Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature

Fennel may have a potential and positive effect in excess water and toxin from the body, some scientists suggested.

The result was reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via number of mechanisms.
Diuresis is a medicine in the stimulation of increased production of urine.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted a significant activities in flushing out of excess water and toxin from body through increased kidney function in secretion of the urine.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in the cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the efficacy of fennel powder, extract and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on a standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of the study, researchers found that
* Injected gentamicin group served as control exhibited strong nephrotoxicity manifested by increased levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialdehyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.


Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.


* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes as increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.


* Moreover, the group treated with fennel oil restores the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine compared to another experimental group.


The results of this study clearly indicate that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats' gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to noneffective of Marrubium treated group.


Additionally, in comparison to Marrubium extract in reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.

Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.


Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)