Get Pregnant Naturally

Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.

Monday, December 31, 2018

Garlic, The Pungent Spice Which Kills Bowel Cancer Cells, Researcher Find

Studies suggested that garlic may have a potential in killing bowel cancer cells before they can spread to form colonization.

Bowel cancer also known as colorectal cancer, is a chronic and medical condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.

Bowel cancer is relatively very common and slowly growing cancer. The progression of cancer and is predictable.

The exact causes of bowel cancer are unknown. researchers as of today do not know why people in the same health condition and age in the same family and similar dietary pattern, some are susceptible to the onset of bowel cancer, while others do not.

However, researchers do know that certain risk factors are associated with the development of the disease, including age, family history

Some researcher suggested that the mutated gene inherited from the parents, certain medical conditions such as inflammatory bowel disease, polyps, obesity are also some of the bowel cancer prevalent risk factors.

A recent study also showed people who smoke and consume high volumes of red meat are also in the elevated risk of the onset of the disease.

Truly, following a healthy diet and active lifestyle can decrease the risk of bowel cancer by 10 folds. Dr. IAIN ROBERTSON, the lead author at the Monash University, in the study "Colorectal cancer, diet and lifestyle factors: opportunities for prevention" wrote " The potential for colorectal cancer risk reduction by decreasing consumption of animal fats, red meat, alcohol, and cigarettes, by increasing physical activity levels, and by increasing intake of fruits, vegetables and dietary fibre".

If you are experiencing symptoms of a change of bowel habits that last longer than one month, persistent rectal bleeding, abdominal pain that does not stop,.and blood in the stool, please check with your doctor to rule out the possibility of bowel cancer.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.

The pungent spice has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

Allicin (diallyl thiosulfinate), is the best-known biologically active component in freshly crushed garlic, found to reduce the risk of bowel cancer through inhibiting bowel cancer cell lines HCT-116, LS174T, HT-29, and Caco-2, via the activity of Nrf2, according to The Hebrew University of Jerusalem.

Nrf2 is a protein that regulates the expression of antioxidant proteins to protect the cells against damage and injury caused by oxidative stress triggered by inflammation.

However, in the colon cancer cell lines, overexpression of Nsf2 can initiate cancer cells apoptosis.

The Chungbuk National University study that uses colon cancer cell (SW620 and HCT116) to investigate whether sulfur compounds thiacremonone isolated from garlic could modulate NF-kappaB activity and thereby induce apoptotic cell death of colon cancer cells, suggested, application of different concentrations ranged from 30 - 150 microg/ml of thiacremonone for the periods from 0 to 48 hour inhibited colon cancer cell (SW620 and HCT116) growth followed by induction of apoptosis in a dose-dependent manner.


Further analysis showed that the efficacy of the novel sulfur compound against colon cancer cell growth and induction of apoptotic cell death was attributed to the compound's function in modulating of NF-kappaB, a protein that controls transcription of DNA, cytokine production and cell survival.

In vitro, intake of garlic and its lipid-based extracts, induced cell cycle arrest, through a fourfold increase in caspase activity (apoptosis) in PC-3 cells when treated at a dose of 0.5 or 1 μg/m and may be considered a potential as promising anticancer agents, including colon cancer.

Dr. Baena R and Dr, Salinas P said, " Dietary factors and lifestyle may contribute to the increasing colorectal cancer (CRC) incidence... Fish consumption may decrease CRC risk by 12% whereas garlic intake is not significantly associated with reduced CRC risk".

In fact, diet represents 30-35% of risk factors that contribute to the onset of cancer, adding garlic in your diet together with the reduction of meat intake can reduce the risk of various cancers, including colorectal cancer

However, in the order to confirm garlic isolated compounds anti bowel cancer efficacy, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W1, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfur compound isolated from garlic in human colon cancer cells by Ban JO1, Yuk DY, Woo KS, Kim TM, Lee US, Jeong HS, Kim DJ, Chung YB, Hwang BY, Oh KW, Hong JT. (PubMed)
(3) Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro by Bagul M1, Kakumanu S1, Wilson TA1,2. (PubMed)
(4) Diet and colorectal cancer by Baena R1, Salinas P2(PubMed)
(5) Diet and cancer: risk factors and epidemiological evidence by Baena Ruiz R1, Salinas Hernández P2.(PubMed)
(6) Colorectal cancer, diet and lifestyle factors: opportunities for prevention by IAIN ROBERTSON, RONA BOUND and LEONIE SEGAL, (Monash University)

The Vegetable Which Boosts The Body's Defense System Against Onset of Diseases, Scientists Reveal

Asparagus may have a profound effect to stimulate immune system fighting against foreign invasion, some scientists suggested.

Immunomodulators are agents that have unique functions to modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.



In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending to the body needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play important roles in helping the immune system defend against viruses and bacteria attacks.

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.


The herb has been used in early times as a vegetable and medicine, because of its delicate flavor and diuretic properties. Asparagus racemosus Linn. (Fam. Liliaceae) is considered as an ethnopharmacologically acclaimed Ayurvedic medicinal plant which may enhance immune function.


Nutrients and chemical constituents
1. Vitamin K
2. Folate
3. Vitamin C
4. Vitamin A
5. Vitamin B Complex
a) Vitamin B1
b) Vitamin B2
c) Vitamin B3
d) Vitamin B6
6. Fiber
7. Manganese
8. Copper
9. Phosphorus
10. Potassium
11. Protein

Its chemical constituents include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.



According to the study, application of an aqueous extract of A. racemosus (ARC) showed a dose-related stimulation of NK cell activity.


More precisely, ARC demonstrated a higher immune stimulatory activity up to 51.8% at a dose of 25 μg/ml.

Furthermore, in the searching for natural immunomodulatory agents where decrease of parasitic burden and simultaneous enhancement of adaptive immunity can be achieved in replacement of current drugs for the treatment of visceral leishmaniasis with side effect of suppressing immune function during the course of infection, researchers at the Panjab University, launched an investigation based on combination of Asparagus racemosus, an immunomodulatory drug, in combination with cisplatin against Leishmania donovani infected BALB/c mice.

Experiential mice were given A. racemosus (650 mg/kg b.wt./day for 15 days, orally) in combination with cisplatin (5 mg/kg b.wt./day for 5 days, intraperitoneally) with an aim to enhance the clearance of parasites determined by Giemsa-stained liver impression smears.

At the end of the study, researchers found that
* Application of combination group achieved increased production of disease resolving Th-1 response (IFN-gamma, IL-2), heightened DTH (delayed type hypersensitivity) response and augmented levels of IgG2a

IFNγ, or type II interferon, a cytokine plays an important role in regulating innate and adaptive immunity against viral, some bacterial and protozoal infections

Interleukin-2 (IL-2), a type of inflammatory cytokine with a function that signals molecule in the immune system plays a critical role to regulate the activities of white blood cells in response to immunity.

Delayed-type hypersensitivity (DTH) is an inflammatory response of immunity that develops within 24 to 72 hours after exposure to an antigen.

IgG2a is an antibody produced during an immune response.
* The combined application not only provided an enhanced protective immune response but also resulted in remarkable improved kidney and liver function. the human detoxed organs.

Moreover, researchers also discovered, the combined application also boosts and restores both cellular and humoral immunity in L. donovani infected BALB/c mice.

Dr. Sachdeva H, the lead author after taking into account  co and confounders said, "....in view of severe immunosuppression in visceral leishmaniasis, a better and effective strategy for optimum efficacy of future antileishmanial drugs would direct not only killing of parasite by the drug, but also simultaneous generation of immunity against the disease".


Taking all together, herbal Asparagus used alone or combined with cisplatin may have a strong effect in boosting the immune system against foreign invasion through immunomodulatory activity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd. by Thakur M, Connellan P, Deseo MA, Morris C, Praznik W, Loeppert R, Dixit VK.(PubMed)
(3) Asparagus racemosus ameliorates cisplatin induced toxicities and augments its antileishmanial activity by immunomodulation in vivo. by Sachdeva H, Sehgal R, Kaur S.(PubMed)

Sunday, December 30, 2018

Yoga In the Prevention and Treatment of Neurological Disorders

Yoga, an integrated form of exercise may be used for reduced risk and treatment of neurological disorders, some scientists suggested.

Neurological disorders are a medical condition characterized by any disorder of the nervous system caused by structural, biochemical or electrical abnormalities.

There are many forms of neurological disorders. The most common types of the disease include neurodegenerative disease, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.

According to the Medical press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy etc) has increased substantially over the past 25 years. These may be results of over 25 years of economic expansion that have increased the living standard of billion of people in the Southeast Asian region.

Today, people who have made a lot of money in that region have abandoned traditional diet with abundant vegetables and fruits and replaced them with the Western diet which is considered as a risk factor of neurological disorders.



A new report from the World Health Organization (WHO) showed that neurological disorders, ranging from epilepsy to Alzheimer disease, from stroke to a headache, affect up to one billion people worldwide. And, An estimated 6.8 million people die every year as a result of neurological disorders.

In Europe alone, neurological diseases cost the health care system estimation of 139 billion euros in 2004.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a review of literature published online, including randomized, controlled trials with yoga as the central component of the intervention, researchers filed the following reports
* 6 selected trial expressed a significant effect of yoga lessons in reduced symptoms and treatment of neurological disorders
* 10 out 13 trials chosen indicated a positive effect in use of yoga as an ancillary treatment of in patients with psychiatric disorders.

Researchers also note that Trials were excluded in this review if yoga was not the central component of the intervention.

These results suggested that long-term participation in yoga affects the adrenal gland of the central nervous system in the production of hormones which have strong implications for stress and anxiety, such as serotonin, adrenaline, and cortisol.

Furthermore, yoga meditation and posture also enhanced blood circulation to the central nervous system, thus reducing the risk of neurological disorders.


Also in the review of article used comprehensive scientific, evidence-based studies to analyze the efficacy of various basic and applied aspects of yoga in disease prevention and health promotion, particularly in neurological disorders from various resources including PubMed, Ovid, MD-Consult, USC, and U.C.L.A. libraries, researchers at the USC, after adjusting to other co confound factors, indicated that patients who participated in the class of yoga demonstrate statistically encouraging physiological and psychological improvements in the aforementioned neurological disorders.

Additionally, in the investigate promotion of mind-body medicine for health promotion, disease prevention and as a possible treatment modality for neurological disorders, researchers at the S-VYASA University performed a comprehensive search in the PubMed/Medline found that 94 out of 700 examine demonstrated a strong improvement in patients with various neurological disorders

Martin Jones, the lead author in the article of Yoga for Neurological Health, For those with MS, Parkinson's, or Other Neurological Disorders wrote, " (Yoga) Exercises that train neuromuscular coordination, as well as draw vitality and strength to all parts of the body" and "Techniques to draw on the healing aspects of the parasympathetic (“rest and repose”) nervous system and meditation to retrain the brain and create more efficient pathways to the pre-frontal lobes, the most highly evolved part of our nervous system, where we experience our most inspired, creative thinking and elevated levels of consciousness".


Base on information collected, there is no doubt that yoga may be considered as a secondary form of exercise used conjunction with the standard application for reduced symptoms and treatment of neurological disorders


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Yoga as an ancillary treatment for neurological and psychiatric disorders: a review by Meyer HB1, Katsman A, Sones AC, Auerbach DE, Ames D, Rubin RT.(PubMed)
(2) The therapeutic value of yoga in neurological disorders by Mishra SK1, Singh P, Bunch SJ, Zhang R.(PubMed)
(3) Evidence based effects of yoga in neurological disorders by Mooventhan A1, Nivethitha L2(PubMed)
(4) Yoga for Neurological Health, For those with MS, Parkinson's, or Other Neurological Disorders, Led by Maitri Jones

Friday, December 28, 2018

How to Protect Your Stomach Against Onset of Atrophic Gastritis and Gastric Cancer

Scientists may have found a whole food which has a unique function in protecting the stomach against the onset of atrophic gastritis and gastric cancer, some studies suggested.

Atrophic gastritis is a condition of loss of gastric glandular cells caused by long-term inflammation of the stomach mucous membrane (mucosa).

Loss of the gastric glandular cells in the long term eventually is replaced by intestinal and fibrous tissues.

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.

Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.

If you experience some of the above symptoms, please see your doctor to rule out gastric cancer possibility.

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

In vitro, with an aim to find the natural ingredient from food sources for treatment of atrophic gastritis and gastric cancer without inducing adverse effects, researchers conducted an experiment, including 5-8 week-old Mongolian gerbils inoculated with Helicobacter pylori for four weeks without (atrophic gastritis group) or with N'-methyl-N'-nitro-N-nitroso-guanidine (MNNG) (gastric cancer group) in drinking water, and were then rested for two weeks.

During the 7th-32th (atrophic gastritis group) or the 7th-52th (gastric cancer group) weeks were given various doses (0-60 mg/kgbw/day) of apigenin, a major bioactive compound isolated from celery.

Observation at the end of the 32th (atrophic gastritis group) or the 52th (atrophic gastritis group) week, after sacrificing, researchers found that
*Application of Apigenin at the doses range from 30-60 mg/kgbw/day effectively decreased atrophic gastritis (atrophic gastritis group) and dysplasia/gastric cancer (gastric cancer group).

* Apigenin treatment (60 mg/kgbw/day) significantly decreased Helicobacter pylori colonization and Helicobacter pylori-induced histological changes of neutrophil and monocyte infiltrations and atrophic gastritis in both atrophic gastritis and gastric cancer.


These results suggested that apigenin isolated from celery processes a remarkable ability to inhibit Helicobacter pylori-induced atrophic gastritis and gastric cancer progression as well as possessing potent anti-gastric cancer activity.


Additionally, the study in finding of natural compound which processes mechanisms of apoptosis in tumor cells for tumor therapy and cancer molecular biology and inhibits loss of cell cycle control, leading to uncontrolled proliferation in healthy cells, suggested that celery seed extract (CSE), in a dose- and time-dependent manner, exhibited anti-proliferation effect on human gastric cancer BGC-823 cells, through cell cycle arrest and apoptosis-related proteins.

Dr. Gao LL, the lead scientist said, at the end of the experiment, "The molecular determinants inhibition of cell proliferation, as well as apoptosis of CSE, may be associated with cycle arrest in the S phase".

Furthermore, Celery seed oil, in benzo[a]pyrene- (BP) induced forestomach cancer in mice, the chemical constituents. 3-n-butylphthalide and sedanolide showed to reduce tumor incidence from 68% to 30% and 11%, and 67% and 83% in tumor multiplicity, respectively.

These results suggest that phthalides, as a class of bioactive natural products occurring in edible umbelliferous plants, may be effective chemopreventive agents for cancer.

Moreover, in the differentiation of the nutritional epidemiology of gastric cancer in 293 cases and neighborhood-, age-, and sex-matched controls in communities throughout the counties of Niagara, Monroe, and Erie in western New York researcher discovered that ingestion of carotene from raw vegetables (including celery, cucumbers, carrots, green peppers, tomatoes, and onions), as well as with the increased use of low-temperature food storage exerts a significant inhibition of oxidation products that could act as carcinogens in the stomach.

Taken altogether, celery whole food and celery seed containing high amounts of bioactive Apigenin and phthalide respectively may be used to prevent and treat atrophic gastritis and gastric cancer without no adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils by Kuo CH1, Weng BC2, Wu CC3, Yang SF4, Wu DC5, Wang YC(PubMed)
(2) Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line by Gao LL1, Feng L, Yao ST, Jiao P, Qin SC, Zhang W, Zhang YB, Li FR(PubMed)
(3) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK(PubMed)
(4) Diet in the epidemiology of gastric cancer by Graham S1, Haughey B, Marshall J, Brasure J, Zielezny M, Freudenheim J, West D, Nolan J, Wilkinson G.(PubMed)

Thursday, December 27, 2018

Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Revealed

Fennel may have a potential and positive effect of eliminating excess water and toxin from our body, some scientists suggested.

Diuresis is a medicine with a function to stimulate increased production of urine.

Detoxification is a process of eliminated toxin accumulation from our body. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lung.

According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances which may reduce or cause harm to our body organs and tissue.

According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote,  " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".

Truly, harmful and toxic substances not removed from our body may have substantially negative implication to cause of many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...


Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in the cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the efficacy of fennel powder, extract and oil on gentamicin-induced nephrotoxicity through a study of total 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of the study, researchers found that

* Injected gentamicin group served as control exhibited a strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.

Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by imbalanced of the ratio of ROS and antioxidants in the host.

* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts.

Furthermore, the applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.

* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and confounders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulated kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.

The results of this study clearly indicate that fennel powder, extract and oil are potent antioxidants which ameliorate the levels of gentamicin-induced nephrotoxicity in rats.

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium and potassium excretion in compared to no effect of Marrubium treated group.

Additionally, in compared to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.

Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.

Taken together, fennel and its extracts may be considered as a kidney detoxed functional food in getting rid of body toxins through its diuretic activities.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)

Wednesday, December 26, 2018

The Herb Which Speeds Up Bruise Healing, Scientists Reveal

Herbal Arnica may process property of speeding bruise healing without inducing adverse effects, some studies suggested.

A bruise is a condition characterized by black and blue marks on the skin due to trauma, caused by an object or force strikes the body, leading to damage to capillaries and sometimes venules that allow blood to seep, hemorrhage, or extravasate into the surrounding interstitial tissues.

A bruise can also be induced by surgery caused by instruments which pierce into the deep layer of the skin to create an opening.

Most Bruising resolves themselves in a few days or weeks.

Some bruise may cause pain but the pain usually goes away when the color of the area fades away.

Bruising, also known as a contusion, is defined as a condition of

Some researchers suggested that
Most common causes of bruising are sport related.

Sport physical activities can sometimes cause broken bones, strains and sprains, dislocations, torn tendons,..... and muscle swelling. Overuse of body muscles in sport is one of risk factor that can cause, inducing bruising.

Ice and heat therapies by Appling ice or heat immediately after the injury to reduce blood flow around the area. were found to be effective in preventing bruising.

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The herb has been used in traditional medicine for centuries to treat strains, sprains, and bruises.

The chemical ingredients besides major bioactive compound helenalin, Anica also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside,..... and six dibenzylbutyrolactol derivatives.

In the assessment of the comparative utility of topical formulations in hastening the resolution of skin bruising, researchers at the Northwestern University, conducted a double (patient and rater) blinded randomized controlled trial with numbers of healthy volunteers, age range 21-65 years.

After four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). on each subject, each bruising area was injected by one topical agent, including 5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum, twice a day for 2 weeks.

At the end of the 2 weeks experiment, researchers found that
* All four treatment score a significant improvement in the change in the rater bruising score.

* The mean improvement associated with 20% arnica was greater than with white petrolatum (P=0·003), and the mixture of 1% vitamin K and 0·3% retinol.

* However, 5% vitamin K cream processes the highest bruise healing score compared to other applications.

These results suggested that topical 20% Arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

In a double-blind, placebo-controlled, randomized trial with three parallel arms to reaffirm Arnica efficacy in the control of bruising, reducing swelling and promoting recovery after local trauma, 64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic Arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery.

According to the summary of the experiment final report, researchers showed

* There were no group differences on the primary outcome measures of pain (P=0.79) and bruising (P=0.45) at day four.

* Swelling and use of analgesic medication also did not differ between arnica and placebo groups.

* Adverse events were reported by 2 patients in the arnica 6C group, 3 in the placebo group and 4 in the arnica 30C group.

These results strongly indicated that Arnica does not process analgesic property.

Moreover, in the study to assess Arnica decreases bruising and muscle pain efficacy, the Memorial Family Medicine Residency Program conducted a randomized, double-blind, placebo-controlled trial including 53 subjects.

Measurement of ankle range of motion and muscle tenderness were also recorded during Leg pain induced by calf raises.

Then, each participant received 2 tubes of cream, 1 with active Arnica and 1 with placebo.

The creams were applied to the lower legs immediately after the exercise, and again at 24 and 48 hours post-exercise according to the "RIGHT" or "LEFT" labels.

At 48 hours post-exercise, subjects had their ankle range of motion and muscle tenderness measured.

Subjects used the analog scale to rate pain in each leg at baseline, 24 hours, 48 hours, and 72 hours.

At the final day of study, by analyzing the reported returned by participants, scientists found that

* No significant differences in pain scores were seen before exercise.

* Pain scores on legs treated with Arnica were higher than scores on those receiving placebo 24 hours after exercise respectively.

* Pain scores on day 3 and day 4 were not significantly different.

* There was no difference in muscle tenderness.

* Ankle range of motion did not differ significantly on either day 1 or day 3.

Dr. Adkison JD, the lead author suggested, Arnica may increase pain in the affected area within 48 hours immediately after application.



Taking all together, herbal Arnica may be used as a therapeutic treatment for speeding up bruise healing however, patients should be aware that topical application of herbal Arnica does not process analgesic property. In some cases, it may increase pain in the affected area.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
2. Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. by Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M.(PubMed)
3. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. by Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(Pubmed)
4. The effect of topical arnica on muscle pain" by Adkison JD, Bauer DW, Chang T., (PubMed).
5. Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?" by Paulsen E, Chistensen LP, Andersen KE., (PubMed)
6. Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S., (PubMed)

Tuesday, December 25, 2018

The Bioactive Phytochemical Allyl isothiocyanate Which Stops Prostate Cancer Cells From Proliferating



Phytochemicals may be next potential sources of new medications for the treatment of diseases with little or no side effects, some scientists suggested.

Phytochemicals, the natural chemical constituents formed the plants outer's color protect the plants against environmental threats like predator insects, pollution and disease.

Although they are important to sustain plants life, phytochemicals are truly non-essential nutrients.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in cruciferous vegetables, horseradish, mustard, wasabi, etc.

Prostate cancer is a chronic and medical characterized by cells growth disorderly and irregularly in the prostate tissue. In most cases, change of DNA starts in the cells on the prostate surface.

At the advanced stage, cancerous cells can travel a distance away from the original site to infect other healthy cells of the tissue and organs through fluid and blood circulation.

Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

In an aim to reaffirm the effects of allyl isothiocyanate (AITC), a constituent of cruciferous vegetables inhibiting survival of PC-3 and LNCaP human prostate cancer cells in culture, researchers at the University of Pittsburgh School of Medicine launched an investigation to examine whether allyl isothiocyanate (AITC) administration retard growth of human prostate cancer xenografts in vivo.

Bolus i.p. injection of 10 micromol AITC, three times per week (Monday, Wednesday and Friday) to experimental human prostate cancer xenografts beginning the day of tumor cell implantation was carried out for 26 days.

At the final report of the study, researchers found that

* The application exerts a significant effect to inhibit the growth of PC-3 xenograft

* Mice treated with AITC shows a statistically significant increase in the number of apoptotic bodies, using the histological analysis of tumors excised at the termination of the experiment.

* AITC-treated mice induces approximately 70% reduction in the levels of anti-apoptotic protein Bcl-2 in the tumor lysate, compared with that of control mice, according to Western blot analysis.

After taking into account of other co and confounders, researchers wrote, " (AITC shows a) Statistically significant reduction in the expression of several proteins that regulate G2/M progression".

Furthermore, in cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cells, the injection of allyl isothiocyanate (AITC), also significantly inhibits proliferation of all cancer cell lines in a dose-dependent manner with an IC(50) of approximately 15-17 micro M.

Moreover, researchers also discovered that survival of a normal prostate epithelial cell line (PrEC) was minimally affected by AITC even at concentrations that were highly cytotoxic to the prostate cancer cells and AITC reduces proliferation of PC-3 as well as LNCaP cells correlated with accumulation of cells in G(2)/M phase and induction of apoptosis.

These results suggested that AITC, and possibly other ITCs, may find use in the treatment of human prostate cancers.

Taken altogether, phytochemical allyl isothiocyanate (AITC) found abundantly from the cruciferous vegetables, horseradish, mustard, wasabi may be considered as function supplement for treatment of prostate cancer, pending to the results of further large sample size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV. (PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis by Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV. (PubMed)

Monday, December 24, 2018

16 Remarkable Health Benefits of Herbal Aloe Vera, Scientists Revealed



Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.

The herb has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

It is also one of many popular herbs studied in scientific ways with some conflicting results.

The Ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

1. Acne Vulgaris
There are many types of skin diseases in this world, the most common one is acne.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body.

If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins.


Ance vulgaris, one of the skin diseases with areas of scaly red skin with seborrhea, blackheads, and whiteheads.

Aloe vera one of many herbs has been studied and researched in the pharmaceutical world, because of the common problem to the young ages and commercial profits.

The study to compare the efficacy and safety of the combination of tretinoin (TR) cream (0.05%) and Aloe vera topical gel (50%) with TR and vehicle, has been well tolerated and significantly more effective than TR and vehicle for the treatment of mild to moderate acne vulgaris and with less side effects.

Other researchers in the observation of traditional medicines of many cultures used to treat skin diseases, indicated that certain ingredients, including aloe vera, have been identified in the treatment of psoriasis and atopic dermatitis,



2. Skin diseases
Skin diseases are defined as a condition of skin damage and classified according to each pathogenic causes of diseases.

In the systematic review of Aloe vera's clinical effectiveness, topical application of aloe vera is not an effective preventative for radiation-induced skin injuries, but might be effective for genital herpes and psoriasis.

In support to the above, the study by Feily A, Namazi MR. indicated that topical application of aloe vera is not effective in sunburn or suntan protection, but might be effective in treating genital herpes, psoriasis, human papillomavirus, seborrheic dermatitis, aphthous stomatitis, xerosis, lichen planus, frostbite, burn, wound healing and inflammation.


3. Aloe vera and Irritable bowel syndrome
Irritable bowel syndrome is defined as a condition, if a patient is diagnosed with abdominal pain or discomfort, bloating, and alteration of bowel habits at least three times a month for the last 3 months without preexistence of other diseases.

Aloe vera (AV) has long been suggested by herbal medicine in treating irritable bowel syndrome (IBS) symptoms.

In the comparison of the effectiveness of a mixture of Aloe vera (AV) and Matricaria recutita (German chamomile, GC) in treating Irritable bowel syndrome, GC inhibited only small bowel transit while the AV/GC mixture delayed gastric emptying at the doses of 150 and 300 mg/kg. The AV/GC mixture also reduced colonic transit and small bowel transit at the dose of 150 mg/kg.

In other randomized double-blind placebo-controlled trial of to test the effects of aloe vera for irritable bowel syndrome, researchers found that there is no evidence that AV benefits patients with IBS and superior to placebo in improving quality of life in irritable bowel syndrome patients.

But in 49 completed the protocol to 1 month and 41 to 3 months studies, aloe vera (AV) is effective in eleven of thirty-one (35%) AV patients and 6 of 27 (22%) placebo patients responded at 1 month (p = 0.763).

Diarrhoea-predominant patients showed a trend towards a response to treatment at 1 month (10/23 V 2/14, p = 0.07).


4. Psoriasis
Psoriasis is a chronic condition of inflammatory skin disease, affecting the joints and mostly happens to people who are obese are predisposed to diabetes and heart disease.


Many herbal extracts have been used as topical management of plaque psoriasis, including Aloe vera based on multiple studies.

Aloe vera gel is used in alternative medicine over the century for the treatment of skin diseases, including psoriasis.

And a recent study showed that ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness and an overall antipsoriatic activity of high effective rate.

In the comparison of comparison to evaluate the efficacy of topical aloe vera (AV) and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis, AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis.

Unfortunately, in diverse dermatologic conditions, even though there are some promising results with the use of aloe vera, but the clinical effectiveness of oral and topical aloe vera may require further studies, according to the study of Dr. Feily A, and Dr. Namazi MR.


5. Gingivitis
Gingivitis is defined as a condition of Inflammation of Gum Diseases.

Aloe Vera anti-inflammatory property may be the result of the plant used in the treatment of gum diseases.

In the study of 45 patients diagnosed with plaque-induced gingivitis were included, aloe mouthwash is proven to be the most potential in a reduction of gingival inflammation caused by plagues.

In the randomized, controlled, and double-blind study, a total of 148 systemically healthy subjects, showed a statistically significant decrease in PI, MGI, and BI scores after the rinse regimen began in comparison with the use of chlorhexidine.

But Dr. de Oliveira SM and the research team in comparison of Aloe vera and fluoridated dentifrice found that there was a significant reduction on plaque and gingivitis in both groups, but no statistically significant difference was observed among them (p>0.01).

Aloe vera did not show any additional effect on plaque and gingivitis control compared to the fluoridated dentifrice.



6. Gastric Ulcers
Gastric ulcer is a condition of localized tissue erosion in the lining the stomach. as a result of bacteria Helicobacter pylori (H pylori) in most cases.

Some people with gastric ulcers may be not experiencing any symptoms at all, while others may experience burning pain, severe nausea, and vomiting.

In the comparison of the effects of aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels, and gastric ulcer healing, researchers showed that aloe vera reduces leukocyte adherence and TNF-alpha level, elevate IL-10 level and promotes gastric ulcer healing.

Because of its anti-inflammatory effects, treatment of A. vera processes the enhancement in leukocyte-endothelium interaction associated with a reduction in TNF-alpha level.

In the study of acute gastric mucosal lesions induced by 0.6 M HCl and acid output, scientists indicated that aloe vera is endowed with gastric acid anti-secretory activity and could protect the gastric mucosa at low concentrations against injurious agents.

Other components of aloe vera, the polymer fraction (Avpf; molecular weight cut-off ≥50 kDa; 150 mg/kg body weight, p.o.), reduces 50% of the mRNA expressions of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS), according to the study.


7. Wound Healing
Wound healing is the natural process of skin repair after it was damaged

In a systematic review, there is cumulative evidence support that aloe vera might be an effective intervention used in burn wound healing for first to second-degree burns as the use of aloe vera shortens the healing time.

In acute and chronic wounds, although there is an absence of high-quality clinical trial evidence to support the use of Aloe vera topical agents or Aloe vera dressings as treatments for acute and chronic wounds, but some studies found the reduction in healing time with Aloe vera was noted after haemorrhoidectomy (RR 16.33 days, 95% CI 3.46 to 77.15) and application of Aloe vera cream on the surgical site is effective in reducing postoperative pain both on resting and during defecation.

In a study of a herbal gel of Aloe vera extract containing Carbopol 93, shows a promising effect on the wound healing process.


8. Immunity
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

It does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In the study to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. In the pharmacological study of Aloe arborescens Miller leaf components,

The Aloe extract (1.2 mg ml(-1)) acted as a powerful immune stimulant in LPS- or poly I:C-activated SAF-1 cells, inducing a synergic effect on interconnected genes that are expected to be involved in different aspects of the immune responses.

Aloe polymannose, a chemical compound found in Aloe Vera, also enhances the cognitive and immune functioning in patients of Alzheimer's disease by decreasing tumor necrosis factor-α, vascular endothelial growth factor, and interleukins-2 and-4.

9. Aloe Vera and Type II Diabetes
Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.

It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

As a popular herbal remedy in the United Kingdom, oral administration of aloe vera might be a useful adjunct application for lowering blood glucose in diabetic patients as well as reducing blood lipid levels in patients with hyperlipidemia.

In another study of Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus, oral administration of PAG for 8 weeks was found to balance circulating blood glucose concentrations to a normal level in these DIO mice.

The herbal leaf is also found to be useful for treating diabetes. A study said A. vera leaf pulp extract showed hypoglycemic activity on type I (IDDM) and type II (NIDDM) diabetic rats, in comparison with glibenclamide.

On the contrary, A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats.

10. Aloe Vera and Cancers
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Aloe-Emodi, a chemical compound found in Aloe vera, specifically suppresses breast cancer cell proliferation by targeting ER α protein stability through distinct mechanisms may be used as a possible application of anthraquinones in preventing or treating breast cancer in the future.

Also in another study, Aloe-Emodi is considered as a potential value for the treatment of gastric cancer and cervical cancer because of its mechanisms of inducing cell cycle interruption, differentiation.

Radiotherapy is most often used to treat head and neck cancer patients. In a study of Aloe Vera, Dr. Ahmadi A. found that oral Aloe vera mouthwash not only prevents radiation-induced mucositis but also reduces oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.


11. Aloe Vera and Skin Aging
Aloe Vera Supplementation has long been used to promote anti-skin aging by cosmetic industrials.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cells, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA, etc., leading to aging of the organisms,

The widespread od skin damage is a result of free radical inducing a set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

Free radicals oxidative effects can also speed up the skin aging process.

30 healthy female subjects over the age of 45 in the study were given 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin, researchers found that the facial wrinkles improve significantly (p<0.05) in both groups, and facial elasticity also improve in the lower-dose group.

In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group.

In UVB-induced skin photoaging in vitro, aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect in blocking UVB rays in normal human dermal fibroblasts (NHDFs).

As an anti-inflammatory agent, aloe vera, has been identified as beneficial in the treatment of psoriasis and atopic dermatitis.

12. Aloe Vera and Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and effecting fertility.

The syndrome affects over 5% of women population or 1 in 20 women.

According to the study by Desai BN, Maharjan RH, Nampoothiri LP. almost 70% of PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

Several classes of pharmacological agents have been used to manage dyslipidemia. However, studies have shown adverse effects associated with these drugs.

Aloe Vera may be a potential herb for treating Polycystic Ovarian Syndrome by enhancing the reductions of plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol or by restoring the ovarian steroid status.

According to the study of PCOS was induced in Charles Foster female rats by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days), AVG treated PCOS rats exhibited significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol.

The Aloe Vera gel treatment also induces reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities, bringing them to normal.

Another study also indicated that Aloe vera gel formulation exerts a protective effect against the PCOS phenotype by restoring the ovarian steroid status and altering key steroidogenic activity.

Dr.Pérez YY and the research team in the study of the effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice also indicated that the gel decreases significantly both body weight (p < 0.008) and blood glucose levels.

Also in the confirmation of above result, the study of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models, vera leaf pulp extract showed hypoglycemic activity on IDDM and NIDDM rats.

The effectiveness is in comparison with glibenclamide.

13. Aloe vera and breast cancer
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases that breast cancer may start in other areas of the breast.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.


Aloe-Emodin, chemical components found in Aloe-vera and other herbs such as rhubarb, have been researched for treatment of certain kinds of diseases, including cancers.

The efficacy of the components is found to inhibit breast cancer cell proliferation by downregulating ER α protein levels, thereby suppressing ER α transcriptional activation.

In the study of another constituent, a natural anthracycline from Aloe plant found to exhibit the cytotoxic activity against two human breast cancer cell lines; without (MCF-7) and with (SKBR-3) erbB-2-topoIIalpha amplification.

14. Aloe vera and prostate cancer
Prostate cancer is a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Aloe-emodin, an anthraquinone presented in aloe latex from the aloe plant has been found to suppress breast cancer cell proliferation through ER α Inhibition.

In prostate cancer study, the phytochemical inhibited both proliferation and anchorage-independent growth of PC3 cells by targeting mTORC2 as mTORC2 which plays an important role in PC3 androgen-refractory prostate cell proliferation and anchorage-independent growth.

15. Aloe vera and colon cancer
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.

Aloe-emodin (AE), found in Aloe vera has been suggested to have antiproliferative activity in various cancer cell lines in many studies.

In the study of colon cancer, AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6, depending on caspase-

Another study on colon cancer also showed efficacy of AE in suppressed the nuclear translocation and DNA binding of NF-κB, which is an important transcription factor for controlling MMP-2/9 and VEGF gene expression.

16. Aloe vera and lung cancer
Lung cancer is a condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancers is derived from epithelial cells.

In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.

Aloe-emodin has been studied extensively through the scientific community for their effects against cancer by induced apoptosis in lung carcinoma cell lines CH27 (human lung squamous carcinoma cell) and breaking of DNA strands (DNA ladders and sub-G(1) formation) and regulating of the expression of Bcl-2 family proteins (a suppressor of apoptosis).

In the study of the effects of aloe-emodin-induced cell death in the human lung nonsmall cell carcinoma cell line H460, aloe-emodin exerts a significant activity in regulating apoptotic cell death through the class of mitogen-activated protein kinases(p38).

These results suggested that aloe-emodin found in Aloe Vera may be a potential agent for preventing and treating lung cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. by Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A.(PubMed)
(4) Innovations in natural ingredients and their use in skin care. by Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(5) Oral aloe vera-induced hepatitis(PubMed)
(6) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(7) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(8) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(9) Aloe vera: a systematic review of its clinical effectiveness by Vogler BK, Ernst E. (PubMed)
(10) Aloe vera in dermatology: a brief review. by Feily A, Namazi MR (PubMed).
(11) Oral aloe vera-induced hepatitis(PubMed)
(12) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

(13) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)

(14) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(15) Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects by Asadi-Shahmirzadi A, Mozaffari S, Sanei Y, Baeeri M, Hajiaghaee R, Monsef-Esfahani HR, Abdollahi M.(PubMed)
(16) Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome.
Davis K, Philpott S, Kumar D, Mendall M.(PubMed)
(17) A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life by Hutchings HA, Wareham K, Baxter JN, Atherton P, Kingham JG, Duane P, Thomas L, Thomas M, Ch'ng CL, Williams JG.(PubMed)
(18) Oral aloe vera-induced hepatitis(PubMed)
(19) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(20) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(21) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(22) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis. by Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(23)A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)
(24) Aloe vera in dermatology: a brief review by Feily A, Namazi MR.(PubMed)
(25) Oral aloe vera-induced hepatitis(PubMed)(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(26) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(27) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(28) Aloe vera: It's effect on gingivitis by Ajmera N, Chatterjee A, Goyal V.(PubMed)
(29) A randomized, double-blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse by Chandrahas B, Jayakumar A, Naveen A, Butchibabu K, Reddy PK, Muralikrishna T.(PubMed)
(30) Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans by de Oliveira SM, Torres TC, Pereira SL, Mota OM, Carlos MX.(PubMed)
(31) Oral aloe vera-induced hepatitis(PubMed)(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(32) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(33) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(34) Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats, by Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D.(PubMed)
(35) Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats by Prabjone R, Thong-Ngam D, Wisedopas N, Chatsuwan T, Patumraj S.(PubMed)
(36) The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats by Yusuf S, Agunu A, Diana M.(PubMed)
(37) Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions.
Park CH, Nam DY, Son HU, Lee SR, Lee HJ, Heo JC, Cha TY, Baek JH, Lee SH.(PubMed)
(38) Oral aloe vera-induced hepatitis(PubMed)
(39) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

(40) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)

(41) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(42) The efficacy of aloe vera used for burn wound healing: a systematic review.
Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(43) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)
(44) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)
(45) Formulation development, optimization and evaluation of aloe vera gel for wound healing.
Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)
(46) Oral aloe vera-induced hepatitis(PubMed)
(47) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(48) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(49) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(50) The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. by Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA.(PubMed)
(51) Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line. by Picchietti S, Bernini C, Belardinelli MC, Ovidi E, Taddei AR, Guerra L, Abelli L, Fausto AM.(PubMed)
(52) The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. by Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, Woolger JM, Ali KH.(PubMed)
(53) Oral aloe vera-induced hepatitis(PubMed)
(54) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(55) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(56) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(57) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK, Ernst E.(PubMed)
(58) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.(PubMed)
(59) Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N.(PubMed)
(60) Oral aloe vera-induced hepatitis(PubMed)
(61) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(62) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(63) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(64) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(65) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(66) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(67) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(68) Oral aloe vera-induced hepatitis(PubMed)
(69) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(70) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(71) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(72) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH.(PubMed)
(73) A Comparative Study of Baby Immature and Adult Shoots of Aloe Veraon UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY.(PubMed)
(74) Innovations in natural ingredients and their use in skin care.
Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(75) Oral aloe vera-induced hepatitis(PubMed)
(76) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(77) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(78) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(79) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model (PubMed)
(80) Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice (PubMed)
(81) Oral aloe vera-induced hepatitis(PubMed)
(82) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(83) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(84) Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: topoisomerase IIalpha coamplification by Esmat AY, Tomasetto C, Rio MC.(PubMed)
(85) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(86) Oral aloe vera-induced hepatitis(PubMed)
(87) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(88) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double-blind placebo-controlled study(PubMed)
(89) Oral aloe vera-induced hepatitis(PubMed)
(90) Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2) by Lin SY, Yang JH, Hsia TC, Lee JH, Chiu TH, Wei YH, Chung JG. (PubMed)
(91) Aloe-emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells by Suboj P, Babykutty S, Srinivas P, Gopala S.(PubMed)
(92) Aloe-emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB, and VEGF via reduced DNA binding activity of NF-κB by Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S.(PubMed)
(93) Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
Lee HZ, Hsu SL, Liu MC, Wu CH. (PubMed)
(94) Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. by Yeh FT, Wu CH, Lee HZ(PubMed