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Friday, December 4, 2020

Coffee Reduces the Risk of Melanoma, Particularly in People with Altered GSTM1 and GSTT1 Gene

Intake of coffee regularly may have a positive effect in reduced risk of Melanoma, particularly in healthy people with alternated genes GSTM1 and GSTT1 expression, a renowned institute study suggested.

Melanoma is a type of malignant skin cancer caused by DNA damage, most often caused by ultraviolet radiation from sunshine or tanning beds inducing irregular growth of skin cells.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Istituto Dermopatico dell Immacolata, in comparison to low coffee intake, high frequency of coffee drinking (>once daily) with ≤7 times weekly, showed a significantly lower risk of melanoma.

Interestingly, in the group of people with GSTM1 and GSTT1 null polymorphisms(altered gene expression) subjects, coffees showed an extremely high protective effect against the forming of Melanoma.


Also in the searching of PubMed and EMBASE databases from the earliest available online indexing year to March 2017 for a dose-response meta-analysis on prospective cohort studies, researchers at the Jagiellonian University Medical College, insisted that linear dose-dependent are associated with the development of melanoma risk and total coffee consumption.

The risk of melanoma is reduced by 3% for every cup of coffee intake per day.

Dr. Micek A, the lead author in the joint study said, "(According to) a total of seven studies eligible for meta-analysis were identified that comprised 1,418,779 participants and 9211 melanoma cases,......coffee intake may be inversely associated with the incidence of melanoma".

Further in the demonstration of 2 case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases), in compared the lower and higher caffeine intake daily, caffeinated coffee showed a pooled relative risk (RR) of 0.81.

Risk of an additional cup of coffee caffeine consumption, the relative odds ratio of the risk of melanoma decreased by 0.955
Importantly, the study found no correlated and linear dose-dependent of decaffeinating coffee and risk melanoma regardless of the volume of daily intake in teasing subjects.


Taking all together, there is no doubt that caffeine coffee has a significant effect in reducing the risk of melanoma in healthy and altered GSTM1 and GSTT1 expression subjects in linearly dose-dependent
manner.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms by Fortes C1, Mastroeni S, Boffetta P, Antonelli G, Pilla MA, Bottà G, Anzidei P, Venanzetti F.(PubMed)
(2) Caffeinated and decaffeinated coffee consumption and melanoma risk: a dose-response meta-analysis of prospective cohort studies by Micek A1, Godos J2, Lafranconi A3, Marranzano M2, Pajak A1(PubMed).

Friday, October 23, 2020

Brassica Oleracea Vegetables Kills Colorectal cancer Cells in Vitro

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Cancer is a class of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

On finding a potential wholefood for the treatment of cancer, researchers examined the effect of principle bioactive compounds, isothiocyanates (ITCs) on a colorectal cancer cell line (HT-29).


According to the chemicals analysis, purple cabbage extract showed the highest ITC concentration per gram, fresh weight, followed by black cabbage and Romanesco cauliflower.

ITC at the concentrations of 7.08 microg/mL decreased cancer cell viability by inducing the caspase-3 associated with cell death and DNA fragmentation at 48h.

Brussels sprouts showed the strongest effects on cell viability and caspase-3 activity.

Furthermore, all varieties of Brassica Oleracea with rich sources of ITCs potently inhibit the growth of colon cancer cells by inducing apoptosis.

All the extracts showed anticancer activity at ITC concentrations of between 3.54 to 7.08 mug/mL,

Based on the finding, researchers said, " ITC concentration and the chemopreventive responses of plant extracts vary among the varieties of Brassica Oleracea studied and among their cultivars".

Taken altogether, Brassica Oleracea vegetables may be considered functional foods for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea by Mas S1, Crescenti A, Gassó P, Deulofeu R, Molina R, Ballesta A, Kensler TW, Lafuente A. (PubMed)

Tuesday, October 20, 2020

Green Tea may Serve as Functional Food in Reduced early Onset and Treatment of Hypercholesterolemia

Green tea may be the next potential functional food used in reduced risk of early-onset and treatment of high blood cholesterol, a renowned institute study suggested.

Hypercholesterolemia is a condition of abnormally high levels of cholesterol in the bloodstream.

Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the University of Agriculture, ethanolic extracts of green tea fed mice in 8 weeks in vivo model expressed significant effects in normalized levels of cholesterol in hypercholesterolemic rats up to 15.45% in comparison control.

The study also revealed that the administration of green tea does not adversely affect the red blood cell, white blood cell, and platelet count of the tested rats.

Additionally, in compared efficacy of black tea (BT) and green tea (GT) in serum and hepatic oxidative abnormalities in hypercholesterolemic rats, after 8 weeks, green and black tea fed groups displayed a significantly lower levels of serum and hepatic cholesterol, triglycerides, serum low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels.

More importantly, in comparison to the control group, the fed group with hypercholesterolemic also expressed lower levels in the serum and hepatic lipid peroxidation, body weight gain, and food efficiency.

Furthermore, in-support of green tea in lower levels of high blood cholesterol, Dr. Nomura S, the lead author at the NARO Institute of Vegetable and Tea Science postulated, the efficacy of green tea with significantly decreased the plasma oxidized low-density lipoprotein level in mice fed a high-cholesterol diet is depending to the flavonol-rich tea cultivars.

Taking together, green tea with tons of phytochemicals may be served as functional found with purpose in reduced risk of early onset and treatment of high blood cholesterol in the adult population.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months




Sources
(1) The role of green tea extract and powder in mitigating metabolic syndromes with special reference to hyperglycemia and hypercholesterolemia by Yousaf S1, Butt MS, Suleria HA, Iqbal MJ.(PubMed)
(2) Black and green tea improves lipid profile and lipid peroxidation parameters in Wistar rats fed a high-cholesterol diet by Alshatwi AA1, Al Obaaid MA, Al Sedairy SA, Ramesh E, Lei KY.(PubMed)
(3) Effects of flavonol-rich green tea cultivar (Camellia sinensis L.) on plasma oxidized LDL levels in hypercholesterolemic mice by Nomura S1, Monobe M1, Ema K1, Matsunaga A1, Maeda-Yamamoto M2, Horie H1.(PubMed)

Saturday, October 17, 2020

Ginger Combined with Other Herbal Medicines for The Treatment of Erectile Dysfunction

Scientists may have found a natural ingredient for the treatment of erectile dysfunction with no side effects, according to studies.

Erectile dysfunction is a condition in which a man can not get or keep an erection to have sexual intercourse, affecting the self-confidence and contributing to relationship problems.

According to the statistics provided by the Massachusetts Male Aging Study, erectile dysfunction increased with age, affecting 40% and 70% of men in the age group of 40 and 70, respectively.

In other words, the prevalence of complete ED increased from 5% at age 40 to 15% at age 70. 150 million men worldwide have ED.

Age, hypertension, use of antihypertensive drugs, diabetes mellitus, heart disease, and daily stress at home, and work have been found to associate with the prevalent risk of ED.

Some researchers suggested the prevalence of ED may be correlated to widespread obesity in the Western world.

Dr. Skrypnik D, the lead scientist said, "In The United States it (obesity) causes more than 300 000 deaths per year. It leads to many complications, such as ischemic heart disease, hypertension, dyslipidemia, atherosclerosis, and abnormal carbohydrate metabolism".


And, " obesity is also an independent risk factor for erectile dysfunction in men. 79% of men presenting erectile disorders have BMI of 25 kg/m2 or greater. BMI in the range 25-30 kg/m2 is associated with 1,5 times, and in the range of over 30 kg/m2 with a 3 times greater risk of sexual dysfunction".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural treatment for patients with erectile dysfunction with no side effects, researchers examined the effects of oral administration of Revactin twice daily (total daily dose of 500 mg of ginger root, Muira puama, and Paullinia cupana and 1,600 mg of L-citrulline in 54 middle-aged men with erectile dysfunction.

Based on the results from the complete IIEF-15 questionnaire [domains: erectile function (EF), orgasmic function (OF), sexual desire (SD), intercourse satisfaction (IS), overall satisfaction (OS)] at baseline (B), 1 month (M1), 2 months (M2) and 3 months (M3) and report any side effects, Revactin exerted a strong effect on the increase in median domain scores of OF, SD, IS, OS over 3 months compared to baseline median scores.

However, after taking other factors into account, statistical significance was found only in the EF, IS, and OS median domain scores.

5 patients in the study showed the reporting treatment side effects (e.g., dyspepsia, heartburn, migraine) and none considered severe.
Overall, approximately 50% of the patients reported a significant improvement in EF (P<0.05), compared to baseline.

Dr. Nguyen S, the lead scientist said, "Revactin®, a combination of 3 nutraceuticals packaged with L-citrulline, appears to have the same excellent safety profile known for each of its individual four components".

Take all together, ginger combined with other herbal medicines may be considered functional alternatives for the treatment of erectile dysfunction, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Safety and efficacy of daily Revactin® in men with erectile dysfunction: a 3-month pilot study by Nguyen S1, Rajfer J2, Shaheen M. (PubMed)
(2) Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells by Ferrini MG1, Garcia E2, Abraham A2, Artaza JN3, Nguyen S2, Rajfer J4. (PubMed)
(3) [Obesity--significant risk factor for erectile dysfunction in men].[Article in Polish] by Skrypnik D, Bogdański P, Musialik K. (PubMed)

Tuesday, October 13, 2020

Cabbage Processes Immunomodulatory Activity

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, the immunomodulatory activity involved antimicrobial agents is to modulate the genes involved in immune reactions, or of the neurohormonal system which regulates immune functions and any toxic or immunotoxic effects such as allergic reactions or destruction of immune effectors, that may cause harm to the body or interfere with the body normal function.

The overactive immune system is a class of autoimmune diseases or chronic inflammatory diseases caused by the immune system attacking the body's tissue, including rheumatoid arthritis (RA), rheumatoid arthritis, systemic lupus erythematosus,.... and multiple sclerosis.

The widespread chronic inflammatory diseases in modern society are a burden to humans because of life-long debilitating illness, increased mortality and high costs for therapy and care.


The underactive or weakened immune system caused by a primary immune deficiency or acquired immune deficiency.may not protect the body against foreign organisms in initiated infection.

Sometimes, temporarily weaken the immune system may also be caused by the intake of certain conventional medicine, such as chemotherapy or drugs that treat cancer.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the improvement of immune functioning, researchers examined the immunomodulatory effect and mechanism of Lactococcus lactis A17 (A17), isolated from Taiwan fermented cabbage, on ovalbumin (OVA)-sensitized mice.


In live (A17-A) and heat-killed A17 (A17-H) orally administered to OVA-sensitized BALB/c mice effects, researchers found that live (A17-A) and heat-killed A17 (A17-H) induced allergic effects by increasing the

* B-cell response that was modulated by diminishing IgE production and raising OVA-specific IgG2a production and the T-cell response that was modulated by increasing IFN-γ production and decreasing IL-4 production.

* Furthermore, the mRNA expression of NOD-1, NOD-2, and TLR-4 associated with the expression of inflammation and infection was down-regulated by A17.

In other words, a naïve Lactococcus lactis A17 strain exerted a significant immunomodulatory activity against allergic diseases via oral administration


Based on the results, researchers wrote, "the ameliorative effects of A17 may be caused by modulating NOD-1 NOD-2, and TLR-4 expression".

Taken altogether, cabbage processes immunomodulatory activity, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice by Mei HC1, Liu YW, Chiang YC, Chao SH, Mei NW, Liu YW, Tsai YC. (PubMed)

Saturday, October 10, 2020

Green Tea, The Best Anti Metabolic Syndrome Whole Food Medicine

Green tea may be served as a functional food for reduced risk and treatment of metabolic syndrome, a renowned institute study suggested

Metabolic Syndrome is a group of risk factors used to calculate the incidence of early onset of diabetes and cardiovascular diseases.

Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.

In a total of 35 obese participants with metabolic syndrome randomly assigned to receive one of the following for 8 weeks: green tea (4 cups per day), control (4 cups water per day), or green tea extract (2 capsules and 4 cups water per day), blood samples collected from green tea and green tea extract-treated groups showed a significantly increased plasma antioxidant capacity (1.5 to 2.3 μmol/L and 1.2 to 2.5 μmol/L, respectively in compared to control group.



The study also found that the efficacy of green tea in ameliorated early progression of metabolic syndrome is attributed to the improved expression of serum antioxidant enzymes (glutathione peroxidase, glutathione, catalase) and plasma antioxidant capacity in inhibited free radicals in exhibition of pro-inflammatory cytokines.



Furthermore, in the total of 55 obese men and women recruited, injection of 280 and 360 g GTRB provided daily totals of 123.2 and 158.4 mg caffeine, and 188.3 and 242.1 mg of epigallocatechin gallate significantly reduced expression of metabolic syndrome in attenuated weight gain, high-density lipoprotein-cholesterol, triglycerides, and glucose concentrations.

More importantly, the study also found that administration of green tea also reduced levels of blood pressure in obese subjects but can not maintain the weight loss after study.


Other researchers in the investigation of decaffeinated green tea extract (GTE) and voluntary running exercise (Ex) alone or in combination against obesity and metabolic syndrome in high fat (HF) fed C57BL/6J mice, insisted that the combination of green tea injection and exercise treatment reduced final body mass (27.1% decrease) and total visceral fat mass (36.6% decrease), levels of fasting blood glucose (17% decrease), plasma insulin (65% decrease), and insulin resistance (65% decrease) compared to HF-fed mice.


Taking together, green tea may be one of the best candidates used for the prevention of onset and treatment of metabolic syndrome in the adult population, but the long-term injection of the large amounts may induce liver and kidney toxicity as shown in previous articles.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome by Basu A1, Betts NM, Mulugeta A, Tong C, Newman E, Lyons TJ.(PubMed)
(2) Effects of rye bread enriched with green tea extract on weight maintenance and the characteristics of metabolic syndrome following weight loss: a pilot study by Bajerska J1, Mildner-Szkudlarz S2, Walkowiak J1,3.(PubMed)
(4) Voluntary exercise and green tea enhance the expression of genes related to energy utilization and attenuate metabolic syndrome in high fat fed mice by Sae-Tan S1, Rogers CJ, Lambert JD.(PubMed)

Friday, October 9, 2020

Coffee and Coffee Caffeine in Improved Complexity of Cognitive Performance?

Epidemiological studies do not agree that regular coffee consumption may associate to improve cognitive function, a joint study lead by the Universidade Federal de Minas Gerais suggested.

Cognitive function is a cerebral activity in acquired knowledge, including all means and mechanisms of acquiring information.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In a cohort of 14,563 public service workers (35-74 years old) to examine the coffee consumption habits and cognitive function using a standardized neuropsychological test, researchers at the above institutes filed the following results
1. Elderly drinking 2-3 cups/day, showed a significant improvement in the mean words remembered on learning, recall, and word recognition in comparison to never/almost never groups.

2. And those drinking more than 3 cups a day exhibited increased mean words pronounced, according to the semantic verbal fluency test in comparison to the same groups.

Dr. Araújo LF, the lead author said, "coffee consumption might be slightly beneficial to memory in elderly but lacks a dose-response relationship".



Further more, in 2,914 participants from the population-based Rotterdam Study (mean age: 59.3±7.2 years, 55% females) to assess coffee consumption, performed brain MRI, and cognition at baseline, researchers found that
1. Higher coffee consumption showed a lower prevalence of lacunar infarcts [odds ratio per cup increase: 0.88 (95% CI:0.79;0.98)]involved development of stroke, and smaller hippocampal volume in the expression of memory ability.
2. Coffee consumption promoted better performance on the Letter Digit Substitution Task
3. But do not improve on the 15-Word Learning test delayed recall.


Dr. Araújo LF, again said, "...(there is a) complex associations between coffee consumption, brain structure, and cognition. Higher coffee consumption was cross-sectionally associated with a lower occurrence of lacunar infarcts and better executive function.

Interestingly, according to the study of coffee consumption and other baseline variables of 2606 middle-aged Finnish twins assessed in 1975 and 1981 by postal questionnaires, with after the median follow-up of 28 y, coffee consumption was not an independent predictor of cognitive performance in old age, according to the linear regression analysis.

The study also insisted that coffee drinking did not affect the risk of mild cognitive impairment or dementia, but expressed an inconsistent cognitive score.


Taking all together, coffee and coffee caffeine can only improve the performance of some cognitive function but not as a whole, particularly in the older population.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Inconsistency of Association between Coffee Consumption and Cognitive Function in Adults and Elderly in a Cross-Sectional Study (ELSA-Brasil) by Araújo LF1, Giatti L2, Reis RC3, Goulart AC4, Schmidt MI5, Duncan BB6, Ikram MA7, Barreto SM8.(PubMed)
(2) Association of Coffee Consumption with MRI Markers and Cognitive Function: A Population-Based Study by Araújo LF1,2, Mirza SS2, Bos D2,3, Niessen WJ3,4, Barreto SM1, van der Lugt A3, Vernooij MW2,3, Hofman A2, Tiemeier H2,5,6, Ikram MA2,3,(PubMed)
(3) Coffee drinking in middle age is not associated with cognitive performance in old age by Laitala VS1, Kaprio J, Koskenvuo M, Räihä I, Rinne JO, Silventoinen K.(PubMed)

Wednesday, October 7, 2020

Tualang Honey, The Potential Anti Cervical Cancer Functional Food

Scientists may have located a natural whole food for the prevention and treatment of cervical cancer with no side effects, some studies found.

Cervical cancer is a chronic condition caused by cell growth disorderly in the tissue of the cervix.


Most cases of cervical cancer start on the cells in the surface of the inner lining tissue of the cervix.
Most patients at this stage of cervical cancer do not experience any symptoms.

As cancer progresses, most patients may experience the symptoms of blood spots or light bleeding between or following periods, longer than usual and heavy menstrual bleeding, increased vaginal discharge, particularly, bleeding after intercourse, douching.

At this stage, cervical cancer can travel a distance away to cause metastasis to other healthy tissue and organs through fluids and blood circulation.

If you have experienced some of the above symptoms, please check with your doctor to rule out the cervical cancer possibility.


Although certain risk factors such as having many sexual partners, long-term use of birth control pills (oral contraceptives), early engaging in sexual contact are associated with the onset of the disease, Human papillomavirus (HPV) infection is one of major cause that has been under intensive investigation.

Belief or not, there are over 100 different HPV types have been identified and classified as high risk in almost all cervical cancers (>99.7%).

Out of this 100 different HPV, HPV16 is the most prevalent type in both low-grade disease and cervical neoplasia.

Dr. Doorbar J at the National Institute for Medical Research, said, "Most cervical cancers arise within the cervical transformation zone at the squamous/columnar junction, and it has been suggested that this is a site where productive infection may be inefficiently supported"


"Cancers usually arise in individuals who fail to resolve their infection and who retain oncogene expression for years or decades. In most individuals, immune regression eventually leads to clearance of the virus, or to its maintenance in a latent or asymptomatic state in the basal cells".

These results clearly stage, most of the initiation of HPV infection is stopped by the immune system first line of defense before the virus penetrates through the cervical cell membrane on the surface of the inner lining.

In other words, women who have a weakened immune system are at substantial risk to the disease.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers examined the Tualang honey (Agromas) anti-cancer effect.

Tualang honey (Agromas) (TH) were applied with increasing doses of TH (1-10%) for up to 72 h to the human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines; as well as in the normal breast epithelial cell line, MCF-10A.

At concentrations (EC(50)) of 2.4-2.8%., Tualang honey increased in lactate dehydrogenase (LDH) leakage from the cancer cell membranes, an indication of cytotoxicity to all three cancer cells.

Furthermore, application of TH also reduced the mitochondrial membrane potential (Δψ(m)) in response to energy storage in the cancer cell lines after 24h of treatment.

TH also stimulated the proteins associated with cancer cells apoptosis.

The evidence suggested that TH has significant anticancer activity against human cervical cancer cell lines.

Additionally, in the evaluation of bee bread (BB), a fermented mixture of plant pollen, honey, and bee saliva against HeLa (cervical carcinoma) cancer cells line, researchers found that application of BB displays a moderate activity in the inhibition of the cancer cell line through cytotoxicity with doses ranging from >400 to 68 µg/mL).

The inhibition of the human cervical cancer cell line was attributed to the main phenolic compounds also found abundantly in the Tualang honey.


The in-depth analysis suggested that BB induces HeLa cell death through stimulating the function of free radicals in the induction of oxidative stress to cause cytotoxicity.

Taken altogether, honey or Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cervical cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines by Fauzi AN1, Norazmi MN, Yaacob NS. (PubMed)
(2) Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal by Sobral F1, Calhelha RC2, Barros L3,4, Dueñas M5, Tomás A6, Santos-Buelga C7, Vilas-Boas M8, Ferreira IC9. (PubMed)
(3) Molecular biology of human papillomavirus infection and cervical cancer by Doorbar J. (PubMed)

Tuesday, October 6, 2020

Green Tea, The Best functional food for Prevention and Treatment of Nonalcoholic Fatty Liver Disease

Green tea may be considered as a functional food in lower risk and treatment for patients with nonalcoholic fatty liver disease, a respectable institute opinionated.

Non-alcoholic Fatty Liver Disease is a condition caused by over accumulated of fat in the liver.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will solve the aversion.

According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with nonalcoholic fatty liver disease is associated to polyphenolic catechins in induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.

These chemical compound have also found to mitigate the occurrence and progression of NAFLD.


Dr. Masterjohn C, the lead author said, "(The phytochemical compounds) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD"

Furthermore, in mice fed on a high-fat diet for 24 weeks., then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice showed a significant improvement of a high-fat diet in induced the body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation, and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia, and insulin resistance.

The phytochemical EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.


In fact EGCG not only promoted weigh loss but also attenuated symptoms of mice with nonalcoholic fatty liver disease.

Promisingly, in the study of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, researches also indicated that, GTP intervention not only decreased weight gain and significantly lowered visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides outflux from liver.


Taking together, green tea has expressed a significant enhancement in reduced risk and treatment of
nonalcoholic fatty liver disease, through many aspects. But large amount intake regularly should be taken with care to prevent toxicity.


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Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Sources
(1) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(2) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(3) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)

Healthy Veggie Broccoli, the Natural Anti Hyperlipidemic Activity

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

The condition is normally known as high blood cholesterol in the general population.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, produces vitamin D and steroid hormones.

Cholesterol can either be produced by the liver or consumed form the food sources. There are 2 types of cholesterol
*The high-density lipoprotein is also known as "good" cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in a moderate amount.

In a healthy individual, the bad cholesterol is returned to the liver.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anti-anti-hyperlipidemia, researchers examined the serum LDL-cholesterol (LDL-C)-lowering effects of two types of canned beverages containing mixed green vegetables and fruits, with or without broccoli and cabbage (B&C).

The randomized double-blind study design included 77 adult subjects with mild to moderate hypercholesterolemia (Forty-nine out of 77 subjects, whose LDL-C levels were greater than or equal to 140 mg/dl and less than 180 mg/dl) were randomly divided into groups either by a placebo sample made from the same materials but without B&C. The subjects were administered 2 cans of 160 g contents/can) per day for 12 weeks.

According to the results of the experiment,
* Serum LDL-C levels in the test group were significantly reduced at 3, 6, and 9 weeks after administration in comparison to the baseline levels (155.7 mg/dl on average).

* The average LDL-C value at 9 weeks was 142.5 mg/dl and the reduction rate was 8.5% compared to serum LDL-C levels in the control group that was not significantly reduced.

* Significant differences(p < 0.05) between the groups were observed in the LDL-C levels at 6 and 9 weeks and also in the total cholesterol levels at 9 weeks.

Collectively, researchers said, " intake of the beverage tested containing B&C is useful for lowering serum LDL-C levels in hypercholesterolemic subjects".

Taken altogether, broccoli used combination with cabbage may be considered a functional food for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [LDL-cholesterol-lowering effect of a mixed green vegetable and fruit beverage containing broccoli and cabbage in hypercholesterolemic subjects].[Article in Japanese] by Takai M1, Suido H, Tanaka T, Kotani M, Fujita A, Takeuchi A, Makino T, Sumikawa K, Origasa H, Tsuji K, Nakashima M. (PubMed)

Sunday, October 4, 2020

Coffee and Coffee Caffeine Intake and Risk of Gallstone and Gallstone Diseases

Epidemiological studies, linking coffee consumption in reduced risk of gallstone, but not gallstone disease have been contradictory.

Gallstone is a stone formed within the gallbladder out of bile components as a result of building up of undissolved cholesterol over a prolonged period of time.

Coffee, a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of 174 cases of gallstones determined by ultrasonography, 104 cases of postcholecystectomy, and 6889 controls of the normal gallbladder in the total of 7637 men received a health examination at four hospitals of the Self-Defense Forces (SDF) with 174 cases of prevalent gallstones, 50 had been aware of having gallstones, researchers found that coffee and coffee caffeine drinkers express a high risk of gallstone incidence in compared to non-drinkers.

In these group of middle-aged Japanese men, the relative odds ratios of gallstone disease 1.7 for coffee consumption of five cups or more per day vs. no consumption and 2.2 for caffeine intake of 300 mg/day or more vs. less than 100 mg/day.

Obviously, these findings contradicted to other studies in support of risk of gallstone reduced by coffee and caffeine intake, including the study conducted by Harvard School of Public Health.


Other, in the review literature of database from PubMed and EMBASE of all published studies before June 2015 researchers at The First Affiliated Hospital of Zhengzhou University files the following results
1. Coffee intake regularly and daily had a significantly reduced risk of gallstone disease, in related females, but not in males. based on prospective studies.

2. For patients drinking one cup of coffee per day, the risk of of gallstone disease was 0.95
3. For patients drinking 2, 4 and 6 cups of coffee per day, the estimated RRs of gallstone disease reduced to 0.89 (95% CI, 0.79 to 0.99), 0.81 and .75 respectively.
4, Coffee intake showed a linear association with the ameliorated risk of gallstone diseases.


Interestingly, in a cohort of 80,898 women age 34-59 years in 1980 who had no history of gallstone disease, during 20 years of follow-up, researchers filed the below results
1. Compared to non-caffeine coffee drinkers women, the multivariate relative risks of gallstone disease with cholecystectomy in comparison to consistent intake of caffeinated coffee (0, 1, 2-3, and > or =4 cups/day) were 1.0, 0.91, 0.78, and 0.72 respectively.
2. Coffee caffeine intake was inversely associated with the risk of cholecystectomy.
3. Caffeine intake (< or =25, 26-100, 101-200, 201-400, 401-800, and >800 mg/day) is linearly associated with a reduced risk of gallstone disease with the multivariate relative ratio of 1.0, 1.03, 1.01, 0.94, 0.85, and 0.85 4. Decaffeinated coffee was not associated with risk.

There is no doubt that the study addresses a significantly inverse association in reduced risk of gallstone disease among coffee drinkers linearly.


Taking all together, the contradictory result may warrant further study, before one can make a decision of the effect of coffee and coffee caffeine in concern of risk of gallstone, but not in the attenuated risk of symptomatic gallstone disease.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months




Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men by Ishizuk H1, Eguchi H, Oda T, Ogawa S, Nakagawa K, Honjo S, Kono S.(PubMed)
(2) Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease by Zhang YP1, Li WQ1, Sun YL1, Zhu RT1, Wang WJ1.(PubMed)
(3) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men by Leitzmann MF1, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E.(PubMed)

Saturday, October 3, 2020

Garlic, The Best Whole Food That Gobbles Up Cancer Cells

Garlic (Allium sativum) may have a potential effect in the prevention and treatment of cancers by gobbling up cancer cells before they can proliferate to the invasive tumor, some studies suggested.

Cancers are a class of chronic diseases characterized by uncontrollable cells grown in tissue in the body.

At the later stage, the cancerous cells can infect other healthy cells and tissue far away from the original site by traveling through blood and lymph.

The diseases are the second cause of death in the US.

According to statistic, between 2011-2015, by the National Cancer Institute, 440 per 100,000 adults are diagnosed with cancers, inducing 163.5 per 100,000 death

Depending on the types of cancer, patients may experience certain general and specific symptoms.


DNA alternation caused by an inherited gene mutation in the induction abnormal cell proliferation is the major cause of cancers.

The National Cancer Institute suggested that age, excessive alcohol consumption, unhealthy diet and lifestyle, smoking, radiation, viruses, carcinogens, obesity,... and chronic inflammation, are also considered as some major risk factors that can cause cancers. (As these factors are accumulated through many studies in which all point to a similar association between a potential risk factor and an increased risk of cancer).


Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.

The pungent herb has been used popularly in traditional and Chinese medicine for treating common cold and flu, blood pressure cholesterol levels,..... and as a natural antibiotic.

Garlic appears to be generally safe although some people may suffer mild allergic reactions.

A recent study lead by author Dr. Oommen S indicated that allicin, the main ingredient found in garlic induces the formation of apoptotic bodies, nuclear condensation, and a typical DNA ladder in cancer cells, causing cell death.

Researchers in the study of ingredient allicin also showed that the phytochemical is capable of inducing an increase in the rate of apoptosis by obstructing the expression of the cell cycle division and pro-inflammation.

On cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway through promoted GSH depletion and changes in the intracellular redox status.

In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.

Other compounds found in garlic such as organosulfur, its extract and phyto-compounds also suppressed cancer cell proliferation and induced cell cycle arrest.

Therefore, people who are at higher risk of the diseases may consider adding a portion of garlic whole food into their diet for preventive measures.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC.(PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3.(PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)

Thursday, October 1, 2020

Regular Intake of Vegetables, Fruits, Fish, and Tea Associated with Reducing the Risk Anxiety Symptoms

The central nervous system is a part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.

Neurological diseases are the medical conditions of brain disorder. Anything that involves the structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves, including brain damage are considered as neuro diseases.

Mental illnesses or mental health disorders refer to a group of mental health conditions that affect your mood, thinking, quality of life, and behavior.

Poor lifestyle choices, such as smoking, overuse of alcohol, lack of physical activity and inadequate relief of chronic stress, and poor diet with high in saturated and trans fat, red meat, processed foods and less in fruits and vegetable and whole-grain are some of the key contributors in the development and progression of chronic diseases, including neurological diseases.
Anxiety is a mental disorder characterized by worry about future events and fear of current events.

People experience anxiety differently. Some people feel a sudden moment of anxiety just a bad feeling, it comes and goes, only lasting a short time. Depending on how people cope with the moments of anxiety, the events can be brief or last a few days.

However, in some persons, if anxiety does not go away, they may require treatment from the related field specialists.

If you are frequently experience symptoms of nervousness, restlessness, or being tense feelings of danger, panic, or dread rapid heart rate rapid breathing, or hyperventilation,..... you may have developed an anxiety disorder.

Conventionally, Treatment of anxiety is totally depending on the nature of the anxiety disorder and individual preferences. Often, treatment combines different types of therapy and medication.

On finding a natural ingredient for the prevention and treatment of mental disorders, scientists examined prepregnancy dietary patterns and prospective variations on anxiety symptoms from mid-pregnancy to early postpartum in Brazilian Women.

A prospective cohort study included 207 healthy pregnant women who were followed at 5 to 13, 20 to 26, and 30 to 36 gestational weeks, and once at 30 to 45 days postpartum.

According to the analysis of The State-Trait Anxiety Inventory returned from the participants
* The mean anxiety symptom scores were 40.4, 40.5, and 37.2 for the second trimester, third trimester, and postpartum, respectively.

* The rate of variation of the State-Trait Anxiety Inventory score was 0.535 (95% CI -0.035 to 1.107; P=0.066) and -0.010 (95% CI -0.018 to -0.002; P=0.019) when accounting for gestational age and quadratic gestational age, respectively.

* The dietary pattern associated with the anxiety symptoms found in the common-Brazilian pattern, comprised mainly of rice and beans (β=-1.200, 95% CI -2.220 to -0.181; P=0.021)

* The healthy pattern comprised mostly of vegetables, fruits, fish, and tea were found to be associated with negatively prospective changes in anxiety symptoms.


Based on the results, researchers suggest, "High adherence to the common-Brazilian or healthy patterns was negatively associated with higher anxiety symptom scores from mid-pregnancy to early postpartum in this group of Brazilian women".

In other words, regular intake of vegetables, fruits, fish, and tea in women during the pregnancy was associated with the reduced risk of anxiety.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Prepregnancy Dietary Patterns and Anxiety Symptoms from Midpregnancy to Early Postpartum in a Prospective Cohort of Brazilian Women by Vilela AA, Pinto Tde J, Rebelo F, Benaim C, Lepsch J, Dias-Silva CH, Castro MB, Kac G. (PubMed)

Wednesday, September 30, 2020

Cruciferous Vegetables Inhibit the Risk of Kidney Cancer

The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.

The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules.

In the urinary system, kidneys reabsorbed some necessary substances back into the blood, while waste, such as urea and ammonium are deposited into the pelvis then into the ureter to the bladder for secretion.

Kidney Cancer is a medical condition characterized by irregular cell growth in the tissue of kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spreads to the lung is called kidney cancer with lung metastases.

At the very early stage of the kidney, cancerous tumors are localized on the surface of the kidneys.


The most common type of kidney cancer is renal cell cancer.

The causes of kidney cancer are unknown. Some researchers suggested that genetic mutation, cigarette smoking, obesity, family history,..... and exposed to chemicals, such as asbestos and benzene are all associated with increased risk of kidney cancer.

Kidney cancer affects only 2% of the general population. Approximately 14 percent of the US population suffer some forms of chronic kidney disease (CKD), including 661,000 cases of kidney failure.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential remedy for reducing the risk chronic diseases, researchers examined the effects of cruciferous vegetable consumption in the risk of renal cell carcinoma.

The meta-analysis included 3 cohort and 7 case-control studies retrieved via both computerized searches and review of references.

According to the summary of the calculation of the relative risks (RRs) with 95% confidence interval (CI) for the highest vs. the lowest consumption of cruciferous vegetables,

in cruciferous vegetables consumption group (RR = 0.73; 95% CI, 0.63-0.83) and subgroup of case-control studies (RR = 0.69; 95% CI, 0.60-0.78), compared to statistically insignificant in cohort studies (RR = 0.96; 95% CI, 0.71-1.21).

No heterogeneity and publication bias was detected across studies.


In other words, the meta-analysis supported the cruciferous vegetable consumption for decreasing the risk of renal cell carcinoma.

However, because of the limited number of studies, researchers said, "further well-designed prospective studies and researches need to be conducted to better clarify the protective effect of cruciferous vegetables on renal cell carcinoma and potential mechanism".


Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of kidney cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous vegetables consumption and risk of renal cell carcinoma: a meta-analysis by Liu B1, Mao Q, Wang X, Zhou F, Luo J, Wang C, Lin Y, Zheng X, Xie L. (PubMed)

Sunday, September 27, 2020

Green Tea, in Reducing the Risk of Early Onset and Progression of Dementia

Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people. About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Green tea may be used as a functional food for the prevention of early-onset and treatment of dementia due to aging progression, a renowned institute study suggested

Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the neutralization trick.

In the 5.7-year prospective cohort study, using a questionnaire, information on daily green tea consumption, and other lifestyle factors collected from elderly Japanese individuals aged 65 years or more, green tea consumption is associated with a reduced risk of dementia with an incidence of the occurrent rate of 8.7%.

Furthermore, in the intracerebroventricular (ICV) infusion of streptozotocin (STZ) animal model explicted chronic brain dysfunction involved long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit, mice treated with green tea EGCG at a dose of 10mg/kg/day for 4 weeks, showed a significant improvement in reduced oxidative stress parameter against the production of inflammatory and free radical expression.

These inhibitions can be seen in the diminished AChE activity, glutathione peroxidase activity as well as NO metabolites, and reactive oxygen species contents

More importantly, the enhanced antioxidant status-induced neuroprotective effect is a result of EGCG injection in ameliorated inflammatory and free radical causes of cell death in the brain of treated mice.


Dr. Tomata Y, the lead author of the study said, "The lower risk of incident dementia was consistent even after selecting participants who did not have subjective memory complaints at the baseline."


More explicitly, in the finding of natural food for reverse or delay of risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors involved the development of dementia and late-life cognitive disorders, green tea with a high amount of caffeine stimulate the psychoactive effects in attenuated cognitive impairment/decline and dementia through heightened alertness and arousal and improvement of cognitive performance.

Promisingly, such results have been proposed by several cross-sectional and longitudinal population-based studies, particularly in patients with mild cognitive impairment and progression to dementia.


There is no doubt that green tea may be considered as a function of foods for reduced risk of early-onset and delay progression of dementia, but longer follow-up periods are necessary before the use of green tea can open new ways for diet-related prevention and treatment of dementia.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Sources
(1) Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study by Tomata Y1, Sugiyama K2, Kaiho Y2, Honkura K2, Watanabe T2, Zhang S2, Sugawara Y2, Tsuji I2(PubMed)
(2) Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia by Biasibetti R1, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, Gonçalves CA.(PubMed)
(3) Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review by Panza F1, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G.(PubMed)

Saturday, September 26, 2020

Healthy Veggie Broccoli Inhibits Cardio-Risk Parameters in Diabetes

Cardiovascular diseases (CVD) are a group of conditions associated with blood vessels and the heart.

According to the statistics provided by the World Health Organization, cardiovascular diseases are the number 1 cause of death globally. Approximately, 17.9 million people died from CVDs in 2016, representing 31% of all global deaths.

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

The most common symptoms of type 2 diabetes are an increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.

* Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Therefore, LADA shares the same risk factors and symptoms similar to those type 1 and 2 diabetes

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes chronic diseases, researchers compared the effects of broccoli sprouts powder, as an alternative and complementary treatment, to those of standard triple therapy, as a common medical treatment in cardiovascular diseases (CVD) risk in patients with type 2 diabetes.

The study included 86 type 2 diabetic patients with positive H.pylori stool antigen test (HpSAg) who were randomized to receive one of the three following regimens:
* STT) Standard triple therapy (omeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1000 mg, twice a day for 14 days),

* BSP) 6 g/d broccoli sprouts powder for 28 days, and

* Combination of these as STT + BSP. After 4 weeks of treatment.

Based on the results of the analysis of 77 participants who completed the study [STT (n = 28), BSP (n = 25), STT + BSP (n = 24)],

* Before treatment, the H.pylori eradication rates were 89.3%, 56.0% and 91.7% in STT, BSP and STT + BSP groups, respectively.

* After the treatment, both systolic and diastolic blood pressure significantly decreased in STT + BSP group (P < 0.05).

* Serum triglycerides and TG/HDL-C ratio increased in STT patients group (<0.05).

* Serum hs-CRP levels significantly decreased in the patients who were treated with BSP per se (3.0 ± 2.5 at baseline vs. 2.3 ± 2.1 after the treatment, P < 0.05).

Collectively, researchers said, "Compared to standard triple therapy, BSP regimen in addition to considerable effects on H.pylori eradication had also favorable properties on cardiovascular risk factors following the H.pylori eradication".

Taken altogether, broccoli may be considered a functional food for reducing the risk of CVD in diabetes, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes by Mirmiran P1, Bahadoran Z2, Golzarand M2, Zojaji H3, Azizi F. (PubMed)

Manuka Honey, The Antioxidants Functional Sweety

Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.

Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.

Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and

"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".

These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.

Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.

Honey treated rats displayed a clinically significant decrease of the ulcer index by completely protected the mucosa from lesions and preserved gastric mucosal glycoprotein.

Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.


These results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.

The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.


In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.

Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcer in the rat model, researchers examined three different concentrations of honey applied to the tested rats.

During the experiment, researchers found that all 3 different concentration display a strong effect in It reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.

In other words, manuka honey protects the rat stomach by inhibiting the overexpression of free radical and pro-inflammatory cytokines in inducing oxidative stress.


Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.


The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.

The information collected strongly supports the use of manuka honey for the treatment of chronic ulcer and preservation of mucosal glycoproteins.

Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.


Taken all together, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.


Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)

Friday, September 25, 2020

Coffee and Coffee Caffeine In Reduced Risk and Management of Obesity


In comparison to herbal medicine, food therapy even takes longer to ease symptoms, depending on stages of the treatment which directly address the cause of the disease.

Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Obesity is a medical condition of excess body fat accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity.

Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.

According to the joint study lead by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factors expression

According to animal studies.
In human, it is the result from decreased body weight and visceral fat stored within the abdominal cavity.

Further more, the study also expressed the important of coffee intake in influence the gut microbiota in obese animals and humans.

Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. GCBE treated group showed a significantly decreased body weight gain, liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.
2. The efficacy of treatment group in reduced obesity risk may also benefit to the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.
3. In compared to other treated group, GCBE treated mice displayed a lower fat mass and relative body weight and decreased fat mass.

More importantly, in the review of papers from in vivo, ex vivo, in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study lead by the South University School of Pharmacy said, " there are mounting evidences of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".

Taking altogether, there is no doubt that coffee and coffee caffeine have a significant and potential effect in reduced risk and management of obesity, through various active biochemicals in dose deepening manner.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Coffee consumption, obesity and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)

Thursday, September 24, 2020

Coffee Intake in reduced Risk of Stroke, Particularly in Women

Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

A stroke is a medical condition characterized by interrupted blood supply, thus reducing oxygen and nutrients delivery to the brain, resulting in the death of brain cells.


Intake of coffee and coffee caffeine may have a profound effect in reduced risk of stroke incidence, a renowned institute study suggested.

In a third National Health and Nutrition Examination Survey (1988-1994; NHANES III) data to examine coffee consumption and stroke with participants aged ≥17 years old, researchers found that
coffee intake of this population showed a significant inverse association to stroke risk incidence, regardless to smoking status.


Interestingly, the study also discovered that frequent coffee drinkers displayed a less occurrence of heart failure, diabetes, and hypertension but the risk of high cholesterol for those consuming ≥3 cups per day.


Dr. Liebeskind DS, the lead author said, "Heavier daily coffee consumption is associated with decreased stroke prevalence" and ". Multivariate analyses revealed an independent effect of heavier coffee consumption (≥3 cups/day) on reduced stroke".

Furthermore, in an analyzed data from a prospective cohort of 83,076 women in the Nurses' Health Study without a history of stroke, coronary heart disease, diabetes, or cancer at baseline, with coffee consumption assessed first in 1980, then repeatedly every 2 to 4 years, and follow-up through 2004, researchers at the Harvard School of Public Health filed the following results

1. The relative risk ratio of stroke in participants coffee consumption (<1 cup per month, 1 per month to 4 per week, 5 to 7 per week, 2 to 3 per day, and >or=4 per day) were 1, 0.98, 0.88, 0.81, and 0.80 repetitively.
2. Intake of coffee and coffee caffeine daily and regularly showed a significantly positive effect in reduced stroke risk after taking in to count of other favors, including high blood pressure, hypercholesterolemia, and type 2 diabetes.
3. Risk of stroke also associated stronger correlation among never and past smokers (RR for >or=4 cups a day versus <1 cup a month, 0.57) than among current smokers (RR for >or=4 cups a day versus <1 cup a month, 0.97).
4. Decaffeinated coffee intake also was associated with a trend in a lower risk of stroke after adjustment for caffeinated coffee consumption.

5. Caffeine consumption of other beverage do not associate to risk or reduced risk of stroke.
The findings suggested that long-term coffee consumption was not associated with risk of stroke but modestly reduce the risk of stroke.


Promisingly, an Asian study of data obtained from the Health Examinees (HEXA) study, involved 146,830 individuals aged 40-69 years demonstrated that high coffee consumption was associated with a 38% lower odds ratio for stroke in women in compared to (none drinkers vs. ≥ 3 cups/day drinkers in women but not in men.

The expression of coffee intake in reduced risk of stroke also found greater in women who are healthy, younger, non-obese, non-hypertensive, non-diabetic, non-smokers, and non-alcohol drinkers.


Taking together, there is no doubt that the intake of coffee daily and regularly has a remarkable effect on the reduced risk of stroke, particularly in women.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months




Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The coffee paradox in stroke: Increased consumption linked with fewer strokes by Liebeskind DS1, Sanossian N2, Fu KA2, Wang HJ3, Arab L4(PubMed)
(2) Coffee consumption and risk of stroke in women by Lopez-Garcia E1, Rodriguez-Artalejo F, Rexrode KM, Logroscino G, Hu FB, van Dam RM.(PubMed)