Cruciferous Vegetables, the Best Natural Whole Food Medicine for Reduced risk of Inflammation in Adult with Gene GSTT1

Inflammation is a natural expression by the immune system in induction of while blood cells for protection our body against infection with foreign organisms,



Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

In a randomized controlled trial in healthy young adults, isothiocyanates found in cruciferous vegetable, exhibited anti-inflammatory effects through altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP)), in increased increases in the presence of inflammation in the body tumor, and necrosis factor (TNF) α,, involved in systemic inflammation.



Intake of Cruciferous Vegetables has shown to reduce the circulation of proinflammatory cytokines, namely IL-6 through inhibiting the expression of an abnormal function of gene Glutathione S-Transferase Theta 1(GSTT1) metabolism in lower the levels of glutathione, the antioxidant with anti-inflammatory properties.


Dr. Navarro SL, the lead researchers said, " IL-6 concentrations were significantly lower on day 14 of (the double-dose cruciferous) (2xC) and (cruciferous plus apiaceous (carrot family) 1xC+A diets than with the basal diet,...respectively]" and " Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1".


In support of the above study, isothiocyanates (ITC) from cruciferous vegetables showed to increase levels of serum of Glutathione S-transferases (GST), the enzymes that detoxify a broad range of free radicals in reduced risk of inflammation, particularly in GSTM1-null women.

Furthermore, the phytochemical also increased GSTA1/2, the antioxidant enzyme in GSTM1-null/GSTT1-null men.


Taking all together, intake of Cruciferous Vegetables regularly is associated to lower the effect of proinflammatory cytokines, particular to adults with gene GSTT1.


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Sources
(1) Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults by Navarro SL1, Schwarz Y2, Song X2, Wang CY2, Chen C2, Trudo SP3, Kristal AR2, Kratz M2, Eaton DL4, Lampe JW2.(PubMed)
(2) Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes by Navarro SL1, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW.(PubMed)