Green Tea Inhibits the Oxidative Stress That Cause Fibromyalgia, Researchers Find

Green tea may have a therapeutic and positive effect in reducing symptoms and treatment of
fibromyalgia caused by oxidative stress, some scientists suggested.

Oxidative stress is a condition of imbalance of the ratio of antioxidants and free radical in the body. In other words, overproduction of free radicals accompanied by the decreased levels of antioxidants may cause cytotoxicity in the induction of oxidative stress.

Some researchers suggested long-term suppression by oxidative stress can activate the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules,...


Truly, oxidative stress-activated inflammatory pathways can also lead to the transformation of a normal cell to a cancer cell, protecting tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis.


Dr. Khansari N, the lead scientists in the study ' Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer" said, " Overproduced free radicals react with cell membrane fatty acids and proteins impairing their function permanently. In addition, free radicals can lead to mutation and DNA damage that can be a predisposing factor for cancer and age-related disorders" and "chronic inflammation could have a serious role in a wide variety of age-related diseases including diabetes, cardiovascular and autoimmune diseases".

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in the US alone.

According to the study in review of literature of the frequency and pattern of complementary and alternative medicine (CAM) of 289(95%) patients who completed the survey (263 women and 26 men) between February 2003 and July 2003, green tea was recommended at 24% for treatment of fibromyalgia (FM).

Some evidence in the medical literature suggested that overproduction of ROS in the induction of oxidative stress may have a strong implication in the pathophysiology of FM.

In the investigation of the effect of green tea epigallocatechin-3-gallate (EGCG) in the protection of oxidative stress to cardiac cells cultured in the conditions of control, 400 μM H2O2 exposure for 30 min with and/or without 10 to 20 μM EGCG pre-treatment, researchers at the National Tsing Hua University found that treatment of green tea in H(2)O(2) group demonstrated a significant reduction of levels of reactive oxygen species through its antioxidant and its ability to induce production of natural antioxidant presented in the cardiac cells, compared to overexpression of ROS in H2O2 treatment group without injection of EGCG.

Also, application of green tea reduced levels of cytosolic Ca2+ overload in the H(2)O(2) group in induced oxidative stress in experiment cell apoptosis through the improved antioxidant protein.

Interestingly, EGCG ameliorated H(2)O(2) expression in the increased glycolytic protein in response to the degree of oxidative stress in the culture cells and α-enolase, a key glycolytic enzyme on the surface of several cell types in the contribution of impaired glycolytic activity through oxidative and nitrative stress.

Additionally, green tea EGCG also decreased levels of peroxiredoxin-4, an antioxidant with function in the protection of cells against oxidative stress by detoxifying peroxides and mitochondrial proteins with a function of redox reactions of oxidative phosphorylation.

After taking into account confounders, researchers suggested that ingestion of green tea EGCG inhibited the damage of H(2)O(2) group through inhibition of the downstream signaling for Akt in expression glucose oxidation and cell apoptosis in cellular processes, and loss of phosphorylation of GSK-3β and cyclin D1 depletion in oxidative stress facilitation.

These result postulated that green tea EGCG exerted the similar inhibited the effect of those of GSK-3β inhibitor (SB 216763) in significantly improved H(2)O(2)-induced suppression on cell viability, phosphorylation of pAkt (S473) and pGSK-3β (S9), and level of cyclin D1 in cells.

The above differentiation was supported by the study conducted by the Universidad de Sevilla, in evaluated some evidence of green tea in reduced oxidative stress in the facilitated pathophysiology of FM in initiating signs and symptoms of muscular alteration and mitochondrial dysfunction.

Truly, in primary rat model, administration of green tea EGCG in different concentrations for 24 h before being exposed to hydrogen peroxide (H(2)O(2)) for 2 h to induce oxidative stress, researchers found that pretreatment with 10, 25, and 50 µM EGCG significantly inhibited the expression of H2O2 in reduced substantial decrease in cell viability.

Further analysis also showed that green EGCG application at a dose of 50 µM ameliorated the proportion of propidium iodide (PI)-positive cells increased in cultures caused by H(2)O(2) injection, thus reducing H(2)O(2) in the induction of cell death.

Taken all together, green tea and its bioactive polyphenols EGCG may be considered a functional food for treatment of fibromyalgia caused by overexpression of oxidative stress. However, the intake of green tea supplement should be taken with extreme care as acute liver toxicity has been reported in numbers of medical literature.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Use of complementary and alternative medical therapies by patients referred to a fibromyalgia treatment program at a tertiary care center by Wahner-Roedler DL1, Elkin PL, Vincent A, Thompson JM, Oh TH, Loehrer LL, Mandrekar JN, Bauer BA. (PubMed)
(2) Oxidative stress and mitochondrial dysfunction in fibromyalgia by Cordero MD1, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM(PubMed)Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)
(3) Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)