Ginger, The Pungent Spice Which Processes Anti Colon Cancer Potential

Ginger may process certain bioactive compounds with a function to protect our body against the onset of colon cancer, some scientists found.

Colon cancer is a medical condition characterized by cell growth irregularly due to the alternation of DNA.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At this stage, most patients do not experience any symptoms and discomfort.

However, at the advanced stage, the cancerous cells in the colon not only can travel a distance far away to infect others healthy tissue and organ but also cause localized severe pain and symptoms as the proliferation of cancer have suppressed the nearby nerve cells and tissue.

Researchers do not know the exact causes of the disease. But they do know a history of polyps, ethnicity, high-fat diet and low fiber, the increase in age, the long-term infection of colon diseases are some of the prevalent risk factors associated with the onset and progression of colon cancer, according to epidemiological studies.

Out of that group of risk factors, the increase in age has been under intensified studies by many scientists.

According to the statistic, colorectal cancer is the third common cancer in the US. The median age at diagnosis for colon cancer is 68 in men and 72 in women.

Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly, in 39% of colon cancer diagnosed at the localized-stage disease, the five and ten years survival rate is 90%.

Dr. Elmer E. van Eeghen, the lead scientist in the cancer program at the Zaans Medisch Centrum, in the concerns of the increase in the age that impact on the development of colon cancer launched an investigation on the influence of age and comorbidity on survival and cause of death in a non-selected population.


In the study "Impact of age and comorbidity on survival in colorectal cancer" wrote, "Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score" and " In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis defining illness in the majority of patients".

These results furtherly confirm the prognosis of colon cancer in the aging population. However, most aging population do not develop colon cancer.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The pungent kitchen spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.


With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of the crude ginger extract against many types of cancer, including colorectal cancer.

The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.

During the experiment, researchers showed that

* Ginger displays a significant effect in the inhibition of colon cancer cells by blocking the communication of a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell and regulating the cell cycle division.

* Ginger the concentration of the IC50 of 5.2 mg/m simulated the early apoptosis by enhancing the functional proteins associated with the execution of cancer cells and

* Decreasing the expression of proteins associated with cancer cells spreading.

Further differentiation of the anti-proliferative effects of ginger efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that ginger (IC50 of 3mg/mL) is more potent than the Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.

These results once against suggested ginger extract could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.

Additionally ginger in the study of cells divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined researcher found that

Taken altogether, the ginger extract used alone or combined with honey might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)