Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health
The prevalence of childbearing age obesity is wide spreading in US,
approximately, 50% of them are either overweight [body mass index (BMI)
25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Obesity on conception and implantation
Obesity has been associated with impaired fecundity. According to the study by the Seacroft Hospital, Posted in PubMed, obese women, particularly those with central obesity,
are less likely to conceive per cycle. Obese women suffer perturbations
to the hypothalamic-pituitary-ovarian axis, menstrual cycle disturbance
and are up to three times more likely to suffer oligo-/anovulation. A
fine hormonal balance regulates follicular development and oocyte
maturation, and it has been observed that obesity
can alter the hormonal milieu. Leptin, a hormone produced by
adipocytes, is elevated in obese women, and raised leptin has been
associated with impaired fecundity. Obesity
impairs ovulation but has also been observed to detrimentally affect
endometrial development and implantation. The expression of polycystic
ovary syndrome (PCOS) is regulated, in part, by weight, and so obese
women with PCOS often have a more severe phenotype and experience more
also impairs the response of women to assisted conception treatments.
Weight loss through lifestyle modification or bariatric surgery has been
demonstrated to restore menstrual cyclicity and ovulation and improve
the likelihood of conception.
Chinese Secrets to Fatty Liver and Obesity Reversal
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