Herbal Chamomile Enhances Immune System Integrity and Immune Cells Viability

Herbalism or phytotherapy a traditional medicine used botany and plants as medical treatment, linking health benefits in the prevention, management, and treatment of diseases has drawn many interests in today respectable scientists.

But herbal qualities, because geographic differences, time of grown,..... and harvest, are still raised some concerns of conventional researchers.

How many conscientious scientists do believe that some days phytotherapy will replace conventional single-ingredient medicine for treatment of diseases without inducing serious side effects.

Would the big pharmaceutical companies whose bottom line is nothing but profits and more profits allowed that to happen?

The immunomodulatory effect is a function that stimulates T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCcs),.... and nitric oxide (NO) production.

In other words, improving immune function of modulation of a gene or neurohormonal system may exert a strong efficacy in protected our body against harmful agents, including microorganisms,......and immunotoxins.

Immune dysfunction can be expressed in several different ways, depending on whether the immune system is overactive or underactive.

In long-term overactive immune function, the patient may be experiencing some symptoms of chronic inflammation caused by the overproduction of pro-inflammatory cytokines. Diseases associated with these syndromes include asthma, rheumatoid arthritis (RA), type 1 diabetes...... and Inflammatory bowel disease



Long-term of the underactive immune system can reduce immune function in fighting against various pathogens or toxins, leading to the development of diseases. Diseases associated underactive immune function include Human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS),...



The causes of immune dysfunction, in joint investigation of " Immune Dysfunction as a Cause and Consequence of Malnutrition" lead by the Queen Mary University of London, suggested "Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect." and " Defects emerge before birth via modifications in the immunoepigenome of malnourished parents"(3).


Patients with chronic immune dysfunction are associated to increase the risk of morbidity and mortality(4)(5).


Chamomile is also known as camomile, the common name of many species daisy-like plants, belonging to the family Asteraceae, a native of the Old World.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.


Chamomile (Matricaria chamomilla), in a recent study conducted by some institutions, restored the resistance against lethal infection with the predominately granulocyte-dependant Candida albicans in immunosuppressed mice.

Administration of the chamomile extract in five doses enhanced the total white blood cells count (up to 1.2 × 10(4) cells/mm(3)) and increased significantly bone marrow cellularity.

Some researchers suggested, "Changes in bone marrow cellularity can be an indicator of systemic toxicity and, therefore, bone marrow should be included in the battery of tissues examined for enhanced histopathology of the immune system"(6).

In other words, increased numbers of bone marrow cellularity have a strong effect in enhanced immune function.

Heteropolysaccharides found in Matricaria chamomilla L. also showed to normalize the developing of the immune response upon air cooling as a result of initiated immunostimulating properties of enlargement of red blood cells and activation of immunoregulation cells.

Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".

There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in protection of our body against various diseases, but intake of large quantity should be taken with care to avoid toxicity.

However, further data collection with larger example size and multi-centers performed on human consumption over a long-term and during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.

Additionally, while addressing the possible advantages of chamomile's immunomodulatory activities, researchers must also take into account of potential, risk such as quality controls, dosages, and dosage induced the adverse effect of acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA. (PubMed)
(3) Immune Dysfunction as a Cause and Consequence of Malnutrition by Claire D. Bourke,1,⁎ James A. Berkley,2,3 and Andrew J. Prendergast(PMC)
(4) Extrahepatic morbidity and mortality of chronic hepatitis C by Negro F1, Forton D2, Craxì A3, Sulkowski MS4, Feld JJ5, Manns MP(PubMed)
(5) [Morbidity and mortality in HIV infection].[Article in German] by Stöckle M1, Elzi L, Rockstroh JK, Battegay M(PubMed)
(6) Enhanced Histopathology of the Bone Marrow by SUSAN A. ELMORE, the Society of Toxicologic Pathology