Get Pregnant Naturally

Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Tuesday, March 31, 2020

Healthy Food Onion Protects the Healthy Cell Against Cyto and Geno-Toxicity

Cytotoxicity is the process that kills cells by inducing toxic substances.

Cancer cytotoxicity is the stage of killing cancer cells by toxicity with or without inducing side effects.

Most cases of cytotoxicity of a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.

In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.


Before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.

Free radicals have also been found to induce cytotoxicity to cause cancer death by oxidative stress.

Dr. Clifford Fong wrote, "An analysis of the cytotoxicity data for a wide range of anti-cancer drugs applied to triple-negative breast cancer (TNBC) cells and ovarian cancer cells under normoxic, hypoxic and anoxic conditions have shown that free radical forms of the drugs are involved".

And " This finding is consistent with the known involvement of oxidative stress in the TNBC and ovarian cancer cells. A mechanism to explain the formation of these drug-free radicals and how they can be involved in oxidative stress is proposed".

Genotoxicity is the term associated with chemical agents that damages the genetic information within a cell, causing mutations of cell DNA, a major cause of cancer.


Not all genotoxicity is mutagenicity, However, all mutagens are genotoxic.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of cancer, researchers examined the effect of an onion extract on cyto- and genotoxicity in human lymphocytes treated with bleomycin (BLM), a radiomimetic agent.

In radiation exposure -induced oxidative DNA damage in the increased risk of cancer, the risk the richest sources of dietary flavonoids found in onion inhibited the frequency of micronuclei (MN) and DNA damage following treatment with BLM, according to the cytokinesis-blocked micronucleus assay and a single cell gel electrophoresis assay.

Phytochemicals in the onion showed a significant increase in cell viability in lymphocytes exposed to BLM compared to cells treated with BLM alone.

Onion also suppressed the increased frequency of BLM induced MN and DNA damage in a dose-dependent manner evidenced by lymphocytes viability pretreated with onion extract (10 and 20 μL/mL).

Moreover, the frequency of BLM-induced MN was decreased at all doses of BLM and DNA damage was decreased by the administration at 3 μg/mL of BLM.

Based on the findings, researchers said, "onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes".

Taken altogether, onion processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of cytotoxicity and genotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes by Cho YH1,2, Lee JW3, Woo HD4, Lee S5, Kim YJ6, Lee Y7, Shin S8, Joung H9, Chung HW. (PubMed)
(2) Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model by Ribeiro TP1, Sousa TR1, Arruda AS1, Peixoto N1, Gonçalves PJ2, Almeida LM. (PubMed)
(3) Free radicals in chemotherapy-induced cytotoxicity and oxidative stress in triple negative breast and ovarian cancers under hypoxic and normoxic conditions by Clifford Fong (HAL)

Monday, March 30, 2020

Tomatoes, the Natural Prevention and Treatment of Hypercholesterolemia

Hypercholesterolemia is a condition of high blood cholesterol. A condition is a form of hyperlipidemia or high blood lipids.

The cause of hypercholesterolemia is a result of overexpression of low-density lipoprotein with reduced levels of high-density lipoprotein in the blood.

Believe it or not, cholesterol produced by the liver or from outside sources is essential for the building of strong cell membranes, the production of steroid hormone and vitamin D.

However, overexpression of blood cholesterol-induced hypercholesterolemia has been found to exhibit the risk of cardiovascular disease and diabetes.

Compared to hypercholesterolemia, the healthy levels of LDL/HDL are any numbers that are less than 4.

There is no single cause of hypercholesterolemia. Epidemiologically, diet, obesity, genetic preposition and medical conditions such as diseases such as type 2 diabetes and an underactive thyroid are some the prevalent factors associated with the risk of the condition.

According to the statistics, over 34 million American adults are living with elevated blood cholesterol levels (higher than 240 mg/dL). ...


The most common inherited form of high blood cholesterol is called familial hypercholesterolemia found in 1/500 people.

By adopting a healthy lifestyle and moderate exercise, you may do just fine without medication.


Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a natural ingredient or whole food for the treatment of hypercholesterolemia, researchers compared the effect of dried tomato, grape and apple pomace (5% in diet) on the cholesterol levels in serum in an animal model

The study included selected male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning followed by administration of individual fruits contained 47.2, 67.0 and 46.2 g of total dietary fiber per 100 g of dry matter for tomato, grape and apple pomace, respectively.

Compared to apple pomace reduced the liver cholesterol by 11% tomato showed a better-reduced cholesterol level in the liver by 15%


Tomatoes and other tested pomace species reduced cholesterol content in the heart by 18-21%.

Only tomatoes exerted a significant effect on the levels of triacylglycerol content in the heart compared to other tested pomaces.

All products strongly reduced (up to the half of the original value) the activity of enzymes HMG-CoA reductase associated with the production of cholesterol in the liver and increased the fractional catabolic rate of plasma cholesterol by 60-120%.

In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reducing the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.

Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, LDL-C, particularly in the cerebral LDL-C.



In other words, serum lycopene found in the tested model showed a strong effect against brain cholesterol in facilitating neuron damage.

Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".

Taken altogether, tomatoes processed high amounts of lycopene may be considered supplements for the prevention and treatment of hypercholesterolemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia by Bobek P1, Ozdín L, Hromadová M. (PubMed)
(2) The dose-response effect of lycopene on cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)

Sunday, March 29, 2020

Apricot, the Potential Anti Breast Cancer Remedy, Scientists Say

Finding a cure for breast cancer from the botanical plants without inducing side effects has been a lifetime dream of many scientists. Unfortunately, as of today, the finding is still ongoing without much success.

However, according to some studies, apricot, the edible fruit may be the next pharmaceutical target to extract potential ingredients for the cure for breast cancer.

Breast cancer is a medical and chronic condition as the result of irregular cell growth originated from the breast tissue. why women in the same health conditions, family history, and race, some are prone to develop the early onset of the disease while others do not.

Breast cancer is caused by the alternation of DNA of the cells in the breast tissue. Epidemiologically, certain prevalent factors are associated with an increased risk of the disease.

According to the probability for women to develop or die from breast cancer provided by the Canadian Cancer Statistics publication, the lifetime risk of a woman to develop is 1/8 and 1/31 of them will die from the disease.

The 5 years survival rate of the early stage of breast cancer is 100% compared to much less in the advanced stage.

Therefore, women with higher risk such as genetic preposition of gene BRAC1 and 2 should have their breast mammogram taken every year.


More importantly, Dr. Zainab Taha, the lead author in the study "The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East" wrote,
"There is an alarming epidemic of obesity among women in most of the EMR countries, especially Gulf Coopers action Council (GCC) countries. The rise in the new breast cancer cases among women could be attributed to excess body weight. Their dietary pattern, which correlates with obesity, can be an important factor in the etiology of cancer.".

These results\ strongly suggested that diet and lifestyle associated with the onset of obesity are major contributors to the early onset of breast cancer.

In other words, if you follow a healthy diet with a lot of fruits and vegetables, whole grain with less in saturated and trans fat, red meat and processed and lifestyle with moderate exercise, you are at the lower end in the risk factor scale of breast cancer.

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

Chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides, (b),

In the reaffirming the MK615, an extract mixture containing hydrophobic substances from Japanese apricot. anti-cancer possibility, researchers at the Dokkyo University School of Medicine conducted an evaluation to examine the antineoplastic effects of MK615 against breast cancer cells.
The experiment includes 2 breast cancer cell lines, MDA-MB-468 (MDA) and MCF7, were cultured with (600, 300, and 150 mug/mL) or without MK615.

After 72 hours of incubation, researchers showed that

* MK615 inhibited the growth of MDA and MCF7 in a dose-dependent manner.

* The percentage growth inhibition of MDA at dosages of 600, 300, and 150 mg/mL was 59.2%, 52.4%, and 23.3%, respectively, and that for MCF7 was 83.5%, 52.7%, and 16.6%, respectively.

* MK615 treatment included massive vacuolization in the cytoplasm and apoptotic changes in the nucleus.

* Cell cycle analysis showed that MK615 increased the proportion of cells in the G2-M phase in both MDA (7.8-11.7%) and MCF7 (8.1-18.7%), and finally both cell lines became apoptotic.

These results suggested MK615 effectively inhibits the growth of breast cancer cells in vitro, through cell cycle arrest and apoptosis.


Furthermore, in the concerns of breast cancer continued to cause high cancer death rates among women worldwide, researchers at the joint study led by the Universiti Sains Malaysia launched an evaluation to examine the plant-based products which have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth.


Out of the medical plants selected including Glycyrrhiza glabra, Uncaria tomentosa, Camellia sinensis, Panax ginseng, Prunus armenaica (apricot), Allium sativum, Arctium lappa and Curcuma longa, malic acid and quinic acid isolated from apricot exerted a significant activity in regulating the immune system potentially applicable in breast cancer treatment via anti-inflammatory and lymphocytes activation.


Taken all together, apricot may be considered a functional food for the prevention and a secondary therapy combined conventional medicine for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) [Studies on the chemical constituents of flowers of Prunus mume].[Article in Chinese] by Zhang QH1, Zhang L, Shang LX, Shao CL, Wu YX.(PubMed)
(1) New antineoplastic agent, MK615, from UME (a Variety of) Japanese apricot inhibits growth of breast cancer cells in vitro by Nakagawa A1, Sawada T, Okada T, Ohsawa T, Adachi M, Kubota K. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS. (PubMed)
(3) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East by Zainab Taha1 and Sakina E. Eltom. (PMC)

Saturday, March 28, 2020

Strawberries Reduce Risk and Treatment of Type 2 Diabetes

The rise of obesity-associated with the increase in the incidence of Type 2 diabetes has been a significant burden on health care systems in many countries.

Strawberry processed abundant phytochemicals may be the next target for pharmaceutical companies to extract a single ingredient for the treatment of type 2 diabetes, some scientists suggested.

Type 2 diabetes is the medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as the results either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

Researchers do not why people in similar health conditions, diet and family history are susceptible to the development of insulin resistance, the early stage of diabetes while others do.

Some researchers suggested that genetic proposition and unhealthy lifestyle accompanied physical activity are the most common risk factors associated with the onset of type 2 diabetes.

Dr. Karla C. Paz-Salinas, the lead author in the study "Do People with Type 2 Diabetes Think They are Unhealthy?" wrote, "A healthy lifestyle and understanding of diabetes management are important factors for delaying the onset of comorbidities associated with Type 2 diabetes".

In genetic preposition front, researchers at the Medical College of Wisconsin, said, "Very few T2D risk genes were identified using candidate gene and linkage-based studies, but the advent of genome-wide association studies has led to the identification of multiple genes, including several that were not previously known to play any role in T2D. Highly genes, for example, TCF7L2, KCNQ1, and KCNJ11, are discussed in greater detail".



We can not prevent the onset of type 2 diabetes caused by a genetic mutation, however, the risk of type 2 diabetes can be reduced substantially and type 2 diabetes can be easily managed if we are following the healthy lifestyle that processes the diet high in fruits and vegetable, less in saturated and trans fat, red meat and processed food with moderate exercise.


Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

In the finding of a natural ingredient for the treatment of diabetes with no side effects, researchers at the University of California launched a study to examine the anti-inflammatory and blood glucose (BG)-regulating capacity of strawberries in a mouse model of diet-induced obesity.

In a total of thirty-six male C57BL/6J mice were included in the study randomly divided into four groups (nine mice per group), including mice fed a low-fat diet (LF, 13 % fat), the LF supplemented with 2·6 % freeze-dried strawberry powder (LFSB), a high-fat diet (HF, 44 % fat) or the HF supplemented with 2·6 % strawberry powder (HFSB).

The dietary intake of SB approximated one human serving of strawberries


Before the administration of strawberry powder, a blood sample of HF group showed an increased non-fasted BG, insulin, soluble intracellular adhesion molecule-1, the important biomarkers for inflammatory processes involving activation or damage to cells, E-selectin, leptin, resistin, and plasminogen activator protein-1, the indication of the inflammatory process.

High dietary fat decreased IL-4 production, an anti-inflammatory cytokine from activated splenocytes, the white blood cells.

The levels of BG concentrations were lower in the mice supplemented with SB (10·64 mmol/l) compared to the non-supplemented mice.

BG values were approximately 6·5 % lower in the supplemented mice.

These results firmly supported a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes and regulating the levels of inflammatory markers in non-obese individuals.

The study was published Nov 28 on the US National Library of Medicine and National Institutes of Health. You can view the abstract by clicking the link in the resources box.

Please note that strawberry contains a measured amount of oxalates, if you have kidney disease, please check with your doctor before applying.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice, and selectively lowers plasma C-reactive protein in lean mice by Parelman MA, Storms DH, Kirschke CP, Huang L, Zunino SJ.(PubMed)
(2) Do People with Type 2 Diabetes Think They are Unhealthy? by A Cross-Sectional Study in Celaya, Mexico by Karla C. Paz-Salinas,1 Nicolas Padilla-Raygoza,1,2 Silvia C. Delgado-Sandoval,1,2Georgina Olvera-Villanueva,1,2 and Ma Laura Ruiz-Paloalto. (PMC)

Friday, March 27, 2020

Healthy Food Onion Protects the vascular endothelial Functioning Against Cardiovascular Disease

Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.

Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

There 3 main types of the blood vessel are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.

The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels has been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.

Endothelial dysfunction is a condition characterized by the damage of the vascular endothelium, the thin layer of cells that lines blood vessels, a leading cause of the cardiovascular disease (CVD).

In other words, the vascular endothelium dysfunction reduced the function of targeting free radical that lead to the onset of oxidative stress.

Most common risk factors associated with vascular endothelium dysfunction are impaired vasodilation, deficiency of nitric oxide, and inflammation, and thrombosis.

Dr. Hirata Y. at The University of Tokyo.wrote, "Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function".

And, "There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes bodyweight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta-blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants".

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potent ingredient which processes vasoprotective activity researchers examined quercetin, a dietary polyphenol found abundantly in onion on vascular endothelial dysfunction (VED).

Epidemiologically, quercetin showed significant activity against the VED complication in the induction of oxidative stress, impaired vasodilation, platelet aggregation, and monocyte adhesion leading to the early event of morbidity and mortality in patients with cardiovascular disease (CVD).

Quercetin efficacy that protects against VED and decreases CVD risk was attributed to its antioxidant, vasodilatory, anti-platelet, and anti-atherogenic activities.

Futhermore, in vitro, quercetin exerted multiple actions on the NO-guanylyl cyclase pathway associated with the smooth muscle tone in bronchi or vessels, endothelium-derived hyperpolarizing factor(s) and endothelin-1 involved in vasoconstriction and endothelial function.

Moreover, the phytochemical also protected endothelial cells against apoptosis.

In vivo, quercetin prevented endothelial dysfunction by reducing blood pressure, oxidative stress and end-organ damage in hypertensive animals.

In other words, regular intake of quercetin improves the endothelium functioning against the risk of VED inducing cardiovascular disease, particularly in patients with hypertension and ischemic heart disease.

Taken altogether, onion processed a higher mount of quercetin may be considered a remedy for the prevention and treatment of vascular endothelial dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Vasoprotective activities of quercetin by Richard S Bruno. (Research Gate)
(2) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols by Perez-Vizcaino F1, Duarte J, Andriantsitohaina R. (PubMed)
(3) Diagnosis and treatment of endothelial dysfunction in cardiovascular disease by Hirata Y1, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. (PubMed)

Thursday, March 26, 2020

Strawberries, The Functional Food Which Inhibits the Risk Factors of the Onset of Atherosclerosis, Researchers Suggest

Strawberries may be considered a functional food that blocks the plaque accumulated in the arteries, causing atherosclerosis, some scientists suggested.

Atherosclerosis is a medical condition of heart disease characterized by plaque building up in the inner wall of the arteries.

Where arteries are blood vessels that carry oxygen and nutrient-rich blood to the heart and other organs and tissue of the body and plaque is the substance made up mostly with fat, cholesterol, calcium.

According to the statistics, atherosclerosis causes 32% of deaths of heart disease. The prevalence rate of the disease onset among adults of 20 years and above is 13.8%.

Dr. Singh RB, the lead author in the assessment of diet and exercise and lifestyle on risk of atherosclerosis conducted a randomized, single-blind, controlled trial, 621 patients assigned either intervention diet A (group A, 310 patients) or control diet B (group B, 311 patients) for a period of 24 weeks.

Where participants of group A are received: (1) a diet with a higher percentage of calories from fruits and vegetables and complex carbohydrates; (2) a higher polyunsaturated/saturated fat ratio diet; and (3) a larger amount of soluble dietary fiber, antioxidant vitamins and minerals, and low saturated fat and cholesterol than group fB. Group A patients also did more physical and yogic exercises than group B.

After 24 weeks of intervention, he wrote. " There was a significant decrease in serum total cholesterol (13.3%), low-density lipoprotein cholesterol (16.9%), triglycerides (19.2%), fasting blood glucose (19.5%) and blood pressures (11.5/6.2 mm Hg) in the intervention group compared with initial levels and changes in group B".

These result suggested that a healthy diet accompanied by moderate exercise are the major factors that can substantially reduce the risk of atherosclerosis. In other words, people who follow the Western diet with physical inactivity are at higher risk of the onset of the disease.


Strawberries are a genius of Fragaria × ananassa belonging to the family Roseaceae.

They have been grown all over the world in a suitable climate for commercial profits and health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Intake of strawberry daily to improve the potent antioxidant status in the body can reduce cardiovascular risk factors, such as elevated blood pressure, hyperglycemia, dyslipidemia, and inflammation in limited studies.

Dr. Basu A, the team leader at the Oklahoma State University, Stillwater study showed that freeze-dried strawberry supplementation improves blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects suggested.

The randomized controlled trial included 27 subjects with metabolic syndrome (2 males and 25 females; body mass index, 37.5 +/- 2.15 kg/m(2); age, 47.0 +/- 3.0 years [means +/- SE]) consumed 4 cups of freeze-dried strawberry beverage (50 g freeze-dried strawberries approximately 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups of water) daily for 8 weeks.

Strawberry supplementation intake significantly decreased total and low-density lipoprotein cholesterol (5.8 +/- 0.2 to 5.2 +/- 0.2 mmol/L and 3.5 +/- 0.2 to 3.1 +/- 0.1 mmol/L, respectively [means +/- SE], P < .05) and low-density lipoprotein particles compared to controls at the week 8.

Furthermore, strawberry supplementation also decreased circulating levels of vascular cell adhesion molecule-1 vs controls at the end of the study.

The team at the final report said, "short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome".

In additional examing the therapeutic roles of strawberries, blueberries, and cranberries in metabolic syndrome, a prediabetic state characterized by several cardiovascular risk factors, Dr. Basu A said, "strawberries lowering total and LDL-cholesterol, but not triglycerides, and decreasing surrogate biomarkers of atherosclerosis (malondialdehyde and adhesion molecules)".

Strawberry also extended a lowering systolic and diastolic blood pressure and lipid oxidation and improving insulin resistance but in the lesser effect compared to the blueberry

Cranberry juice selectively decreasing biomarkers of lipid oxidation (oxidized LDL) and inflammation (adhesion molecules) in metabolic syndrome compared to lesser effect in those of strawberry.

The tested berries demonstrated a potential effect in up-regulation of endothelial nitric oxide synthase activity in the protection of the cardiovascular system, reduction of renal oxidative damage, and inhibition of the activity of carbohydrate digestive enzymes or angiotensin-converting enzyme in controlling the blood pressure by regulating the volume of fluids in the blood.


Taken all together, strawberry may be considered a function\al food for the prevention of atherosclerosis and combined with the primary therapy for the treatment of the disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Reference
(1) The strawberry: composition, nutritional quality, and impact on human health. by Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M.(PubMed)
(2) Phenolic Composition of Strawberry Genotypes at Different Maturation Stages(ACS Publication)
(3) Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.
Basu A, Fu DX, Wilkinson M, Simmons B, Wu M, Betts NM, Du M, Lyons TJ.(PubMed)
(4) Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives.
Basu A, Lyons TJ.(PubMed)
(5) Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study by Singh RB1, Singh NK, Rastogi SS, Mani UV, Niaz MA. (PubMed)

Wednesday, March 25, 2020

Whole Food Tomato and Its Bioactive Compound Lycopene Protect the Obese Patients Against Complications

Obesity is a progressive chronic disease, associated with abnormal or excessive fat accumulation in the body.

People who have a BMI of over 30 is considered to be obese.
According to the statistics provided by Obesity Cabada, the rate of obesity has increased at an alarming rate in Canada over the past few decades.

Approximately over 30% of Canadian adults are considered obese that may require medical support to manage their disease.

Epidemiologically, type 2 diabetes, high blood pressure, heart disease, stroke, arthritis, cancer and other major health problems have been found in most obese patients, causing concern to the scientist community in the health care system.

Believe it or not, obesity has been found contributing to one 10 premature deaths among Canadian adults age 20 to 64. As of today, the health care system in Canada has spent between $5 billion and $7 billion for the treatment of obese related complications.

Furthermore, obesity is associated with increased mortality and a number of complications including diabetes, heart disease, dementia, and cancer.

And, the commitment of reduced weight through a healthy diet accompanied by moderate exercise has been proposed to target the complications.

Out of many risk factors associated with the onset of obesity, the social economy may have some implication involved in the onset of the disease.

Dr. BRIAN HOULE, wrote in the article "How Obesity Relates to Socioeconomic Status" "...obesity rose with a nation’s economic development, but also that socioeconomic status as it related to obesity changed. In lower-income countries, people with higher SES were more likely to be obese. Conversely, in high-income countries, those with higher SES were less likely to be obese".

And, "Why the reversal? It may be that in lower-income countries, higher SES leads to consuming high-calorie food and avoiding physically tough tasks. But in higher-income countries, individuals with higher SES may respond with healthy eating and regular exercise".

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural and potential compound for the treatment of obesity, researchers review the link of high intake of lycopene or tomatoes products in the risk for metabolic diseases by comparing the effect of lycopene and tomato powder on obesity-associated disorders.

The study included selected Male C57BL/J6 mice randomly assigned into four groups to receive: control diet (Chigh-fat fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.

In mice treated with HFD, lycopene and TP supplementation significantly improve the obese complications caused by adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids.

Furthermore, lycopene and TP supplementation also 8-iso-prostaglandin GF2α associated with an increased risk of heart disease and improved glucose homeostasis, against the onset of abnormal blood glucose.

Furthermore, Lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes associated with patients of obesity.

Moreover, lycopene and TP also decreased HFD-induced the production of proinflammatory cytokines in the liver and in the epididymal adipose tissue found in obese subjects.

According to the tested assay, lycopene and TP anti-inflammatory effects were attributed to the inhibition of the protein involved promotion of the expression of inflammation in adipose tissue.

Based on the findings, lycopene, and TP protected significantly obese subjects against the onset of obesity complications.

Dr. Fenni S after taking other factors into account wrote, "These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies".

Taken altogether, tomatoes processed a high amount of lycopene may be considered whole food for the prevention and treatment of diseases associated with obesity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)

Tuesday, March 24, 2020

Healthy Food Onion Promotes the Normal Vascular Functioning

Vascular protection is the process to protect the function of blood vessels associated with the reduced risk of cardiovascular disease.

More precisely, vascular protection is the mediation to enhance endothelial cell survival, suppression of thrombosis, and anti-inflammation accompanied by the inhibition of vascular smooth muscle cell proliferation.

Vascular dysfunction is a condition that causes arterial stiffness, microvascular and endothelial dysfunction and increases the risk of CVD.

Endothelial cells found in the endothelium that line the interior surface of blood vessels and lymphatic vessels by separating the circulating blood or lymph in the lumen and the rest of the vessel wall process some main functions, including acting as a semi-selective barrier between the vessel lumen and surrounding tissue and transporting white blood cells into and out of the bloodstream.


Endothelial dysfunction is a medical condition that reduces the function of the endothelium caused by the failure of the endothelial inner lining of the small arteries to function normally, affecting the cardio-functioning.

Epidemiologically, endothelial dysfunction has been found to induce cardiovascular conditions, including coronary artery disease (CAD), hypertension, and diastolic dysfunction.

Coagulation is a process of blood clotting. Overexpression of coagulation has been found to induce thrombosis.

Inflammation associated with plaque biology has been found to trigger the thrombotic complications and arterial stiffness of atherosclerosis.

Microvascular dysfunction is a condition that causes abnormal function of the small blood vessels feeding the heart muscle, leading to heart diseases and stroke.


Collectively, cardiovascular protection plays a critical role to reduce the risk of cardiovascular disease.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient to protect the blood vessel against inflammation, researchers investigated the vascular protective effects of onion and garlic on vascular inflammation in an animal model.

The study included 30-day-old male Wistar rats that were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O with aqueous G and O extracts administered orally in doses of 150 and 400 mg/kg/d respectively, followed by injection of tempol during the last 8 weeks of a 14-week period.

Fructose-fed rats (FFR) before treatment of garlic and onion had developed insulin resistance, aortic NADPH oxidase activity associated with the elevated levels of free radicals.

Furthermore, systolic blood pressure and plasma TBARS associated with lipid peroxidation and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries were also found to increase in the fructose-fed rats (FFR) rats.

In other words, fructose-fed rats (FFR) showed a significant plaque accumulation in the arteries.

Moreover, endothelial nitric oxide synthase (eNOS) associated with cardioprotective activity in the heart was also decreased in the FFR rats.

Administration of garlic and onion to FFR rats reversed all parameters involved in cardiovascular dysfunction were inhibited observed by the reduced levels of oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression.

Taken altogether, onion used alone or combined with garlic may be considered remedies for vascular protection, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats by Vazquez-Prieto MA1, Rodriguez Lanzi C, Lembo C, Galmarini CR, Miatello RM. (PubMed)
(2) Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function by Terao J. (PubMed)

Monday, March 23, 2020

Avocado in the Prevention and Treatment of Cardiovascular Disease

Avocado may be considered a functional food in the prevention and treatment of cardiovascular disease, some studies suggested.

A cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
What causes plaques to build up in the wall of the arteries are debatable. Researchers do not why people who have the same health conditions, family history, and diet pattern, are susceptible to the early onset of cardiovascular disease while others do not.

One of the most common and preventable risk factors has been under the intensified debate in the scientific community. If a poor diet pattern and lifestyle can facilitate the onset of the disease, then a healthy diet choice and lifestyle with moderate exercise should provide a strong effect in the prevention and treatment of cardiovascular disease.

In other words, by replacing the Western diet characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks and a dietary risk factor for CVD with the traditional diet characterized by high in fruits and vegetables and less in red meat and processed foods, cardiovascular disease is preventable.



Dr. Sonia S. Anand, the lead scientists in the study "Food Consumption and its Impact on Cardiovascular Disease,... said, " Evidence from different countries, age/race/ethnicity/socioeconomic groups suggest the health effects studies of foods, macronutrients, and dietary patterns on CVD appear to be far more consistent though regional knowledge gaps are highlighted".

"Based on the current evidence, the traditional Mediterranean-type diet, including plant foods/emphasizing plant protein sources, provides a well-tested healthy dietary pattern to reduce CVD".

These result strongly suggested people who understand the effects of macronutrients and micronutrients of food in the contribution of cardiovascular disease, should be more likely to change the diet pattern, which not only prevents the disease onset in the borderline healthy individual but also reduces the risk of the disease progression and complications associated with patients with cardiovascular disease.

Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.

The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B..

In the finding, the natural ingredient for the treatment of cardiovascular disease without inducing any side effects researchers at the University of KwaZulu-Natal launched an investigation to examine the cardiovascular effects of Persea Americana Mill (Lauraceae) aqueous leaf extract (PAE).

In healthy normal Wistar rats in vitro, the application of the leaf extract exerted a significant effect in reducing the levels of high blood pressure.

On guinea pig P Americana aqueous leaf extract (25-800 mg/ml) produced concentration-dependent, significant (p < 0.05-0.001), modified the force or speed of contraction of muscles. and heart rate by inhibiting the positive inotropic and chronotropic responses.

Like acetylcholine (ACh, 10(-8)-10(-5) M), the plant extract (25- 800 mg/ml) produced concentration-related relaxations pre-contracted with noradrenaline.

Furthermore, PAE (25-400 mg/kg iv) caused dose-related, transient but significant reductions in the systemic arterial blood pressure and heart rates of the anesthetized normotensive and hypertensive rats.

Dr.Ojewole JA, the lead scientist said, "the findings of this study tend to suggest that P Americana leaf could be used as a natural supplementary remedy in essential hypertension and certain cases of cardiac dysfunctions".

Moreover, in the examine the cardio effects of avocado through its monounsaturated fatty acids (MUFA) dietary fiber, essential nutrients, and phytochemicals, researchers at the Nutrition Impact launched a study to investigate the relationships between avocado consumption and overall diet quality, energy and nutrient intakes, physiological indicators of health, and risk of metabolic syndrome.

Diet quality was calculated using the USDA's Healthy Eating Index-2005. Subjects included 17,567 US adults ≥ 19 years of age (49% female), including 347 avocado consumers (50% female), examined in NHANES 2001-2008.

Avocado consumers had significantly higher intakes of vegetables (p<0.05); fruit, diet quality, total fat, monounsaturated and polyunsaturated fats, dietary fiber, vitamins E, K, magnesium, and potassium (p<0.0001); vitamin K (p=0.0013); and lower intakes of added sugars with no significant differences were seen in calorie or sodium intakes.

Bodyweight, BMI, and waist circumference were significantly lower (p<0.01), and HDL-C was higher (p<0.01) in avocado consumers.

The odds ratio for metabolic syndrome was 50% (95th CI: 0.32-0.72) lower in avocado consumers vs. non-consumers.

These findings suggested avocado consumption is associated with improved overall diet quality, nutrient intake, and reduced the risk of metabolic syndrome, the leading cause of cardiovascular disease.

Dr. Fulgoni VL 3rd, the lead author, after taking into account co and confounders wrote, "Dietitians should be aware of the beneficial associations between avocado intake, diet, and health when making dietary recommendations".

Taken altogether, avocado processed a high amount of monounsaturated and polyunsaturated fats, dietary fiber may be considered a functional fruit for the prevention and adjunct therapy for the treatment of cardiovascular disease.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals by Ojewole JA1, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT.(PubMed)
(2) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ. (PubMed)
(3) Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation bySonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)

Sunday, March 22, 2020

Strawberries, A Natural Treatment for High Blood Pressure with No Side Effects

Strawberry is a genius of Fragaria × ananassa belonging to the family Roseaceae.

The tasty fruits have been grown all over the world in a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Hypertension is a condition of abnormally high blood pressure.

High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.

Sometimes it can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.

Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.

Dr. Duangtep Y, the lead scientists in the team of heart disease and stroke at the District Health Office, Mae Fah Luang in the examine the risk of an unhealthy lifestyle and hypertension wrote, "Multiple logistic regression analysis shows the factors associated with hypertension among the hill tribe people studied were smoking, no or irregular exercise, being overweight, having obesity, and having a high-frequency intake of fatty foods".

These results strongly indicated that by following a healthy lifestyle, hypertension is preventable.

Unfortunately, according to the statistics, approximately 75 million American adults (32%) have high blood pressure. In other words, high blood pressure affects 1 in every 3 adults in the US.

In the differentiate the association of the high blood pressure in the contribution to cardiovascular disease and stroke, some scientists indicated these results overwhelmingly suggested hypertension has become a global burden and a growing public health problem worldwide.

On finding a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Universidade de São Paulo assessed the fruit extracts of different strawberry cultivars for their potential in inhibition of hypertension.

According to the DPPH radical scavenging assay, the fruit extracts inhibited alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potentially managing hyperglycemia and hypertension.

The Strawberries high alpha-glucosidase and angiotensin I-converting enzyme (ACE) inhibitory activity was attributed to the presence of ellagic acid, quercetin, and chlorogenic acid.

Water extracts of Jewel and Ovation cultivars strawberry had moderated ACE inhibition compared to low inhibition observed in other cultivars.

In vitro, strawberry fruit extracts inhibited the expression of angiotensin-1-converting enzyme (ACE) activity correlated to phenolic content and antioxidant activity.

These results suggested that strawberries could be considered a potential dietary source with anti-hyperglycemic and antihypertensive potential.

Dr. Cheplick S, the lead author said, "Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension".

Furthermore, by examing the potential health benefits of purified ellagitannins from strawberries in relation to the antiproliferative activity and in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension in patients with type 2 diabetes, researchers found that purified ellagitannins isolated from the strawberry have high α-amylase and ACE inhibitory activities.

However, these compounds had low α-glucosidase inhibitory activity.


In the final report of the experiment, Dr. Pinto Mda S, wrote, "the ellagitannins and ellagic acid have good potential for the management of hyperglycemia and hypertension linked to type 2 diabetes".

Taken altogether, adding a portion of strawberry into a daily diet may have a profound effect in reducing the risk and treatment of high blood pressure.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)
(2) Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension. Cheplick S, Kwon YI, Bhowmik P, Shetty K.(PubMed)
(3) Functionality of bioactive compounds in Brazilian strawberry (Fragariax ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. by da Silva Pinto M, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K.
(PubMed)
(4) Association between an unhealthy lifestyle and other factors with hypertension among hill tribe populations of Mae Fah Luang District, Chiang Rai Province, Thailand by Duangtep Y1, Narksawat K, Chongsuwat R, Rojanavipart P. (PubMed)

Saturday, March 21, 2020

Avocado, The Anti High Blood Cholesterol Functional Fruit

Avocado may process certain bioactive compounds with function in inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.

Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membranes walls and stimulated the production of steroid hormone and aided the digestive tract in absorbing the nutrients for our body need.

However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque building up on the arterial wall, leading to heart diseases and stroke.

Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.

People who follow the Western diet with high in saturated and trans fat, red meat, processed food and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".


These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at the lower risk of high blood cholesterol some in the future (weeks or months, depending on the levels of blood cholesterol today).


The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).


If your ratio is lower than 4, you are considered to have a healthy blood cholesterol ratio.


Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.

It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Researchers in the examine of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.


The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.


Rat group treated with additional HAEPA showed a significantly decreased the body mass index (BMI), total fat pad mass and adiposity index, compared to HFD-fed rats.

The LDL and lipid peroxidation levels of HFD+HAEPA group were significantly lower compared to HFD group.


Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ and protein expression of PPAR-γ in mediating the expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in HFD+HAEPA group than in HFD group.


The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.



In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion with 25 rats divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.

* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.

* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.

Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".

Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)

Thursday, March 19, 2020

Tomato Protects Diabetics Against Complications Caused by Oxidative Stress

Oxidative stress is an imbalanced ratio of free radicals and antioxidant enzymes produced by the host.

In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period overexpression free radicals compared to reduced levels of antioxidants.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.

Antioxidants are stable molecules that inhibit oxidation.

Diabetes is a chronic condition of insufficient insulin entered the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged-up by cholesterol.

In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antixodants either produced by the body or intake of antioxidant chemical compounds from the dietary sources.

Free radicals can enter our body from environmental factors, such as the air we breathe, the foods we eat.

Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals are most likely occurred to people with a weakened immunes system such as the elderly due to aging.

Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".

And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural compound for the treatment of diabetes with no side effect, researchers examined the beneficial effect of tomatoes in diabetics.

Participants with type-II diabetic group (n=40) and age-matched control group (n=50 are included in the study.

Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and very high lipid peroxidation rate compared to the control group.

According to the analysis of the short term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.


Once again, in the total of 90 subjects included type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.

Patients with type 2 diabetes significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before application of lycopene.

Long term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.

In other words, long term tomato injection protects diabetics against complication associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Effect of short term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)

Apricots, May Be the Next Generation Chemo Alternative Anti Liver Cancer Functional Food

Apricot, a functional food may be the next pharmaceutical target for the finding of an effective medicine with potential in the treatment of liver cancer, some scientists suggested.

Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissue.
What causes the mutation of liver cell DNA is unknown. However, according to the epidemiological studies, cancer originated from the liver are associated with livers damaged by birth defects, alcohol abuse, or chronic infection with diseases such as hepatitis B and C, hemochromatosis.

Non-alcoholic steatohepatitis (NASH), the advanced form of non-alcoholic fatty liver disease (NAFLD). are one of the major risk factors associated with significant liver damage or the increased risk of liver cancer.

An unhealthy diet pattern and lifestyle also can contribute to the early onset of liver cancer. therefore making positive lifestyle choices such as Not smoking, eating a healthy diet and keeping physically active are some of the ways which can reduce the risk of liver cancer.

The World Cancer Reserve Fund wrote," There is strong evidence that being overweight or obese is a cause of liver cancer, consuming approximately three or more alcoholic drinks a day is a cause of liver cancer, and consuming foods contaminated by aflatoxins (toxins produced by certain fungi) is a cause of liver cancer".

Men are about 3 times more likely than women to be diagnosed with the disease

According to the statistic, in the US., an estimated 30,610 men and 11,610 women will be diagnosed with primary liver cancer, causing the deaths of 20,540 men and 9,660 women.


The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belonging to the family Rosaceae.

Apricot is classified in the family of the plum with yellow to orange, often tinged red on the side which is exposed to the sun.

Chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

In the assessment of MK615, an anti-cancer substance extracted from the Japanese apricot, researchers at the Dokkyo University School of Medicine conducted an investigation to examine the anti-neoplastic effect of MK615 against hepatocellular carcinoma (HCC).

Observation of the assays from 2 HCC lines, HuH7 and Hep3B, were cultured with MK615 at concentrations of 600, 300, 150, and 0 microg/mL found that
* MK615 inhibited the growth of, and lysed, HuH7 and Hep3B cells in a dose-dependent manner

* MK615 decreased the population of cells in G2/M phase, according to the Cell cycle analysis.

* MK615 suppressed the expression of the function of Aurora A. associated with cancer cell proliferation by 34.3%, 32.9%, and 54.3% at 150, 300, and 600 microg/mL MK615, respectively.

Dr. after taking into account co and confounders said, "(These results suggested that) MK615 has an anti-cancer effect against HCC lines in vitro, and the effect is exerted through inhibition of Aurora-A activity".

Furthermore, in the evaluation of the clinical effects and feasibility of administering MK615 for patients with HCC recurred in the liver 8 mo after the surgery.in a 60-year-old female with advanced HCC, researchers found that

* Radiofrequency ablation and transarterial infusion chemotherapy were performed but the recurrence was not controlled and one year after the intrahepatic recurrence, pulmonary and lymph metastasis reappeared.

* Administration of chemo drug Sorafenib was not effective.

* MK615 was administered as a final alternative therapy after informed consent was obtained from the patient.

3 months of MK615 injection exerted a significant effect in decreasing her alpha-fetoprotein level and sizes of both the lymph node and pulmonary metastases. The patient has survived for more than 17 mo after the MK615 administration

These results suggested that MK615 is effective against advanced liver cancer metastases.
Taken all together, apricot may be considered a functional food for the prevention and adjunct therapy for the treatment of liver cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food apricot during the course of the disease will be necessary to complete the picture of apricot anti-liver cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources(1) A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity by Okada T1, Sawada T, Osawa T, Adachi M, Kubota K.(PubMed)
(2) Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot "Prunus mume" by Hoshino T1, Takagi H, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Sato K, Kakizaki S.(PubMed)

Wednesday, March 18, 2020

Whole Food Avocado, the Natural Sources of Antioxidants Against Lipids, Proteins and Cells DNA Damage

In the search of natural therapy for the prevention and treatment of diseases involved oxidative stress, scientists may have found a dietary whole fruit with the efficacy compared to that of conventional medicine, according to studies.

Antioxidants are stable atoms which inhibit free radical and stop the free radicals chain reaction.

Free radicals on the other hand are unstable and highly reactive molecules with a single or unpaired electron on the outer ring. In order to maintain the balance, free radicals are ready either to donate or intercept an electron from another stable atom, leading to a domino's effect which can not be stopped until the electron is paired or inhibited by an antioxidant.

Overexpression of free radicals and suppressed levels of antioxidants cause oxidative stress, leading to the damage cell structure, protein and lipid and alternation of cell DNA.

Every day, the human body is bombarded by the invasion of free radicals. Some foods we eat, the polluted air we breathe, the use of the toxic chemical substances and the body metabolism all contribute to the expression of free radicals in our body.

Luckily, for a healthy individual, our body antioxidant enzymes are good enough to maintain the balance ratio, regardless of the levels of free radicals produced.

However, for the people with suppressed antioxidant enzymes in the body, dietary sources of antioxidants from fruits and vegetables can be very helpful.

Researchers at the Karolinska Institutet suggested that a high intake of fruit and vegetables is related to low oxidative stress.

Dr. Rikard Åsgård, the lead scientist said, "Fruit and vegetable intake was inversely related to oxidative stress" and " An increased intake of fruit and vegetables can, therefore, be beneficial for patients with type 2 diabetes since these patients are documented to have raised oxidative stress and inflammation".


The results clearly encouraged that people who suppress antioxidants produced by the body should add some portions of fruits and vegetables into their diet.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins.

With an aim to find natural ingredients with significant antioxidant effects against bacterial infection in the induction of oxidative stress, researchers examine the thyl acetate, containing 70% acetone, and 70% methanol extracts of the peel, pulp, and seed from two avocadi (Persea Americana Mill) against Gram-positive bacteria.

Peels and seeds were found to possess higher amounts of phenolics and had a more intense in vitro antioxidant potential, compared to the pulp.

The efficacy of the peels and seeds against Gram-positive bacteria was associated with the rich in catechins, procyanidins, and hydroxycinnamic acids, whereas the pulp was particularly rich in hydroxybenzoic and hydroxycinnamic acids and procyanidins.

The results indicated that avocado displays moderate antimicrobial effects against Gram-positive bacteria.

Furthermore, injection of the extracts (70% acetone) from avocado peels and seeds as inhibitors of oxidative reactions in meat patties, researchers also found that avocado extracts protected meat lipids and proteins against oxidation with the effect on lipids being dependent on the avocado variety.


Moreover, in the examine the antioxidant activity of other compounds such as monounsaturated fatty acids, tocopherols, carotenes, acetogenins and sterols found in avocado researchers once again confirmed the antioxidant property by comparing the lipophilic AOC of the pulp and the fruit hydrophilic AOC.

According to the chemical assay of oxygen radical absorbance capacity (ORAC), the highest antioxidant activity of lipophilic AOC was attributed to the presence of high levels of acetogenins, compared to other compounds.

The findings showed that the presence of emulsifying agents which are soluble in both fat and water could serve as novel lipophilic antioxidants in a food matrix.

Interestingly, the University of California in the study "the effect of harvest date on nutritional compounds and antioxidant activity (AOC) in avocado (Persea Americana Mill. cv Hass) fruit" , suggested that AOC in early harvested fruit after storage for 35 days was much higher antioxidant contents than that in late-harvested fruit after storage for 21 days.

Taken altogether, there is no doubt that whole fruit avocado processed a strong antioxidant property may be considered a functional food for the prevention and treatment of oxidative stress-related diseases


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties by Rodríguez-Carpena JG1, Morcuende D, Andrade MJ, Kylli P, Estévez M.(PubMed)
(2) Activity-guided identification of acetogenins as novel lipophilic antioxidants present in avocado pulp (Persea americana) by Rodríguez-Sánchez D1, Silva-Platas C, Rojo RP, García N, Cisneros-Zevallos L, García-Rivas G, Hernández-Brenes C.(PubMed)
(3) Effect of harvest date on the nutritional quality and antioxidant capacity in 'Hass' avocado during storage by Wang M1, Zheng Y, Khuong T, Lovatt CJ.(PubMed)
(4) High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes by Rikard Åsgård,1 Elisabet Rytter,2 Samar Basu,2 Lilianne Abramsson-Zetterberg,3Lennart Möller,1 and Bengt Vessby. (PMC)