct ligated group.

Dr. Ergul E, the lead scientist said, based on these results, "The oral administration of honey can be considered when attempts at conventional internal drainage fail in obstructive jaundice".

Taken altogether, honey may be considered a functional remedy for the treatment of obstructive jaundice (OJ), pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Combined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Study by Oguz S1, Salt O2, Ibis AC3, Gurcan S4, Albayrak D1, Yalta T5, Sagiroglu T1, Erenoglu C. (PubMed)
(2) The effect of honey on the intestinal anastomotic wound healing in rats with obstructive jaundice by Ergul E1, Ergul S. (PubMed)
(3) OBSTRUCTIVE JAUNDICE by D. PHILIP MACGUIRE, M.D.

Herbal Artichoke Inhibits the Incidence of Metabolic Syndrome

On seeking natural therapy with no side effects, scientists may have a herbal remedy for the prevention and treatment of metabolic syndrome, according to studies.

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type II diabetes, including excess body fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.

Individuals are considered to have metabolic syndrome if they process 3 or more of the aforementioned conditions.

Being overweight or obesity, lack of physical activity and Insulin resistance are some of the risk factors associated with the onset of metabolic syndrome.

Some researchers suggested that the promotion of the Western diet over the past few decades may be the major factors that cause widespread metabolic syndrome in the Western world.


Dr. Silvia Moreno-Fernández, the lead scientist in the cross-sectional study of diet pattern in risk of metabolic syndrome wrote, " At the end of the study, HFG animals showed lower expression of energy expenditure genes when compared to the other DIO groups. Oxidative stress biomarkers such as MDA and mitochondrial RT-qPCR analyses showed an increase of oxidative damage together with mitochondrial dysfunction in HFG group".


And, "This group also showed increased insulin and glucose plasma levels, though HFF animals showed the greatest increase on these parameters. All DIO groups showed increased plasma levels of triglycerides".


The finding strongly suggested the correlation between the Western diet and metabolic syndrome risk.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

With an aim to find a natural ingredient for the treatment of metabolic syndrome, researchers examined the Artichoke leaf extract (ALE) anti-metabolic syndrome activity through its antioxidant activity.

The double-blind placebo-controlled randomized clinical trial included 80 patients with MetS randomly allocated to either "ALE group" (received 1800 mg ALE as four tablets per day) or "Placebo group" (received placebo containing cornstarch, lactose, and avicel as four tablets per day) for 12 weeks.

According to the results of 68 patients completed the experiment, dietary intakes of energy, macronutrients, and micronutrients were not significantly different between the two groups throughout the trial, with the exception of zinc.

However, the concentration of oxidative of low-density lipoprotein is decreased significantly in ALE group, compared to placebo without affecting the oxidative stress marker and antioxidant enzymes.

The finding strongly suggested that Artichoke leaf extract (ALE) only reversed one of the conditions of the cluster in metabolic syndrome, namely, hyperlipidemia.

Furthermore, in order to reveal more information of artichoke anti-metabolic syndrome effects, researchers evaluated the activity of Boldocynara®, a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus.

Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) involved the breaking down of carbohydrates.

Artichoke alone displayed a moderate inhibitory activity of 31% at 100 µg/ml.

According to the tested enzymes, the combination had moderate to weak effects against the expression of the metabolic syndrome.

The results indicated a moderate potential of the dietary supplement Boldocynara® and artichoke for the treatment of metabolic disorders.

Taken altogether, artichoke used alone or combined with other herbal medicines may have a potential effect against the onset of metabolic syndrome, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial by Rezazadeh K1, Aliashrafi S2, Asghari-Jafarabadi M3, Ebrahimi-Mameghani M. (PubMed)
(2) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)
(3) High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model by Silvia Moreno-Fernández,1,2 Marta Garcés-Rimón,3 Gema Vera,2,4 Julien Astier,5Jean François Landrier,5 and Marta Miguel. (PMC)

Friday, March 29, 2019

Phytochemical Sinigrin, the Potential Anti Liver Cancer Proliferation Bioactive Ingredient, According to Studies



Sinigrin may be the next-generation natural and bioactive compound processed an antiproliferative activity against the progression of cancer, according to studies.

In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.

In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.

In a suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.

In programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.

In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.

Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.

Dr. Albanes D, in the study of cell proliferation as a major risk factor for cancer, said, "Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans".

And, "A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is postulated that cancer risk is proportional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue".

Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a bioactive compound for the treatment of liver cancer, one of the leading causes of cancer death worldwide. investigated the anti-proliferative activity of sinigrin, the major ingredients present in Brassica nigra.

In a model of carcinogen-induced hepatotoxicity in rats, the selected animals were orally administered with sinigrin on a daily basis for three months before sacrifice.

During the experiment, the injection of sinigrin significantly inhibited the proliferation of liver tumor cells, observed by the reduction of the number of surface tumors in the rat liver.

Sinigrin induced apoptosis of liver cancer cells by exhibiting the expression of a protein associated with the tumor suppression in the host rats, namely, the p53.

Further, the application of sinigrin induced cancer apoptosis by stimulating the production of a protein involved in cell death programming and gene involved cellular differentiation.


Interestingly, additional analysis of the sinigrin anti-liver cancer activity, researchers showed that the bioactive compound not only inhibits cancer cells from proliferation through cell cycle arrest but also restores the liver function without inducing liver toxicity.

The results strongly suggested that sinigrin processed significant anti-liver cancer properties via several genes and pathways.

Dr. Jie M, the lead scientist wrote in the final report, "sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlight the potential of sinigrin as an anti-cancer agent for liver cancer".

Taken altogether, sinigrin found in Brassica nigra may be considered a functional supplement for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(2) Are cell number and cell proliferation risk factors for cancer? by Albanes D1, Winick M. (PubMed)

Papaya, in the Prevention and Treatment of Chronic Inflammatory Diseases

On seeking natural therapy with no side effects, scientists may have found a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.

Inflammation is a natural immune response which protects our body against the invasion of stimuli and foreign pathogens.

During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.

However, overproduction of inflammatory cytokines not only can induce fever, swelling, and pain to the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.

Chronic inflammatory diseases are the class of conditions involved low-grade inflammation to the affect tissue or organ. Some researchers suggested that the immune system has evolved over thousands of year to kill off the foreign invasive pathogens within a period of times, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.

There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involved immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.

Certain risk factors such as long-term exposure to irritants, such as industrial chemicals or polluted air, the increase in age, being obesity or obesity, low sex hormone production, sleep disorder and diet.


The Karolinska Universitetssjukhuset Solna study suggested that cigarette smoking is emerging as a strong risk factor in the otherwise unknown etiology of chronic inflammatory diseases. The risk of nicotine smokers showed a substantial increase in the risk of chronic inflammatory diseases compared to ever-nonsmokers.

Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

With an aim to investigate the therapeutic potential of fruit and vegetables in the inhibition of inflammation, with no side-effects and the whole foods additive and synergistic benefits, researchers at the Universiti Putra Malaysia, examined the role of papaya in mediating inflammatory responses.


On cells of healthy individuals, according to the flow cytometry methods, injection of the fruit significant inhibited the overexpression of IFN-γ(+), a cytokine that is critical for innate and adaptive immunity and CD4(+), in the activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells.

The application also showed to increase the levels of anti-inflammatory cytokines which play a critical role in reducing the risk of inflammation.

These results suggested that papaya suppressed the pro-inflammatory cytokines through its anti-inflammatory response mediated through Tregs, a specialized subpopulation of T cells that act to suppress the immune response.

In other words, papaya modulates the systematic immune response through a set of mechanisms in the acute phase of infection.

Furthermore, on finding a natural ingredient or whole food for the treatment for patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers evaluated the effect of mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya.


Application of mangiferin (MF) was found epidemiologically to attenuate cecal ligation and puncture-induced mortality and acute lung injury (ALI), by reduced systemic and pulmonary inflammatory responses.

In Sepsis patients, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases which play a critic role in directing cellular responses to a diverse array of stimuli, and nuclear factor kappa-light-chain-enhancer of activated B cells signaling (NF-κB) associated with the production of pro-inflammatory cytokine for cell survival.

These actions indicated that pretreatment with MF inhibits production of proinflammatory mediators associated with immune responses.

In the tested animal, MF dose-dependently exhibited the expression and activity of heme oxygenase (HO)-1, a gene which plays a critical role in the prevention of vascular inflammation. in the lung of septic mice.

Dr.Gong X, the lead scientist said, 'MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators", after taking into account co and confounders.


Interestingly, in the evaluated fermented papaya preparation, a functional food supplement, researchers at the Touro College of Pharmacy also found that the fermentation exhibited anti-inflammatory, antioxidant, immunostimulatory (at the level of the mucous membrane), through a set of bioactive compounds found in the fruit.

Taken altogether, papaya may be considered a functional fruit for the prevention and treatment of the diseases associated with chronic inflammation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papayaincreases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
(3) Applications and bioefficacy of the functional food supplement fermented papaya preparation by Aruoma OI1, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L.(PubMed)
(4) Smoking, use of moist snuff, and risk of chronic inflammatory diseases by Carlens C1, Hergens MP, Grunewald J, Ekbom A, Eklund A, Höglund CO, Askling J.(PubMed)

Thursday, March 28, 2019

Ginger Protects Our Eyes Against Cataract

A cataract is a condition with a decrease in vision, caused by the clouding of the lens in the eye found mostly in older adults. Eye injuries, inflammation, and some other eye diseases are also found to initiate the condition.

According to the statistic provided by the World Health Organization, 51% of world blindness, which represents about 20 million people (2010) worldwide are the result of a cataract. The condition can be reversed by surgery.
Aging cataract can be classified into 3 primary types, including
* Nuclear sclerotic cataracts

It is the most common type of cataract in the elderly caused by the gradual clouding of the central portion of the lens.

* Cortical cataracts
It is a type of cloudiness that develops in the lens cortex outside the edge of the lens.

* Posterior subcapsular cataracts
It is a type of cataract begins with a cloudy area on the back surface of the lens.


Epidemiological studies suggested that people who are smokers, occupation associated with ultraviolet light exposure, diabetes mellitus and overweight are susceptible to the higher risk of the disease.

However, some researchers suggested that the widespread cataract in the aging population over the past few decades may be associated with the promotion of a high-fat diet.

Dr. Chung-Jung Chiu, the lead scientist said, "Two major dietary patterns were identified by principal component analysis and named Oriental and Western patterns. The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".

And, "Our data indicate that consuming a Western dietary pattern is significantly associated with increased odds of early nuclear opacity".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of diabetic cataract caused by advanced glycation end products (AGE) examined ginger anti AGE activity.


The study included diabetes Wistar-NIN rats induced by intraperitoneal injection of streptozotocin (35 mg/kg body weight) and the control rats received vehicle alone.

In diabetics rats, a set of diabetic animals was given the AIN-93 diet, another set was given either 0.5 or 3% ginger in their diet for a period of two months.

According to the tested assays, ginger not only delayed the onset but also the progression of cataract in rats.

Ginger significantly inhibited the formation of various AGE products including carboxymethyl lysine in the eye lens.

Furthermore, the injection of ginger also inhibited the hyperglycemia-induced osmotic stress in the lens.

The results suggested ginger protects the eye against cataract in rats through a number of mechanisms involved the development of several pathophysiologies, including diabetic cataract.

Dr. Saraswat M, the lead scientist wrote at the end of the study, "The results indicated that ginger was effective against the development of diabetic cataract in rats mainly through its antiglycating potential and to a lesser extent by inhibition of the polyol pathway".

Moreover, in the study of oxidative stress and aldose reductase induced diabetic complications, researchers analyzed the protective effect against diabetic eye complication of purple waxy corn and ginger.


The study included streptozotocin-induced diabetics with the blood glucose levels >250 mg·dL(-1) orally given the extract at doses of 50, 100, and 200 mg/kg·BW(-1) for 10 weeks.
All doses of PWCG showed significant inhibition of decreased lens opacity, the levels of oxidative stress Malondialdehyde (MDA) and anti-reflective coating (AR) in the lens of diabetic rats.

PWCG also improved the antioxidant profile in the treated rats.


Most importantly, the antiretinopathy property of the combined extract was also confirmed by the increased number of neurons in the ganglion cell layer and thickness of total retina and retinal nuclear layer in diabetic rats.

Dr. Thiraphatthanavong P, the lead researcher said, "PWCG is the potential functional food to protect against diabetic cataract and retinopathy. However, further studies concerning toxicity and clinical trial are still essential".

Take all together, ginger processed a high amount of bioactive compounds may be considered a function alternative for prevention and treatment of cataract, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats by Saraswat M1, Suryanarayana P, Reddy PY, Patil MA, Balakrishna N, Reddy GB. (PubMed)
(2) The combined extract of purple waxy corn and ginger prevents cataractogenesis and retinopathy in streptozotocin-diabetic rats by Thiraphatthanavong P1, Wattanathorn J2, Muchimapura S2, Thukham-mee W2, Lertrat K3, Suriharn B. (PubMed)
(3) American Major Dietary Patterns and Age-related Cataract by Chung-Jung Chiu, Gary Gensler, and Allen Taylor. (FASEB Journal)

Phytochemical Allicin, the Novel Dietary Antioxidant

Phytochemicals may be the next potential sources of new medications for the treatment of diseases with little or no side effects.

Scientists may have found a dietary and bioactive ingredient for the prevention and treatment of diseases associated with oxidative stress.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

Oxidative stress is a condition characterized by the overexpression of free radicals in the host body.

Most cases of oxidative stress are caused the inability of the host liver in stimulating the production of antioxidant enzymes which play a critical role in inhibiting the free radical expression, causing oxidative stress.

In a healthy individual, the ratio of free radicals and antioxidant enzymes is always balanced.

However, an individual whose antioxidant enzymes were suppressed due to damage to the antioxidant enzymes productive system or other sources may have a greater risk of the onset of oxidative stress.

Dietary antioxidant intake such as fruits and vegetable may be helpful to keep the free radical in check.

Oxidative stress has been found to cause damage to cell lipids, proteins, DNA, leading to many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

The oxidative stress that causes chronic ailment is a result of a chain reaction started by free radical donate or steal an electron from another atom, leading to a domino's effect which can not be stopped until all outer ring electron of free radicals is paired or inhibited by antioxidants.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with another cell.

Most free radicals and other ROS are derived internally either from normal essential metabolic processes in the human body or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.

Antioxidants are biomolecules inhibited the oxidation.
On finding a natural ingredient and whole food for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effect of allicin (the active ingredient of garlic) contained in the commercial preparation Garlicin against hydroxyl radicals (.OH) using high pressure liquid chromatographic (HPLC) method.

Allicin equivalent in Garlicin (1.8, 3.6, 7.2, 14.4, 21.6, 28.8 and 36 micrograms) produced concentration-dependent decreases in the formation of 2,3-DHBA and 2,5-DHBA, the OH adduct products.

The inhibition of formation of 2,3-DHBA and 2,5-DHBA with 1.8 micrograms/ml was 32.36% and 43.2% respectively while with 36.0 micrograms/ml the inhibition was approximately 94.0% and 90.0% respectively.


These results suggested that allicin is highly active against the OH adduct products through its free radical scavenging activity.


Furthermore, Allicin also exerted a significant antioxidant activity by preventing the lipid peroxidation of liver homogenate in a concentration-dependent manner.


Additionally, by examing the antioxidant effects of four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers discovered
* Alliin scavenged superoxide, while allyl cysteine and allyl disulfide did not react with superoxide.

* Allicin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol exchange mechanism.

* Allicin did not exhibit hydroxyl radical scavenging activity in this study, probably due to some unknown mechanisms.

The finding suggested that allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage.


Taken altogether, allicin processed high levels of free radicals scavenging activity may be used for the prevention of the overexpression of ROS in the initiation of oxidative stress.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity of allicin, an active principle in garlic by Prasad K, Laxdal VA, Yu M, Raney BL. (PubMed)
(2) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)

Wednesday, March 27, 2019

Phytochemical Anacardic Acid, the Natural Antibiotic Alternative with No Side Effects

Scientists may have found a bioactive compound for the replacement of antibiotics with no side effects, some studies suggested.

Infection is a human disease characterized by the invasion of an organism that multiplied in the specific tissue or organ.

In the bodily injury due to physical impact, the white blood cells of the immune first line of defense stimulates the production of proteins associated with the coagulation to cover the wound against the entrance of the microorganisms and inflammatory cytokines to kill off the infectious pathogens before they can enter the body and cause damage.

Most microorganisms were killed in the acute phase of the infection.


The infection is progressing through 5 stages, including
1. The incubation stage is a stage that the microorganisms have successfully entered the host and started a period of multiplication. At this period patients do not experience any symptoms.
2. The prodromal stage, followed after the incubation period, after gaining the strength in numbers and continued multiplication, the presence of the invasive pathogens is noticed by the immune system, leading to an immune systematic response. At this period, patients may experience symptoms fever, pain, and swelling.

3. The stage of illness is a stage that a disease is formed with signs and symptoms of the disease are most obvious and severe.

4. The stage of decline, the stage that saw the immune system has won the battle. In this stage, the number of pathogens and the signs and symptoms of illness begin to decline.
5. The stage of convalescence is a stage of recovery.

Some scientists in the study of the immune evolution suggested that the immune system is designed to kill off invasive pathogen in 3-8 weeks, otherwise, it will adapt to the change, leading to diseases associated with chronic infection.


Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

With an aim to find a natural antibiotic for the replacement of conventional medicine for the prevention and treatment of microbial infection, researchers examined the anacardic acid mixture antibacterial quorum sensing (QS), which is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity.

An anacardic acid mixture (AAM) use in the experiment was produced by the A. adstringens hexane extract (HE) in bacterial strain Chromobacterium violaceum.

By comparing the 2 extracts, researchers found that
* HE induced a 91.6% of inhibition of the violecin production at 55 μg/mL concentration, whereas AAM showed 94% of inhibition at 166 μg/mL.


* Interestingly, both extracts were found to inhibit violacein production by affecting the viability of the bacterium.* Furthermore, AAM inhibited the substance which stimulates redox cycling in bacteria (pyocyanin 86% at 200 μg/mL) and glycolipid biosurfactants of bacterial structure (rhamnolipid, 91% at 500 μg/mL) production in a dose/response form and decrease the elastase (75% at 500 μg/mL) activity in P. aeruginosa without affecting its development.


Where violecin is a naturally-occurring bis-indole pigment with antibiotic properties produced by the bacteria.

These results indicated that Anacardic acid disrupts the quorum sensing (QS) of bacteria through inhibiting the substances which play a critical role for microbial survival in cell-cell communication.


Dr.Castillo-Juárez I, the lead scientist said, " anacardic acids mixture isolated from A. adstringens demonstrated anti-QS, it could be further exploited for novel molecules to treat the emerging infections of antibiotic-resistant bacterial pathogens".


Additionally, in the evaluated new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method, researchers showed that compounds 1-4 exhibited antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL.

Where compounds 1-4 are 6-[16'Z-nonadecenyl]-salicylic acid (1), 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0), (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4).

Taken altogether, anacardic acid and its bioactive derivatives may be considered antibiotics alternative for the prevention and treatment of bacterial infection with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)

Phytochemicals Phytic Acid, the Anti Prostate cancers Bioactive Compound

Phytochemicals phytic acid may be the next generation natural ingredient for the prevention and treatment of prostate cancer, some scientists found.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body.

As cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction.

Symptoms which are not found in enlarged prostate include blood in the urine and blood in the seminal fluid.

If you are experiencing some of the above symptoms, please check with your doctor to rule out the possibility of prostate cancer

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some risks actors associated with the onset of the disease.

Some researchers suggested that a poor diet is one of the major risk factor found in patients with the disease.


Dr. Amir Bagher, the lead scientist evaluated the dietary patterns and risk of prostate cancer wrote, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".


And, "an unhealthy dietary pattern was associated with an increased risk of prostate cancer. However, a healthy dietary pattern was associated with a decreased risk of prostate cancer".


The results strongly suggested that by following a healthy diet pattern, one can substantially reduce the risk of prostate cancer.

Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

On finding a natural ingredient for the treatment of prostate cancer with no side effects, researchers assessed the effects of phytic acid (inositol hexakisphosphate (IP6)) on the activation of phosphoinositide 3-kinase (PI3K)-Akt pathway in promoting survival, proliferation, and angiogenesis in human prostate cancer cells.

In invasive human prostate cancer, PC-3 and C4-2B cells, IP6 treatment of cells suppressed proliferation, induced apoptosis through protein associated with the apoptotic and cell death programming pathways.

Phytic acid also inhibited cancer cells through protein associated with cancer cell growth, proliferation, differentiation, motility.


Furthermore, IP6 inhibited transcription and cell migration. through cell cycle arrest at the G1 phase.


Dr. Gu M, the lead scientist, after taking into account co and confounders said, " IP6 suppresses cell survival, proliferation, and angiogenesis but induces death in prostate cancer cells, which might have translational potential in preventing and controlling the growth of advanced and aggressive prostate cancer for which conventional chemotherapy is not effective".


In advanced and androgen-independent human PCa PC-3, Treatment of PC-3 cells with 2 mM IP6 strongly inhibited both growth and proliferation and decreased cell viability; similar effects were also observed in other human PCa DU145 and LNCaP cells.

IP6 also caused a strong apoptotic death of PC-3 cells through proteins associated with the activation of cell death programming and induced apoptosis.

The inhibition of PC-3 cancer cell line by IP6 also is associated with the inhibition of the protein involved cells proliferation, differentiation, similar to that of the above study.

Interestingly, researchers also discovered that IP6 also inhibited the transcription factor activity in promoting cancer cell growth and reproduction and regeneration


Where a transcription factor (TF) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA.

Taken altogether, phytochemicals phytic acid may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of prostate cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target by Gu M, Roy S, Raina K, Agarwal C, Agarwal R.(PubMed)
(2) Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells. by Gu M, Raina K, Agarwal C, Agarwal R.(PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

Herbal Butterbur, the Potent Anti Somatoform Disorders Functional Remedy

Scientists may have found a natural herbal medicine for the prevention and treatment of Somatoform disorders with no side effects, according to studies.

Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.

Researchers do not the exact cause of the disorders. However, genetic preposition and family history are the 2 most common risk factors associated with the onset of the condition.

Most common symptoms include persistent pain or fatigue, emotional distress and problems functioning.

The American Family Physician in the article Somatoform disorders suggested up to 50 percent of primary care patients present with physical symptoms that cannot be explained by a general medical condition. Some of these patients meet criteria for somatoform disorders.

Dr. Bener A, the lead scientist, in examining the gender effects on somatoform disorders in a sample size of 1689 patients, including 892 men and 797 women suggested
* The prevalence rate of somatoform disorders among the total screened sample was 23.9%.

* Housewives (43.5%) and men in administrative posts (37.9%) reported higher somatic symptoms compared to other professions.

* Prolonged depressive reaction was significantly higher in women compared to men.

* There was a significant gender difference in certain psychiatric diagnostic categories such as depressive episode, recurrent depressive disorder, dysthymia, and brief depressive reaction.

* Backache was the most commonly reported symptom in men, whereas a headache was more common in women.


These results clearly suggested being female is a risk factor of Somatoform disorders and symptoms of Somatoform disorders. Somatoform disorders affect the different aspects of the patient depending on gender.


Women with Somatoform disorders are more likely to experience psychological symptoms compared to male.


Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.

With an aim to find a natural formula for the treatment of Somatoform disorder with no side effects, researchers at the University Hospital Zurich examined the effects of mixed herbal drug combination with and without butterbur (Ze 185) on patients with somatoform disorders.

In a total of 182 patients randomized for a 3-arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo) compared to a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders in a 2-week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), researchers discovered the 4-combination was significantly superior to the 3-combination and placebo (4-combination > 3-combination > placebo) in all the primary and secondary parameters (PP-population).

The levels of anxiety and depression, according to the Anxiety (visual analog scale - VAS) and depression (Beck's Depression Inventory - BDI) are also decreased more in 4 combinations compared to others.

According to the Clinical Global Impression (CGI) rating scales, 4 combinations also showed reduced symptom severity and improved treatment response compared to 3 combinations.


The results are further reconfirmed by the ITT population analysis.

Where (ITT) analysis is a treatment in which patients enrolled and randomly allocated to treatment are included in the analysis and are analyzed in the groups to which they were randomized.


All tested subject expressed no serious adverse effects during the course of experiments.

These results suggested the herbal preparation (Ze185) may be an efficacious and safe short-term treatment in patients with somatoform disorders.


Taken altogether, herbal Butterbur used alone or combined with other herbal medicine may be considered a functional herbal for prevention and combined with the primary medicine for the treatment of Somatoform disorder with no serious side effects,

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)

Herbal Andrographis, the Potential Anti-inflammation and Infection Functional Remedy

Scientists may have found a herbal plant for the treatment of inflammatory diseases with no side effects, according to the studies.

Inflammation is a natural reaction of the immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage of the body through activating the protein associated with the production of pro-inflammatory cytokines.

The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.

The immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness and fever.

Chronic inflammation is a serious condition caused by the immune system to adapt to the new change due to its inability to kill all the invasion within a set of times.

Some researchers in the observation of the history of immune evolution suggested that immune system also try to adapt to the new environment such as chronic inflammation if, for whatever reasons, it can not fill all invasive pathogens within 3 to weeks, leading to the development of several diseases and conditions, including some cancers and rheumatoid arthritis.

Furthermore, chronic inflammation can also be caused by the autoimmune disorder, which involves your immune system mistakenly attacking healthy tissue, long-term exposure to irritants, such as industrial chemicals or polluted air.

Dr. Anne M. Minihane, the lead scientist in the study "Low-grade inflammation, diet composition, and health: current research evidence and its translation" wrote, "An unresolved inflammatory response is likely to be involved from the early stages of disease development" and " The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation–health/disease associations".


And. " Such approaches are likely to provide a more discriminating means of quantifying inflammation–health/disease associations, and the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".


The results clearly suggested that adding certain amounts of anti-inflammatory foods into your diet may be the best way to prevent chronic inflammatory diseases.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.


With an aim to reaffirm the traditional use of Andrographis paniculata for treatment of infection and inflammation, researchers examined the effects of Andrograpanin, one of the diterpene lactones in A. paniculata in vivo and in vitro.


Application of Andrograpanin inhibited the NO and other 3 pro-inflammatory cytokines in a range from 5-90 microM at a dose-dependent manner.


The efficacy of anti-inflammatory activity of Andrograpanin was associated with the reduction of the expression of iNOS, enzymes in catalyzing the production of NO and pro-inflammatory cytokines gene (proteins) expression.

Furthermore, the anti-inflammatory effects were contributed by inhibiting the protein (p38) and (mitogen-activated protein kinase (MAPKs)) which are responsive to stress stimuli, p38 and stress response.


Dr. Liu J, after taking into account co and confounders wrote, "andrograpanin might be useful as a potential anti-inflammatory leading compound for inflammatory drug development".


Additional analysis of other major compound isolated from herbal Andrographis, researchers looked into Human β-defensin-2 (hBD-2), an inducible antimicrobial peptide that plays an important role in innate immunity.


As a prediction, according to the PCR and Western blot assays, injection of Andro (1.0-10 µmol/L) exhibits the expression of hBD-2 in a dose-dependent manner.

However, under the expression of SB203580 (an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK)), MG-132 (an inhibitor of nuclear factor κB (NF-κB)), and an NF-κB activator inhibitor, but not by an inhibitor of ERK (PD98059) or by an inhibitor of JNK(SP600125), the effects of hBD-2 mRNA and protein expression in responsive to andro were attenuated.


These results clearly suggested andro exert its antimicrobial effects by exhibiting the expression of hBD-2 through regulating the functions of the innate immune response against stress and stimuli.


Taken altogether, herbal Andrographis processed high levels of bioactive compounds may be considered a functional remedy against inflammation and infection.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(2) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells BY He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD. (PubMed)
(3) Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells by Shao ZJ, Zheng XW, Feng T, Huang J, Chen J, Wu YY, Zhou LM, Tu WW, Li H.(PubMed).
(4) Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways by Liu J, Wang ZT, Ge BX.(PubMed)
(5) Low-grade inflammation, diet composition and health: current research evidence and its translation by Anne M. Minihane, 1 ,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)

Monday, March 25, 2019

Herbal Burdock, the Best Anti Diabetes and Diabetic Complications Functional Remedy, Scientists Find



Scientists may have found a herbal medicine for the prevention and treatment of diabetes with no side effects, according to studies.

Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

The disease is either caused by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.

Some researchers suggested that high blood cholesterol is one major risk factor not only contributed to the risk of obesity but also facilitates the onset of diabetes.

How to calculate your blood cholesterol, If the ratio your blood cholesterol is higher than 4, you have high blood cholesterol.

The normal ratio of blood cholesterol is 4 (low-density lipoprotein or bad cholesterol)/ 1 ( high-density lipoprotein or good cholesterol). Any number which is higher than 4 is considered high blood cholesterol.

How high blood cholesterol associated with diabetes
* Most patients with diabetes also have a syndrome oh high blood cholesterol.

* According to Dr. Michael Greger M.D long-term intake of a high-fat diet is associated with diabetes. According to the study of young, healthy people and split them up into two groups, high fat intake within 2 days demonstrated, a significant rise of glucose intolerance. During the course of study, the high-fat diet group ended up with twice the blood sugar compared to the carbohydrate-rich diet group.

* Also the spike of blood sugar in the high-fat diet group may also increase the onset of insulin resistance due to insulin no longer performs its function in activating the function of the insulin receptors site which now clogged up by cholesterol to stimulating the enzymes associated with glucose transport.


In other words, the pancreas beta cells will continue to produce insulin but can not lower the blood glucose due to the disruption of glucose metabolism, leading to insulin resistance, the major cause of diabetes.


Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal medicine has been using thousands of year in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.

It contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate,11-tridecadien-3,5,7,9-tetraynde-hydrocostus lactone,dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

With an aim to find a natural medicine for the treatment of diabetes and reduced the diabetic retinopathy is one of the most common and severe complications of diabetes mellitus, researchers at the Third Military Medical University examined Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L.(Burdock), antidiabetic activity.

Male Sprague-Dawley rats induced diabetes are randomly divided into five groups (n = 20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na and 20 nondiabetic sham-treated rats were treated with 0.5 % CMC-Na.

In the beginning, there was no significantly different occurrence of diabetic retinopathy among the groups.

However, at the week 16, the glycosylated hemoglobin (HBA1c) level was significantly decreased in all of the arctiin-treated groups when compared with the control group, and the serum glucose level was also decreased in the rats treated with the highest dose of arctiin


The normal levels of HbA1c of 6.5% and HbA1c are used as an objective measure of glycaemic control.


The highest dose of the arctiin group showed a decrease in the serum glucose level which was elevated by the induction of diabetes.


Arctiin treatment group displayed a reduced inflammatory in the expression of retinal edema, detachment of the retina, and levels of pro-inflammatory cytokines observed by the histological and immunochemical examinations.


Furthermore, arctiin also increased the viability of retinal microvascular endothelial cells which reduced in diabetic rats, in vitro.

Dr. Lu LC, the lead scientist wrote, "these findings demonstrate that arctiin decreases the severity of diabetic complications, demonstrating the importance of this compound as an inhibitor of diabetic retinopathy".


Additionally, in the review of anti-diabetes effects of the active compounds present in the different botanical parts of burdock, researchers examined the active ingredients in the roots and seed.


The results of chemical analysis suggested that the compounds isolated from root showed a strong effect in the inhibition of diabetes through its antioxidant activity.

In the seeds, some active compounds possess anti-inflammatory effects similar to that of arctiin treatment rats group.

These results suggested that herbal burdock exerted a strong anti-diabetes and diabetic complication through its glycaemic control and antioxidant and anti-inflammatory properties.


Taken altogether, herbal Burdock processed high numbers of the bioactive compound may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of diabetes and diabetic complication.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats by Lu LC, Zhou W, Li ZH, Yu CP, Li CW, Luo MH, Xie H.(PubMed)
(2) A review of the pharmacological effects of Arctium lappa (burdock) by Chan YS1, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW. (PubMed)
(3) Fat is the Cause of Type 2 Diabetes by Written By Michael Greger M.D. FACLM on November 17th, 2016. (Nutrition Facts)

Monofloral Honey, the Potential Anti- Human immunodeficiency virus HIV-1 Functional Foods

Honey may have a profound effect in reducing the risk and treatment of HIV-1, some scientists suggested.

Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).


According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, infected mother to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches and joint pain similar to those of influenza in the early stage of the viral attacks.


At the final stage of the infection, the virus can weaken the immune system to the point that causes the onset of AIDS and induces more severe symptoms including the general symptoms of cancers accompanied by soaking night sweats, recurring fever and persistent white spots or unusual lesions on your tongue or in your mouth.

Dr. Seth C Kalichman and colleagues in the infectious team, in the concern of the risk of HIV in people with multiple sexual partners in the examining the 209 HIV positive men and 291 HIV positive women recruited conveniently from HIV/AIDS support groups and antiretroviral clinics found that 63% and 309 (62%) participants were currently sexually active, of whom 247 (80%) reported only one sex partner in the previous 3 months and 62 (20%) reported two or more partners during that time".


Although the use of a condom may have some protective effects in the prevention of HIV transmitting disease, however, the team said, "Steady sex partners of participants with multiple partnerships were significantly less likely to be protected by condoms than steady partners of individuals with only one sex partner".


Dangerously, at the final report, the team wrote, "individuals with multiple sex partners were also significantly less likely to have disclosed their HIV status".

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the inhibition of human immunodeficiency virus HIV-1 before they can cause acquired immunodeficiency syndrome (AIDS), researchers evaluated the anti-HIV-1 activity of eight different kinds of honey.

The tested Monofloral Iranian honey from eight floral sources was analyzed to determine their anti-HIV-1 activities as well as their effects on lymphocyte proliferation.

According to the quantitative polymerase chain reaction (PCR) assay and high pure viral nucleic acid kit, 6 out of 8 monofloral kinds of honey from Petro selinum sativum, Nigella sativa, Citrus sinensis, Zataria multiflora, Citrus aurantium, and Zizyphus mauritiana flowers exerted a significantly inhibitory HIV-1 activity at different doses.


The half maximal effective concentration (EC50) values of 6 out of 8 monofloral kinds of honey are 37.5, 88, 70, 88, 105 and 5 µg/ml respectively.

The monofloral Iranian kinds of honey from Astragalus gummifer and Chamaemelum Nobile flowers had a weak anti-HIV-1 activity, compared to others.

The frequency and intensity of cluster of differentiation CD4 expression on Peripheral blood mononuclear cell (PBMC) increased in the presence of all honey types, an indication of immune activity.


Peripheral blood mononuclear cell (PBMC) are round nucleus peripheral blood cells consisted of lymphocytes (T cells, B cells, NK cells) and CD4 cells or T4 helpers play critical roles to send signals to other types of immune cells with a function to destroy invasive pathogens.

Treatment with monofloral kinds of honey from Z. multiflora and N. sativa also increased the CD19 markers for normal and neoplastic B cells.

According to the spectroscopic analysis, monofloral kinds of honey from P. sativum, N. sativa, Z. multiflora, and Z. mauritiana flowers processed a potency to be anti-HIV-1 agents.


In-depth differentiation, researchers showed that the inhibitory effect of methylglyoxal is higher on the late stage of HIV-1 infection.

The chemical compound found to exert the anti-HIV-1 activity was methylglyoxal.

Taken altogether, monofloral kinds of honey containing high amounts bioactive compound methylglyoxal may be considered a functional food for the prevention of HIV-1 infection and combined with the primary therapy for the treatment of AIDs.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-HIV-1 activity of eight monofloral Iranian honey types by Behbahani M1. (PubMed)
(2) Recent multiple sexual partners and HIV transmission risks among people living with HIV/AIDS in Botswana by Seth C Kalichman, Dolly Ntseane, Keitseope Nthomang, Mosarwa Segwabe, Odireleng Phorano, and Leickness C Simbayi. (PMC)