Herbal Catnip, The Potential Anti Chronic inflammatory Diseases Remedy

Scientists may have found a natural ingredient in reducing the risk and treatment of chronic inflammatory diseases, some studies suggested.

Inflammation is a systematic immune response caused by the production of proinflammatory cytokine activated by the white blood cells in the immune system responsible for the first line of defense.

In the early phase of bodily injury and damage, the reaction of the immune system also encompasses a wide range of pathophysiological responses to minimize tissue damage while enhancing the repair process.

Inflammation also can be caused by viruses and bacteria, some of the most common stimuli of inflammation by either entering or destroying the host body cells or producing endotoxins, respectively.

Malfunctioning immunological responses attack the body tissue can incite inappropriate and chronic inflammation.

Believe or not, tissues die from a lack of oxygen or nutrients can also cause inflammation.


Chronic inflammation in another hand, caused by the immune response that can not kill off all infectious agents in the acute phase of infection.


Some researchers argued that the evolution of the immune system is to kill off all infectious stimuli or pathogen within 3 - 8 weeks, otherwise, the immune system will adapt to their existence, in another word, chronic inflammation.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The plant has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc.

Besides the major constituent of terpenoid nepetalactone, herbal catnip also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Thymol, Nepetalactone, Nepetalactone, etc.

On finding an effective anti-inflammatory natural ingredient or whole food with little or side effects, researchers at the Bangabandhu Sheikh Mujib Medical University examined herbal Catnip antinociceptive and anti-inflammatory activities.


A total of 24 male Wister rats weighing 225 ± 25 gm were included in the study, the experimental groups. were randomly injected with essential oil of NP intraperitoneally at the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg with control rats received equal volume (2 ml/kg) of normal saline.

All the doses of essential oil of herbal Catnip showed a strong antinociceptive activity compared to the control.

The highest dose of 200 mg/kg reduced the pain sensation in the tail flick (p <0.01), according to the formalin test.


Injection of the dose at 100 and 200 mg/kg significantly reduced the inflammation in tested subjects paw edema.

These results suggested that the natural ingredient of herbal Catnip essential oil may minimize both the acute and chronic forms of nociception and may have a potential role against inflammation.

Furthermore, the study by the Tarbiat Modares University to evaluate the similar effect of Catnip filed a similar result.


Using the tail-flick and formalin test pain models and the paw edema model of inflammation similar those of the above study in the male Wistar rats, application of essential oil dose-dependently produced analgesia in the acute pain models, including the tail-flick and the first phase of the formalin test.

In the late phase of the formalin test, as a model of chronic pain, the essential oil significantly reduced the pain-induced behavior.


Injection of essential oil exerted a potent anti-inflammatory effect found in the in the formalin-induced paw inflammation model and significant reduction of the paw edema in all applied doses.
The efficacy of herbal Catnip essential oil inhibited both the acute pain and chronic pain and inflammation probably were attributed to its interaction with both central and peripheral nervous system.


Taken altogether, Herbal Catnip may be considered an anti-inflammatory herbal medicine for the prevention and combined with the primary therapy for the treatment of chronic inflammatory disease without inducing any side effect.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)