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Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Sunday, January 26, 2020

Ginger, The Potent Anti Obesity Functional Food

Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.

Obesity is a medical disease associated with extreme overweight.

In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

What causes obesity? Some researchers suggested that too much calorie consumption and lack of physical exercise are the 2 main causes of obesity in once healthy individuals.

Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of Americans and the promotion of the Western diet in the past few decades.

Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".

And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".

These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.

Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,


Diet-induced obesity was attenuated in C57BL/6J mice treated with the dietary ginger extract (GE)also exhibited an increase of energy expenditure.

GE also exerted an anti-obesity effect through promoting the increased the number of Types I muscle fibers, running endurance capacity and upregulated PPARδ-targeted gene expression in skeletal muscle

Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.

After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".

Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers at the showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).

In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.

Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".

Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.





Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)

Healthy Food Cucumber (Cucumis sativus) That inhibits the Initiation and Progression of Esophageal Cancer in Vitro

Esophageal cancer is a chronic and medical condition arisen from the esophagus due to the alternation of cell DNA.

Most cases of esophageal cancer start in the cell on the surface of the inner lining of the esophagus between the throat and the stomach. At the early stage, due to the very small size of the tumor, most patients are asymptomatic.

As the tumor continues to grow, patients may experience symptoms of difficulty swallowing, persistent chest pain and pressure, pain burning sensation, coughing or hoarseness and heartburn.

If you persistently experience chronic acid reflux, accompanied by some of the aforementioned symptoms, you should check with your doctor immediately to rule out of the possibility of esophageal cancer.

Some patients may also vomit blood if the tumor has pressed onto the nearby blood vessels.

At the advanced stage, the primary cancer cell can also travel a distance away to infect other healthy tissues and organs, leading to the secondary metastasis.

According to the statistics, in the US, aproximately17,650 adults (13,750 men and 3,900 women) in the United States will be diagnosed with esophageal cancer this year, accounting for 1% of cancers diagnosed.

Although there are many risk factors associated with the onset of the disease, some researchers suggested patients with chronic gastroesophageal reflux disease (GERD) are found to have a strong implication on the disease onset.

Dr. Shaheen N, the lead scientist at the University of North Carolina-Chapel Hil, wrote, "Gastroesophageal reflux disease (GERD) is a risk factor for adenocarcinoma of the esophagus, rare cancer whose incidence is increasing".

However, "Strong evidence supports the association of GERD and adenocarcinoma of the esophagus; however, the risk of cancer in any given individual with GERD is low".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to discover a potential ingredient for the treatment of esophageal cancer, researchers investigated the possible cytotoxic effect of freeze-dried aqueous extract of E. elaterium fruit on KYSE30 (human esophageal squamous cell carcinoma).

The study included the free dried aqueous extract of the fruits of E. elaterium incubated for 24, 48, and 72 h. on KYSE30 cancer cell lines.

The extracts showed a significant effect in the inhibition of KYSE30 cell line at IC(50) values at concentrations of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.

According to the EB/AO staining, the extract showed an increase in apoptotic cells of the KYSE30 cell line.

Furthermore, the free dried aqueous extract of the fruits of E. elaterium exerted a significant increase in cell density at the G2/M phase before inducing cell cycle arrest, according to the cell cycle analysis.

Based on the findings, researchers suggested that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on esophageal cancer cell lines via the induction of apoptosis.


Dr. Bohlooli S, the lead scientist wrote, " It seems that several compounds are possibly responsible for the cytotoxic effect of the extract".

In other words, several compounds in the extract worked synergistically to exhibit the cytotoxicity against the tested cancer cell line.

Taken altogether, cucumber may be considered supplements for the prevention and treatment of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastricadenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review by Shaheen N1, Ransohoff DF. (PubMed)

Eggplant In Reduced Risk and Treatment of High Blood Pressure

Eggplant may have a potential and substantial effect in reduced risk and treatment of high blood pressure, some scientists suggested.

Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Hypertension is a long term medical condition characterized by abnormally high blood pressure.

According to statistics from the World Health Organization, high blood pressure affects 1.13 billion people worldwide and from 1975 to 2015, mean systolic blood pressure and blood pressure have stayed more or less the same in men and have decreased slightly among women.

According to the University of Massachusetts, eggplant containing high fiber and low soluble carbohydrate content and the phenolic-linked antioxidant activity and alpha-glucosidase exerted powerful antioxidant effects in inhibited free radical expression and ROS chain reaction to induce type 2 diabetes' complications such as hypertension.

Further analysis also suggested that functional food also inhibited the angiotensin hormone which has been found to elevate vasoconstriction and increase blood pressure in diabetics.

Dr. Kwon YI, after taking into account of other confounders, suggested. " high angiotensin I-converting enzyme (ACE) inhibitory activity (Of eggplant),....... provide a strong biochemical basis for ....... reducing associated hypertension".

Indeed, the recommendation to include portion eggplant in daily diet by the National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association may be a choice to reduce diabetes complication risk of hypertension.

The illustration strongly indicated that oxidative stress initiated by ROS may place an important role in the risk of diabetes and diabetes' hypertension.


Interestingly, in the study to evaluate the cardiovascular action of Solanum melongena extract (SME) in vivo and in vitro, researchers found that application of SME display a significant and produced dose-dependent effect in reduced hypertensive responses in normotensive albino rats through modulated expression of β-adrenoceptor on cardiac and smooth muscle tissues in precipitated high blood pressure.

Additionally, the administration of SME regulated the stimulation of the expression of the muscarinic receptors in reduced high blood pressure as well as improving heart rate.

Furthermore, SME injection also decreased the efficacy of the medication of β-adrenoceptor blocker, propranolol, and the cholinergic receptor blocker, atropine in regulated abnormal heart rhythms, and to protect the heart from a second heart attack (myocardial infarction) after a first heart attack (secondary prevention).

In other words, increasing doses of β-adrenoceptor blocker, propranolol, and the cholinergic receptor blocker may be necessary to achieve the same effect in reduced risk of heart attack with the intake of eggplant.

More precisely, researchers suggested that SME modulated high blood pressure through induction of vaso-relaxation and negative inotropy and mediation of the β-adrenergic and acetylcholine receptors in promoted vasodilation of the resistant vessels and a reduction in heart activity, respectively.

Conclusively, in comparison to Captopril, a hypertensive medicine, researchers also indicated that possibly, the hypotensive effect of SME could be attributed to by SME influence on the activity of the renin-angiotensin system, which is a hormone system with function in regulated blood pressure and fluid balance.

In fact, the effect of eggplant in regulated function of diuresis in the renin-angiotensin system may be resulted of ameliorated risk of high blood pressure as diuretics were found to associate to the function of kidneys in removal of more sodium and water from the body, triggering relaxation of the blood vessel walls, thereby lowering blood pressure.

Taken together, eggplant and its phytochemicals may be considered as a functional food processed a therapeutic and potential effect in reduced risk of hypertension naturally.


For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) Hypotensive action of Solanum melongena on normotensive rats by O. L. Shum and K. W. Chiu(Wiley Online Library)

Saturday, January 25, 2020

Healthy Foods Cruciferous Vegetables Reduce the Risk of Atherosclerosis

Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain.


Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis, including 13.8% among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.


Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential remedy for the prevention of plaque accumulated on the arterial wall, researchers the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles on atherosclerosis.

According to the food-questionnaire returned by the participants, using the total vegetable intake calculated at baseline (1998),
* Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean common carotid artery IMT (CCA-IMT, P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming <2 servings of vegetables.

* Furthermore, for each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P<0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P<0.01).

* Some vegetable types showed no associated with CCA-IMT (P>0.05).

* Interestingly, there were no associations observed between vegetables and plaque severity (P>0.05).


Based on the results, researchers said, "Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women".

Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women by Blekkenhorst LC1,2,3, Bondonno CP4,2, Lewis JR4,3,5,6, Woodman RJ7, Devine A4, Bondonno NP2, Lim WH8, Zhu K9, Beilin LJ2, Thompson PL10, Prince RL3,9, Hodgson JM. (PubMed)

Carrots, The Potent functional Food Which Protects the Brain Against Onset of Neuro-degenerative Disorders, Scientists Reveal

Carrots may have a profound and positive effect in reducing risk, progression, and treatment of the neurodegenerative disorder, some scientists suggested.

Neurodegeneration is the progressive loss of neurons including the death of neurons, characterized by structure loss-induced reduction of brain function.

The exact causes of neurodegenerative disorders are unknown. Researchers also do not why people with the same health conditions, some are susceptible to certain neurodegenerative disorders such as
Huntington's disease. ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease, Parkinson's disease or other forms of dementia, while others do not.

However, some researchers suggested that genetic mutation inherited from parents, certain illness and traumatic injury to the brain are some of the major causes of the onset of the disease.

According to Dr. Chaudhuri K, in the study of unhealthy diet and lifestyle on risk of neurodegenerative disorders, the onset of some neurodegenerative disorder was attributed to the unwholesome diet that disturbed mental health in initiating etiopathogenesis of senile dementia.

Further differentiation showed that psychological syndromes such as disturbed sleep, anxiety, tension, depression, difficulty in concentration, and memory, and the tendency to indulge in defective dietary habits, Kapha vitiating diets, and lifestyle are some predominant risk factors associated to the development of the disease.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the evaluate the neurodegenerative disorder such as Alzheimer's and Parkinson's diseases affecting the central nervous system with debilitating effect to the patient, researchers at the University Technology of Mauritius launched a study to test the efficacy of flavonoids, found in many vegetables including carrot.

Flavonoids are phytochemicals containing numbers of the member, including curcumin, lycopene, ginsenoside, vitexin, and baicalin with a proven record of anti-cancer and antioxidant and immunomodulation properties in numbers of studies.

At the results of the analysis, researchers showed that the application of flavonoid to the brain ischemia patient also exerts potential neuroprotective effects by increasing neuronal viability, tissue perfusion, and cerebral blood flow and reducing ischemic-related apoptosis.



Moreover, patients treated with flavonoids also demonstrated a significantly anti-amyloidogenic effect and reduced the loss of dopaminergic neurons in the brain that has a strong implication in patients with Pakistan's disease.


After taking into account other co and confounders, researchers concluded that flavonoids found in numbers vegetables and fruits, including carrot, may be served as a potential therapeutic agent in brain disorders.

Further differentiation of the oxidative stress which causes neurodegenerative disorder, including oxidative damage to neuron in induction of mitochondrial dysfunction and apoptosis, scientists at the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region conducted a experiment to test the effect of lycopene, a polyunsaturated hydrocarbon with the highest antioxidant capacity compared to the other carotenoids against the expression of the diseases.

In rat model randomly divided into 5 groups: the sham group, the spinal cord injury (SCI) group and 3 SCI groups pre-treated with lycopene (5, 10, or 20mg/kg) researchers found that

* Spinal cord injury (SCI) group without treatment group displays a significant increase of malondialdehyde (MDA) content and a decrease of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels, compared to other groups.

Malondialdehyde (MDA) the final form of polyunsaturated fatty acids peroxidation is considered as a natural marker for oxidative stress.


* Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) are natural antioxidants that produced the host body tissue with an aim to maintain the balance of ratio of reactive oxygen species and antioxidants in the body.

The expression of lower levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) is a strong indication of overabundant free radicals, compared to levels of antioxidant in the body.

* Group treated with lycopene regardless to concentration exerted an overwhelming effect in blocking the change of mRNA of the mitochondrial membrane caused by spinal cord injury (SCI), including cytochrome b and mitochondrial transcription factor A (Tfam), with functions in the induction of mitochondrial dysfunction.

Cytochrome b, a protein in the mitochondria of eukaryotic cells functioned as a part of the electron transport chain which was oxidated in this case.

Mitochondrial transcription factor A (mtTFA or Tfam), a protein with functions as a key regulator of mammalian mitochondrial (mt) DNA transcription and replication which was altered caused by the presence of MDA.

Further analysis also found that the application of lycopene also reduces the risk of neuron cell apoptosis through decreased levels of pro-inflammatory and increased levels of anti-inflammatory expression in the tested rats.

These results suggested that lycopene found in vegetable including carrot significantly ameliorated oxidative damage, mitochondrial dysfunction, and cell apoptosis via some parameters indicated above.

Dr. Hu W, the lead authors said in the classification of doses application said, " lycopene significantly ameliorated the hind limb motor disturbances in the SCI+lyco10 group and the SCI+lyco20 group compared with the SCI group".

Taken together, carrot with a high amount of bioactive flavonoids, particularly lycopene may be considered a functional food in reducing the risk and treatment of various forms of the neurodegenerative disorder, including Alzheimer's and Parkinson's diseases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway by Hu W1, Wang H2, Liu Z2, Liu Y2, Wang R2, Luo X2, Huang Y3(PubMed)
(2) Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases by Putteeraj M1, Lim WL2, Teoh SL3, Yahaya MF(PubMed)
(3) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PuibMed)

Cucurbitacin B (CuB) Isolated from Cucumbers (Cucumis sativus), a Natural Antiangiogenic and Antimetastatic Potential Bioactve Compound

Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.

Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.

Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.

In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.

Angiogenesis is the process by stimulating the growth of new blood vessels from preexisting blood vessels used by the tumor to obtain nutrients in facilitating cancer proliferation.

Anti-angiogenic activity is an action in which substances such as drugs and herbal medicine are used to stop tumors from growing their own blood vessels.

Conventionally, medicines that block the block vascular endothelial growth factor (VEGF) from attaching to the receptors on the cells that line the blood vessels. such as bevacizumab (Avastin). Bevacizumab is considered anti-angiogenic drugs.

Believe it or not, as of today, there is no anti-metastatic drug on the market, even over 90 percent of cancer deaths today are due to metastasis formation. Dr. Stock AM, the lead scientist in the examined the targets for anti-metastatic drug development, wrote, "Tumor cell migration is the essential prerequisite for invasion and metastasis formation. It is regulated by signal substances in terms of the grade of activity and in terms of direction (chemotaxis)".

And, "Moreover we provide with the example of beta-blockers, how established drugs in other indications are possibly effective and can be co-opted as such anti-metastatic".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.

During the experiment, CuB showed significant activity in the inhibition of cellular proliferation and induction of apoptosis in the tested cancer cells in a time- and dose-dependent manner.

Furthermore, at the sub-IC50 concentrations, the injection of CuB inhibited the migratory and invasive potential of highly metastatic breast cancer MDA-MB-231 and 4T1 cells.


In HUVECs, the administration of CubB also inhibited migratory, invasive and tube-forming capacities.

In chick embryo chorioallantoic membrane, CuB exerted a strong anti-angiogenic effect in the prevention of new blood vessels.

According to the tested assay, the efficacy of Cub antimetastatic and angiogenic properties was attributed to the blocking of the matrix and proteins (VEGF/FAK/MMP-9) in signaling the development of new blood vessels from the existing vessels to induce cancer cells proliferation.


Additionally, the anti-angiogenesis was also evidenced by the decreased protein CD31 associated with more than 90% of angiosarcomas.

Dr. Sinha S, the lead scientists said, "Collectively, our findings suggest that CuB inhibited breast cancer metastasis and angiogenesis, at least in part, through the downregulation of VEGF/FAK/MMP-9 signaling".

In non-small cell lung cancer (NSCLC) both in vitro and in vivo, at nanomolar concentrations injection of CuB demonstrated a strong anti-migratory and anti-invasive ability against metastatic NSCLC by blocking the migratory, invasive and tube-forming capacities.

The efficacy of the tested compound in this experiment inhibited metastasis and angiogenesis was attributable to the suppression of proteins (Wnt/β-catenin) associated with pass signals into a cell through cell surface receptors to induce cell proliferation and formation of new blood vessels.

Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)

Friday, January 24, 2020

Cucumber Extract, A Natural Prevention and Treatment of Osteoarthritis

Osteoarthritis (OA) is an inflammatory disease mostly caused by work-related occupations and the working environment, affecting the muscles, joints, tendons, ligaments, and nerves, over time.

The disease is most prevalent in the US. Approximately 10% in men and 13% in women over the age of 60 years suffer from the condition.

In the general population, OA affecting over 25 million people in the United States alone.

And, the numbers are increasing at an alarming rate due to the aging of the population and the obesity epidemic.

The most common symptoms of OA include pain in the joint(s), reduced movement of the joint(s), joint(s) tenderness and stiffness, particularly, the loss of flexibility and bone spurs.


If you have experienced some of the symptoms that do not get better in a short period of time, you may have OA.

Believe it or not, patients with OA are associated with the complications of a rapid, complete breakdown of cartilage, bone death (osteonecrosis) and stress fractures.

As of today, there is no cure for the condition, Treatment of OA conventionally are focusing on reducing the pain and progression of the disease and improving quality of life.

If you are taking medication for the treatment of OA, please make sure that you know all the side effects
Prolonged use of Acetaminophen has been found to cause liver damage.

In the prevention and management of OA, some researchers suggested
* Prevented recurrent injury to damage menisci
The meniscus is an important issue because if its function in shock absorption and load distribution in the healthy knee joint(111). A meniscal tear can lead to knee osteoarthritis (OA), but knee OA can also lead to a spontaneous breakdown of meniscal tear and damage to meniscal structure(112). Meniscus damage or recurrent injury might be considered as a signifying feature of incipient OA in middle-aged and elderly people(113).

*. Take precaution if your occupation is at increased risk of osteoarthritis
Osteoarthritis (OA) is one of the most important diseases as it frequently affects the active age group of the population contributed to the loss of working hours and of disability(114)(115)(117). Compressive, torsional, pulling and angular movements common in certain occupations or sports may result in injuries of soft tissue, thus increasing the development of OA(116).

* Muscle strengthening and aerobic exercises
Enhanced muscle strengthening with neuromuscular electrical stimulation(118), aerobic exercises(119) and exercise(220) are effective in reducing pain and improving physical function in patients with mild to moderate OA of the knee(220).

* Maintain a healthy weight(117)
Increased BMI and obesity are associated with more severe cartilage degeneration(121)(123) as assessed by both morphological and quantitative MRI measurements(122).

*Avoid dehydration
Dehydration has shown to reduce the mobility of collagen amino acid residues and carbon sugar ring structures in glycosaminoglycans, according to University of Michigan(124) of that may affect the functions of cartilage and induce the risk of OA(125), but dehydration effects are reversible, through the restoration of molecular structure and mobility(124).

* Avoid intake of inflammatory foods
Loading up on junk foods and fast foods contains a high amount of trans fat of that increases the risk of inflammation(126) exhibits pro-inflammatory effects(127) causes of osteoarthritis (OA)(128). Red meat, eggs, and wheat products all contain a high amount of arachidonic acid, too much arachidonic acid maybe worsen the inflammation process(129), etc.

* Eat your fruits and vegetables
Fruits and vegetables containing high amount of nutrients and antioxidant(130), can enhance immune defense system(131)within the joint through direct influences of transferrin performance for reduction of inflammation(131)(132) as well as suppressing free radicals and the chain of free radicals reaction cause of elevating the swelling and promoting degeneration(133)(134).

* Replace regular beverage with green tea
Epigallocatechin-3-gallate, a green tea polyphenol(135)(136), was found to be effective in reducing inflammatory cytokines induced inflammatory diseases(137)(138).

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural compound for the treatment of osteoarthritis (OA), age-related disease researchers compared the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against GC in the management of moderate knee OA.

The randomized double-blind, parallel-group clinical trial included 122 patients (56 males and 66 females) aged between 40 and 75 years with moderate knee OA took place in three different centers

Participants were divided evenly into 2 groups (n= 61) the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally10 mg twice daily of CSE in a 180-day intervention.

According to the results from the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), the WOMAC score of CSE group was decreased by 22.44% and 70.29% on Days 30 and 180, respectively, compared to a 14.80% and 32.81% to the decrease in the GC group.

Similarly, the GC also showed a decrease in pain score compared to the CSE group without inducing any adverse effect.

Based on the finding, researchers said, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".


In order to reveal additional information about the anti-inflammatory properties of cucumber, researchers examined the antioxidant effect on cucurbitacins (Cub), a major compound found in the fruit.

Compared to grape-seed extract, wheat, alfalfa, and ginkgo biloba extracts, CuB showed a broad spectrum radical-scavenging capacity.


CuB exerted a similar activity to that of the aforementioned study by inhibiting the expression of TNF in macrophages and lymphocytes and the expression of pro-inflammatory mediators such as nitric-oxide synthase-2 and cyclooxygenase-2.

Collectively, Dr. Adebowale Bernard Saba, the lead scientist wrote," It is general knowledge among researchers working with natural medicinal products that any of the cucurbitacins have the attributes or the potential to become fully patented as anti-inflammatory...drug".

Taken altogether, cucumber processed abundantly amount of CuB may be used for the treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Search for a novel antioxidant, anti-inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba and Olayinka Oridupa. (Research Gate)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Do and do not’s list by Kyle J. Norton.