Dried peas with high fiber may have a potential effect in the prevention and treatment of colon cancer.
Colon cancer is a chronic and medical condition characterized by cells growth uncontrollably and disorderly that start on the surface of the inner lining of colon tissue.
At the advanced stage, the cancerous cell can travel a distance away from the original site to affect other healthy tissue and organ through the circulation of blood and fluids.
The exact causes of colon cancer are unknown. However, researchers do know that unhealthy diet and lifestyle with physical inactivity are associated with a substantially increased risk of colon cancer.
Epidemiological studies agreed that the Western diet is associated with the increased risk and recurrent risk of colon cancer.
Ms. Marilisa Racco at the National Online Journalist, Smart Living Global News wrote "There’s more bad news for lovers of red meat and refined grains — also known as a Western diet — from cancer researchers. A new study has found that a pro-inflammatory diet that’s heavy in processed red and organ meat, refined grains, and sugary drinks, will significantly increase the risk of developing colorectal cancer in both men and women".
Furthermore, a higher intake of a Western dietary pattern after cancer diagnosis was also associated with recurrence and death in colon cancer patients.
Publish on the Public Medical Literature, the study includes a total of 1009 patients with stage III colon cancer.
Researchers said, "During a median follow-up of 5.3 years for the overall cohort, 324 patients had a cancer recurrence, 223 patients died with cancer recurrence, and 28 died without documented cancer recurrence".
These result suggested that genetic preposition and an unhealthy diet and lifestyle the major risk factors that associate to the onset of colon cancer and recurrent colon cancer.
Dried peas are the small but nutritionally mighty member of the legume family, the genus Pisum belonging to the family Fabaceae.
The bean has a healthy source of protein, fibers, vitamins, and minerals that are good for everyone's diet.
Besides its main component of the polyphenolic compound, dried bean also contains saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside, etc.
In the study to reaffirm the polyphenolics and saponins effect in the stimulation of antioxidant enzymes in the host and anticarcinogenic activity, researchers launched an investigation to examine the naturally occurring plant protease inhibitors which have potential health-promoting properties within the mammalian gastrointestinal tract against the risk of colon cancer.
Bowman-Birk inhibitors (BBI) isolated from peas exerts anti-carcinogenic and anti-inflammatory properties in the large intestine by surviving from both acidic conditions and the action of proteolytic enzymes in the stomach and small intestine,
A recombinant form of TI1B (rTI1B), representing a major BBI isoinhibitor from pea also inhibited the growth of human colorectal HT29 cells in vitro.
The proliferation of HT29 colon cancer cells was significantly affected by the injection of rTI1B in a dose-dependent manner (IC50 = 31 (sd 7) μm), compared to the novel engineered mutant.
Interestingly, the application of rTI1B induced HT29 colon cancer cells apoptosis without affecting the nearby healthy cells.
Furthermore, the rTI1B proved to be active against trypsin and chymotrypsin in facilitating the colorectal carcinogenesis and promotes proliferation, invasion, and metastasis.
Proteases inhibitor isolated from the peas may process a potential chemopreventive effect during the early stages of colorectal carcinogenesis.
Adding 1 or 2 portions of dried peas into a daily diet in high colon cancer risk patients may reduce the incidence of colon cancer.
Taken all together, dried peas may be considered a function legume in the prevention and adjunct therapy for the treatment of colon cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the dried peas or its bioactive compounds during the course of the disease will be necessary to complete the picture of its anti-colon cancer possibilities.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Review of the health benefits of peas (Pisum sativum L. by Dahl WJ, Foster LM, Tyler RT. (PubMed)
(2) The anti-proliferative effect of TI1B, a major Bowman-Birk isoinhibitor from pea (Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition by Clemente A, Carmen Marín-Manzano M, Jiménez E, Carmen Arques M, Domoney C.(PubMed)
(3) Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer by Meyerhardt JA1, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS. (PubMed)
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