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Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Thursday, July 9, 2020

Fennel Essential Oil and Extract, The Potent Anti Hypoglycemic Remedies, Scientists Reveal

Fennel may process a strong effect in preventing the abnormal rise of blood glucose in patients with diabetes, some scientists found.

In comparison to hyperglycemia with an excessive amount of glucose that circulates in the blood plasma, hypoglycemia is a condition of blood sugar, that falls below the levels of the normal range.

Patients with acute hypoglycemia may experience symptoms of clumsiness, trouble talking, confusion, loss of consciousness, seizures, or death.

Most cases of hyperglycemia in patients with diabetes are due to poor management. However, eating more carbohydrates than usual, less physical activity compared to normal day being sick or high levels of stress in patients with diabetes also can cause blood glucose uptake.

Some researchers suggested that not getting the right dosage of insulin and glucose-lowering medication also causes increased blood glucose levels.

Long-term untreated hyperglycemia can elevate the onset of some serious complications including nerve damage, kidney damage and failure, heart disease, and eye disease, particularly in food and skin problems. or retinopathy foot problems caused by damaged nerves and poor blood flow skin problems, such as bacterial and fungal infections

Fennel (Foeniculum vulgare) is a plant species belongings to the family Apiaceae (Umbelliferae), native to the Mediterranean

The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the examine the antihyperglycemic activity of fennel essential oil in an animal model, researchers launched an investigation to evaluate of rats induced by bacterial streptozotocin.

At the concentrations of 30 mg/kg body weight, essential oil of fennel demonstrated correction of hyperglycemia in the doses from 162.5 mg/dL to 81.97 ± 1.97 mg/dL by increased the serum of antioxidants activity of serum glutathione peroxidase from 59.72 U/g Hb to 99.60 U/g Hb produced by the host.

The application also improved the pathological changes noticed in their kidney and pancreas, compared to the control group.

After making the final adjustment, researchers suggested that the study not only reaffirms the use of essential oil of fennel for the treatment of hyperglycemia in folk medicine but also raises the possibility of essential oil inclusion in the antidiabetic drug industry.

Further analysis of the ethanolic and aqueous extracts of selected Sudanese plants, including fennel that is traditionally used to treat diabetes, researchers at the Khartoum College of Medical Sciences, suggested that fennel extract reveals a significant antioxidant activity in DPPH free radical scavenging assay.

However, the injection of fennel extract exhibited the highest toxicity.

These findings indicated that although fennel extract processes a substantial and positive effect in reducing the spike of blood glucose intake and the use of the fennel extract can only be prescribed by herbalists and professionals in the related field.

Additionally, in the testing, the hypoglycemic effect of a single dose of Gluconorm-5 (150, 300 and 600 mg/kg body weight) made up of five plants namely Camellia sinensis, Punica granatum, Macrotyloma uniflorum, Foeniculum vulgare and Trigonella foenum-graecum in normal, glucose loaded normal and diabetes-induced rats, researchers found that

* Fifteen days of oral feeding of the Gluconorm-5 (300 and 600 mg/kg) to diabetic rats resulted in a significant (P < 0.01) reduction of blood glucose, lipid profile, liver weight, and marker enzymes as compared to those rats in whom STZ induced toxicity was untreated.

* The diabetic rats treated with the formula showed the expanded islets compared to the untreated diabetic rats, which showed the shrunken islets.

* Treated rats received 300 mg/kg of Gluconorm-5 showed pronounced antidiabetic, antihyperlipidemic, and hepatoprotective effect.

This comprehensive differentiation showed that Gluconorm-5 processes a potent antidiabetic antihyperlipidemic and hepatoprotective effect properties.

Taken altogether, fennel extract, fennel essential oil used alone or combined with other herbal antidiabetic herbal medicine can be considered an adjuvant in the treatment of hyperglycemia and diabetes mellitus.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential by Hilmi Y1, Abushama MF, Abdalgadir H, Khalid A, Khalid H(PubMed)
(3) The Dietary Furocoumarin Imperatorin Increases Plasma GLP-1 Levels in Type 1-Like Diabetic Rats by Wang LY1,2,3, Cheng KC4, Li Y5,6, Niu CS7, Cheng JT8,9, Niu HS(PubMed)
(4) Antidiabetic antihyperlipidemic and hepato-protective effect of Gluconorm-5: A polyherbal formulation in steptozotocin induced hyperglycemic rats by Gengiah K1, Hari R2, Anbu J(PubMed)

Wednesday, July 8, 2020

Healthy Food Tomato, A Potential and Natural Prevention and Treatment of Cancer

Cancer is a class of chronic and medical condition caused by cell growth irregularly in the tissues of the body.

Cancer can be classified into
* Primary cancer or original cancer is a tumor at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

* Secondary metastasis is tumor spread from primary cancer.

Most cases of cancer begin in the cells on the surface of the inner lining of the organs' tissues. For example, breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell growth to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body tissues and organs, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors.

However, in cancer, mutated cells can grow indefinitely by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death, leading to the formation of cell mass or tumor.

The exact causes of cancer are unidentified. Researchers can not explain why people with the same health conditions and family history in the same family, some are prone to cancer development while others do not.

According to the statistic, In 2018, approximately 1,735,350 new cases of cancer were diagnosed in the United States. The diseases also cause the death of 609,640 Americans in the same year.

Believe it or not, cancer mortality is higher among men than women (196.8 per 100,000 men and 139.6 per 100,000 women), according to the National Cancer Institute.

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural ingredient for the prevention and treatment of cancer with no side effects researchers examined several HDACi of natural and dietary origin such as tomatoes against cancer developing.

Where histone deacetylase inhibitors (HDACi) regulated the activity of histone deacetylase enzymes (HDACs) have been used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy.

According to the differential, HDACi exhibited antitumor effect by the activation of cell cycle arrest, induction of apoptosis and autophagy, angiogenesis inhibition.

Furthermore, the cancer inhibition of HDACi is also found in increased reactive oxygen species generation that causes oxidative stress, and mitotic cell death in cancer cells.


In order to reveal more information about tomatoes' anti-cancer property, scientists investigated lycopene loaded whey protein isolate nanoparticles (LYC-WPI-NPs) anti-cancer activity.

The percent lycopene entrapment of prepared LYC-WPI-NPs was estimated in the range to 50 and 65%.

The WPI-NPs was found to enhance the oral bioavailability and absorption of lycopene by controlling its release from nano-formulation and lymphatic pathways.

Moreover, lycopene improved the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation and increased the survival rate of treated animals, in the form of loaded protein nanoparticles.

Taken altogether, tomatoes processed high amounts of lycopene may be considered a functional food for the treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy by Singh AK1, Bishayee A2, Pandey AK. (PubMed)
(2) Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity by Jain A1, Sharma G2, Ghoshal G3, Kesharwani P4, Singh B5, Shivhare US4, Katare OP. (PubMed)

Tuesday, July 7, 2020

Honey, The Best to Inhibits Chemo-toxicity and Improves Chemotherapy For Treatment of Cancers

Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.

Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.

Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.

However, as cancer progresses, the continued growth tumor may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.

At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.

According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.

Chemotoxicity is the side effects of chemo drugs.

The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.

According to the information of the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.

The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and easily infected.
Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food which processes chemopreventive properties and anti chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.

A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.

AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage of liver and kidney

After treatment of KH, AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by blood profile.

Furthermore, KH was not toxically identified by the KH treated group not induced with AOM.

These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs activity without inducing any side effects.

Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.

Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function in stimulating cancer cell multicity and activation of pathways associated to cell death programming.

Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing to harm to the nearby cells and tissue.

This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.

Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.

The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting the toxicity and cancer cell resistance.

Taken altogether, KH and MH can be considered functional foods for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)

Monday, July 6, 2020

Whole Food Onion, the Best Anticancer Functional Food


Cancer is a group of medical conditions caused by irregular cell growth in the tissues organs due to the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.

Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body

*The stage of cancer, most often refers to the size and metastasis of cancer.

** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage have invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)

**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.

**Stage III
this stage, cancerous cells have spread to the tissues immediately surrounding the organ.

**Stage IV
In the stage, IV is the most advanced stage of cancer as cancerous cells have spread to the distant parts of the body

In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.

* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

* Certain traits of cancer cells include
** How cancer cell stimulates their own growth


** How cancer cells resist inhibitory signals that stop their growth

** How cancer cells inhibit programmed cell death signaling.


Some researchers also include the age, health of patients and how patients responded to previous cancer treatment

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.

Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.


More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.

Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.

In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.


In esophageal cancer, the intake of raw garlic/onion at least one time per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.

In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.

Taken altogether, onion may be considered a remedy for the prevention of cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)

Sunday, July 5, 2020

Ginger, the Natural Alternative for Treatment of Bacterial and Fungal Infection

Scientists may have found a pungent spice that processes the potential to inhibit microbial infection, according to studies.

Microbial infection is the infection caused by the multiplication of microbes after entering the body successfully.

The process of infection can be divided into many stages. However, most microbes try to invade the body were killed in the acute phase of infection by the immune system response through the production of the protein associated with the pro-inflammatory cytokines.

Most people do not experience any symptoms until the microbe multiplication to the peak in its’ population.

Acute infection in most cases is recovered with a week or two. However, if the immune function cannot destroy all the microbes within a certain period of time, it will adapt to the new change, leading to chronic low-grade inflammatory diseases.

The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), type 2 diabetes.

A most common risk of microbial infection is a weakened immune system, particularly in the elderly.

The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examing the risk of infection in elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".

And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural alternative for the treatment of bacterial infection examined the ginger antimicrobial and antifungal properties associated with periodontitis in the human oral cavity

The application of ethanol and n-hexane extracts of ginger exhibited antibacterial activities that cause periodontal diseases. against three anaerobic Gram-negative bacteria, Porphyromonas gingivalis ATCC 53978, Porphyromonas endodontalis ATCC 35406 and Prevotella intermedia ATCC 25611.

Two highly alkylated gingerols, such as [10]-gingerol and [12]-gingerol effectively inhibited the growth of these oral pathogens at a minimum inhibitory concentration (MIC) range of 6-30 microg/mL.

Furthermore, these 2 compounds also killed the oral pathogens at a minimum bactericidal concentration (MBC) range of 4-20 microg/mL compared to other failed compounds such as 5-acetoxy-[6]-gingerol, 3,5-diacetoxy-[6]-gingerdiol and galanolactone.

In order to reveal more information about the ginger antimicrobial activity, researchers examine the newly isolated compound including 6-paradol (1) and 6-shogaol (2) as the major antimycobacterial agents.

Injection of these isolates was found to be active against Mycobacterium chelonei, M. intracellulare, M. smegmatis and M. xenopi (MIC 10-15 µg/ml).

The desmethyl derivative of compound (1) retained the antimycobacterial activity. However, derivatives are more active against Candida albicans, compared to (1) and (2).

Interestingly, newly compound Gingerone (9)was found to be inactive against the microbial activity.

Taken altogether, ginger processed abundantly bioactive ingredients may be considered a natural alternative for the prevention and treatment of microbial infection, and diseases associated with micro bacterial infectious disease, pending to the confirmation of larger sample size and multicenter human infection.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria by Park M1, Bae J, Lee DS.(PubMed)
(2) Antimicrobial Activity of 6-Paradol and Related Compounds by Ahmed M Galal. (Journal, International Journal of Pharmacognosy)
(3) The Second Fifty Years: Promoting Health and Preventing Disability by The Institute of Medicine (US) Division of Health Promotion and Disease Prevention

Saturday, July 4, 2020

Manuka Honey, the Best Anti-influenza Functional Food

Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.

Influenza, also known as the flu, is an infectious disease caused by an influenza virus.

There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of the general population.

Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.

Healthy individuals who have influenza are usually recovered within one week.


However, people with the immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.

Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.


Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.

Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individuals associated with the impairment of the adaptive immune response at substantial risk of influenza.

The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".

"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".

The most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at the joint study led by the Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.

Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.

Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.

Dr.Watanabe K, the lead scientist said, "honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.


Moreover, by re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.

By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.


* MGO exerted a promising activity against various influenza strains.


* MGO increases the effect of NA inhibitors by decreasing the to the ∼1/100(th) of their single usage.

* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.

Taken altogether, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending to a larger and multi=centers human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).

Friday, July 3, 2020

Honey, the Natural Whole Food for Prevention and Treatment of Dandruff

Honey may have a potential effect in the prevention and treatment of dandruff, a common skin problem of many adults, some scientists suggested

Dandruff is a condition of the scalp most commonly caused by the dry skin resulting from dry air.


However, in many instances, the condition also is associated with seborrheic dermatitis. leading to rough, scaly skin on the scalp.

In other words, patients with oily skin accompanied by seborrheic dermatitis can lead to overexpression of yeast that causes the development of the large white flakes or yellow scales due to uneven shedding and clumping of dead skin cells.


Belief or not dandruff affects over 50% of the general population.

There are many causes of dandruff. Researchers suggested that dry skin, use of wrong kinds of hair products, and skin conditions such as seborrheic dermatitis or eczema are associated with the onset of dandruff.

In some people, an overgrowth of a yeast-like fungus can also cause dandruff.

The increase of age hormone imbalance and prolonged periods of stress are the most common prevalent risk factors associated with the condition.

Most cases of dandruff can be treated with daily shampoo to reduce the oil on the scalp. In severe cases, due to overexpression of fungi, pyrithione zinc shampoos may be recommended.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Dandruff, if left untreated can cause itchy and inflamed scalp that it lead to temporary hair loss.

On finding a natural ingredient for the prevention and treatment of dandruff with no side effects, researchers examine the anti-dandruff effects from honey, a bee-derived, supersaturated solution composed mainly of fructose and glucose, and contains proteins and amino acids, vitamins, enzymes, minerals, and other minor components.


The application of honey exerted a significant effect in reducing dandruff, through its moisturizing and antimicrobial property.

The effective doses range between 1 and 10%, but concentrations up to 70% can be reached by mixing with oils, gel, and emulsifiers, or polymer entrapment.

With an aim to reaffirming the honey anti-dandruff activity, a researcher at the Dubai Specialised Medical Centre and Medical Research Labs, investigated the potential use of topical application of crude honey in the management of seborrheic dermatitis and dandruff.

The study included 30 patients (20 patients were males and 10 were females, their ages ranged between 15 and 60 years) with chronic seborrheic dermatitis of scalp, face, and front of the chest.

Before applying honey to treat the condition, participants showed conditions of scaling, itching, and hair loss. The lesions were scaling macules, papules, and dry white plaques with crust and fissures.

All patients were asked to apply diluted crude honey (90% honey diluted in warm water) every other day on the lesions with gentle rubbing for 2-3 mins. And, honey was left for 3 hr before gentle rinsing with warm water.

After 4 weeks of treatment, honey showed a significant effect on prophylactic phase, which lasted for six months.

Furthermore, in half of the patients treated with the topical honey once weekly and the other half served as control.

The treatment group demonstrated a reduction of Itching and disappeared scaling within one week. Skin lesions were healed and disappeared completely within 2 weeks.

Moreover, honey administration also improved in hair loss.

None of the patients treated with the honey application once weekly experienced a relapse for six months

Dr. Al-Waili NS, after taking into account co and confounders, said, "crude honey could markedly improve seborrheic dermatitis and associated hair loss and prevent relapse when applied weekly".


The findings clearly suggested that honey may be considered a replacement of chemical ingredients for the prevention and treatment of dandruff associated with seborrheic dermatitis, with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L.(PubMed)
(2) Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff by Al-Waili NS1. (PubMed)

Thursday, July 2, 2020

Onion, the Anti- Platelet Aggression Functional Remedy

Antiplatelet activity is an action that prevents and treat blood clots.

Platelets are tiny blood cells that protect the other to prevent injury and infection by forming clots to stop bleeding.

Platelets are made in the bone marrow that also produces white and red blood cells.

Diseases associated with low and abnormal blood platelet include
* Thrombocytopenia is a condition characterized by low blood platelet due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, nosebleed.

Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.

* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.

* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.

Most cases of secondary thrombocytosis are associated with other medical conditions such as anemia. The most common symptoms of secondary thrombocytosis are infection, inflammation, some types of cancer, and reactions to medicines.

* Platelet dysfunction is a rare condition that links to poor platelet function. In other words, it is a disease caused by abnormal function of blood platelets without affecting the numbers of platelets in the blood.


This means the number of platelets is normal, but the platelets don't work as they should. Medicines such as aspirin can cause this. It's important to know which medicines affect platelets. Know that while taking these medicines you have an increased risk of bleeding.

Antiplatelet agents used in conventional medicine that process the main function to prevent platelets from clumping. However, they also exert a similar effect as of anticoagulation in the prevention of blood clots from forming and growing.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of platelet aggression against the risk of cardiovascular disease, researchers examined the pharmacological aspect of onion antiplatelet activity in human subjects

The study included 12 human subjects received yellow hybrid storage onions that are steamed for 0, 1, 3, 6, 10, and 15 min.

According to the tested assay, steamed onions not only destroyed the antiplatelet activity between 3 and 6 min of steaming but also stimulated platelet activity at 10 min of steaming without affecting the polyphenolic concentration and soluble solids.

Furthermore, cooked onion extracts also reverse the inhibitory effect on blood platelets by 25%, compared to a steamed onion.

The findings were consistent across all donors.

The results strongly suggested that cooked onion preparations may result in the destruction or reversal of antiplatelet activity.

Moreover, in examining the anti-blood platelet activity of f2 different cooking systems of a convection oven and microwaves) in several time-temperature variables, researchers also found that
* Whole", "quarters", and "crushed" onions lost their antiplatelet activity after 30, 20, and 10 min of oven heating, respectively.

* Extensively cooked onions may stimulate platelet aggregation instead of antiplatelet aggregation.

Collectively, raw onion processed anti antiplatelet activity compared to the cooked and extensive cooked onion in the promotion of platelet aggregation

Taken altogether, raw onion may be considered an antiplatelet remedy for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Steam-cooking rapidly destroys and reverses onion-induced antiplatelet activity by Hansen EA1, Folts JD, Goldman IL. (PubMed)
(2) Effect of processing and cooking conditions on onion (Allium cepa L.) induced antiplatelet activity and thiosulfinate content by Cavagnaro PF1, Galmarini CR. (PubMed)

Wednesday, July 1, 2020

Fennel, the Function Food Which Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body

Imbalancing the ratio of the free radicals and antioxidants in the facilitation of oxidative stress was associated with the increased risk of the early onset of many chronic diseases, scientists found.

Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), and native to the shores of the Mediterranean, may process a potential effect in improving the levels of antioxidant enzymes produced by the human body, therefore, adding a portion of fennel on your daily diet should be helpful in reducing the risk of diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke ...

Dr. Moylan JS, the lead author in the study "Oxidative stress, chronic disease, and muscle wasting", wrote, "If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensue. In some cases, oxidative stress is assigned a causal role in disease pathogenesis, whereas in others the link is less certain".

Free radicals are unstable molecules with unpaired electrons produced daily in our body, reactive oxygen species, and reactive nitrogen can induce a domino's effect by stealing an electron from other molecules, leading to a continued function that cannot stop until they are paired or inhibited by the presence of antioxidant molecules.

If the generation of free radicals exceeds the protective effects of antioxidants and some co-factors, the process can cause oxidative damage accumulated during the life cycle, leading to the disruption in the function of the cells.

There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, air pollutants.

Therefore by changing your diet pattern with more in fruits and vegetables, whole grains and less in red meat and processed foods and maintaining an active lifestyle, you can absolutely balance the ratio of free radicals and antioxidants in your body, thus decreasing the risk of many related chronic diseases.

In the review of the traditional use of fennel essential oils (EO) possess antimicrobial, anti-inflammable oil and insect repellent, anti-cancer, and antioxidant properties, researchers launched a comparison of essential oil and their main constituents in Citrus aurantium, C. limon, Cupressus sempervirens, Eucalyptus globulus, Foeniculum vulgare, and Thymus vulgaris.

EO of fennel showed the best free radicals scavenging capacity compared to others.

Fennel EO also was most effective against lipid peroxidation along with EO of C. limon.

Interestingly, after an in-depth analysis, researchers discovered the antioxidant and anti-inflammatory activities of the EOs were plant species-dependent and not always attributable to the EOs main components.

Additionally, in the evaluation of chemical constituents from essential oil from (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce and Foeniculum vulgare var. vulgare, researchers suggested
* trans-Anethole, estragole, fenchone and limonene found highly abundant in all of the examined oils demonstrated strong antioxidant activities in the DPPH radical scavenging, lipid peroxidation, and metal chelating assays

* All 3 tested essential display significant antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.

Finally, in the study to assess the efficacy of medicinal plants used traditionally in folk medicine as natural healing remedies with therapeutic effects as prevention of cardiovascular diseases, inflammation disorders, or reducing the risk of cancer, researchers found that fennel in comparison to other medical exerts a strong antioxidant effect through many of its bioactive compound such as phenolic compounds


However, Dr. Škrovánková S, the lead scientist in the concerns of some condition which may affect the herbal quality, said, "The antioxidant properties of medicinal plants depend on the plant, its variety, environmental conditions, climatic and seasonal variations, geographical regions of growth, degree of ripeness, growing practices, and many other factors such as postharvest treatment and processing.

Taken all together, adding a portion of fennel into your diet may have a potential effect in increasing the levels of antioxidants in your body and countering the risk of overexpression of free radicals.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-oxidant, anti-inflammatory and anti-proliferative activities of Moroccan commercial essential oils by Aazza S, Lyoussi B, Megías C, Cortés-Giraldo I, Vioque J, Figueiredo AC, Miguel MG. (PubMed)
(4) Distillation time modifies essential oil yield, composition, and antioxidant capacity of fennel (Foeniculum vulgare Mill) by Zheljazkov VD1, Horgan T, Astatkie T, Schlegel V.(PubMed)
(3) Antioxidant activity and protecting health effects of common medicinal plants.
(4) Oxidative stress, chronic disease, and muscle wasting by Moylan JS1, Reid M. (PubMed)

Tuesday, June 30, 2020

Whole Food Tomato Promote the Ratio of Gut Microbiota For Optimal Health

Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.

Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system

* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.

* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.

Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".

And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".


Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.

The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.

At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.

However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.

According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.

Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplement for the gut health, pending to large sample size and multicenter human study.


Intake of polyphenols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)

Monday, June 29, 2020

Honey, Better Than Over the Counter Medicine for Treatment of Acute Cough in Children

Scientists may have found a natural whole food that processes a significant activity in reducing the risk and treatment of acute coughing in children with no side effects, some studies suggested.

Coughing can be a natural and reflex reaction to expel phlegm from the airway or a result of viral and bacterial infection of the upper airway.

A cough that lasts less than three weeks is considered an acute cough.


A chronic cough is a medical condition that lasts more than 3 weeks. In children, the condition can be caused by allergies and sinusitis, asthma, whooping cough, cystic fibrosis, aspiration, acid reflux and a blockage in the airway.

The most common causes of acute cough are cold and flu. However, the chronic condition in adults can be the result of smoking, sinus infection, allergic rhinitis, and diseases associated with upper airway dysfunction, including asthma, chronic bronchitis, and long-term use of angiotensin-converting enzyme (ACE) inhibitors for the treatment of high blood pressure.

Most common symptoms of coughing in children are accompanied by the itchy throat, runny nose, watery eyes, sore throat, or rash.

Most parents use over the counter medicine for the treatment of acute coughing in children such as antitussives and expectorants


However, according to the warning from the FDA, warns that children younger than 12 shouldn’t take codeine products to treat pain or cough because of the risk of developing potentially life-threatening breathing problems.


"The FDA recommends against the use of codeine in youths ages 12 through 18 who are obese or have conditions such as obstructive sleep apnea (blocked airflow during sleep) or severe lung disease. These risk factors can increase their chances of developing serious breathing problems when taking these medications".

Therefore, if your child experiences severe coughing, you may want to check your doctor before applying any over the counter medicine. Most cases of acute coughing in children are recovered within a few days.

Please noted that there’s no cure for the common cold caused by viral infection. You will get better on your own in a week or two without needing medications and your child will get better on their own in a week or two without the need for medications.


Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the treatment of acute coughing accepted by children without inducing any side effects, researchers examined the effectiveness of honey for acute cough in children in ambulatory settings.

The study includes the searching of available randomized controlled trials (RCTs) comparing honey, given alone, or in combination with antibiotics, versus nothing, placebo or other over-the-counter (OTC) cough medications to participants aged from two to 18 years for acute cough in ambulatory settings.

Out of hundreds of studies reviewed by the researchers, only 2 studies were selected for the review.

Compared to dextromethorphan, diphenhydramine, and 'no treatment' on symptomatic relief of a cough using the 7-point Likert scale. honey was much better medicine than no treatment in reducing the frequency of cough and exerted similar or better effects to those of over counter medicine.

However, mild adverse events were found in seven children (9.3%) from the honey group and two (2.7%) from the dextromethorphan group.

After taking into account co and confounders, Dr. Oduwole O. the lead scientist said, "There was no significant difference between honey versus dextromethorphan or honey versus diphenhydramine".

Furthermore, in the concerns of the side effects of honey and over the counter medicine, researchers examine the effects of two kinds of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents.

A total of 87 patients included in the study were randomly assigned to one of three treatment groups: Group 1, Honey type 1 (Kimia Company, Iran) (n = 42), Group 2, Honey type 2 (Shahde-Golha, Iran) (n = 25), and Group 3, DPH (n = 20).

Each group received double doses of the respective treatments on two successive nights, researchers indicated that
* Honey type 1 was superior to DPH in improving all aspects of coughs, except the frequency,

* Honey type 2 was more effective than DPH in improving all aspects of coughs, except the sleep quality of the child.

* There was no significant difference between Honey type 1 and 2 in any aspects of cough relief.

After examing the standard validated questionnaire completed by the parents before and after treatment.

Dr. Ayazi P, the lead author wrote in the final report, " honey may provide better cough relief than DPH in children and improve the sleep quality of children and their parents".

By comparing the above studies, there is no doubt that honey may be used for the treatment of acute cough in children.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey for an acute cough in children by Oduwole O1, Meremikwu MM, Oyo-Ita A, Udoh EE. (PubMed)
(2) Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents by Ayazi P1, Mahyar A2, Yousef-Zanjani M1, Allami A3, Esmailzadehha N4, Beyhaghi T. (PubMed)

Sunday, June 28, 2020

Ginger, the Anti Cervical Cancer Functional Remedy, According to Studies

Scientists may have found a natural and pungent spice for the prevention and treatment of cervical cancer, according to the studies.

Cervical cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the cervix tissue.

According to the statistics provided by the American Cancer Society, in 2018, approximately, 13,240 new cases of invasive cervical cancer were diagnosed. The disease causes the death of 4,170 women in the same year.

The 5-year survival rate for women with invasive cervical cancer is 92% if the cancer is detected at an early stage. About 46% of women with cervical cancer are diagnosed at an early stage.
Most cases of cervical cancer are detected during the annual physical exam during the Pap test.

The exact cause of cervical cancer is due to the alternation of the cells on the surface of the inner lining of the cervical tissue. Researchers do not know, Why? some women are more susceptible to the onset of cervical cancer while others do not, even have the same health conditions and family history in the same family.

However, researchers do know that certain risk factors such as human papillomavirus (HPV) infection, the increase in age, herpes infection, smoking are associated with the onset of cervical cancer.

Ethnicity also plays a critical role in cervical cancer, the American Cancer Society wrote, "In the United States, Hispanic women are most likely to get cervical cancer, followed by African-Americans, Asians, and Pacific Islanders, and whites. American Indians and Alaskan natives have the lowest risk of cervical cancer in this country".

Furthermore, some researchers suggested that oral sex which refers to sexual activities involving the stimulation of the genitalia by the use of the mouth, tongue, teeth, or throat also has a strong linkage to cervical cancer. Dr. Rajiv Saini examined the link between oral sex and cervical cancer wrote, "Current research suggests that oral sex may transmit human papillomavirus (HPV), the virus implicated in the majority of cervical cancers. HPV is ubiquitous, with 120 strains isolated from human beings, about 40 of which are in the mouth and genital tracts".

Researchers on finding a natural compound for the treatment of cervical cancer examined the antitumor activities of 6-Gingerol, a potent nutraceutical isolated from the ginger on human cervical cancer (HeLa) cell lines with or without wortmannin, rapamycin, and cisplatin.

Injection of 6-Gingerol showed dose-dependent cytotoxicity on human cervical cancer (HeLa) cell lines.

Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity that was equivalent to IC50 of 6-gingerol alone.

Treatment with 6-gingerol resulted in G2-phase arrest in HeLa cells. 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of a pro-apoptotic protein in the tested cell line.

The finding strongly suggested that 6-gingerol may be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in cervical tumor cells.

In order to reveal more information about ginger Anti-cervical cancer properties, researchers examined the polyphenolic alkanone, 6-Gingerol (6G), presented in the pungent extracts of ginger (Zingiber officinale Roscoe) anti-tumorigenic and pro-apoptotic activities against cervical cancer.

In vivo. 6G potently inhibited the proliferation of the HPV positive cervical cancer cells.

Additionally, 6G was found to inhibit the chymotrypsin activity associated with the induced degradation of tumor suppressor proteins, reactivate the gene involved regulating cell cycle and tumor suppression, and suppress the protein involved a cellular response to cytokines, chemokines, stimuli.

More interestingly, injection 6G also expressed an inhibitory activity against cervical cancer cell lines through inducing DNA damage of the tumor cell and G2/M cell cycle arrest and potentiate the cytotoxicity of cisplatin

6G treatment induced a significant reduction of tumor volume, tumor weight, inhibition of proteasome that breaks down protein, and tumor-suppressive gene accumulation in HeLa xenograft tumor cells in vivo.


Dr. Rastogi N and colleagues said, " our data underscore the therapeutic and chemosensitizing effects of 6G in the management and treatment of cervical cancer".

Taken altogether, ginger with abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of cervical cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(2) Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells by Rastogi N1, Duggal S2, Singh SK3, Porwal K1, Srivastava VK2, Maurya R4, Bhatt ML2, Mishra DP. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)

Saturday, June 27, 2020

Onion, the Best in the Management of Surgical Wounds

Surgery is a medical practice that uses operative manual and instrumental techniques on a patient to investigate or treat an injury or disease

The aim of the medical procedure is to promote bodily function,

Most common types of surgery in the US
* Appendectomy is the common surgery that removes the appendix in patients with acute inflammation of the appendix due to infection.

* Breast biopsy. A biopsy that removes breast tissue to diagnose cancer.

* Carotid endarterectomy is used to remove the blockage from carotid arteries

* Cataract surgery is to remove the cloudy lens and replace it with a clear artificial lens.


* Cesarean section or c-section helps to deliver a baby by making an incision through the mother's abdomen and uterus.

* Cholecystectomy is a surgery that removes the gallbladder.

The Atlantic General Hospital in examining the benefits and risk of surgery wrote,
"Benefits of having surgery
• Prevention of or improvements to medical conditions caused by a patient's obesity
• Surge in energy
• Increased life expectancy
• Increased self-esteem
• Weight loss
Risks to having surgery:
• A blood clot in a vein (deep venous thrombosis or DVT)
• Bleeding or infection
• Bowel obstruction caused by scar tissue
• Leakage of fluid (if opting for gastric banding)
• Adverse reaction to anesthesia
• Nausea and Vomiting
• Band slippage (if opting for gastric banding)
• Gallstones
• The overall risk of death".

Please make sure that you discuss all the health benefits and risks of having surgery with your surgeon ahead of the operation.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

On finding a natural compound for the reducing scar after surgery, researchers investigated the effects of onion extract-based topical gel (Mederma, Merz Pharmaceuticals, Greensboro, NC, USA) that has been marketed as a product to improve scar appearance and texture.

The randomized, double-blinded, split-scar study including 24 patients with new surgical wounds of at least 4 cm in length was divided into two equal portions with each half treated by either onion extract gel or petrolatum ointment at the time of suture removal by applying three times daily for 8 weeks.

By comparing the efficacy between the onion extract gel and a petrolatum-based emollient (Aquaphor, Beiersdorf, Inc., Wilton, CT, USA), researchers at the Harvard Medical School showed that
* According to patients evaluated at 2, 8, and 12 weeks following initiation of treatment and a follow-up telephone interview conducted at least 11 months postoperatively, onion extract gel improved the wound healing compared to those of petrolatum-based topical agents.


* According to the paired t-test and the Wilcoxon signed-rank test at the end of the experiment, there was no statistically significant difference (p < .1) between the two treatment groups.

In other words, onion extract-based topical gel demonstrated a similar effect as those of petrolatum ointment but did not improve scar cosmesis or symptomatology.

Where Petrolatum ointment has been used in standard therapy in the management of postoperative wounds.

Taken altogether, onion may be considered a remedy in the management of postoperative wounds, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study by Chung VQ1, Kelley L, Marra D, Jiang SB. (PubMed)
(2) Risks & Benefits of Surgery by The Atlantic General Hospital

Friday, June 26, 2020

Healthy Food Tomato Promotes Immunomodulatory Activity Against the Onset of Colitis In Vivo

Colitis is chronic a condition associated with the inflammation of the large intestine, including the colon, caecum, and rectum.

Colitis can be classified into the microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a), according to the Catholic University of the Sacred Heart.

Most common symptoms of colitis are totally depending on the types. However, the general symptoms include

* Adnominal pain and diarrhea
There is a report of a 25-year-old Iranian gentleman was admitted to hospital with severe bloody diarrhea and abdominal pain as a result of herbal-induced weight loss adverse effects. On flexible sigmoidoscopy, a continuous length of congested mucosa with multiple small ulcers was seen extending up to the mid-transverse colon, in keeping with ulcerative colitis, according to the study by
Homerton University Hospital NHS Foundation Trust(1)

2. Bleeding per rectum
Acute ischaemic colitis (AIC) is being increasingly recognized as an uncommon cause of abdominal pain associated with fresh bleeding per rectum and diarrhea, according to the study by University Central Hospital(2).

3. Distention with bloody diarrhea
The typical clinical presentation is acute sudden abdominal pain and distention with bloody diarrhea(3).

4. Abdominal bloating and flatulence
In the study to estimate the prevalence of microscopic colitis and SIBO in patients with IBS, to evaluate the symptoms and the efficacy of treatment found that out of the 132 patients initially diagnosed with IBS 3% (n=4) had microscopic colitis and 43.9% (n=58) had SIBO. Diarrhea was the main symptom in patients with microscopic colitis and SIBO (p=0.041), while abdominal pain, abdominal bloating, and flatulence were prominent in IBS patients (p=0.042; p=0.039; p=0.048)(4).

5. Changes in bowel habits
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders(5).

6. Fever and severe dehydration
There is a report of a 19-year-old man with a 1-year history of ulcerative colitis presented with fever, bloody diarrhea, and severe dehydration. He was on po.48 mg methylprednisolone and 3 g mesalazine daily and has recently finished taking clarithromycin for Campylobacter jejuni infection(6).

7. Urgency
The study to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs), indicated that fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life over the same period. Patients ranked urgency and pain as the most bothersome symptoms(7)

8. Other symptoms
There is a report of a case of a 51-year-old Caucasian male who was evaluated for abdominal pain, elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea as a result of granulomatous enterocolitis. due to Sarcoidosis(8). Another study conducted by Anhui University of Traditional Chinese Medicine, with rats in the model group, showed lethargy, poor appetite, loss of energy, diarrhea, and bloody stool(9).

If you have experienced some of the aforementioned symptoms persistently with no signs of stopping, please make sure you check with your doctor to rule out the possibility of colitis.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding healthy foods for the treatment of colitis, researchers examined the impact of tomato lycopene extract (TLE) on intestinal inflammation.

The study included mice lipopolysaccharide (LPS)-induced innate signaling and experimental colitis fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76).

According to the tested assays, TLE blocked LPS-induced IkappaBalpha degradation and RelA translocation associated with the onset of colitis by blocking the inhibition of the protein involved in cytokine production.

Furthermore, MIP-2, a small cytokine mRNA accumulation in IEC-18 cells and pro-inflammatory cytokine Interleukin 12 (IL-12) induced by LPS were inhibited by the injection of TLE.

Moreover, the application of TLE also increased the expression of anti-inflammatory cytokines IL-6, TNF-alpha, a regulator of inflammation and MCP-1 mRNA associated with macrophage recruitment in the colon of TLE-fed subjects.

The results strongly suggested that tomato extract inhibited the colitis in mice through its modulatory of immune and inflammatory activity.


Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of colitis, pending to large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice by Joo YE1, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C. (PubMed)
(2) Colitis - Types and Symptoms by Kyle J. Norton

Thursday, June 25, 2020

Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases



Honey may the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.

Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.

After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.

In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.

In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.

Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.

Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.

In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.

Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).

Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.




Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.




At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.




Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.



During the stud, Manuka honey treated group displayed a significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.


Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.



Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and plasma of proinflammatory cytokines.




Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".



Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)