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Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Thursday, January 31, 2019

Papaya inhibits the Acute and Chronic Inflammatory Diseases, According to Studies

Scientists may have found a whole fruit with potential in inhibiting the overexpression of inflammation caused by the acute and chronic phases of infection, some studies suggested.

Inflammation is a natural systematic immune response in activating the production of the inflammatory cytokines to protect our body against microorganisms during the acute phase of body damage or injury.

However, overexpression of noninflammatory agents activity in a prolonged period can damage the healthy nearby cells and damage the cells in the affected region. In severe cases, this action may lead to cell apoptosis, causing abnormal scars formation that damage the infected organs.


Many chronic diseases, such as cirrhosis are the results of liver scars formation caused by excessive alcohol drinking and infected by hepatitis viruses.


Some researchers suggested that anti-inflammatory cytokines under a normal condition at the acute phase of infection can also switch to pro-inflammatory cytokines.


Dr. Opal SM, in the elevated function of anti-inflammatory cytokines, wrote, "The anti-inflammatory cytokines are a series of immunoregulatory molecules that control the proinflammatory cytokine response. Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response".


These result suggested that anti-inflammatory cytokines also act according to the stimulation of the immune system.


Chronic inflammation is a condition that can last for months, sometimes years, in which the immune system has a failure to eliminate all microorganisms, in the acute inflammation.


Some chronic inflammations also are the results of autoimmune disorder, caused by the immune system attacks normal healthy tissue, by mistaking them for pathogens that cause disease.


Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

In the findings of a natural ingredient to reduce the economic burden for healthcare systems, with high mortality and limited treatment in sepsis patients, a hyperinflammatory condition, researchers at the Chongqing Medical University launched an investigation to evaluate whether mango and papaya process anti hyperinflammatory effect against sepsis.


Mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya showed a significant effect in attenuating the cecal ligation and puncture-induced mortality and acute lung injury (ALI), through reducing the systemic and pulmonary inflammatory responses.


Further analysis, the function of the isolated compounds from the experimental fruits, exerted the anti-inflammatory functions in inhibiting production of proinflammatory mediators through a set of actions including deactivated sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer in stimulating the pro-inflammatory production.


Additionally, application of mangiferin (MF), also inhibited the levels of free radicals and increased the expression of heme oxygenase-1 (HO-1), an Nrf2-regulated gene that plays a critical role in the prevention of vascular inflammation found in the lung of septic mice.


Dr. Gong X, the lead author, after taking into account co and confounders said, "MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators:


Interestingly, in the reaffirm the potency of fermented papaya preparation (FPP) (a product of yeast fermentation of Carica papaya Linn) and a food supplement, in chronic and degenerative disease conditions (such as thalassemia, cirrhosis, diabetes and aging through modulating the immunological, hematological, inflammatory, vascular and oxidative stress damage parameters, researchers found that* Fermented papaya preparation (FPP) does not cause a genotoxic effect when exposed to HepG2 cells nor and the PC12 cells.


* Application of exerts a strong effect in reducing levels of free radicals and increasing antioxidants by balancing the ratio of antioxidants produced by the host tissue and ROS.

Thus, decreasing the levels of oxidative stress caused by overexpression ROS in stimulating the onset of cell damage and inflammation, which have a strong implication in causing a variety of cancers, diabetes, arthritis, cardiovascular dysfunctions, neurodegenerative disorders (such as stroke, Alzheimer's disease, and Parkinson's disease), exercise physiology (including performance sports) and aging.


These results suggested that fermented papaya and its bioactive compound may be considered functional food used conjunction with conventional medicine for prevention and treatment of acute and chronic inflammatory diseases.

However, additional data collection on large example size and multi-centers studies performed with human consumption of fermented papaya and its bioactive compound during the course of the inflammation will be necessary to complete the picture of papaya anti-inflammatory possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
(2) Applications and bioefficacy of the functional food supplement fermented papaya preparation by Aruoma OI1, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L.(PubMed)
(3) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)

Wednesday, January 30, 2019

Green Tea Epigallocatechin-3-gallate (EGCG), The Bioactive Compound Which Kills Esophageal Cancer Cells Before They Can Spread

Green tea may have a therapeutic and positive effect in reducing risk and treatment of esophageal cancer, some scientists suggested.

Esophageal cancer is a medical condition characterized by irregular cell growth in the tissues of the esophagus. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs.

According to statistic, in 1028 over 17,000 adults in the United States will be diagnosed with esophageal cancer.

The disease accounts for 1% of all cancers diagnosed in the United States.


The means of the 5-year survival rate of esophageal cancer is 19%. It is very low compared to other types of cancer. Sadly, early diagnosed with 5 years survival rate of esophageal cancer is only 43%.

The exact causes of esophageal cancer are still unknown.

Researchers as of today, do not know why people with the same health condition and family history, some are susceptible to the early onset of the disease while others do not.

However, researchers do know that smoking, age, family history, unhealthy diet and occupation that requires frequent contact with irritants are associated to increase the risk of esophageal cancer.


Other researchers suggested that certain medical condition such as obesity, GERD, achalasia and genetic mutation inherited from the parents are also the prevalent risk factors in the onset of the disease.

If you are experiencing symptoms of difficult or painful swallowing, a persistent sensation of having food lodged in the chest, and pain in the throat or back, behind the breastbone or between the shoulder blades, unintentional weight loss, coughing up blood, and heartburn that cannot go away, you may have esophageal cancer, please check with your doctor to rule out the possibility.


Green tea a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemo drug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.

According to flow cytometry assay, the combined application induced the elevation of ROS and ADM concentration in the production of cytotoxicity to the tumor cells by reducing the expression of mitochondrial membrane potential and ABCG2 protein that protect cancer cells apoptosis. without harming healthy cells.

ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reaction to chemo-medicine.

Mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy deletion and subsequently, causing cells death.

Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorating anti-apoptotic bcl-2 protein expression and promoted Bax and caspase-3 protein expressions with functions of promoting apoptosis in a dose- and time-dependent manner.

BCL2 family members form hetero- or homodimers and play an important anti-apoptotic protein.

Caspase-3 protein plays a central role in the execution-phase of cell apoptosis.

BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in the mediation of cell death by apoptosis.

Compared to ADM treatment alone, the Eca109/ABCG2 multi-drug resistance cancer cells, the rate of apoptosis and ADM concentration were significantly higher and levels of mitochondrial membrane potential and ABCG2 expression were lower.

In other words, injection of green tea plus ADM was more effective in inducing cells death in Eca109/ABCG2 multi-drug resistance cancer cells through expression ROS and ADM in enhancing elevation of cytotoxic activity compared to ADM treatment alone.

After taking into account others co and confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".

In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay, after 24 hours also inhibited cancer site proliferation by increasing the expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and increase caspase-3 protein function in the induction of malignant cellular apoptosis, in a dose-and time-dependent manner.

Furthermore, in the examine the PCR-TRAP argentation analysis during the experiment, EGCG also inhibited the viability of Eca109 and Ec9706 cells by suppressing cancer cell in alternating DNA transcript through telomerase activity.

More interestingly, the continuation of the study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discovered, EGCG decreased cancer cell viability and increased cancer apoptosis through expression of p16 gene demethylation in cancer cell cycle arrest.

P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.

Low level of p16 mRNA expression is associated with the progression of cancer with malignant and aggressive behavior.

Abnormalities of p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.


Taken together, green tea with an abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered an adjunct therapy or in combination with standard chemo-medicine for treatment of esophageal cancer.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3. (PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1. (PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3. (PubMed)

Tuesday, January 29, 2019

The Herbal Remedies That Detox and Nourish Our Body For Optimal Health


The Western diet or standard American diet (SAD) is a modern dietary pattern characterized by high-carb foods with low in nutrients, manufactured trans fats in the form of hydrogenated or partially hydrogenated oils, unrefined sugar, molasses, cane syrup and maple syrup,.... and refined flour.

In a long-term, all these foods can overwhelm the body organs, causing toxins accumulation that can lead to varying types of chronic illness.

Sadly but truthfully, the health line in the article of "The Effects of Fast Food on the Body" wrote, " millennials alone spend 45 percent of their budget’s food dollars on eating out'. and "In comparison to 40 years ago, the average American family now spends half their food budget on restaurant food. In 1977, just under 38 percent of family food budgets were spent eating outside the home".

Continuously, the author suggested that these types of fast foods only cause digestive and cardiovascular, respiratory, central nervous system, reproductive, integumentary and skeletal disorders but also induce a strongly negative effects on society, including more than one-third of children ages 6 to 19 are also considered overweight or obese and financial burden to the health care system.

Dr. Donjete Statovci, at the University College Cork, in the study of "The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces" said, "Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions"(2).


Herbal Remedies That Detox and Nourish Our Body include

1. Garlic
Garlic is a widely used medication in the world.

The herb has a proven record for prevention and treatment of heart disease(3) by decreasing the risk factors of hypertension and high blood cholesterol through it's a form of aged garlic extract and protection of liver from being damaged by the forming of free radicals through its form of garlic juice(4).

Furthermore, application of garlic extract also strengthens our system's fighting against the degeneration of our body, though it's a form of aqueous garlic extract(5).

2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica. It is said to have a strong effect in treating nervous system disorder caused by inflammation(6) and improving learning and memory(7).

It's antioxidant property also rejuvenates our body against the forming of free radicals(8) and protects against early aging(9).

3. Astragalus
Astragalus contains antioxidants(10) that have been used in traditional Chinese medicine for strengthening our body in fighting against oxidative stress in the induction of diseases.

The herbal medicine also processes anti-virus and anti-bacterial properties(11), and promotes selectively in modulated cells of the immune system(11).

4. Reishi Mushroom
Reishi Mushroom contains ganoderic acids that strengthen our immune system's fight against inflammation(12) and abnormal cell growth in the induction of cancers(12).

The herb also keeps our liver in top form and improves the circulation of blood and increases the oxygen level in the bloodstream(13).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Effects of Fast Food on the Body by health Line
(2) The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces by Statovci D1, Aguilera M1, MacSharry J1,2, Melgar S(PubMed)
(3) Garlic and Heart Disease by Varshney R1, Budoff MJ(PubMed)
(4) Antioxidant effects of heated garlic juice on cadmium-induced liver damage in rats as compared to ascorbic acid by Olalekan Lawal A1, Lawal AF, Ologundudu A, Adeniran OY, Omonkhua A, Obi F.(PubMed)
(5) Protective effects of aqueous garlic extract in reducing water avoidance stress-induced degeneration of the stomach, ileum, and liver: morphological and biochemical study by Zeybek A1, Ercan F, Cetinel S, Cikler E, Saglam B, Sener G(PubMed)
(6) Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats by Teerapattarakan N1, Benya-Aphikul H2, Tansawat R3, Wanakhachornkrai O4, Tantisira MH5, Rodsiri R(PubMed)
(7) Study of ameliorating effects of ethanolic extract of Centella asiatica on learning and memory deficit in animal models by Doknark S, Mingmalairak S, Vattanajun A, Tantisira B, Tantisira MH(PubMed)
(8) Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tert-butylhydroquinone by Rababah TM1, Hettiarachchy NS, Horax R(PubMed)
(9) Trends in aging and skin care: Ayurvedic concepts by Datta HS1, Paramesh R(PubMed)
(10) Mineral and Phytochemical Profiles and Antioxidant Activity of Herbal Material from Two Temperate Astragalus Species. by Butkutė B1, Dagilytė A2, Benetis R2, Padarauskas A3, Cesevičienė J1, Olšauskaitė V3, Lemežienė N(PubMed)
(11) Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review by Tan BK1, Vanitha (PubMed)
(12) Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms by Rubel R1, Santa HSD1, Dos Santos LF2, Fernandes LC3, Figueiredo BC4, Soccol CR(PubMed)
(13) Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers by Chiu HF1, Fu HY2, Lu YY3, Han YC2, Shen YC4, Venkatakrishnan K2, Golovinskaia O5, Wang CK(PubMed)
(14) Cardioprotective Activity of Ganoderma lucidum Extract during Total Ischemia and Reperfusion of Isolated Heart by Lasukova TV1, Maslov LN, Arbuzov AG, Burkova VN, Inisheva L(PubMed)

Monday, January 28, 2019

The Legume Which Restores The Ratio of Free Radicals and Antioxidants in Our Body

Black beam with abundant nutrients and phytochemicals may have a profound effect in restoring the health of human systems by rebalancing the ratio of reactive oxygen species and antioxidants in the body, some scientists suggested.

A free radical is an atom that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, protein, unsaturated fatty acid, phospholipids, DNA..... and RNA through a set of chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

Epidemiological studies agreed that overexpression of free radicals is an association of a wide range of medical conditions including chronic syndromes and diseases.

Antioxidants, opposite to free radicals are substances that inhibit free radicals activity in the induction of oxidation.

In a healthy individual, antioxidants produced by antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases found in the tissue are more than enough to balance the ratio of ROS and antioxidant which in turn enhances the function of body systems in protection against diseases associated to overexpression of free radicals.

However, in the prevention of free radicals in the induction of diseases, some people may opt for supplementation, including free radical scavenging antioxidant vitamins, such as vitamins A, C, E, folic acid, and beta-carotene.

Some researchers suggested, phytochemical produced by plants with a function to protect the plant to grow and defense against competitors, pathogens, or predators may also improve antioxidant status in the body if they are consumed by a human.

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.

Dried and canned forms of black beans can be bought in most grocery stores all around the year in . It is believed that black bean was first domesticated growth in South America.


Nutrients and Chemicals constituents
a. Nutrients
1. Carbohydrate
2. Dietary fiber
3. Protein
4. Fat
5. Vitamin A
6. Vitamin B
7. Folate
8. Vitamin C
9. Calcium
10. Magnesium
11. Manganese
12. Phosphorus
13. Molybdenum
14. Iron

b. Chemicals constituents
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

In the study to classify the maximum antioxidant effect of legume including black and red varieties of adzuki beans, researchers found that Adzuki bean (black) contain high levels of antioxidant 2,2'-diphenyl-1-picrylhydrazyl and superoxide anion scavenger compared to other beans.
* Adzuki bean (black) also processes the hydrogen peroxide scavenging and metal chelating abilities, but lesser compared to adzuki bean (red) variety.


* Phenolic extracts found in black adzuki bean also showed distinct variations compared to other beans in the inhibition of enzymes associated with hyperglycemia and hyperlipidemia.

* α-glucosidase inhibitory activity was superior in the black variety of adzuki bean (IC(50,) 26.28 mg/mL), both adzuki bean varieties (black and red) with no significant difference in their IC(50) values (7.32 to 9.85 mg/mL).

Dr. Sreerama YN, the lead scientist at the final report of the study wrote." Vigna species of legumes are a potential source of antioxidant phenolics and also great sources of strong natural inhibitors for α-glucosidase and lipase activities" and "Vigna species of legumes are good sources of phenolic antioxidants and strong natural inhibitors of enzymes associated with diabetes and obesity".

Furthermore, with an aim to reaffirm the antioxidant status of varieties of legume species, researchers at the Bhabha Atomic Research Center launched an investigation using numbers of a different technique, including Ferric Reducing Antioxidant Power (FRAP) and metal ion (Fe²⁺) chelation assays.

Thirty different varieties of commonly consumed legumes in India were screened for phenolic content and antioxidant in the study.

All 30 bean varieties process a high level of antioxidants. Beans with a dark coating such as black bean have higher levels of antioxidants compared to beans with the lighter coating.

Moreover, Antioxidant activity showed a positive correlation (r²>0.95) with phenolic contents.

These result suggested that black color bean may be considered functional food in improved antioxidants in the body. In other words, intake of black bean daily may protect us against chronic syndromes and diseases caused by an imbalance of ratio free radicals and antioxidants in our body.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

References

(1) Differential accumulation of polyphenolics in black beangenotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Phenolic antioxidants in some Vigna species of legumes and their distinct inhibitory effects on α-glucosidase and pancreatic lipase activities by Sreerama YN, Takahashi Y, Yamaki K. (PubMed)
(3) Comparative study on antioxidant activity of different varieties of commonly consumed legumes in India. by Marathe SA, Rajalakshmi V, Jamdar SN, Sharma A.(PubMed)

Sunday, January 27, 2019

How to Protect Your Body From Heavy Metals and Chemicals Toxicity, Effectively


Carrots may have a profound and positive effect in expelling heavy mental and chemical toxins from our body through the gastrointestinal tract, some scientists suggested.

The digestive system, including the salivary glands, mouth, esophagus, stomach, liver, gallbladder, pancreas, small intestine, colon, and rectum. is a system responsible for extracting the nutrients and fluids from the foods intake to provide energy for the body needs and expelling the feces from the body.


Some people with the digestive problem may experience symptoms of acid reflux and GERD with burning sensation, gas, bloating, constipation, diarrhea, indigestion. In serious cases, the condition can also cause gallstone, irritable bowel syndrome, hemorrhoids,...


Some researchers suggested that eating 7 or more serving of fruits and vegetable daily, replacing refined grain product with whole grain products, reducing intake of processed food and red meat and engaging in daily physical activity are the best to optimize the digestive health.


Including vitamin D and calcium in the diet are also helpful.


Carrot, a root vegetable with an orange color is sub-species of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the concerns of the damage of heavy metal damage to the body, researchers at the Northwest A&F University, launched an investigation to examine whether insoluble dietary fiber from carrot pomace effect in exerting the protection of the digestive tract,

Researchers found that using the ultra-micro grinding process, the insoluble dietary fiber exerts far better potential in inhibited levels of glucose-, nitrite-, and lead ion- compared to the raw insoluble dietary fiber.


Truly, the ultra-micro grinding process could significantly decrease the particle size of carrot insoluble dietary fiber and increase its Brunauer-Emmett-Teller surface area from 0.374 to 1.835 m(2) g(-1).
The method also improved the water-holding capacity, swelling capacity, and oil-holding capacity increased by 62.09%, 49.25%, and 45.45%, respectively.


These may be the reasons the insoluble dietary fiber from carrot pomace treated with an ultra-micro grinding process displays a significant effect in the protection of the digestive system through absorption of the far greater level of heavy and toxic metals.

The processed application also effectively protect Caco-2 cells from lead ion damage, according to the apoptosis assessment by AO/EB, compared to the raw contents

At the concentration of 10.0 mg, carrot insoluble dietary fiber has no toxicity for Caco-2 cells, the MTT assay showed.


The results of this study highlighted the potential of the ultra-micro grinding process to produce a high added-value fiber ingredient from carrot residue with function in protecting the gastrointestinal tract against heavy and toxic chemicals.



Taken all together, carrot's insoluble dietary fiber may be used as a functional food in improving the digestive function in absorbing heavy and toxic chemicals before causing harm to the body tissue and organs.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Physicochemical properties and intestinal protective effect of ultra-micro ground insoluble dietary fibre from carrot pomace by Ma S1, Ren B, Diao Z, Chen Y, Qiao Q, Liu X(PubMed)

Saturday, January 26, 2019

How to Prevent Over Production of Free Radicals in Your Body For Optimal Health

Anise may have a potential and substantial antioxidant effects in balancing the ratio of antioxidant and free radical in the body, some scientists suggested.

Free radicals are the unstable and uncharged molecule which are highly reactive by having an unpaired valence electron.


Some researchers suggested that due to the nature of free radical high reactivity, free radicals have the potential to be the extremely harmful contaminants and extremely powerful chemical tools for the treatment of diseases through inducing cytotoxicity.


Free radicals exert their powerful reactivity through a chain reaction. Without inhibiting the unpaired electrons by antioxidants, the chain reaction can go on forever.

Radical chain reactions are processed in three distinct phases: initiation, propagation, and termination.


Contrastly, an antioxidant is a molecule with a function to inhibit oxidation, especially in the counteracting oxidative stress caused by overproduction of free radicals.


Researchers suggested that antioxidants found in the plant not only exerts the activity in the inhibition of free radicals but also stimulating the antioxidant enzymes in the host body.


Interestingly, in some cancer cells in vitro, application of antioxidants found in the plant such as green tea not only protect the healthy cells of the host but also increase the function of free radicals in killing cancer cell through cytotoxic activity.


One theory suggested if we can maintain a healthy ratio of antioxidants and free radicals in the body, we may live a life of diseases free.


Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...

Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the study of the effect of EtOAc soluble extract (PBet) isolated from Anise researchers found that at dose of PBet (0.5-2mg/mL), Anise extract demonstrates a protective effect of Bel-7404 cells from free radical Hydrogen peroxide H(2)O(2) and prevent free radical in inducing cell damage through scavenging of intracellular ROS.


Further analysis also suggested that bioactive compound such as β-sitosterol in the EtOAc soluble extract (PBet) improved the antioxidant status of the extract and stimulated the production of the host natural antioxidant profile in the inhibition of lipid peroxidation.

At a dose of 0,03 - 12g/kg BW, the extract expressed no acute toxic effect observed by the bone marrow polychromatic erythrocyte micronucleus test in determined the cytogenetic damage.



Dr. Lu J, the lead author, after taking into account other co-founders suggested that "PBet could be considered as a safe functional food with antioxidant activities".


Further evaluation of the expression of antioxidants in the inhibited free radical reactive activity in the development of degenerative diseases, researchers at the joint study led by the West Bengal State University, in compared antioxidant capacities of extracts of some commonly used in Indian spices (anise, cardamom, Ceylon cinnamon, and clove) along with their purified components (anethole, eucalyptol, cinnamaldehyde, and eugenol, respectively) indicated that anethole isolated from Anise displays a comparative antioxidant capacities in free radical scavenging activity against some ROS species.


Moreover, Anise spices as a whole are more potent antioxidants than their purified active components, and at higher concentration, purified components are more toxic than their respective crude extract.

The above illustration was supported by the study in the analysis of the antioxidant and protective effects of Pimpinella anisum (P. anisum) against gentamicin (GM) in the induction of drug
nephrotoxicity.

In the total of 40 male Wistar rats divided into four groups: control and sham administrated normal saline orally and intraperitoneally (i.p.), gentamicin (GM) group received 100 mg/kg bw/day i.p., GM and ethanolic extract of P. anisum with oral dose of 300 mg/kg bw/day for 8 days, researchers suggested that application of Anise reduces kidney and liver toxicity and inhibits overexpression of reactive oxygen species in initiating chain reaction in oxidative stress the facilitation, and normalizes the levels of excretion of sodium and potassium induced by free radical expression, caused by injection of gentamicin (GM)
All inhibitions were observed through the expression of levels of creatinine, associate to kidney damage and blood urea nitrogen (BUN), an indication of liver toxicity and Malondialdehyde MDA, an oxidative stress marker and the absolute excretion of sodium and potassium.


Interestingly, compared to the control, application of Anise at 300 mg/kg bw/day significantly reduced the plasma concentrations of renal function markers (serum creatinine) in the group receiving GM (P < 0.05) and protected them against GM in inducing tubule damage.


Dr. Changizi-Ashtiyani S, the lead author suggested that "potential therapeutic impact of P. anisum to attenuate GM-induced nephrotoxicity. Therefore, the simultaneous use of the ethanolic extract of P. anisum during GM administration is recommended to reduce its nephrotoxicity effects".


Taken all together, the findings suggested that Anise may be considered a functional herb in the improved antioxidant status against ROS and drug-induced toxicity through its bioactive compounds by stimulating the production of natural antioxidants in the host.


However, intake of Anise extract in high concentration should be taken with exceptional care as liver acute toxicity has been reported by some medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Phytochemical composition and toxicity of an antioxidant extract from Pimpinellabrachycarpa (Kom.) Nakai by Lu J1, Qian W2, Xu L2, Huang G2, Cong W2, Wang Z2, Deng X3, Wang D3, Guan S4.(PubMed)
(2) Evaluation of the Antioxidant Activity of Extracts and Active Principles of Commonly Consumed Indian Spices by Patra K1, Jana S1, Mandal DP1, Bhattacharjee S1.(PubMed)
(3) Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats by Changizi-Ashtiyani S1, Seddigh A2, Najafi H3, Hossaini N4, Avan A5, Akbary A6, Manian M7, Nedaeinia R8. (PubMed)

Friday, January 25, 2019

Chaste tree berry, The Herbal Remedy Which Blocks the Onset of Premenstrual Syndrome (PMS), Scientists Show

The use of plants for healing purposes have been predated long before the existence of modern medicine.

Herbal plants have formed fundamental sources for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Chaste tree berry, the queen of all herbs may have potency in the prevention and treatment of premenstrual syndrome.

Premenstrual syndrome is a faulty function of the ovaries related to the women's menstrual cycle, affecting women's physical and emotional state, and sometimes interfering with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.

The exact causes of the premenstrual syndrome are unknown. researchers also do not know why? women with the same health condition, some are more prone to the onset of PMS than others.
However, researchers do know that chemical changes in the brain during the menstrual cycle and period, leading to fluctuations of serotonin, a brain chemical (neurotransmitter) may play a crucial role in mood states and the imbalance of the levels of the hormone estrogen and progesterone could trigger PMS symptoms.

Truly, some researchers also suggested that insufficient amounts of serotonin produced a few days before menstruation may contribute to premenstrual symptoms such as depression, food cravings, and sleep problems.

Moreover, in the investigation of genes inherited from the parents and the risk of premenstrual syndrome, some researcher suggested that family history, ethnicity, and certain mutated gene could cause some women to succumb to PMS whereas others are left relatively unscathed.


Conventional medicine used to relieve pain in PMS, such as Nonsteroidal anti-inflammatory drugs and painkillers may be effective, but they induce certain side effects including stomach pain and heartburn, headaches and dizziness,.... and skin rash due to an allergic reaction.


In serious cases, the medicine cause stomach ulcers, liver and kidney condition,... and hypertension. If you are taking the medicine for a long-term, please make sure that you discuss the adverse effects with your doctor.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, considered as Queen herb in treating menstrual problems and discomforts, The herb also has been used in herbal medicine for thousands of year as an aphrodisiac agent.

In a prospective, double-blind, placebo-controlled, parallel group, multi-center clinical trial in compared VAC BNO 1095 extract and placebo for up to three cycles, conducted by the Peking Union Medical College Hospital, group treated with extract of vitex agnus castus showed a significant reduced symptoms of PMS with mean total PMSD score decreased from 29.23 at baseline (0 cycle) to 6.41 at the termination (3rd cycle) with no serious of side effects.

Furthermore, the extract of vitex agnus castus (VAC, BNO 1095) oral administrated in 67 patients enrolled and randomly assigned to receive one tablet of VAC or placebo once a day, exhibited the decreased premenstrual syndrome symptoms at the 3rd cycle, including symptoms of negative affect, water retention, food cravings, and pain, in the treatment group, compared to placebo group, especially in symptoms of water retention.

The moderate-to-severe premenstrual syndrome in Chinese women study also showed significantly greater improvement of symptoms with intake of vitex agnus castus (VAC, BNO 1095)group than placebo, including symptom of insomnia.

Additionally, according to Dr. Döll M, the extract of chaste tree berry decreased the levels of prolactin serum during the first 3 weeks of the cycle of the premenstrual period, inducing stress involved expression of symptoms of PMS.

Taking together, Chaste tree berry may be a safe herbal medicine for prevention and treatment of PMS, through decreasing the levels of prolactin, and negative factors and enhancing the function of alleviating symptoms of the syndrome.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [The premenstrual syndrome: effectiveness of Vitex agnus castus].[Article in German]by Döll M1. (PubMed)
(2) Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo-controlled study in China by He Z1, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, Yao Y, Lu J, Lin S.(PubMed)
(3) Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus(BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Wang X.(PubMed)
(4) Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Zhang Y, Chen F, Wang X.(PubMed)

Thursday, January 24, 2019

Fennel, a Natural Anti Fever Functional Food

Scientists may have found food and plant processes the antipyretic activity comparable to those of acetaminophen in patients with fever, some studies suggested.

Fever is a natural reaction caused by the production of pro-inflammatory cytokines of the immune system in protecting our body damage and injury against foreign pathogens during the acute phase of infection.

According to medical literature, a person is not considered to have a significant fever until the temperature is above 100.4 F (38.0 C).

Although fever is a common syndrome, however, if you or your kid are experiencing fever accompanied by symptoms of a severe headache, unusual skin rash, sensitivity to bright light, persistent stiff neck and pain, mental confusion, particularly a persistent vomiting and difficulty breathing or chest pain, you or your kid should go to the hospital right the way.

Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The plant and food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the study to evaluate the antipyretic effect of the aqueous extract of herbal coded formulation containing an equal amount of Salix alba, Emblica officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, in a yeast induced pyrexia model in rabbits, researchers found that after recording the results immediately before the administration of the extractor paracetamol and again at 1 hour, application of the extract at 240mg/kg dose significant reduces elevated temperature as compared with that of standard drug paracetamol (150mg/kg).

Fennel extract applied alone showed antipyretic activity against hyperpyrexia in mice, induced by S.C. administration of 2 mL/100 g of a 20% aqueous suspension of brewer's yeast.

As an antipyretic agent, ethanolic extract of F. vulgare fruit showed a moderate antipyretic activity that was statistically significant after 30 and 90 min.

These results showed that herbal coded medicine at a dose of 240mg/kg and fennel extract have marked an antipyretic activity in animal models and this was strongly supported by the ethnopharmacological uses of medicinal plants.

Furthermore, in the examine the hepatotoxicity induced by acetaminophen caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI) in induction of symptoms such as fever due to inflammation, researchers showed that application of trans anethole, an aromatic compounds isolated from fennel exerted a significant effect in the inhibited pro-inflammatory mediators such as such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitric oxide (NO)thus decreasing the risk of fever caused by over reaction of the immune system.

Application of AN at doses 125 and 250mg/kg once a day for seven days prevented the changes caused by the APAP overdose.


Additionally, researchers also discovered, AN infection prevents the overexpression of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α, and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10), thus reducing the onset of fever.

Taken all together, there is no doubt that fennel may be considered a functional food for treatment of inflammatory induced fever.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Antipyretic potential of herbal coded formulation (Pyrexol) by Khan MS1, Hamid A2, Akram M3, Mustafa SB3, Sami A1, Shah SMA4, Usmanghani K(PubMed)
(3) Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole by da Rocha BA1, Ritter AM2, Ames FQ3, Gonçalves OH4, Leimann FV5, Bracht L6, Natali MR7, Cuman RK8, Bersani-Amado CA(PubMed)

Wednesday, January 23, 2019

Green Tea Inhibits the Oxidative Stress That Cause Fibromyalgia, Researchers Find

Green tea may have a therapeutic and positive effect in reducing symptoms and treatment of
fibromyalgia caused by oxidative stress, some scientists suggested.

Oxidative stress is a condition of imbalance of the ratio of antioxidants and free radical in the body. In other words, overproduction of free radicals accompanied by the decreased levels of antioxidants may cause cytotoxicity in the induction of oxidative stress.

Some researchers suggested long-term suppression by oxidative stress can activate the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules,...


Truly, oxidative stress-activated inflammatory pathways can also lead to the transformation of a normal cell to a cancer cell, protecting tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis.


Dr. Khansari N, the lead scientists in the study ' Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer" said, " Overproduced free radicals react with cell membrane fatty acids and proteins impairing their function permanently. In addition, free radicals can lead to mutation and DNA damage that can be a predisposing factor for cancer and age-related disorders" and "chronic inflammation could have a serious role in a wide variety of age-related diseases including diabetes, cardiovascular and autoimmune diseases".

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in the US alone.

According to the study in review of literature of the frequency and pattern of complementary and alternative medicine (CAM) of 289(95%) patients who completed the survey (263 women and 26 men) between February 2003 and July 2003, green tea was recommended at 24% for treatment of fibromyalgia (FM).

Some evidence in the medical literature suggested that overproduction of ROS in the induction of oxidative stress may have a strong implication in the pathophysiology of FM.

In the investigation of the effect of green tea epigallocatechin-3-gallate (EGCG) in the protection of oxidative stress to cardiac cells cultured in the conditions of control, 400 μM H2O2 exposure for 30 min with and/or without 10 to 20 μM EGCG pre-treatment, researchers at the National Tsing Hua University found that treatment of green tea in H(2)O(2) group demonstrated a significant reduction of levels of reactive oxygen species through its antioxidant and its ability to induce production of natural antioxidant presented in the cardiac cells, compared to overexpression of ROS in H2O2 treatment group without injection of EGCG.

Also, application of green tea reduced levels of cytosolic Ca2+ overload in the H(2)O(2) group in induced oxidative stress in experiment cell apoptosis through the improved antioxidant protein.

Interestingly, EGCG ameliorated H(2)O(2) expression in the increased glycolytic protein in response to the degree of oxidative stress in the culture cells and α-enolase, a key glycolytic enzyme on the surface of several cell types in the contribution of impaired glycolytic activity through oxidative and nitrative stress.

Additionally, green tea EGCG also decreased levels of peroxiredoxin-4, an antioxidant with function in the protection of cells against oxidative stress by detoxifying peroxides and mitochondrial proteins with a function of redox reactions of oxidative phosphorylation.

After taking into account confounders, researchers suggested that ingestion of green tea EGCG inhibited the damage of H(2)O(2) group through inhibition of the downstream signaling for Akt in expression glucose oxidation and cell apoptosis in cellular processes, and loss of phosphorylation of GSK-3β and cyclin D1 depletion in oxidative stress facilitation.

These result postulated that green tea EGCG exerted the similar inhibited the effect of those of GSK-3β inhibitor (SB 216763) in significantly improved H(2)O(2)-induced suppression on cell viability, phosphorylation of pAkt (S473) and pGSK-3β (S9), and level of cyclin D1 in cells.

The above differentiation was supported by the study conducted by the Universidad de Sevilla, in evaluated some evidence of green tea in reduced oxidative stress in the facilitated pathophysiology of FM in initiating signs and symptoms of muscular alteration and mitochondrial dysfunction.

Truly, in primary rat model, administration of green tea EGCG in different concentrations for 24 h before being exposed to hydrogen peroxide (H(2)O(2)) for 2 h to induce oxidative stress, researchers found that pretreatment with 10, 25, and 50 µM EGCG significantly inhibited the expression of H2O2 in reduced substantial decrease in cell viability.

Further analysis also showed that green EGCG application at a dose of 50 µM ameliorated the proportion of propidium iodide (PI)-positive cells increased in cultures caused by H(2)O(2) injection, thus reducing H(2)O(2) in the induction of cell death.

Taken all together, green tea and its bioactive polyphenols EGCG may be considered a functional food for treatment of fibromyalgia caused by overexpression of oxidative stress. However, the intake of green tea supplement should be taken with extreme care as acute liver toxicity has been reported in numbers of medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Use of complementary and alternative medical therapies by patients referred to a fibromyalgia treatment program at a tertiary care center by Wahner-Roedler DL1, Elkin PL, Vincent A, Thompson JM, Oh TH, Loehrer LL, Mandrekar JN, Bauer BA. (PubMed)
(2) Oxidative stress and mitochondrial dysfunction in fibromyalgia by Cordero MD1, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM(PubMed)Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)
(3) Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)

Tuesday, January 22, 2019

Green Tea, The Functional Beverage Which Protects the Stomach Against Gastric Ulcer

Green tea may have a therapeutic and positive effect in reducing the risk and treatment of gastric ulcer, some scientists suggested.

Gastric ulcers are sores that develop in the lining of the stomach as a result of bacterial infection or by overproduction of stomach acid. In other words, the gastric ulcer is a condition characterized open sores developed in the stomach, affecting the function of the stomach.


There are a set of factors that cause a gastric ulcer, including the infection of Helicobacter pylori (H. pylori), frequent use of anti-inflammatory medicine, aging, smoking and excessive alcohol drinking


Some researchers suggested that people who have radiation therapy for stomach cancer are also a higher risk to gastric ulcer development.


According to the study "Are genetic influences on peptic ulcer dependent or independent of genetic influences for Helicobacter pylori infection?" by the Veterans Affairs Medical Center and Baylor College of Medicine. "Genetic influences are of moderate importance for liability to peptic ulcer disease. Genetic influences for peptic ulcer are independent of genetic influences important for acquiring H. pylori infection".


If you are experiencing the symptoms of dull pain in the stomach. weight loss. refuse to eat because of pain. persistent gastrointestinal discomforts, acid reflux, and heartburn, you may have a gastric ulcer. Please make sure that you check with your doctor to rule out the possibility.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.


In the testing of healing of the hydroalcoholic extract including ethyl acetate fraction, (GEAc) and epigallocatechin gallate (EGCG) from green tea (GEt) in the risk of gastric ulcer induced by application of 80 % acetic acid on serosal mucosa of rats, researchers showed that application of the extract after 7 days inhibited ulcer area by exhibiting the antioxidant activity in reducing the free radical overexpression.

Furthermore, application of the hydroalcoholic extract also inhibited the oxidative stress that cause gastric damage by injection of acetic acid by enhancing the production of antioxidant enzyme GSH, superoxide dismutase (SOD) and Glutathione-S-transferase (GST) enzymes and ameliorating the production of lipid hydroperoxides (LOOH), a free radical in precipitated ulcer development by withdrawing electrons from the lipids in cell membranes.


Additional analysis also suggested that rats fed with green tea (GEt) improved the capacity of mucin content in gastric juice which has been found at reduced levels in rats with an ulcer after infecting of acetic acid.


Interestingly, injection of green tea (GEt) also decreased inflammatory infiltration of Myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) which has been used as biomarkers in the measurement of severity in some diseases including gastric ulcer.


Importantly, the application did not alter gastric acid secretion and induced acute toxicity.

Dr. Borato DG, the lead authors, after taking into account con-founders said, "GEt had a pronounced antiulcer effect, possibly through maintenance of mucin content and reduction of inflammation and oxidative stress".


Other polyphenol compound L-Theanine, isolated from green tea on NSAID (indomethacin)-induced maximum ulceration in the stomach on the third day at dose of 18 mg/kg inhibited the expression of the overproduction of reactive oxygen species (ROS) in the induction of lipid peroxidation, oxidation and protein carbonylation which is considered one of the most harmful irreversible oxidative protein that cause damage to the stomach.

The application also reduced expression of type 1 T helper (Th1) cells in the production of inflammatory cytokines, interferon-gamma, interleukin (IL)-2, and tumor necrosis factor (TNF)-beta, in the facilitated immune response in exhibiting inflammation in the acute stomach damage infection.

Additionally, L-Theanine also increased the levels of total thiol in the stomach tissue, mucin content in the gastric juice. The enhanced antioxidant levels not only improve digestion but also protect the stomach against damage by foreign substances.

Moreover, at a higher dose of 40 mg/kg b.w. At 10 mg/kg b.w., Dr. Chatterjee S, the lead author said, "L-theanine significantly alleviated the adverse oxidative effect of indomethacin through enhanced synthesis of PGE2 by modulation of cyclooxygenase-1 and 2 [COX-1 and COX-2] expression, Th1/Th2 cytokine balance, and restoration of cellular antioxidant status at the gastric ulcer margin".

Taken together, been tea with abundant bioactive polyphenols may be considered functional food for treatment of gastric ulcer without causing any adverse effects.

However, high doses and long-term applications of green tea supplement were associated with acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Healing mechanisms of the hydroalcoholic extract and ethyl acetate fraction of green tea(Camellia sinensis (L.) Kuntze) on chronic gastric ulcers by Borato DG1, Scolaro CT2, Maria-Ferreira D1, da Silva LM1, de Souza LM2, Iacomini M2, Werner MF1, Baggio CH3. (PubMed)
(2) L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin by Chatterjee S1, Chatterjee A, Roy S, Bera B, Bandyopadhyay SK. (PubMed)

Monday, January 21, 2019

Infectious Diseases: Herbal Anise, The Natural Antibiotic Alternative With No Side Effects, Scientists Found

Herbal Anise may have a synergistic antibacterial activity effect in reduced risk and treatment of infection, some scientists suggested.

Bacteria are microorganism consisted of consist of a single cell with a simple internal structure. harmless. most of them are harmless to human and can be distinguished by the nature of their cell walls, by their shape, or by differences in their genetic makeup.


Bacteria reproduced through cell cycle division. in other words, they multiply by making a copy of the DNA and grows large in size by doubling its cellular content. before splitting it into two identical "daughter" cells.

Bacteria can also be beneficial to human health as they help to maintain the orderly functioning of the digestive system such as digesting food that the stomach can not digest, producing the vitamins for our body needs, improving the immune function and most importantly, ensuring the optimal digestive functioning.


Some infectious bacteria are dangerous to human health. As they can divide quickly, after entering the body. Many produce chemicals called toxins, which not only fence off the attack from immune system but also can damage.

Due to antibiotics overuse over large 3 decades, some infected bacteria have developed antibiotic resistance, a phenomenon where infectious bacteria are no longer susceptible to previously effective antibiotics.

Synergistic antibacterial activity is a condition in which whole herb application exerts a greater effect than the sum of individual ingredients combined.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...


Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the comparison of the antibacterial effect against a wide range of foodborne Gram-positive and -negative bacteria, yeasts and moulds by an agar well diffusion method in five different varieties of Ocimum basilicum L. plants, including Anise, researchers found that application Anise essential oil exhibited a strong effect in decreased expression the acid-tolerant microorganisms including Lactobacillus curvatus and Saccharomyces cerevisiae, synergistically, compared to mixtures of the predominant components of pure linalool and methyl chavicol.

In a tomato juice medium, Anise oil injection also exerted antibacterial activity at doses of 0·1% and 1% Anise oil, against Lact. curvatus and S. cerevisiae, respectively.

The inhibitory effect of Anise oil was substantially higher, comparison to the mixtures of the predominant components of pure linalool and methyl chavicol, against the acid-tolerant organisms, Lactobacillus curvatus and Saccharomyces cerevisiae, examined in broth by an indirect impedance method.

Furthermore, essential oil extracted from the Anise seed used alone or combined with essential oil extracted from from aerial parts of Thymus vulgaris, also displayed a significant effect in inhibiting nine Gram-positive and Gram-negative pathogenic bacteria: Staphylococcus aureus, Bacillus cereus, Escherichia coli, Proteus vulgaris, Proteus mirabilis, Salmonella typhi, Salmonella typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa.

Pimpinella anisum essential oils methanol extracts at doses of MIC 15.6 and 62.5mug/ml) were particularly effective against Staphylococcus aureus, Bacillus cereus, and Proteus vulgaris.

Some researchers suggested that Anise antibacterial effect probably was attributed to the bioactive major compound anethole in the modulation of the immunity.

According to some studies, application of essential oil in mice model, trans-anethole and estragole, a derivative of anethole improved the host immunity by reducing the expression of hypersensitivity response and increasing the numbers of white blood cells(leucocytes) in the circulatory system with function in counteracting foreign substances and diseases.


Further differentiation also found that trans-anethole improved the immune function in stimulating the transformation of B cells into plasma cells in the produced and secreted antibodies whether a foreign substance was scented.


Additionally, anethole isolated from Anise also exhibited a strong effect in protecting the immunity against mice fed with cyclophosphamide to induced chemo suppression of immunity.


Indeed, an Anise essential oil demonstrated a significant effect in the immune responses by modulating the levels of immune-inflammatory factors interleukins (IL6, IL8, and IL10) and tumor necrosis factor(TNFα ) against infectious microorganism in initiating the acute phase of infection.

Additionally, in animal tested with E. acervulina-infected, application of essential oil isolated from Anise also increased expression of lymphocytes in the infectious intestinal area.

Taken all altogether, the findings suggested that Anise essential oil including the bioactive phytochemical anethole may be used as an antibacterial agent, particularly in the externally acute phase of infection.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The synergistic preservative effects of the essential oils of sweet basil (Ocimum basilicum L.) against acid-tolerant food microflora K.J. Lachowicz1 , G.P. Jones1 , D.R. Briggs1 , F.E. Bienvenu2 , J. Wan3 , A. Wilcock3 and M.J. Coventry3 1School of Nutrition and Public Health, Deakin University, Geelong, 2Ovens Research Station, Department of Natural Resources and Environment, Myrtleford, and 3Australian Food Industry Science Centre, Werribee, Victoria, Australia(Letters in Applied Microbiology Volume 26, Issue 3, Version of Record online: 4 JAN 2002)
(2) Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts by Al-Bayati FA1.(PubMed)
(3) Evaluation of immunomodulatory activity of trans-anethole and estragole, and protective effect against cyclophosphamide-induced suppression of immunity in Swiss albino mice by Luiz Alexandre Marques Wiirzler, Francielli Maria de Souza Silva-Comar, Saulo Euclides Silva-Filho, Michael Jefferson Amorim de Oliveira, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman(International Journal of Applied Research in Natural Products)
(4) Immune effects of dietary anethole on Eimeria acervulina infection by Kim DK1, Lillehoj HS, Lee SH, Jang SI, Park MS, Min W, Lillehoj EP, Bravo D.(PubMed)

Sunday, January 20, 2019

Herbal Cinnamon, The Natural Alternative for Treatment of Infertility, Scientists Say

Scientists may have found a kitchen spice which processes some underline mechanisms in enhancing the rate of fertility, some studies suggested.

Infertility is a condition characterized by the inability of a couple to conceive after 12 months of unprotected sexual intercourse or the cannot carry the pregnancy full term.

The syndrome affects over 5 million couples alone in the US. Because of the unawareness of treatments, only 10% seek help from professionals.

According to the statistic, about 35% of infertility is caused by the male's inability to fertilize. 35% is caused by the female's inability to conceive, 10% attributes to both, and 10 % is considered a failure with an unknown cause.

Dr, Romero Ramos R, in the study [Risk factors associated to female infertility], wrote, "There were 6 factors with statistical significance: advanced age (p < 0.001), elevated body mass index (p < 0.001), age of onset of sexual activity (p < 0.001), prior pelvic surgeries (p < 0.001), and presence of stress (p < 0.001). Other risk factors such as smoking, chemical, and radiological treatments, pelvic inflammatory disease, exercise, contraceptive use, alcohol intake, drugs, coffee, solvents, glue, and insecticides, were not significant".

In male infertility, according to a case-control study conducted by Dr. Buiatti E and colleagues, about coffee and alcohol consumption, smoking habits, x-ray exposure, usual sitting posture, drug consumption, other nonoccupational risk factors, socioeconomic status, education level, and occupational history are some of prevalent risk factors associated to male infertility.

And, the high relative risk was associated with (a) occupation in the radioelectric industry, (b) nonsedentary clerical workers, (c) clerical work in the typographic industry, and (d) occupation in the textile industry,


Cinnamon, a kitchen spice in many cultures, may be best known for its effect in reducing the levels of blood glucose in diabetics and lipid peroxidation through its antioxidant activity(4).

In a total of 45 women with Polycystic Ovary Syndrome, randomized, 26 women completed 3 months of the study, and 17 women completed the entire 6 months of the study, researchers showed,
* Application of cinnamon exerts a positive effect in improvement of menstrual cyclicity associated with luteal phase progesterone levels and ovulatory menses without altering insulin resistance or serum androgen levels

* Cinnamaldehyde, a major chemical compound of cinnamon enhances fertility through selectively induced progesterone production and inhibits production of testosterone and dehydroepiandrosterone in human adrenal cells.

* Further differentiation, suggested that cinnamon extract not only reduces insulin resistance in vitro and in vivo by increasing phosphatidylinositol 3-kinase activity with insulin stimulation in the insulin signaling pathway but also improves menstrual cyclicity in female induced PCOs.

Moreover, in the infertile male rat study conducted by Fırat University, long-term cinnamon bark oil(CPO) improved the effect on testicular oxidant-antioxidant balance and sperm quality with significantly decreasing the abnormal sperm rate and apoptotic germ cell count.

Interestingly, in the study to investigate the likelihood of detrimental effects of carbon tetrachloride (CCl4 ) on the male reproductive system through oxidative stress mechanism and also protective effects of cinnamon bark oil (CBO), researchers at the Firat University conducted an experiment including 28 healthy male Wistar rats.

The tested subjects were divided into four groups, seven rats in each. Group 1 received only olive oil daily; group 2 was treated with 100 mg kg(-1) CBO daily; group 3 was treated with only 0.25 ml kg(-1) CCl4 weekly, and group 4 received weekly CCl4 + daily CBO.

All administrations were made by the intragastric catheter and maintained for 10 weeks.

At the final report, researchers suggested that
* CCl4 administration caused significant decreases in body and reproductive organ weights, testicular catalase (CAT) activity, sperm motility and concentration, and significant increases in lipid peroxidation (LPO) level, abnormal sperm rate and apoptotic index along with some histopathological damages compared with the control group.

* Pretreatment of CBO following the administration of CCl4 significant improvements in absolute weights of testis and epididymis, all sperm quality parameters, LPO level, apoptotic index, and testicular histopathological structure Cl4, compared to the group given CCl4 only.


Taken altogether, Cinnamon may be effective in promoting fertility in both sexes through enhancing the menstrual cycle in women and improving sperm performance in men.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Preliminary Evidence that Cinnamon Improves Menstrual Cyclicity in Women with Polycystic Ovarian Syndrome: a Randomized Controlled Trial by Kort DH1, Lobo RA. (PubMed)
(2) Effects of cinnamon (Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality by Yüce A1, Türk G, Çeribaşi S, Sönmez M, Çiftçi M, Güvenç M.(PubMed)
(3) Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells by Iwaoka Y1, Hashimoto R, Koizumi H, Yu J, Okabe T.(PubMed)
(4) Preventive effect of cinnamon essential oil on lipid oxidation of vegetable oil by Keshvari M1, Asgary S, Jafarian-Dehkordi A, Najafi S, Ghoreyshi-Yazdi SM(PubMed)
(5) Popular #Herbs - #Dang Qui (Angelica Sinensis)
(6) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(7) Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system by Yüce A1, Türk G, Çeribaşı S, Güvenç M, Çiftçi M, Sönmez M, Özer Kaya Ş, Çay M, Aksakal M.(PubMed)
(8) The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study by Wang JG1, Anderson RA, Graham GM 3rd, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. (PubMed)
(8) [Risk factors associated to female infertility].[Article in Spanish] by Romero Ramos R1, Romero Gutiérrez G, Abortes Monroy I, Medina Sánchez HG. (PubMed)

Saturday, January 19, 2019

Green tea Bioactive Compound Theanine Which Protects the Brain Against Manic and Depressive Episodes in Bipolar Disorder

Green tea major bioactive theanine may have a potential and positive effect in blocking the onset of bipolar disorder, some scientists suggested.

Bipolar disorder is a condition of brain disorder characterized by unusual shifting mood, energy, activity levels, and interfering the brain function in carrying out day-to-day tasks.

According to the National Institute of Mental Health, the conditions can be classified in to
* Bipolar I disorder with severe manic episodes last at least 7 days, most people with bipolar I disorder needs immediate hospital care.

* Bipolar II disorder is characterized by a pattern of depressive episodes and hypomanic episodes.

* Cyclothymic disorder also known as cyclothymia is a condition with numerous periods of hypomanic and depressive symptoms that lasting for at least 2 years.

*4. Other conditions that do not match the 3 above.

Dr. Steve Bressert, Ph.D. in the article Manic Episode Symptoms, wrote, "The symptoms of mania include: elevated mood, inflated self-esteem, decreased need for sleep, racing thoughts, difficulty maintaining attention, increase in goal-directed activity, and excessive involvement in pleasurable activities" compared to depressive episode that characterizes with low mood and other depression symptoms that lasts for 2 weeks or more. In some cases, a depressive episode may last several weeks or months at a time.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the investigation to determine whether theanine (n-ethylglutamic acid), a non-proteinaceous amino acid component of green and black teas have any protective effects on the central nervous system, researchers found that
* Theanine exerts a variety of neurophysiological and pharmacological effects through crosses the blood-brain barrier.

* Application of theanine also demonstrates the anxiolytic and calming effect by up-regulation of inhibitory neurotransmitters and possible modulation of serotonin and dopamine in selected areas and increasing levels of the brain-derived neurotrophic factor.

* The bioactive compound also displays a neuroprotective effect following cerebral infarct and injury,

* Theanine also elicits improvements in cognitive function including learning and memory,

* Interestingly, theanine administration elicits selective changes in alpha brain wave activity with concomitant increases in selective attention during the execution of mental tasks and inhibits depression.


These results suggested that theanine can be considered a therapeutic role in the treatment of some psychiatric disorders such as anxiety disorders, panic disorder, obsessive-compulsive disorder (OCD), and bipolar disorder.

Additionally, in a study by Portland VA Medical Center of adults with schizophrenia, schizoaffective disorder or bipolar disorder who were maintained on antipsychotic and other psychotropic medications randomized to supplemental EGCG or placebo including a total of 34 participants (17 EGCG, 17 placebo) and 25 participants (14 EGCG, 11 placebo), researchers showed that

* Both treatment groups showed significant reductions in psychotic, depressive and anxiety symptoms from baseline to end of treatment.

* However, EGCG did not significantly affect psychiatric symptoms or inflammatory markers, as compared with placebo.

* Adverse effects were mild and comparable between groups.


The finding indicated that green tea extract EGCG exerts an insignificant effect on psychiatric symptoms in patients with bipolar disorder compared to Theanine, another major ingredient in green and black tea.

Taken all together, green and black tea major bioactive theanine may be considered a secondary therapy in protecting the brain against manic and depressive episode in patients with bipolar disorder.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of epigallocatechin gallate supplementation in schizophrenia and bipolar disorder: an 8-week, randomized, double-blind, placebo-controlled study by Loftis JM1, Wilhelm CJ, Huckans M.(PubMed)
(2) Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders by Lardner AL. (PubMed)