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Sunday, October 20, 2019

Herbal Turmeric Eradicate the progression of Prostate Cancer in Vitro and Vivo

Cancer is a class of medical conditions associated with cell growth irregularly due to the alternation of cell DNA with unknown causes.

Most cases of primary cancer start in the cell on the surface of the inner lining, before growing in size to invade other nearby healthy tissue and organ by spreading via lymph or blood.

The prostate formed part of the male reproductive organ, warped around the urethra, is a gland found in front of the rectum and just below the bladder that is responsible for making some of the semen to carry sperm.

Prostate cancer is a chronic condition caused by abnormal cell growth in the prostate tissue. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

According to the statistics provided by the Cancer Net, prostate cancer is the most common cancer among men, besides skin cancer.

In 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer with over 60% of cases in men over 65.

The average age of diagnosis is 66. The disease rarely occurs before age 40. The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%.

Prostate cancer can be diagnosed by

*Digital Rectal Examination (DRE)

A digital rectal examination is included in a physical exam. In DRE, your doctor inserts a lubricated, gloved finger into the rectum to feel the surface of the prostate gland to check for any abnormality of the prostate.

* Transrectal Ultrasound (TRUS)
Ultrasound allows your doctor to visualize and assess the size of your prostate and check for any abnormality and surrounding area with an image taken from the test.

* Prostate-specific antigen (PSA) test
The test is to measure the levels of prostate-specific antigen (PSA), a protein produced by the prostate. The high levels of PSA may be an indication of higher risk of prostate cancer.

* Prostatic Acid Phosphatase (PAP) test
Prostatic acid phosphatase (PAP) is a test to measure the level of prostatic acid phosphatase, an enzyme produced by the prostate. The higher the levels of PAP is an indication of the disease progression.

* Prostate biopsy
In a prostate biopsy, samples of the prostate tissue are taken by a thin, tube-like instrument to examine under microscopy to review the stage of cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of cancer, researchers examined the anticancer action of curcumin in hormone-independent prostate cancer cells (DU145, and PC-3).

Based on the tested differentiation, curcumin was more effective in the inhibition of PC-3 cells compared to that of DU145 cells.

In other words, curcumin induced cancer cells apoptosis, depending on the maspin expression associated with the inhibition of tumor progression.

More precisely, curcumin administration inhibited the maspin-knockdown cells involved in expression levels of pro-apoptotic proteins compared with control cells.

In other words, curcumin treatment promoted the expression of maspin that enhances the phytochemical sensitivity to prostate cancer cells.

Moreover, in a mouse prostate cancer xenograft model, curcumin treatment inhibited the growth of prostate cancer in vivo as well as promoting apoptosis of LNCaP cells in vitro.

The efficacy of curcumin on LNCaP cells.was attributed to the inhibition of the JNK pathway associated with cancer development and progression and regulation of gene (H3K4me3) expression.

Dr. Zhao W, the lead scientist wrote, "curcumin inhibits JNK pathway and plays a role in epigenetic regulation of prostate cancer cells by repressing H3K4me3".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation by Zhao W1, Zhou X1, Qi G1, Guo Y2. (PubMed)
(2) Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells by Cheng WL1, Huang CY2,3, Tai CJ4,5, Chang YJ6,2,7,8, Hung CS. (PubMed)

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