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Friday, January 3, 2020

Cruciferous Vegetables Inhibit the Risk and Progression of Prostate Cancer

Cancer is a class of diseases characterized by abnormal cell growth of cells caused by the alternation of prostate cell DNA.

Prostate gland wrapped around the around a tube (the urethra), is a gland of the male reproductive system found in front of the rectum and just below the bladder with a function that produces some of the semen that carries sperm.

Prostate cancer is cancer originating from the inner lining of the prostate gland caused by irregular prostate cell growth. Prostate cancer is a slow-growing cancer. However, they can be deadly in the advanced stage by traveling a distance away to infect other healthy tissue and organs.

Most prostate cancers are found in the yearly annual physical exam, designed for the male at a higher risk of prostate cancer.

The exact causes of prostate cancer are unknown. However, the most common risk factor associated with the onset of the disease is genetic mutation inherited from the parents. mutation of BRCA1 and BRCA2 reserves the function of tumor suppressor genes which normally repair mistakes in a cell's DNA to allow DNA mutation of the prostate cells.

According to the statistic provided by the American Cancer Society, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases in 10 are diagnosed in men aged 65 or older.

The most common symptoms of prostate cancer include frequent urination, weak or interrupted urine flow or the need to strain to empty the bladder. and the urge to urine frequently at night due to the large size of the tumor that suppresses the bladder and the flow of urine.

Some patients may also experience symptoms of blood in the urine, blood in the seminal fluid and pain or burning during urination caused by the tumor that breaks the nearby small veins and nerve cells.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods that process anti-cancer property, researchers investigated the protective effect of sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables against prostate cancers.

According to the tested analysis,
* SF exerted a strong antioxidative and chemopreventive activity by delaying or blocking carcinogenesis, in vivo.

* SF induced biochemical and epigenetic changes, preventing, delaying, or reversing preneoplastic or advanced prostate lesions, associated with the risk of cancer developing through increasing the expression of antioxidant protein NRF2.

* SF activity networks involved in cell death programming through ceratin intrinsic methods of apoptosis by causing cell cycle arrest, mitosis interruption, activation of caspases and mitochondria depolarization.

Based on the evidence, researchers said, "These outcomes encourage the consumption of Brassica specimens, which could be easily achieved by the incorporation of food and vegetables rich in cruciferous isothiocyanates in the diet".

Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the protection of the prostate against cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Cruciferous Vegetables as Antioxidative, Chemopreventive and Antineoplasic Functional Foods: Preclinical and Clinical Evidences of Sulforaphane Against Prostate Cancers by Ferreira PMP1, Rodrigues LARL2, de Alencar Carnib LP2, de Lima Sousa PV2, Nolasco Lugo LM2, Nunes NMF1, do Nascimento Silva J1, da Silva Araûjo L3, de Macêdo Gonçalves Frota K2. (PubMed)

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