Isoflavone glycitein 7-O-beta-D-glucoside 4''-O-methylate inhibits EGF-induced mucus hypersecretion in the human lung mucoepidermoid cells.

Posted by Chantel Martiromo. research contributed by PubMed
Glycitein 7-O-beta-d-glucoside 4''-O-methylate (CGLM), isolated recently from Cordyceps militaris grown on germinated soybean extract was investigated for its suppression of airway mucous hyper-secretion in epidermal growth factor (EGF)-treated human lung mucoepidermoid cells, posted in PubMed, found that CGLM directly inhibited down-regulated NF-κB activity, and significantly inhibited the phosphorylation of p38 and ERK1/2 (p42/p44) in NCI-H292 cells. These results suggest that CGLM protects NCI-H292 cells from EGF-induced damage by down-regulation of COX-2, MMP-9 and MUC5AC gene expression, mediated via blocking the NF-kappa-B and p38/ERK MAPK pathways.

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