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Tuesday, October 29, 2019

Green Peas (Pisum Sativum) Reduces the Risk of Inflammatory Bowel Disease

An inflammatory bowel (IBD) disease is a group of chronic inflammatory diseases associated with the gastrointestinal tract, including ulcerative colitis and Crohn's disease.

Ulcerative colitis has been found to induce chronic inflammation and ulcers in the inner lining of the large intestine (colon) and rectum, causing diarrhea, often with blood or pus, abdominal pain, and cramping, rectal pain, and bleeding and urgency to defecate.

Crohn's disease is a type of IBD associated with the inflammation of the lining of the digestive tract, leading to symptoms of frequent, recurring diarrhea, rectal bleeding, unexplained weight loss, fever.
and abdominal pain and cramping.

According to the statistics, provided by the CDC in the US, IBD affects over 1.3% or 3 million US adults including Crohn's disease or ulcerative colitis in 2015.

Most common symptoms of IBD include diarrhea, fever, and fatigue, abdominal pain and cramping, loss of appetite and unintended weight loss and blood in the stool.

Conventionally, most cases of IBD are treated with anti-inflammatory medicine, immune suppressor or antibiotics, and drugs that reduce symptoms, depending on the severity of the conditions.

Most cases of IBD has been found in older adults in the age of 45 years or older.

Dr. Danielle Nimmons and Jimmy K Limdi said, "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing globally. Coupled with an aging population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences".

And, "In addition, age-specific concerns such as co-morbidity; loco-motor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximizing benefit and minimizing harm".

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of inflammatory bowel disease, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis.



The study included 6-week-old C57BL/6J female mice fed a 45% HFD or HFD supplemented with 10% GP. for 7-week before colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.

Based on the tested analysis, BP supplement showed a significant effect in ameliorating the disease index score in HFD-fed mice during the recovery stage by reducing neutrophil infiltration and chemokine associated with a pro-inflammatory response.

Furthermore, pro-inflammatory markers in the tested mice such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ) were also inhibited by the administration of GP supplement.

Moreover, the mucin 2 content and goblet cell differentiation markers associated with the protection of digestive functioning were significantly increased by the GP supplement.


Additionally, the endoplasmic reticulum (ER) stress induced by the 2.5% DSS that cause digestive cell dysfunction was inhibited by the GP application.

Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".

Taken altogether, green peas may be considered a functional food for the prevention of inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)

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