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Thursday, November 21, 2019

Asparagus, the Natural Whole Food for Neuroprotective Effects

Asparagus may be a potential whole food medicine for reduced risk and treatment of neurodegenerative disease, a renowned institution suggested.

Methanol extract from Asparagus cochinchinensi, in vivo and in vitro is found to exhibit neuroprotective effects through activation of the Shp-2, antibody and ErK1/2 Akt and Akt involved the cell apoptosis, cell proliferation.


Asparagus is a flowering plant belongs to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia. Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

In animal study of neurodegenerative disorders involved Alzheimer's disease (AD) , biological stresses, such as oxidative and inflammatory stress, induced neural cell damage, asparagus extract (ETAS) exerted anti neuroprotective effects, through expression of mRNAs in information transfer of DNA factors in exerted cytoprotective and anti-apoptotic functions against death of neuronal cells and early cognitive impairment.
Dr. Sakurai T, the lead researcher in the study insisted, this efficacy may be contributed by the extract in attenuated neuro-cell damage through improved hippocampus function in the expression of memory.


Furthermore, other chemical compound isolated roots of Asparagus cochinchinensis may be also effective in treating cognitive impairment by ameliorated neuroinflammation through decreased production of free radical NO and suppressed microglia cell activation cause of neuronal cell death.


Taking all together, there is no doubt that asparagus extract may be a potential agent for delay neurodegenerative disease through the improved function of hippocampal regions associated with the learning and memory functions, increased neurotransmitter activity, attenuated neuroinflammatory expression and inhibited oxidative stress-induced free radical in damage of neurons.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(2) Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice by Sakurai T, Ito T, Wakame K, Kitadate K, Arai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Fujiwara T, Akagawa K, Ishida H, Ohno H.(PubMed)
(3) Anti-neuroinflammatory constituents from Asparagus cochinchinensis by Jian R1, Zeng KW, Li J, Li N, Jiang Y, Tu P.(PubMed)
(4) Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus Willd on learning and memory in young and old mice: a comparative evaluation by Sharma K1, Bhatnagar M, Kulkarni SK.(PubMed)

Herbal Coltsfoot(Tussilago farfara) Promotes Skin Health

Skin, a large external organ in the human body is the outer layer, with a total area of about 20 square feet which protect the internal organs, bones, and tissues against damage.

The skin processes 3 main layers
* Epidermis is the outer most layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.

* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.

* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.

Skin inflammation is a condition that occurs when your immune system responds to a stimulus or trigger inflammation on the skin.
Inflammation is a natural process of the immune system which tries to protect our body against the invasion of stimuli and pathogens.

This process has been found to involve several stages after the bodily injury caused by physical impact or internal damage.

In the acute phase of infection, the white blood cells of the first line of immune defense stimulate to the production of blood coagulation to cover the wound and activate the protein associated with the production of inflammatory cytokines to kill off the invaders before they can enter the body.

However, overproduction of proinflammatory cytokines can lead to damage and death of the healthy cells, causing irreversible scars as in liver hepatitis infection.

Chronic inflammation (CI) is a result in which the immune system can not destroy the invasive pathogens in the acute phase of infection within 3- 8 weeks, leading to the immune adaptation of the new change in facilitating low-grade inflammatory diseases, including arthritis and diabetes.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of skin disease, researchers examined the effect of tussilagonone (TGN), a sesquiterpene compound isolated from T. farfara anti-inflammatory activity.

In RAW 264.7 cells, based on the tested analysis, administration of TGN enhanced the HO-1 expression associated with reducing inflammatory stress, oxidative stress, and ER stress and nuclear factor-E2-related factor 2 (Nrf2), associated with the antioxidant defense in a time- and dose-dependent manner.

Futhermore, TGN also suppressed the proteins associated with the production of proinflammatory cytokines such as nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by reducing the mRNA expression of proinflammatory cytokines.

In vivo, TGN also reduced iNOS and COX-2 expression in a mouse model skin inflammation induced by the injection of 12-O-tetradecanoylphorbol-13-acetate (TPA).

Based on the findings, researchers said, " these findings suggest an important role for TGN-induced HO-1 activation in regulating inflammatory responses.".

Taken altogether, coltsfoot may be considered a remedy for the improvement of skin condition caused by inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Heme oxygenase-1-mediated anti-inflammatory effects of tussilagonone on macrophages and 12-O-tetradecanoylphorbol-13-acetate-induced skininflammation in mice by Lee J1, Kang U2, Seo EK2, Kim YS. (PubMed)

Chickpeas Lectin in reduced Risk and Treatment of Oral cancer

Ckickpeas lectin may have a profound effect in ameliorated risk and treatment of oral cancer, some scientists suggested.

Garbanzo beans also are known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

Oral cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the mouth region. At the later stage, the cancerous cell may travel a distance away from the original site to infect healthy tissues and organs.

Investigation of the process of chickpea lectin in reduced oral cell proliferation and tumor expansion
may involve the expression of several aspects and mechanisms.

According to the All India Institute of Medical Sciences, chickpeas reduced the cell proliferation of human oral carcinoma cells at the concentration of 37.5 μg/mL (IC50) and no toxic effect.

Further analysis, chickpeas anti-cancer activity probably is a result of the pro-apoptotic effect induced by phytochemical agent lectin found abundantly in the legume.

Lectin is a type of protein with the important function of binding to cell membranes and influence cell-cell interaction.

In oral cancer cell line, injection of lectin showed a significant effect in inhibition of the p38α MAP kinase activated under cellular stresses as well as in response to inflammatory cytokines and involved function in the control of many other aspects of the physiology of the cell, such as control of cell cycle or cytoskeleton remodelling,.. for cell survival of the cancer in presence of substrate (ATP).

By blocking the physiological expression of cancer cells, lectin reduced cell proliferation and subsequently, shrinking the cancer site.

Furthermore, phytochemical lectin isolated from chickpeas also demonstrated a binding affinity with p38α in regulated the production of certain inflammatory cytokines which may have certain effect in the induction of cancer growth.

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes including to protect cell in responses to inflammation and injury,


Specifically, in the influence of the production of inflammatory cytokines by p38α, lectin regulated the potent pro-inflammatory cytokine produced by cells of the innate immune system IL-1β in the induction of tumor growth and metastasis in cells under prolong period of inflammation. According to general belief, many cancers have found to arise from sites of infection, chronic irritation and inflammation.

In tumor necrosis factor-alpha TNF-α, the application of chemical lectin to oral cancer site suppressed the inflammatory expression of the protein in induced cell survival and proliferation and promoted the pro-apoptotic function of TNF-α in the program of cell death and cell cycle arrest.



Tumor necrosis factor-alpha TNF-α is a cell signal protein with function in induced inflammation in the acute phase of injuring and in numbers of cellular processes, including cell survival, proliferation, differentiation, and death.

Importantly, the binding of kinase p38α MAPK also activated the function of IL-6, in inhibited the factors in induced production of inflammatory cytokines which have been found to have a negative impact in oral cell oncogenesis and enhanced the expression of boosting T cell trafficking to tumor sites to induced cytotoxic effect to cause apoptosis.

IL-6, an interleukin with duo functions in both pro-inflammatory cytokines and anti-inflammatory cytokines,

Taken together, chickpea lectin may have a therapeutically potential in reduced risk and considered as an adjunct therapy used combination with standard chemo-drugs for treatment of oral cancer


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens by Kumar S1, Kapoor V2, Gill K1, Singh K1, Xess I3, Das SN2, Dey S1(PubMed)
(2) Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells by Shetty P1,2, Bargale A3,4, Patil BR5, Mohan R6, Dinesh US7, Vishwanatha JK8, Gai PB9, Patil VS3,4, Amsavardani TS10.(PubMed)
(3) Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms by Ochoa-Alvarez JA1, Krishnan H1, Pastorino JG1, Nevel E1, Kephart D1, Lee JJ1, Retzbach EP1, Shen Y1, Fatahzadeh M2, Baredes S3, Kalyoussef E3, Honma M4, Adelson ME5, Kaneko MK6, Kato Y6, Young MA1, Deluca-Rapone L1, Shienbaum AJ1, Yin K1, Jensen LD7, Goldberg GS1.(PubMed)

Intake of Raw and Incompletely Cooked Kidney Bean May Induce Toxicity

Hemagglutinating lectin, the main component isolated from several varieties of kidney bean (Phaseolus vulgaris) may induce toxicity, affecting abnormal development of microvilli of tiny hairlike folds in the plasma membrane of the small intestine, a respectable institute study suggested.

In South Africa, dried red kidney beans are prohibited for cultivation or consumption because of the potential toxicity to humans. However, the toxicity levels of hemagglutinating lectins activity in uncooked and incompletely cooked kidney bean is not higher in compared to the other bean varieties sold in the regions.

Researchers, in the compared toxicity of uncooked red kidney bean and other dried beans, found that toxic potentials and health risks associated with red kidney beans are similar to those of other dry beans already commercially available to South Africans. Therefore, the red kidney should have a commercial preference as of other beans.

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish-brown in nature used often as an excellent dietary selection because of its enormous health benefits with a good source of protein and minerals.

According to the recent advanced study, intake of raw kidney bean may cause lectin-induced disruption of intestinal in interference with the intermediate and final stages of nutrient break down in the gut.

Dr.Pusztai A, the lead author said, "In nitrogen balance studies it was found that rats ingesting pure bean lectins were in negative nitrogen balance" and "These nitrogen losses may have been partly the result of systemic effects, possibly caused by a selective uptake of lectins by the gut".
The poorly digested chemical compound actually disrupted borders cells and intestinal absorptive cells of the duodenum.

Taking together, regardless of levels of toxicity of bean varieties, epidemiological studies agreed that consumption of fully cooked kidney bean provides many nutrients with numerous health benefits. but kidney beans should not be eaten as raw.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biogrphy
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The nutritional toxicity of Phaseolus vulgaris lectins by Pusztai A, Clarke EM, King TP.(PubMed)
(2) Recent advances in the study of the nutritional toxicity of kidney bean (Phaseolusvulgaris) lectins in rats by Pusztai A, King TP, Clarke EM.(PubMed)
(3) Red kidney beans--to eat or not to eat? by Venter FS1, Thiel PG.(PubMed)

Dried Peas in Weight Loss and Weight Control

Dried peas may be considered as a functional food in promote weight loss in overweight and obese population, a renowned institute study postulated.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

In the study to assess the effects of yellow pea fiber intake on body composition and metabolic markers in overweight/obese adults with all participants (9 M/41 F; age 44 ± 15 y, BMI 32.9 ± 5.9 kg/m2) received isocaloric doses of placebo (PL) or pea fiber (PF; 15 g/d) wafers for 12 weeks, researchers after measuring changes in anthropometrics, body composition (DXA), oral glucose tolerance test (OGTT), food intake (ad libitum lunch buffet), and biochemical indices filed the following results

1. Group received peas fiber diet showed a significant weight loss of 0.87 ± 0.37 kg of body weight, primary due to body fat lost.

2. The same group consumed 16% less energy at the follow-up lunch buffet in compared to unchange in other groups.

3. Increased insulin and lower glucose expression are also observed in peas fiber group.

4. There are no differences in gut microbiota in all groups.

These findings indicated that intake of peas fiber may have strong effect in increased weight loss, through improvement of insulin and glucose and reduced appetite in overweight and obese subjects.

In support of the above differentiation, a double blind, placebo controlled, parallel group study with overweight and obese (BMI = 25-38) adults randomized to either a 15 g/d yellow pea fibre supplemented group or isocaloric placebo group for 12 weeks (n = 30/group), researchers at the University of Calgary, reported the following results

1. Increased consumption of fiber derived from yellow peas enhanced weight loss and specifically body fat loss in compared to control

2. Pea fiber expressed a significant in improved glucose tolerance, reduced appetite and serum lipids and inflammatory markers.

3. Intake of peas fibers also promoted function of gut microbiota and serum and fecal water metabolites

In other words, peas fiber displayed a strong effect in promoted weight loss in overweight and obese subjects through regulating glucose tolerance, appetite and serum lipids and inflammatory markers as well as increasing function of gut microbiota.

Taking altogether, there is no doubt that peas fiber may be served as functional food to provide healthy and balanced in macronutrient proportions for people who want to lose weight without implication of unwanted side effects.


Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial by Lambert JE1, Parnell JA2, Tunnicliffe JM3, Han J4, Sturzenegger T5, Reimer RA6.(PubMed)
(2) Evaluation of yellow pea fibre supplementation on weight loss and the gut microbiota: a randomized controlled trial by Jennifer E Lambert,1 Jill A Parnell,2 Jay Han,3 Troy Sturzenegger,3 Heather A Paul,4 Hans J Vogel,4,5 and Raylene A Reimer1,4(PubMed)

Wednesday, November 20, 2019

Navy Bean in the Prevention and Treatment of Chronic Diseases

Chronic diseases are a class of conditions that last longers than 3 months, leading to long-term symptoms, physical impairments, disabilities.

Most cases of chronic diseases are associated with low-grade inflammation, including arthritis, asthma, cancer, chronic obstructive pulmonary disease, diabetes and some viral diseases such as hepatitis C and acquired immunodeficiency syndrome.


Inflammation is a natural reaction to a systematic immune response which protects our body against the stimuli of invasive pathogens by stimulating the production of the pro-inflammatory cytokines and switching the anti-inflammatory activity of proteins which process duel inflammatory property

Acute inflammation is a result of the immune white blood cell response to tissue damage or injury that lasts less than a few days or weeks. After the foreign invaders are destroyed, the damaged tissues are healed quickly.


Unlike acute inflammation, chronic inflammation is a condition of low-grade inflammation adopted by the immunity caused by the immune inability to kill off all invaders in the acute phase of infection.

In the examined immune evolution over thousands of years Some researchers suggested that the immune system has evolved to destroy the foreigner pathogens in a specific time within 3 -8 weeks, otherwise, it will adapt to the change.

The causes of chronic diseases are vary depending on the types of disease. However, epidemiological studies suggested that primary factors that cause chronic conditions are an unhealthy diet, physical inactivity; tobacco use and the intermediate factors of high blood pressure, glucose levels, and blood lipids, overweight, and obesity are also elevating the risk of chronic diseases.


The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

With an aim to find a potential compound for the prevention and treatment of chronic disease, researchers examined the effects of Consumption of Phaseolus vulgaris bean species including, navy beans.

Epidemiologically,* Navy beans reduce postprandial glucose elevations in short-term studies in non-diabetic and diabetic individuals.

* Navy bean exerted glycaemic control in non-diabetic and diabetic individuals by improving markers of longer-term glycaemic control (HbA1c and fructosamine).
* Navy bean exerted a beneficial effect on short-term satiety and weight loss when combined with energy restriction.

* Navy bean decreased LDL-cholesterol, a well-known risk factor for CVD in normocholesterolaemic and hypercholesterolaemic participants

* Navy beans also reduced the oxidative stress, endothelium-dependent vasodilation, and increased blood pressure associated with increased risk for T2DM, complications of T2DM and CVD.

* Navy bean modulated hormone expression associated with hyperinsulinemia in increasing cancer risk.

Finally, The mechanism of action responsible for the reducing risk of chronic disease may be involved in the high content of viscous fiber, protein, relatively high amylose starch, and antinutrients found in navy bean and other Phaseolus vulgaris bean species.

Based on the findings, researchers concluded, "Traditional foods such as beans should be retained in the diet because of their many health benefits, including a positive impact on postprandial glycaemic response. Hyperglycaemia, whether it occurs following a meal or due to poorly controlled T2DM, is known to increase oxidative stress, contribute to hypertension and increase the risk for CVD".

And "Examination of the glycaemic response to meals, especially culturally important food combinations such as beans and rice, is important for the prevention and control of hyperglycemia-induced diseases".


Taken altogether, the fermented navy bean may be considered a remedy for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)

Chick (Garden) Peas Inhibited Platelet Aggregation in Ameliorated Risk of Cardiovascular Disease

Methanolic extract of Chick (Garden) Peas may have a potential effect in decreased platelet aggregation and inhibited thrombus formation, thus improving blood circulation for the prevention of cardiovascular disease, some scientists suggested.

Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.

Inflammation is a natural process of immune defense against infection caused by injuring through the removal of injurious agents, necrosed cells and tissues.

Evaluation of pea family effects in reduced platelet aggregation for prevention of cardiovascular disease has been found associated with a number of mechanisms involved in many aspects.

Methanolic extract isolated from garden pea and Desi chickpea demonstrated an inhibited arachidonic acid (AA) expression in the induction of platelet aggregation (IC50 = 35 microg/mL)

Arachidonic acid, an omega-6 unsaturated fatty acid with function in growth and repair of muscle tissue is also important as a proinflammatory and immune-supportive substance in response to acute and chronic tissue damage.




Several reports have suggested that arachidonic acid-induced expression of platelet aggregation by mediators thromboxane A2 and/or prostaglandin H2 (PGH2) in signaling expression of thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor occupation.

Thromboxane A2 (TXA2) is a type of thromboxane with function in stimulation of the production of new platelets to induce platelet aggregation.

Prostaglandin H2 is a type of prostaglandin acted as mediators involved in physiological processes, including platelet aggregation, muscle movement, and inflammation.

Further differentiated the other effects of methanolic extract isolated from garden pea and Desi chickpea on platelet aggregation, showed that the extract isolated from garden pea displayed a positive inhibition of platelet-activating factor (PAF)(IC50 = 38 microg/mL) in a dose-dependent fashion, in induction of platelet aggregation, but this action was not found in Desi chickpea extract.

Platelet-activating factor (PAF), is a lipid mediator with function in the exhibited expression of platelet aggregation, immune response, and inflammation.


Interestingly, the methanolic extract isolated from Kabuli chickpea also expressed a strong platelet aggregation effect without activation of either arachidonic acid (AA) or platelet-activating factor (PAF) expressions.

The findings suggested that there must exist other mechanisms in reduced platelet aggregation, other than inhibition of arachidonic acid (AA) and platelet-activating factor (PAF) activities by the testing extract isolated from the above members of the pea family.

Further differentiation showed that methanolic extract isolated from the pea family also inhibited platelet aggregation through endothelial cells COX-2 lining the interior surface of blood vessels and lymphatic vessels in the production of platelet PGE2 precipitated by inflammatory cytokine expression during the acute phase of tissue damage.


COX-2 is an enzyme with a function in response to inflammation and pain.


Prostaglandin E2 (PGE-2) is also released by blood vessel walls with function in response to infection or inflammation.


Indeed, the extract displayed a strongly inhibited effect at a dose of concentration 20 microg/mL in lower the levels of synthesis of PGE2 by 92%, 87% and 65% in the extract of Garden pea, Desi chickpea, and Kabuli chickpea, respectively, according to COX-2 essay.


Taken together, peas family including Garden pea, Desi chickpea, and Kabuli chickpea could be useful as natural anti-thrombotic and anti-inflammatory whole foods. People who are at high risk of CVD due to platelet effect may want to add a portion of chickpeas into their daily diet.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpeaand Kabuli chickpea by Zia-ul-Haq M1, Khan BA, Landa P, Kutil Z, Ahmed S, Qayum M, Ahmad S.(PubMed)