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Saturday, October 26, 2019

Tualang Honey, The Potential Anti Cervical Cancer Functional Food

Scientists may have located a natural whole food for the prevention and treatment of cervical cancer with no side effects, some studies found.

Cervical cancer is the chronic condition that caused cell growth disorderly in the tissue of the cervix.

Most cases of cervical cancer start on the cells on the surface of the inner lining tissue of the cervix.
Most patients at this stage of cervical cancer do not experience any symptoms.

As cancer progresses, most patients may experience the symptoms of blood spots or light bleeding between or following periods, longer than usual and heavy menstrual bleeding, increased vaginal discharge, particularly, bleeding after intercourse, douching.

At this stage, cervical cancer can travel a distance away to cause metastasis to other healthy tissue and organs through fluids and blood circulation.


If you have experienced some of the above symptoms, please check with your doctor to rule out the cervical cancer possibility.


Although certain risk factors such as having many sexual partners, long-term use of birth control pills (oral contraceptives), early engaging in sexual contact are associated with the onset of the disease, Human papillomavirus (HPV) infection is one of major cause that has been under intensive investigation.

Belief or not, there are over 100 different HPV types have been identified and classified as high risk in almost all cervical cancers (>99.7%).

Out of this 100 different HPV, HPV16 is the most prevalent type in both low-grade disease and cervical neoplasia.

Dr. Doorbar J at the National Institute for Medical Research, said, "Most cervical cancers arise within the cervical transformation zone at the squamous/columnar junction, and it has been suggested that this is a site where productive infection may be inefficiently supported"

"Cancers usually arise in individuals who fail to resolve their infection and who retain oncogene expression for years or decades. In most individuals, immune regression eventually leads to clearance of the virus, or to its maintenance in a latent or asymptomatic state in the basal cells".


These results clearly stage, most of the initiation of HPV infection is stopped by the immune system first line of defense before the virus penetrates through the cervical cell membrane on the surface of the inner lining.

In other words, women who have a weakened immune system are at substantial risk to the disease.


Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers examined the Tualang honey (Agromas) anti-cancer effect.

Tualang honey (Agromas) (TH) were applied with increasing doses of TH (1-10%) for up to 72 h to the human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines; as well as in the normal breast epithelial cell line, MCF-10A.

At concentrations (EC(50)) of 2.4-2.8%., Tualang honey increased in lactate dehydrogenase (LDH) leakage from the cancer cell membranes, an indication of cytotoxicity to all three cancer cells.


Furthermore, the application of TH also reduced the mitochondrial membrane potential (Δψ(m)) in response to energy storage in the cancer cell lines after 24h of treatment.

TH also stimulated the proteins associated with cancer cell apoptosis.

The evidence suggested that TH has significant anticancer activity against human cervical cancer cell lines.

Additionally, in the evaluation of bee bread (BB), a fermented mixture of plant pollen, honey, and bee saliva against HeLa (cervical carcinoma) cancer cells line, researchers found that application of BB displays a moderate activity in the inhibition of the cancer cell line through cytotoxicity with doses ranging from >400 to 68 µg/mL).

The inhibition of the human cervical cancer cell line was attributed to the main phenolic compounds also found abundantly in the Tualang honey.

The in-depth analysis suggested that BB induces HeLa cell death by stimulating the function of free radicals in the induction of oxidative stress to cause cytotoxicity.

Taken altogether, honey or Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cervical cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines by Fauzi AN1, Norazmi MN, Yaacob NS. (PubMed)
(2) Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal by Sobral F1, Calhelha RC2, Barros L3,4, Dueñas M5, Tomás A6, Santos-Buelga C7, Vilas-Boas M8, Ferreira IC9. (PubMed)
(3) Molecular biology of human papillomavirus infection and cervical cancer by Doorbar J. (PubMed)

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