Obesity and gastroschisis in young maternal age

 Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health
The prevalence of childbearing age obesity is wide spreading in US, approximately, 50% of them are either overweight [body mass index (BMI) 25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Obesity and gastroschisis in young maternal age
Young maternal age has been associated with an increased risk of gastroschisis, while high maternal weight status has been associated with a decreased risk. In the study to evaluate the joint effect of these two risk factors to identify thresholds in risk associated with body mass index (BMI) for a given age, from the data from the National Birth Defects Prevention Study included 464 case infants with gastroschisis and 4842 healthy controls, by the University of North Carolina at Chapel Hill, posted in PubMed, showed that women who are younger and who have lower BMI are at the greatest risk; a woman with a BMI of 17 who gives birth at age 15 has 7 times the odds (adjusted odds ratio = 7.0 [95% CI 4.2, 11.5]) of having an offspring with gastroschisis compared with a woman of age 24 with a BMI of 23. Furthermore, there was an interaction between maternal age and BMI for this risk. The increased risk of low maternal age and prepregnancy BMI associated with gastroschisis appears to suggest an aetiological role related to biological immaturity for this particular birth defect.

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