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Friday, January 31, 2020

Fennel, A Potent Chemo-Preventive and Modulatory Functional Herb

Fennel may have a potential and positive effect in modulated the effect of chemo drugs through its chemo modulatory activity, some scientists suggested.

The expression of fennel application in enhanced chemopreventive response was evident in animal models from the reduced tumor burden in reduced cancer cell proliferation and apoptosis and reduced percentage of the tumor through some different publications.

The results were reported by several respectable institutes including Jawaharlal Nehru University and published on online medical literature.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

According to the Jawaharlal Nehru University, in evaluate the chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds on DMBA-induced skin and B(a)P-induced forestomach papilloma genesis in Swiss albino mice, application of fennel seeds displayed a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group.




Biochemical assays showed a significant increase in the content/activities of phase I and II enzymes especially in the case of a 6% test diet, in detoxifying poisonous compounds caused by the injection of DMBA, through significant enhancement of antioxidant activities.



Further examination also found that injection of fennel seed stimulated production of antioxidant enzyme in the body tissue in repaired damage precipitated by peroxidation through lactate dehydrogenase activity.

Dr. Singh B, the lead author said, "A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6%" and "glyoxalase I(with function as an enzymatic defense against glycation) activity and the content of reduced glutathione (antioxidant) were significantly elevated".


Additionally, in the examine the effect of fennel bioactive compound anethole in chemo modulatory activity against the onset and spread of cancer, researchers found that application of fennel oil by inhibited the activated expression of NF-kappa B, a gene-altering and inflammation in triggering molecule in the development of various solid tumors through stimulated cancer proliferation.



Also, anethole injection reduced levels of tumor necrosis factor (TNF, tumor necrosis factor-alpha, TNFα, cachexin, or cachectin), a cell-signaling protein (cytokine) involved in systemic inflammation and one of the cytokines that make up the acute phase reaction. However, at a certain stage of cancer, gene expression in promoted cancer apoptosis is alternated, TNF changes from a cancer killer to a cancer promoter.



Additionally, with abundant fiber, fennel demonstrated a strong effect in the removal of toxins from the colon and therefore may be helpful in colon cancer prevention.


Dr. After taking into account of other co and confounders said, " Fennel contains flavonoid anti-oxidants compounds like kaempferol and quercetin which helps eliminate harmful free radicals from the body....".


In other words, fennel exerted chemo modulatory activity also through its flavonoid anti-oxidants compounds like kaempferol and quercetin in inhibited overexpression of free radicals and free radical chain reactive in protected against cytotoxicity in induction cells damage and alternated cell DNA in the facilitated onset of cancer.


Taking all together, fennel and its bioactive compound may be considered as a chemopreventive and modulatory functional food for reduced risk and treatment of various types of cancers.


For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system by Singh B1, Kale RK(PubMed)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Arzoo and Milind Parle, Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology(EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH)

Green Peas Improve Cognitive Performance in Vivo

Cognitive performance is the process of the brain ability to process thoughts in healthy individuals.
Memory impairment is a condition associated with a slow decline in memory, thinking and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Memory loss frequently is an early sign of memory deficit.

Some memory change can be resolved on their own or cured by medical treatment if the underlying cause is found. However, loss or gradual loss of neurons capacity cannot be revered such as dementia.

According to statistics, in the US, approximately 5.7 million people are living with dementia. A most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.

The most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.

However, an unhealthy diet has been found to promote a gradual loss and death of neurons such as Alzheimer's disease.


Accompanied by aging, both aging and unhealthy diet may be the major culprits that cause memory deficit in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.


Dr. Amy C. Reichelt, said, "The so-called western diet is rich in saturated fat and refined carbohydrates. Excessive consumption of this diet is associated not only with the development of obesity but also with reduced global cognitive function, cognitive decline, and dementia (Morris et al., 2015). This Research Topic explores the effects of diet and diet-induced obesity on learning, memory, and cognition in both experimental and epidemiological settings".

And, "High fat and high sugar foods are highly rewarding and excessive consumption leads to enduring alterations in brain regions involved in learning, memory, and reward. These changes are proposed to drive overconsumption by promoting food-seeking behaviors".

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the improvement of brain functioning, researchers investigated the impact of green pea (GP) supplementation on cognitive performance.

The study included Maze model and Passive avoidance Paradigm served as Exteroceptive Behavioral models induced by Scopolamine and ethanol as amnesic agents were treated by administration of Pisum sativum (PS) at concentrations 2.5% w/w and 5% w/w for 15 successive days.

Based on the tested differentiation, mice treated by Pisum sativum (PS) showed a decrease in transfer latency and an increase in step down latency.

Furthermore, green peas not only ameliorated memory deficits induced by scopolamine and ethanol but a significant increase in brain Glutathione levels,.

Moreover, Pisum sativum (PS) at different concentrations also inhibited brain stress marker observed on declined levels of Malondialdehyde levels and Acetylcholinesterase activity in the brain.

Collectively, researchers said, "Therefore, behavioral effects of PS would be worthwhile in management of cognitive dysfunctions".

Taken altogether, green peas may be considered a functional food for the prevention of cognitive dysfunctions, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of Nootropic Potential of Green Peas in Mice by Sushila Kaura, and Milind Parle. (Journal of Applied Pharmaceutical Science)
(2) Editorial: Impact of Diet on Learning, Memory and Cognition by Amy C. Reichelt,1,* R. Fred Westbrook,2 and Margaret J. Morris. (PMC)

White Button Mushroom Protects the Heart and Blood Vessels Against Cardiovascular Disease (CVD)


Scientists may have found one of the natural food used in many different cultures with potential in reduced risk and protected against CVD.

Cardiovascular disease (CVD) is a group of conditions associated with the abnormal functioning of the heart and blood vessels.

The causes of cardiovascular diseases are associated with certain prevalent risk factors, including metabolic syndrome, diabetes, and prediabetes, smoking, family history, an increase in age and being overweight or obese.

Some researchers suggested that the coincidence of overweight and obesity and cardiovascular diseases has increased proportionally over a few decades probably correlated to the promotion of the Western diet with high fat, salts, and sugar.

Dr. Luma Akil, the lead author in the concerns of the obesity causes of elevated cardiovascular disease (CVD) mortality and morbidity among the American adults conducted an.examination of the associations between the increase in body mass index (BMI) and the increased rates of CVD and high blood pressure (HBP) in the states of Mississippi, Alabama, Louisiana, Tennessee, and Colorado

The study included the data from the Behavioral Risk Factor Surveillance System were obtained and analyzed for obesity rates, percent of myocardial infarction, stroke, and HBP from 2005–2009.

Using regression analysis, researchers found that the highest rates of obesity, CVD, and HBP were found in Mississippi, while Colorado had the lowest rates.

The result suggested that maintaining a healthy weight helps reduce the risks of developing CVD and obesity is among the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity.

In other words, regular consumption of fruits and vegetables is strongly associated with a reduced risk of cardiovascular disease (CVD). Dietary fungi, such as, mushrooms, can protect against chronic disease by altering inflammatory environments through inhibition of cellular processes under pro-inflammatory conditions which are associated with CVD,

Mushroom, a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, contains several important nutrients including Thiamine (Vitamin B1), Riboflavin (Vitamin B2), Niacin (Vitamin B3), Pantothenic acid (Vitamin B5), Calcium, Phosphorus, Potassium, Sodium, Selenium, Iron, Copper and Zinc which are necessary to maintain the growth, body functions as well as protected against chronic diseases.

According to Dr. Martin KR., ergothioneine (ERT), a novel antioxidant, presented in edible mushrooms, accumulated through diet was found effective in interrupting pro-inflammatory induction of adhesion molecule expression associated with atherogenesis(1).

Its antioxidants such as Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, etc. may also consist the magic power in reduced risk and treatment of vary types of cancer, including colon(4), breast and gastric cancers(5) through inhibition of cell cycle arrest, significant suppression of cellular proliferation, in tested cancer cell lines.

These findings showed to support the notion of dietary mushrooms in the protection of CVD, but multi canters and large sample size studies to identify the main ingredients comparable to the current medicine used are necessary to improve its validation.

But, the study of the University of Gdańsk, in the reviews and updates data on macro and trace elements and radionuclides in edible wild-grown and cultivated mushrooms suggested that the coexistence of minerals of nutritional value collected from natural habitats, and co-occurrence with some hazardous elements including Cd, Pb, Hg, Ag, As, and radionuclides should be taken certain precautions(6).

Taken altogether, white button mushroom may be considered a functional food for the prevention and treatment of cardiovascular diseases, depending on the confirmation of the larger sample size and multi-center human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease by Martin KR.(PubMed)
(2) Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment by Martin KR.(PubMed)
(3) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)
(4) Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells Lu-Gang Yu1, David G. Fernig2 an Jonathan M. Rhodes (The Febs Journal)
(5) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR1, Brophy SK.(PubMed)
(6) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)
(7) Fruit and vegetable consumption and all-cause, cancer and CVDmortality: analysis of Health Survey for England data by Oyebode O1, Gordon-Dseagu V, Walker A, Mindell JS.(PubMed)
(8) Seasonal consumption of salad vegetables and fresh fruit in relation to the development of cardiovascular disease and cancer by Cox BD1, Whichelow MJ, Prevost AT.(PubMed)
(9) Intakes of fruits, vegetables and carbohydrate and the risk of CVD by Joshipura KJ1, Hung HC, Li TY, Hu FB, Rimm EB, Stampfer MJ, Colditz G, Willett WC.(PubMed)
(10) Relationships between Obesity and Cardiovascular Diseases in Four Southern States and Colorad by Luma Akil, PhD-C, Candidate and H. Anwar Ahmad, PhD, MBA, MCIS, Faculty. (PMC)

Thursday, January 30, 2020

Green Peas (Pisum Sativum), the Potential Treatment of Colitis

Colitis is a general term associated with the inflammation of the inner lining of the colon.

The disease can be caused by infection, inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.

Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.

Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases have been found to induce both UC and CD.

The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.

Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.

In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.

Some researchers suggested the promotion of a high-fat diet over the past few decades may be one of the most prevalent factors that increase the risk of colitis.

Dr. Max Gulhane, the lead scientist wrote, "Prolonged high-fat diets (HFD) induce low-grade chronic intestinal inflammation in mice, and diets high in saturated fat are a risk factor for the development of human inflammatory bowel diseases".

And, "HFD-induced endoplasmic reticulum (ER)/oxidative stress occurs in intestinal secretory goblet cells, triggering inflammatory signaling and reducing synthesis/secretion of proteins that form the protective mucus barrier".

The finding strongly suggested the mucosal barrier dysfunction induces by a high-fat diet involved in colitis development.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient that processes anti-inflammatory activity with oxidative stress, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD) in an animal model.

The study included Six-week-old C57BL/6J female mice randomly assigned into groups fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, following by colitis induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.

According to the tested analysis, GP supplementation ameliorated the disease activity index score in HFD-fed mice by reducing the expression of pro-inflammatory cytokines.

Furthermore, inflammatory markers associated with inflammatory proteins and enzymes such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS) in HFD-fed mice were also decreased by GP supplement.

Goblet cell differentiation markers in HFD-fed mice.associated with mucus secretion and function during the stage of inflammation were also increased by the administration of GP supplementation.

Furthermore, endoplasmic reticulum (er) stress-induced production of pro-inflammatory cytokines in HFD-fed mice was also inhibited by GP supplement.

Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".

Taken altogether, green peas may be considered a functional food for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)
(2) High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22 by Max Gulhane,1 Lydia Murray,1 Rohan Lourie,1 Hui Tong,1 Yong H. Sheng,1 Ran Wang,1 Alicia Kang,2Veronika Schreiber,1 Kuan Yau Wong,1 Graham Magor,3 Stuart Denman,4 Jakob Begun,1 Timothy H. Florin,1Andrew Perkins,3 Páraic Ó. Cuív,2 Michael A. McGuckin,1 and Sumaira Z. Hasnaina. (PMC)

Ginger, the Potent Free radical Scavenging activities

Ginger may have a potential effect in reducing oxidative stress by inhibiting the overexpression of free radicals as scavengers, some studies suggested.

Free radical is an unstable molecule with the unpaired electron in the outer ring of the atom. In order for them to become stable, free radical is actively to donate or steal an electron from the stable molecules.

Once started, the chain of domino's effect cannot be stopped until the outer ring of the electron is paired or inhibited by the antioxidant.

Free radical scavengers are antioxidants which inhibit the oxidation.

There are 2 types of antioxidants in the body including the antioxidant enzymes produced by the host and dietary sources of antioxidant intake by the host.

Oxidative stress is the expression of the imbalance of the levels of the free radicals and antioxidants in the body.

In other words, oxidative stress can either caused by overexpression of free radicals or low levels of antioxidant enzymes.

A prolonged period of oxidative stress can damage the body tissue, alternated the immune function and cell DNA, leading to the etiology of many chronic health problems including cardiovascular and inflammatory disease, and cancer.

There are many causes of overexpression of free radicals, some researchers suggested that fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more are contributed to the onset of the condition.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding the chemical constituents that constitute the free radical scavenger activity of ginger, a research team at the University of Mysore analyzed the chemical composition and antioxidant activity (in aqueous and solvent extracts) of Ginger root (Zingiber officinale).

During the experiment, application of ethanol, methanol, acetone, 80% methanol and 80% ethanolic extracts to determine free radical scavenging activity, suggesting that the order of antioxidant activity by reducing power and free radical scavenging activity by DPPH was 80% methanolic > 80%ethanolic > methanolic > ethanolic > 30°C water >100°C water > acetonic extract.

These results suggested that ginger efficacy in the inhibition of the free radicals was not attributed to a single ingredient but all members of the antioxidant family.

In the investigation of the free radical scavenger activity of 4 essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger), researchers found
* All prepared ginger essential oils, showed a significant free radical scavenger property

* Essential oil from the seed and air-dried rhizomes demonstrated the highest anti-free radical activity compared to other preparation.

* Essential oil from the seed and air-dried rhizomes also are the better free radical scavenger agents, compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.

* [6]-shogaol, the bioactive compound isolated from the ginger was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.

An additional examination also indicated that ginger oleoresin, and especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals in comparison to essential oils of ginger and other Zingiberaceae plants.

In support of the above differentiation, researchers at the North China Coal Medical College, in the report of "[Scavenging effects of ginger on superoxide anion and hydroxyl radical]" wrote,
"Ginger can significantly scavenge O2-. in hypoxanthine-xanthine oxidase system and.OH in ultraviolet exposure of H2O2 system". and "The scavenging effects of ginger on O2-. and.OH may contribute to explaining some of the pharmacological mechanisms of this drug".


Taken altogether, ginger with the abundant bioactive compound may be considered a free radical scavenger functional food for preventing overexpression of free radical in the initiation of a chain reaction


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) [Scavenging effects of ginger on superoxide anion and hydroxyl radical].[Article in Chinese] by Cao ZF1, Chen ZG, Guo P, Zhang SM, Lian LX, Luo L, Hu WM. (PubMed)
(3) Chemical composition and antioxidant properties of ginger root (Zingiber officinale) (Research Gate)

Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature

Fennel may have a potential and positive effect in excess water and toxin from the body, some scientists suggested.

The result was reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via number of mechanisms.
Diuresis is a medicine in the stimulation of increased production of urine.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted a significant activities in flushing out of excess water and toxin from body through increased kidney function in secretion of the urine.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in the cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the efficacy of fennel powder, extract and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on a standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of the study, researchers found that
* Injected gentamicin group served as control exhibited strong nephrotoxicity manifested by increased levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialdehyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.


Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.


* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes as increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.


* Moreover, the group treated with fennel oil restores the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine compared to another experimental group.


The results of this study clearly indicate that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats' gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to noneffective of Marrubium treated group.


Additionally, in comparison to Marrubium extract in reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.

Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.


Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.


For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)

Wednesday, January 29, 2020

Ginger, the Pungent Spice Which inhibits the Onset and Progression of Arthritis

Scientists may have found a whole food which processes a significant effect in reducing and treatment of arthritis with no side effects, some studies found.

Arthritis is a class of inflammatory diseases that affect the joints.

The most common symptoms of arthritis are joint pain and stiffness.


However, some patients with arthritis may also experience symptoms of redness, warmth, swelling, and decreased range of motion of the affected joints.

The most common causes of arthritis are the improper health of the joint injury in the younger age and infections that affect the integrity of the cartilage.

RA, an autoimmune disorder is a type of arthritis caused by the immune system mistakenly attacks the joints tissues of the body.

The prevalent risk factors associated with the onset of the disease include the increase in age, family history, gender, ethnicity, and obesity.

Some researchers suggested that people who follow the Western diet with high saturated and trans fat, red meat and processed foods and fewer fruits and vegetables and whole grains are also at the increased risk of arthritis.

According to the study published in the journal JCI Insight on April 19, by the University of Rochester Medical Center in New York, after 3 months of feeding mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen, the mice became obese and diabetic and fat percentage was double compared to mice fed with a healthy, low-fat diet.

The contribution of overweight obesity caused by long-term intake of the Western diet may contribute to the link of obesity in the risk of arthritis.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reconfirm the traditional medicine use of ginger for the treatment of chronic inflammatory diseases, the research team at the examine the turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes effect in patients with arthritis rat adjuvant-induced arthritis (AIA) both plants at the dose 200 mg/kg body weight were orally administrated.

Turmeric and ginger exerted a significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing the production of anti-inflammatory and decreasing pro-inflammatory cytokines.

Both turmeric and ginger also restored the antioxidant enzymes in the rats.


In the anti-arthritic activity, turmeric was more effective compared to those of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.


Interestingly, the percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin, respectively.

Dr. the lead author said, after taking into account of co and confounders, "the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model".

The findings indicated a potential effect of ginger against arthritis although to a lesser extent than those of turmeric.

Furthermore, the investigation of the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat collagen-induced arthritis, also found that* Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally significantly enhanced the immune function against the progression of arthritis.

* Continued administration of the said volume for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.

* The anti-arthritis effects were associated with reduced production of proinflammatory cytokines and antibody.

Most importantly, Z. officinale extract at the dose of 200 mg/kg/day was more superior to those of 2 mg/kg/day of indomethacin compared by most of the measured parameters.

Taken altogether, ginger may be used as a functional food for the prevention and combined with primary medicine for the treatment of arthritis


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(2) Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis by Fouda AM1, Berika MY. (PubMed)
(3) Western Diet, With Its High-Fat Content, Linked To ArthritisApr 19, 2018 09:00 AM By Sadhana Bharanidharan, (Medical Daily)

Healthy Food Kale Promotes Bile Acid Binding Naturally Against High Blood Cholesterol

Bile acids synthesized from by oxidation from cholesterol in the liver, flowing to the gallbladder to aid digestion.

Bile acid-binding is a process to interfere with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.

In other words, binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.

By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.

Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 gram/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% compared to high doses of 24 gram/day of only 25%.

In other words, bile acid-binding medicine such as Cholestyramine, used alone are less effective, compared to statins in lowering LDL cholesterol.


The most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.


Bile acid sequestrants such as lovastatin combined with niacin may be used to lower aggressively lower LDL cholesterol levels.

Dr. Gordon Schectman and colleagues in the study published at the American Journals of Cardiology wrote, " Niacin and lovastatin are effective drugs for hypercholesterolemia management in the Veterans Administration Medical Center setting. However, in elderly veterans, bile acid sequestrants were associated with a higher rate of adverse effects limiting compliance, and psyllium was ineffective".

Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe.

Kale's leave is highly nutritious cultivated as foods in most parts of Europe.

On finding a potent compound for the prevention and treatment of hypercholesterolemia, researchers examined the effects of kale bile acid-binding capacity.

The study included the testing of three different compositions of bile acids to establish the optimal dose for bile acid-binding.

Compared to other cruciferous vegetables such as red leaf lettuce, red cabbage, red kale, green kale, and Brussels sprouts, kale showed significantly higher bile acid-binding capacity at 1.5 g sample and remained constant up to 2.5 g.

In kale Comparision, minimally processed (microwaved 3 min or steamed 8 min) green kale showed significantly higher bile acid-binding capacity (91.1 ± 0.3 and 90.2 ± 0.7%, respectively) compared to lyophilized kale (85.5 ± 0.24%).

Furthermore, kale also prevented cholesterol reabsorption into the blood by binding to hydrophobic bile acids, chenodeoxycholic acid, and deoxycholic acid preferably.

These results suggested that kale processes the highest anti hypercholesterolemic activity by binding to bile acids compared to other veggies in the same family.

Based on the findings, researchers said, " regular consumption of kale, especially minimally processed kale, can help excrete more bile acids and, thus, may lower the risk of hypercholesterolemia".

Taken altogether, kale may be considered a functional food for the promotion of bile acid-binding, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In Vitro Bile Acid Binding Capacities of Red Leaf Lettuce and Cruciferous Vegetables by Yang IF1, Jayaprakasha GK1, Patil BS. (PubMed)
(2) Evaluation of the effectiveness of lipid-lowering therapy (bile acid sequestrants, niacin, psyllium and lovastatin) for treating hypercholesterolemia in veterans by Gordon Schectman, Schectmana, Jan Hiatt, Pharm D. Arthur Hartz, MD. (the American Journals of Cardiology)

Button Mushroom's Immunological effects

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.
Nutrients
1. Carbohydrates
2. Protein
3. Thiamine (Vitamin B1)
4. Riboflavin (Vitamin B2)
5. Niacin (Vitamin B3)
6. Pantothenic acid (Vitamin B5)
7. Calcium
8. Phosphorus
9. Potassium
10. Sodium
11. Selenium
12. Iron
13. Copper
14. Zinc
15. Etc.
Chemical constituents
Astraodorol, Psilocybin, Lectin,  ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

Button Mushroom and Immunologic effects
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.
In a number of studies, Mushrooms have been shown to enhance the immune response. according to Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, white button mushroom showed to enhance both innate and T cell-mediated immunity leading to more efficient surveillance and defense mechanism against microbial invasion and tumor development, through the promotion of DC maturation and enhance their antigen-presenting function. (1). A. bisporus polysaccharides isolated from white button mushrooms, exhibited macrophage immunomodulating and antitumor activities, through stimulation of the production of nitric oxide, interleukin-6, and tumor necrosis factor-α via activation of nuclear factor-κB with the production p50/105 heterodimers(2).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Researched articles - Points of view of Vitamins, Foods and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice by Ren Z1, Guo Z, Meydani SN, Wu D.(PubMed)
(2) Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms by Jeong SC1, Koyyalamudi SR, Jeong YT, Song CH, Pang G(PubMed)

Tuesday, January 28, 2020

White Button Mushroom, The Potential Anti Colon Cancer Functional Food, Scientists Say

Scientists may have found an edible mushroom with the potential in reducing risk and treatment of colon cancer, some scientists suggested.

Primary colon cancer is a medical condition characterized the cell growth regularly that starts on the surface of the inner lining tissue of the colon.

After proliferating to the advanced stage, the cancerous cells can dispatch from the original site to infect other healthy tissue and organs far the way from the colon.

The exact causes of colon cancer are unknown. As of today, researchers still wonder, why people with the same health condition, family history, and diet, some are susceptible to the onset of the disease while others do not.

According to the statistic, colorectal cancer(cancer that starts in the colon or rectum) is the third most commonly diagnosed cancer and the second leading cause of cancer death in men and women combined in the United States. About 71% of cases arise in the colon and about 29% in the rectum.


Dr. Milly Ryan-Harshman, in the study of diet and colorectal cancer, suggested, "Whether red meat is a culprit in causing CRC remains unanswered, although any effect it might have is likely moderate and related to processing or cooking"


"The effect of dietary fiber on the risk of CRC has also been difficult to determine because fiber intake is generally low. Evidence that folic acid, calcium, and vitamin D reduce the risk of CRC is stronger"


" In particular, recent research indicates that calcium and vitamin D might act together, rather than separately, to reduce the risk of colorectal adenomas. There might also be an interaction between low folate levels and high alcohol consumption and CRC".


These results indicated a reduced intake of red meat, increase intake of nutrients from the fruits and vegetable including folic calcium and vitamin D are associated with the substantially reduced risk of colon cancer.

However, in the study conducted by the team lead by Dr. Dana-Farber, Cancer Center oncologist Jeffrey Meyerhardt, MD appeared in the Aug. 15 issue of the Journal of the American Medical Association, the Western diet not only associate to the colon cancer risk but also elevate the risk of recurrent colon cancer in colon cancer patients.


Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

It is a genus A. Muscaria and belongs to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.

Chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

Intake of dietary supplementation with Se-enriched white button mushroom can reduce the production of antioxidants produced by the colon tumor by up-regulating the integrity of cell mRNA expression levels.
Se-enriched white button mushroom inhibited the colon cancer cell by stimulating the production of GPx-1 and 2 and anti-antioxidant enzyme activity.
Selenise white button mushroom can positively increase GPx-1 and GPx-2 gene expression and GPx-1 enzyme activity in rat colon cells in the protection of cell DNA alternation due to overexpression free radicals, Dr. Maseko T, the leader in the team at The University of Melbourne suggested at the final report.

The study was published in the United States National Library of Medicine (NLM).

Furthermore, in the reassessment of the 2 epidemiological studies that demonstrated an inverse correlation between mushroom intake and the risk of cancer, researchers launched an investigation to evaluate whether white button mushroom affects the growth of breast and colon cancer cells.

Application of white button mushroom suppressed proliferation of colon cancer (HT-29, HCT-116) cells, without affecting the proliferation of epithelial mammary MCF-10A and normal colon FHC cells.

The inhibition of cell proliferation by the mushroom was associated with the cell cycle arrest at the G0/G1 phase in HT-29 cells.

White button mushroom was also found to the up-regulated expression of p21 in the induction of apoptosis and inhibited Rb phosphorylation, a tumor suppressor protein in HT-29 cells,

The finding confirmed the results from the 2 epidemiological studies that white button mushroom process anti-colon cancer possibility.

Taken all together, dietary white button mushroom intake daily and regularly may have a significant effect in the prevention colon and combined with the primary therapy in the treatment of colon cancer

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(2) Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon by Maseko T1, Howell K, Dunshea FR, Ng K.(PubMed)
(3) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway by Jedinak A1, Sliva D.(PubMed)
(4) Diet and colorectal cancer, Review of the evidence by Milly Ryan-Harshman, Ph.D. RD. (PubMed)

Fennel May Improve Your Heart Functioning Naturally and Permanently, Studies Showed

Fennel may have a potential and positive effect on the improvement of cardiovascular activity, some scientists suggested.

The results of vascular and cardiovascular protective effects were reported by a number of universities including the Birzeit University and published on online medical literature.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc


In the study to investigate the vascular effects of aqueous extracts of Foeniculum vulgare leaves in pentobarbital-anesthetized rats, researchers found that intravenous administration of the lyophilized boiled water extract exerted a significant dose-related reduction in arterial blood pressure, without affecting the heart rate or respiratory rate in compared to histamine antagonists.

However, the application of non-boiled aqueous extract showed very little hypotensive activity.

In contrast to the conventional medicine histamine antagonists, the hypotensive effect of the boiling water extract appeared not to be mediated by adrenergic, muscarinic, ganglionic or serotonergic receptors.


Furthermore, in the examine the cardiovascular effect of the main component of the oil, anethole isolated from on tested guinea pig fennel oil in inhibited arachidonic acid, collagen-, ADP- and U46619-induced aggregation, researchers found that application of anethole displayed comparable NO-independent vasorelaxant activity at antiplatelet concentrations.

Anethole also prevented thrombin-induced clot retraction at concentrations similar to fennel oil in comparison of U46619-induced aggregation (IC(50) from 4 to 147 microg ml(-1)). These results were confirmed in tested mice with application F. vulgare essential oil and anethole in a subacute treatment of 30 mg kg(-1)day(-1) for 5 days.

F. vulgare essential oil and anethole also showed significant antithrombotic activity in prevented paralysis induced by collagen-epinephrine intravenous injection with 70% and 83% protection, respectively.

In the rat model, both F. vulgare essential oil and anethole (100 mg kg(-1) oral administration) provided significant protection toward ethanol-induced gastric lesions.

After taking into account of other co and confounders, together with the collected information Dr. Tognolini M, the lead author said, " F. vulgare essential oil, and its main component anethole, a safe antithrombotic activity that seems due to their broad-spectrum antiplatelet activity, clot destabilizing effect, and vasorelaxant action".


Further to reassess other cardiovascular activity of Foeniculum vulgare L, researchers at the UFR Physiologie-Pharmacologie, launched an investigation to compare the effects of Marrubium vulgare L. and Foeniculum vulgare L. in spontaneously hypertensive rats (SHR).

Interestingly, the oral application of Foeniculum extract exerted lowered the systolic blood pressure of SHR without induced change of normotensive Wistar-Kyoto rats (WKY).

These results were probably associated with the function of Foeniculum in increased water, sodium and potassium excretion.

More importantly, Foeniculum extract hypertensive efficacy was decreased substantially in rat and mice presented with N-nitro-L-arginine.

The results indicated that fennel demonstrated the vascular protective activity as a diuretic and a natriuretic.

Taken together, Fennel and its essential oil and bioactive compound anethole may be considered as a function substance in promoting cardiovascular and vascular activity, particularly in animal models with a high risk of cardiovascular disease.


Intake of fennel extract should be taken with extreme care as overdoses may induce liver toxicity.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis by Tognolini M1, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E.(PubMed)
(2) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
(3) The vascular action of aqueous extracts of Foeniculum vulgare leaves by Abdul-Ghani AS1, Amin R.(PubMed)

Bioactive Cucurbitacin B (CuB) Isolated from Cucumber Harbors Potent Chemopreventive Activity Against Prostate Cancer in Vitro and Vivo

Prostate cancer found mostly in the older men is a chronic condition characterized by irregular cell growth in the prostate tissues caused by the alternation of cell DNA.

Most cases of prostate cancer start in the cells on the surface of the inner lining tissue before penetrating into deeper layers to induce a malignant tumor.

Believe it or not, prostate cancer can be classified into many different types, depending on the type of cell that causes the onset of primary cancer.

* Adenocarcinomas, the most common type of prostate cancer that develops in the gland cells that line the prostate gland.

* Ductal adenocarcinoma, the type of cancer starts in the cells that line the ducts (tubes) of the prostate gland. r

* Transitional cell cancer is cancer that starts in the cells that line the tube carrying urine to the outside of the body (the urethra).
* Squamous cell cancer is found to develop from flat cells that cover the prostate.
* Small cell prostate cancer is found in tissue made up of small round cells.

Prostate cancer can also be classified into different stages

1. Stage 0
If the cancerous cell has not penetrated in deeper tissue but on the surface of the prostate lining.

2. Stage I
In stage I, The cancerous cells are no longer on the surface but have invaded into deep the prostate lining, but still completely inside the prostate.
a. Stage IA1
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.

b. Stage IB:
Cancer in this stage has invaded the connective tissue, & less than 5cm (2 inches).

b.1. Stage IB1: Cancer is 4 cm large (1 3/4 inches).b.2. Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (2 inches)

3. Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the prostate.

4. Stage III
In this stage, cancerous cells have spread to the tissues immediately surrounding the prostate.

5. Stage IV
In this stage, cancerous cells have spread to the tissues immediately outside of the prostate, into other distant parts of the body


The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural and potential ingredient for the treatment of prostate cancer with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables.

In PC-3 and LNCaP prostate cancer cell lines, CuB significantly and specifically inhibited prostate cancer cell growth with low IC50 at a concentration of 0.3 μM.


CuB induced cancer cell apoptosis by modulating the proteins associated with program cell death and pro-apoptotic pathways.

Furthermore, the bioactive compound also increased the accumulation of the Sub-G0/G1 population before exhibiting cell cycle arrest.


According to the results of a chemopreventive model, pre-treatment of mice with CuB(2 weeks before PC-3 prostate cancer cell implantation significantly reduced the rate in vivo tumor-formation.

Moreover, CuB resulted in a 79% reduction in tumor size (accompanied by marked in situ apoptosis) of the treated group without causing noticeable toxicity compared to controls on day 31.


In vitro and in the CuB-chemopreventive mouse model, CuB at a dose-dependent inhibited enzyme ATP citrate lyase phosphorylation associated with cancer cell metabolism.


The findings suggested that CuB harbors potent chemopreventive activity against prostate cancer via a number of mechanisms, without inducing harmful side effects.

Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth by Gao Y1, Islam MS1, Tian J1, Lui VW2, Xiao D. (PubMed)

Monday, January 27, 2020

Fennel, The Potent Food With Cyto-protection and Antitumor Activity

Fennel may have a potential and positive effect in the induction of cytoprotection and antitumor activity against cancer expression, some scientists suggested.

The results of fennel efficacy were reported by several respectable institutes including the National Cancer Institute and National Institute of Health.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc


In the study to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation, researchers found at after 30 days, the application exerted a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at dose of 50 μg/mL for the MCF7 breast cancer cell line and 48 μg/mL for the Hepg-2 liver cancer cell line.



The treatment group also displayed a decreased level MDA and improved natural antioxidants produced by the tissues of the host in comparison to elevation of MDA and significantly reduced levels of catalase and GSH contents.


These results suggested that fennel seed methanolic extract (FSME) inhibited the overproduction of ROS caused by the ingestion of doses of gamma irradiation through its antioxidants and enhanced antioxidants production of the mice tissue via the ratio of ROS and Antioxidants.

In other words, application of the fennel extract may have a potential in

* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.

* Improved natural antioxidants and the oxidative stability of fatty foods during storage.

* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.

Further illustration of the effect of herbal medicine in treatment of cancers and examine the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF, and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.

According to the results of the experiment,

* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81% and 87%, respectively.


* In CWR22R tumors, the application of all supplements exerted a similar effect in the suppression of the cancer cells.

* All applications did not show inhibitory activity against levels of testosterone in comparison to untreated mice. However, supplements PP and FBL101 exerted a significantly reduced VEGF level, a potent angiogenic factor with function in stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.

* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.

Dr. Ng SS, the lead author said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".


The above differentiation was supported by the Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multidrug-resistant (MDR) pathogens and anticancer effects against MCF-7 cell line.


According to the results of the report, the application of Ethanol extract of Foeniculum vulgare exhibited significant inhibition of cancer cell proliferation and induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens, and Methicillin-resistant S. aureus. Pseudomonas aeruginosa


Taken together, fennel and its extracts may be used as a functional food in the exertion of cytoprotection and antitumor activity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2.(PubMed)

Cucumber, the Best Food to Promote Heart Health

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.

Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.

According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting for 1 in 4 deaths.

The most common symptoms of heart disease are poor appetite, weight loss, shortness of breath, sudden collapse, blood clots and stunted growth found in children.

If you have experienced some of the aforementioned symptoms, please check with your doctor to rule the risk of heart disease.

By following a healthy dietary intake, physical activity, weight management, smoking cessation, blood pressure control, and lipid management, most cases of heart disease are preventable.

Dr. Melanie Warziski Turk, in the evaluation of the risk of heart disease in women, wrote, "Because heart disease is frequently preventable, increasing awareness of personal risk and preventative measures is a key element of healthcare for women".

And, "Nurse clinicians can evaluate, educate, and counsel women regarding their risk for this pervasive disease and promote behavior changes that will decrease that risk. Research evidence supports that lifestyle behaviors are the cornerstone of heart disease prevention".

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound for the improvement of heart health, researchers investigated the therapeutic impact of cucurbitacin I on the heart.

According to the tested assay, phenylephrine (PE)-induced muscle cell enlargement and cardiac hypertrophy was inhibited by the pretreatment of the cardiomyocytes with cucurbitacin I.

Furthermore, cucurbitacin I protect the heart connective tissues against the onset of cardiac fibrosis.

More importantly, cucurbitacin I also significantly expressed the heart muscle protective effect by inhibiting the factors associated with the increase of blood pressure.

In order to reveal more information about cucumber anti-cardiac hypertrophy, a leading cause of heart failure, researchers evaluated cucurbitacin B anti-hypertrophy and anti-fibrosis potential both in vitro and in vivo.

Selected mice induced cardiac hypertrophy after 1 week of surgery, were given cucurbitacin B treatment for 4 weeks.

At the end of the experiment, cucurbitacin B demonstrated a strong anti- hypertrophy and anti-fibrosis ability evidenced by decreased heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.

Additionally, the levels of heart systolic and diastolic abnormalities induced by the surgery was also moralized by the application of cucurbitacin B.


Furthermore, gene expressions induced hypertrophic and fibrotic markers, reserved microvascular density in pressure overload-induced hypertrophic mice were also normalized by the injection cucurbitacin B.

Taken altogether, cucumber and its bioactive compound cucurbitacin I and B (CuB) may be used for the improvement of heart health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings by Moon Hee Jeong,# 1 Shang-Jin Kim,# 2 Hara Kang, 3 Kye Won Park, 4 Woo Jin Park, 1Seung Yul Yang, 5 and Dong Kwon Yang. (PMC)
(2) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Yang Xiao, Zheng Yang, Qing-Qing Wu and Xiao-Han Jiang. (Research Gate)
(3) Cardiac Health: Primary Prevention of Heart Disease in Women by Melanie Warziski Turk, PhD, MSN, RN,a Patricia K. Tuite, MSN, RN,b and Lora E. Burke, PhD, MPH, FAHA, FAAN. (PMC)

Carrots, the Veggie Which Normalizes Levels of Blood Glucose in Patient with Hyperglycemia

Carrots may have a profound and positive effect in normalizing the levels of sugar in the blood, some scientists suggested.

Hyperglycemia is a condition characterized by abnormal high levels of plasma glucose circulated in the blood.

The syndrome does not cause any symptom until the levels of sugar are elevated above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L).

Hyperglycemia is considered an early culprit for the onset of type 2 diabetes. Untreated managed type 1 and 2 diabetes that causes prolonged periods of high blood glucose may induce some unpredictable complications, such as nerve, kidney, foot, and eye damage.

If you are diabetic and have fasted and after meal fasting glucose of higher than 130 mg/dL and over 140 mg/dL respectively, you are considered to have the onset of hyperglycemia.

The causes of hyperglycemia are associated with numbers of the factor. However, researchers as of today, do not know why people with the same health condition and family history, are susceptible to the risk of the condition, while others do not.


Some researchers suggested that people who have diabetes skipping or forgetting your insulin or oral glucose-lowering medicine, eat far more carbohydrates compared to the normal intake of insulin and don't take part in the daily exercise are most dangerous to have hyperglycemia.

In comparison to hyperglycemia, prediabetes is a condition in which blood sugar levels are higher than normal but lower than of diabetics.

If you are diabetes, and experiencing symptoms of fruity-smelling breath, persistent gastrointestinal discomforts, shortness of breath and dry mouth, you have hyperglycemia. Please make sure you check with your doctor to rule out the possibility.

In serious cases, some diabetes with hyperglycemia also experience symptoms of confusion, stomach pain, and coma.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the study to investigate the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits in a total of 284 subjects, 133 with a history of diabetes mellitus or 151 with hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n = 151) from among inhabitants of a rural area in Hokkaido, Japan, match with healthy control researchers found that

* The odds ratio (OR) for high HbA1c was 0.49 (95% confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin.

* There are no significant relationships between high HbA1c and intake frequencies of other vegetables and fruits.

These results suggested that carrot and pumpkin have a positive effect in reducing the levels of blood glucose in patients with high HbA1c, compared to the intake of other fruits and vegetables.

Furthermore, in the evaluation of serum carotenoid levels among residents with hyperglycemia who were screened in a health check-up program for the inhabitants living in a rural area of Hokkaido compared with those with normal levels, researchers showed that
* Serum levels of alpha, beta-carotenes, and cryptoxanthin were lower among those with high HbA1c newly detected than among those with a normal level.

* Observation on diabetics who have already been under control in the clinic, showed no significant differences of serum levels of carotenoids, or lipids such as total cholesterol and TBARS compared to other groups

The information indicated that serum carotenoid levels can be used as an indicator of food intake and oxidative stress for the prediabetic condition since newly detected hyperglycemia tends to show lower serum antioxidant levels such as beta-carotene, and higher serum lipid peroxide levels.
Interestingly, researchers after taking other factors into account said, " males who currently smoked and drank alcohol, the intake frequency of carrot or pumpkin was significantly lower for those with high HbA1c than for the others".


Taken all together, people who have diabetes and are at higher risk may want to add a portion of carrot into their daily diet for preventive measures.

Since the studies quoted in this article are observational bases, therefore, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot's anti-hyperglycemic possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Relationship between serum carotenoids and hyperglycemia: a population-based cross-sectional study by Suzuki K1, Ito Y, Nakamura S, Ochiai J, Aoki K.(PubMed)
(2) [A study on serum carotenoid levels of people with hyperglycemia who were screened among residents living in a rural area of Hokkaido, Japan].
[Article in Japanese] by Suzuki K1, Ito Y, Otani M, Suzuki S, Aoki K(PubMed)