Posted by Chantel M. research contributed US National Library of Medicine National Institutes of Health
In the United States, about 25% of infant formula sold is based on soy protein, which is an important source of estrogenic isoflavones in the human food supply.
In the study of a total of 166 full-term infants between birth and 1 year of age were recruited into soy formula, cow milk formula,
or breast milk regimens according to their feeding histories. A total
of 381 urine, 361 saliva, and 88 blood samples were collected at 382
visits, posted in PubMed, researchers showed that Concentrations of daidzein and genistein were undetectable in most blood
or saliva samples from children fed breast milk or cow milk formula.
The proportion of non-detectable values was somewhat lower in urine
than in the other matrices. Concentrations of equol were detectable only
in a few urine samples. For both daidzein and genistein, urine
contained the highest median concentrations, followed by blood and then
saliva. Urinary concentrations of genistein and daidzein were about 500
times higher in the soy formula-fed infants than in the cow milk formula-fed
infants. The correlations between matrices for either analyte were
strikingly lower than the correlation between the two analytes in any
single matrix. We did not find significant correlations between
isoflavone concentrations and the levels of certain hormones in children
fed soy formula.
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