Phytochemical Polysulfides, a Plant Base Anti Bacterial and Fungal Infection Alternative

Scientists may have found a natural antibiotic for the prevention and treatment of bacterial infection, according to the study.

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belongings to the group ofOrganosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

How the immune system protects against infection. As soon as sensing the physical injury in the body, the white blood cells of the immune first line of defense not only activates the protein associated with the coagulation to cover the wound but also stimulates the production of pro-inflammatory cytokines to kill off the foreign invaders.

However, in most cases, overexpression of proinflammatory cytokines can cause death and damage to nearby health, leading to abnormal tissue healing with the formation of scars.

For example overexpression of proinflammatory cytokines produced during the hepatitis infection can induce irreversible liver scars, leading to chronic liver disease, such as cirrhosis.

Some researchers in the examine the immune evolution history, suggested that the immune system must kill off the invaders with 3 to 8 weeks during the acute phase of infection, otherwise, it will adapt to the change, causing low-grade inflammation, such as type 1 diabetes mellitus, coeliac disease, inflammatory bowel disease, and rheumatoid arthritis.

According to the study by the Memorial University of Newfoundland, in the micronutrients perspectively, zinc; selenium; iron; copper; vitamins A, C, E, and B-6; and folic acid have important influences on immune responses" and "Overnutrition and obesity also reduce immunity and protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production".

These results indicated beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In order to understand the range of sulfur-containing natural products from plants in the inhibition of fungi, bacteria infection, researchers investigated the biological activity of these compounds that affect human immunity.

Polysulfides, one of the bioactive compound from the group, exerted a significant redox-activity through increasing the expression of antioxidants (catalysis, metal binding) enzymes in inhibiting the radical generation and protecting the integrity of DNA and cellular membranes.


Furthermore, in order to exert the maximum effect in immunity, the biological activity of polysulfides depends on initial antioxidant-enzymatic activation to be generated with high target selectivity.

Moreover, in examing the polysulfides activity against the increase in the number of systemic fungal diseases, researchers showed that polysulfides found in the garlic extracts or essential oils demonstrated a clinically significant effect in fungal infection. the bioactive compound was considered an alternative way of protection of foodstuffs from contamination.

In vitro and in vivo, polysulfide derivatives isolated by chemical reaction also exhibited a potent antifungal acti.vity against candidosis in the tested mice.


Taken altogether, Polysulfides isolated from garlic may have a therapeutic effect in improving the immune activity against the bacterial and fungal infection with no side effects

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms by Jacob C.(PubMed)
(2) [Pharmaceutical significance of Allium sativum L. 4. Antifungal effects].[Article in Czech]by Sovová M1, Sova P.(PubMed)
(3) Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H- 1,2,4-triazol-1-yl)-2-butanol by Tasaka A1, Tamura N, Matsushita Y, Hayashi R, Okonogi K, Itoh K.(PubMed)
(4) Nutrition and the immune system: an introduction by Chandra RK. (PubMed)