Seborrheic keratosis is a common skin disorder in older adults with appearance a brown, black or light tan growth on the face, chest, shoulders or back.
Although the disorder is painless and required no treatment, the seborrheic keratosis may annoy some people if they develop in the face areas.
The causes of Seborrheic Keratoses are not known. However, some researchers suggested, prolonged sun exposure may play a role in the stimulated onset of the condition.
Luckily, Seborrheic keratoses are not contagious.
Aging and family history also are prevalent risk factors of the skin disease onset.
Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.
In the examine the exposure of skin to a variety of environmental, chemical, and genotoxic agents that contribute to skin disease and carcinogenesis, researchers found that
* Sun ultraviolet light (UVR) is considered the main external stress in the induction of skin disorder including seborrheic keratoses through promoting immunosuppression, oxidative stress, premature aging,...... and
*Application of green tea polyphenols protect the skin of the body against such expressions by exhibiting significant antioxidant, chemopreventive, and immunomodulatory effects.
Further analysis of the effect of skin damage induced by ultraviolet (UV) radiation in animal models of 30 BALB/c mice randomly divided into 3 groups:
* Control group ( mice), without UVB exposure and green tea administration;
*. Exposure group ( mice), which were exposed to UVB light only; and
*. Treatment group ( mice), which were exposed to UVB light and treated with 1 mL of green tea through oral gavage.
After 4 days/week of UVB irradiation (20 minutes/day, 4 weeks), researchers indicated that oral administration of green tea exerted a significant photo-protection against UVB induced hyperplasia, an indication of abnormal cell proliferation.
These results suggested that green tea has had a strong implication of in ameliorated risk of skin disorders in the induction of overgrowth of abnormal cell and skin cell damage caused by prolonged UVB exposure, including seborrheic keratoses.
More importantly, although sun-exposed and non-sun-exposed skin, cumulative exposure to sunlight and aging have been proposed as independent risk factors for their development of seborrheic keratoses, however, in gene expression, researchers found that mutation of protein PTEN may have a strong impact the expression of seborrheic keratoses.
Phosphatase and tensin homolog (PTEN) is a protein with function in signaling the making a tumor suppressor enzyme in regulating cell division.
Mutation of PTEN was a risk factor for the development of many types of cancer.
Some researchers in the investigation of UVB exposure against skin diseases to healthy individual suggested that UVB induced expression of seborrheic keratoses by downgraded PTEN expression.
In other words, exposure to UVB in reduced function of PTEN or mutation of protein PTEN expressed a strong effect in promoted seborrheic keratoses development.
Truly, according to the study with all animal procedures approved by the Institutional Animal Care and Use Committee at the University of Chicago, to compare the tumor formation in the skin between mice with normal PTEN ( þ / þ ) and mice with PTEN hemizygosity, researchers once again confirmed that deleted one allele of the Pten gene in the epidermal keratinocytes causes the formation of tumors resembling human seborrheic keratoses(SKs) as well as of squamous cell carcinomas (SCCs)(3).
According to the University of Regensburg, genetic mutation such as FGFR3 mutations is associated with the pathogenesis of at least a subset of seborrheic keratoses.
Increased age also is also a risk factor of FGFR3 mutations.
Taken together, Green tea and its bioactive polyphenols may have a therapeutic effect in attenuated development of seborrheic keratoses induced by overexpression UVB or UVB in reduced function of Phosphatase and Tensin homolog (PTEN) or PTEN protein mutation,.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Green Tea in Reducing Epidermal Thickness upon Ultraviolet Light-B Injury in BALB/c Mice(Hindawi)
(2) UVA Induces Lesions Resembling Seborrheic Keratoses in Mice with Keratinocyte-Specific PTEN Down-Regulation by Mei Ming,1 Christopher R. Shea,1 Li Feng,2 Keyoumars Soltani,1 and Yu-Ying He1(PMC)
(3) FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization by Hafner C1, Hartmann A, van Oers JM, Stoehr R, Zwarthoff EC, Hofstaedter F, Landthaler M, Vogt T.(PubMed)
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