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Monday, October 21, 2019

Tomatoes Kill Bacterial Staphylococcus Aureus Against the Onset of Pneumonia

Pneumonia is a medical condition associated with the infection of the lung. In adults, the most common causes of pneumonia are a bacterial infection such as Staphylococcus aureus.

Viruses or fungi also have been found to induce the onset of the disease.

Most common symptoms of pneumonia are persistent coughing with phlegm (mucus) fever, sweating, chills and chest pain. However, depending on the types of pathogens that cause the infection.

In severe cases, pneumonia is life-threatening. Some patients at this stage also experience persistently shortness of breath due to severe inflammation in the air sacs of the lungs.

According to epidemiological studies, most cases of pneumonia are acquired from either hospitals and communities caused by people who have the disease.

Some researchers suggested people who have weakened such as elderly or immature immune systems such as babies and underage children are more prone to the disease.


Dr. Sanjay Sethi at the University at Buffalo SUNY wrote, "Pneumonia is an infection of the lungs. Pneumonia in people whose immune system is weakened or impaired (for example, by AIDS, cancer, organ transplantation, or the use of certain drugs) is often caused by different organisms than those that cause pneumonia in healthy people".

In other words, people who are treated by chemotherapy drugs due to cancer or immune suppressants, and disease associated with immunity are susceptible to pneumonia developing.

Most cases of pneumonia are treated with antibiotics. Depending on the condition, treatment may include medicine for reduced coughing, pain and fever with an aim to improve patients' quality of life.

If you are taking certain types of antibiotics for the treatment of pneumonia, please make sure you know all the side effects for preventive measures.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a potential ingredient for the treatment of Staphylococcus aureus pneumonia, researchers examined the effect of naringenin found abundantly in tomato.

In the Staphylococcus aureus pneumonia model, naringenin protected the lung cells integrity and viability by inhibiting the production of α-toxin.

Where α-toxin is an essential virulence factor found in patients with Staphylococcus aureus pneumonia.

Furthermore, at the 16 μg/ml of naringenin, treatment organisms showed reduced expression of α-toxin significantly compared to the untreated group.

Moreover, in vivo, a mouse model of S. aureus pneumonia treated with naringenin demonstrated a significant effect in attenuating symptoms of lung injury and inflammation against infection.

In other words, naringenin acted as a natural antibiotic in preventing the overexpression of α-toxin produced by Staphylococcus aureus through its antibacterial activity.


Based on the findings, Dr. Zhang Y, the lead scientist after taking into account co and confounders wrote in the final report, "These results suggest that naringenin is a promising agent for the treatment of S. aureus infection".

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of Staphylococcus aureus pneumonia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of naringenin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia by Zhang Y1, Wang JF, Dong J, Wei JY, Wang YN, Dai XH, Wang X, Luo MJ, Tan W, Deng XM, Niu XD. (PubMed)
(2) Pneumonia in Immunocompromised People By Sanjay Sethi , MD, University at Buffalo SUNY. (MSD Manual)

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