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Thursday, December 12, 2019

Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Breast Cancer

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

Fresh Garlic Extract beside inhibited colon and gastric cancer in 2 previous articles, it also is found to arrest the growth and alter the morphology of MCF7 breast cancer cells.


Also in MCF7 human breast cancer cells, garlic constituent diallyl trisulfide has highly effective antitumor effects by the suppressing viability of cultured MCF-7 and MCF-12a cells, through decreased the percent of cells in G(2)/M and induced apoptotic cell death.

According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless of the state of estrogen in the tumors.


In a total of 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables has a negative association between the consumption of raw onion and the risk of breast cancer.

Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".

Therefore, the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb. Women who increased intake of garlic every day may see the risk of breast cancer reduced substantially.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR.(PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2.(PubMed)

Bioactive Cucurbitacin B (CuB) Isolated from Cucumber Harbors Potent Chemopreventive Activity Against Prostate Cancer in Vitro and Vivo

Prostate cancer found mostly in the older men is a chronic condition characterized by irregular cell growth in the prostate tissues caused by the alternation of cell DNA.

Most cases of prostate cancer start in the cells on the surface of the inner lining tissue before penetrating into deeper layers to induce a malignant tumor.

Believe it or not, prostate cancer can be classified into many different types, depending on the type of cell that causes the onset of primary cancer.

* Adenocarcinomas, the most common type of prostate cancer that develops in the gland cells that line the prostate gland.

* Ductal adenocarcinoma, the type of cancer starts in the cells that line the ducts (tubes) of the prostate gland. r

* Transitional cell cancer is cancer that starts in the cells that line the tube carrying urine to the outside of the body (the urethra).
* Squamous cell cancer is found to develop from flat cells that cover the prostate.
* Small cell prostate cancer is found in tissue made up of small round cells.


Prostate cancer can also be classified into different stages

1. Stage 0
If the cancerous cell has not penetrated in deeper tissue but in the surface of the prostate lining.

2. Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep the prostate lining, but still completely inside the prostate.
a. Stage IA1
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.

b. Stage IB:
Cancer in this stage has invaded the connective tissue, & less than 5cm (2 inches).

b.1. Stage IB1: Cancer is 4 cm large (1 3/4 inches).b.2. Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (2 inches)

3. Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the prostate.

4. Stage III
In this stage, cancerous cells have spread to the tissues immediately surrounding the prostate.

5. Stage IV
In this stage, cancerous cells have spread to the tissues immediately outside of the prostate, into other distant parts of the body


The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural and potential ingredient for the treatment of prostate cancer with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables.

In PC-3 and LNCaP prostate cancer cell lines, CuB significantly and specifically inhibited prostate cancer cell growth with low IC50 at a concentration of 0.3 μM.


CuB induced cancer cell apoptosis by modulating the proteins associated with program cell death and pro-apoptotic pathways.

Furthermore, the bioactive compound also increased the accumulation of Sub-G0/G1 population before exhibiting cell cycle arrest.

According to the results of a chemopreventive model, pre-treatment of mice with CuB(2 weeks before PC-3 prostate cancer cell implantation significantly reduced the rate in vivo tumor-formation.

Moreover, CuB resulted in a 79% reduction in tumor size (accompanied by marked in situ apoptosis) of the treated group without causing noticeable toxicity compared to controls at day 31.


In vitro and in the CuB-chemopreventive mouse model, CuB at a dose-dependent inhibited enzyme ATP citrate lyase phosphorylation associated with cancer cell metabolism.


The findings suggested that CuB harbors potent chemopreventive activity against prostate cancer via a number of mechanisms, without inducing harmful side effects.

Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth by Gao Y1, Islam MS1, Tian J1, Lui VW2, Xiao D. (PubMed)

Green Beans Gobbles Up Prostate Cancer Cells in Vitro

Cancer is a class of diseases associated with abnormal cell growth in a specific tissue of an organ, due to the alternation of DNA.

A primary tumor or original tumor is a tumor of the original site where it first arose and the tumor progression began and proceeded to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance of the body and alter the metabolic pathways, leading to disordered and violent cellular behavior.

At the early stage, due to the small size of the tumor, most patients are asymptomatic.

Prostate cancer is a medical and chronic condition in which the cells of the prostate have become cancerous due to the alternation of the cell's DNA.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Dr. Anton Stangelberger,, the lead scientist at the joint study led by the University of Vienna, wrote, "
Due to increasing life expectancy and the introduction of prostate-specific antigen (PSA) screening, a rising number of elderly men are diagnosed with prostate cancer. Besides PSA serum levels and Gleason score, age is considered to be a key prognostic factor in terms of treatment decisions".


And, " Not every man who is diagnosed with prostate cancer will develop a clinically significant disease. This has led to the concept of expectant management for screen-detected, small-volume, low-grade disease, with the intention of providing therapy for those men with disease progression.".

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belongings to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent compound that processes chemopreventive activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition of the growth of human prostate cancer.

The application of the mixed product showed a significant effect on inhibiting the growth of prostate adenocarcinoma PC-3 cells without causing obvious side effects.

Furthermore, BN999 induced apoptosis in colon cancer cells without affecting the healthy cells.


Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".
Taken altogether, green beans used combined with fermentation products of soybean, the black bean may be used as an adjunct therapy for the prevention of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Prostate Cancer in Elderly Men by Anton Stangelberger, MD,* Matthias Waldert, MD,* and Bob Djavan, MD, Ph.D. (PMC)

Garlic, The Whole Food Medicine for Reduced Risk and Treatment of Gastric Cancer

Many researchers have raised questions of their's effectiveness, depending too much on geographic differences, time of grown and harvest, etc.. I do believe, these questions can only be answered by experienced herbalist.

Scientists from varies respectable institutions suggested that out of many herbs, garlic may be one of the most powerful whole food medicine in reduced risk of gastric cancer due to the effects of phytochemicals.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfering in cell cycle arrest. Administrated garlic induced the reduction of 23% of live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 µM DADS treatment for 48 hours..

Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo, may be partly due to its antioxidant and immunomodulatory effects"

In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through the influence of cell cycle division and negation of proinflammatory pathways.

Some researchers suggested using garlic as chemopreventive therapy, as the experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.


Therefore, people who add an addition portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH.(PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)

Women’s Health: Protect DNA Integrity Against Breast Cancer with This Single Herb, Online Medical Literature Revealed

Fennel may have a potential and therapeutic effect in reduced risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the breast tissue. At the later stage, cancerous cells may travel a distance away to infect other healthy tissue and organs.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In the evaluation of the essential oil extracted from fennel activity in human breast cancer cell line (MDA-Mb), researchers found that application of fennel extract exerted a significant effect in inhibition of the expression of cancer cell line at a dose of lower than flower than 10 μg/mL with IC50.

According to the University of Malaya in investigation of the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 spices, fennel exerted a potential effect in protection of the DNA integrity and inhibition of nicotine-induced cancer cell migration against Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells pre-treated with spice extracts and then exposed to H₂O₂ and nicotine.

Additional analysis suggested that the result of inhibition was attributed to fennel antioxidants of phenols and flavonoids in ameliorated H2O2 in initiated chain activity in the induction of cytotoxicity in altered DNA of the experiment cell line.

Some researchers suggested that overproduction of hydrogen peroxide may serve as a prodrug in the presence of transition metal ions, in induced production of highly reactive hydroxyl radicals to initiated DNA damage in precipitated apoptosis.

In other words, the application of highly oxidative hydrogen peroxide in the breast cancer cell line may cause a significant cytotoxic effect in cancer cell death.

These results demonstrated the correlation of increase of apoptosis with the rise in the generation of reactive oxygen species in cancer cells.

Due to this potential activity, some researchers suggested that hydrogen peroxide overproduced in tumor cells can serve as a prodrug for the treatment of cancer.

On the other hand, the application of H2O2 in the healthy cells may induce DNA damage in the initiation of cancer cell development.

Furthermore, fennel scored a statistically significant DNA protecting activity, compared to other spices, such as at ginger with 50 μg/ml in reduced 68% of DNA damage in 3T3-L1 cells.

However, Fennel exerted a lesser effect in inhibited cancer MCF-7 cells with nicotine-induced cell migration compared to other spices such as pepper, long pepper, and ginger.

The above differentiation was supported by the joint study lead by the Avicenna Tajik State Medical University, in the evaluation of the antioxidant effect of essential oil of fennel (Foeniculum vulgare) against MCF-7 (human breast adenocarcinoma).
According to the result from Gas chromatographic-mass spectrometric analysis, fennel displayed a moderated antioxidant in precipitated cytotoxic activity against MCF-7 (human breast adenocarcinoma) with IC50 values between 30-210 mg L-1 in compared to cytotoxic reference compounds.
In fact, the efficacy of fennel essential oil in inhibited breast cancer proliferation and migration was attributed to the presence of lipophilic secondary metabolites and anise aldehyde, which have potential in elevated the interference with molecular targets in cells by fennel antioxidant compounds such as anethole.

Taken together, fennel and its bioactive compound may be considered as functional food in reduced risk, progression, and treatment of breast cancer. However, intake of fennel supplements should be taken with extreme care in prevented liver acute toxicity.

For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

\

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
\

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran by Akhbari M1, Kord R1, Jafari Nodooshan S2, Hamedi S3.(PubMed)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8.(PubMed)
(3) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration by Jayakumar R1, Kanthimathi MS.(PubMed)

Wednesday, December 11, 2019

Cucumber (Cucumis sativus) Cucurbitacin B (CuB) The Potential and Natural Anti Chronic Myeloid Leukaemia Functional Food

Chronic myeloid leukemia (CML) also known as chronic myelogenous leukemia is a type of leukemia associated with certain blood-forming cells of the bone marrow.

Chronic myeloid leukemia (CML) is slow-growing cancer compared to the acute forms of leukemia.

In the US, most cases of chronic myelogenous leukemia are found in adults age of 65 and older.


According to the American Cancer Society, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women) in 2019. CML also will cause the death of 1,140 patients (660 men and 480 women) in the same years.

The lifetime risk of CML is 1 in 526 in the United States.

CML besides sharing the common symptoms of other types of cancer, the condition also induce symptoms of easy bleeding, pain or fullness below the ribs on the left side, pale skin and sweating excessively during sleep (night sweats).

If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

Today, due to new drug discovery and improvement of technology, the 5-year survival rate for CML is 68% compared to only 31% in the early 1990s.

Out of many risk factors such as radiotherapy, gender, and aging, some researchers suggested that obesity may be one of the main factors that elevated the risk of the disease.


Dr. Strom SS, the lead researchers in the cancer team at the University of Texas M. D. Anderson Cancer Center wrote, " Obesity, measured as body mass index, has been identified as a possible risk factor for several solid tumors as well as some adult hematopoietic malignancies".

And, "Obesity at all ages was found to be an independent risk factor, with a significant dose-response effect. Among participants > or =45 years, cases gained significantly more weight each year between ages 25 and 40 compared with controls (0.78 versus 0.44 kg/y, P < 0.001) with the association strongest among those who gained >1 kg/y between 25 and 40 years of age (OR, 3.63; 95% CI, 1.46-9.04). Our results suggest that obesity and adulthood weight gain play important roles in CML risk".


The findings strongly suggested that obese are more likely to develop CML, compared to those with normal weight.

The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural and potential compound for the treatment of chronic myeloid leukemia, researchers examined the Cucurbitacin B (CuB) antiproliferative effects on various leukemia cell lines.

Administration of CuB showed strong inhibition against various leukemia, lymphoma cell lines, primary mononuclear bone marrow cells derived from patients with acute myeloid leukemia or myelodysplastic syndrome.

CuB induced myeloid leukemic cells apoptosis through S-phase cell cycle arrest, enlarged cell size, multinucleation, and enhanced expression of a monocytic- and granulocytic-specific CD11b involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.

Furthermore, CuB prominently altered the cytoskeletal network of leukemic cells, leading to cell death.

In order to obtain additional information about cucurbitacin B (CuB) anti myeloid leukemia activity, researchers explored the antitumor effect and action mechanism of cucurbitacin B (CuB) on human T-cell leukemia Jurkat cells.

According to the tested assays, CuB inhibited the proliferation of Jurkat cells in a dose-dependent manner and induced G 2 /M phase arrest.

CuB induced around 10% of cells undergoing apoptosis, after treatment for 24 h.

Moreover, CuB induced cancer cell autophagy observed by the accumulation of LC3-II, an indication of cleaning out damaged cells and regenerating new ones.

The results of autophagy were found to be activated by the protein associated with a significantly increased rate of recurrence and deaths.

Taken altogether, cucumber processed a higher number of CuB may be used for the treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.



Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells by Haritunians T1, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP. (PubMed)
(2) Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells by Zhu JS1, Ouyang DY, Shi ZJ, Xu LH, Zhang YT, He XH. (PubMed)
(3) Obesity, weight gain, and risk of chronic myeloid leukemia by Strom SS1, Yamamura Y, Kantarijian HM, Cortes-Franco JE. (PubMed)

Garlic - The Whole Food Medicine for Antiplatelet Aggregation

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Several sulfur-containing compounds, isolated from garlic may be very effective in inhibition of platelet aggregation, a recent study suggested.

Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.

According to the Ochanomizu University, sulfur-containing compounds in garlic not only inhibited arachidonic acid metabolism but also suppressed aggregation in association with the function of the platelet plasma membrane.


In vitro, garlic mechanisms of action may be comparable to that of the clinically used drug clopidogrel, as the herb exerts antiaggregatory effects. Garlic extracts are acting by inhibition of the ADP pathway, an important physiological agonist of normal hemostasis and thrombosis.

Dr. MacDonald JA lead of researcher said, " The ability of an aromatic disulfide to inhibit platelet aggregation can be enhanced by appending an electron-withdrawing group to the aromatic ring. The results presented establish that the aromatic thiosulfonate is a very effective inhibitor of platelet aggregation"

Besides the sulfur compound, Ajoene, (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, isolated from alcoholic extracts of garlic reversibly inhibited platelet aggregation through platelet deposition on severely damaged vessel wall but not affected platelet adhesion.
In fact, in the comparison of the effect of the Garlic Pill with Plavix on Platelet Aggregation and Bleeding Time, groups treated with 1200 or 2400 mg garlic inhibited platelet aggregation substantially, through an increased time of bleeding.

The use of garlic supplements should be taken with care for patients who are taking Anticoagulant as garlic may increase the risk of bleeding. Also, patients with an ulcer should consult with their doctors.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Improving upon the in vitro biological activity of antithrombotic disulfides by MacDonald JA1, Marchand ME, Langler RF.(PubMed)
(2) Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets by Lim H1, Kubota K, Kobayashi A, Seki T, Ariga T.(PubMed)
(3) Antiplatelet activity of Allium ursinum and Allium sativum by Hiyasat B1, Sabha D, Grotzinger K, Kempfert J, Rauwald JW, Mohr FW, Dhein S.(PubMed)
(4) A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model by Apitz-Castro R1, Badimon JJ, Badimon L.(PubMed)