Beetroot, one of popular functional vegetable may hold a key in reduced risk and treatment of liver cancer, a respectable study opinionated.
Liver cancer is a medical condition characterized by irregular cell growth and multiplied uncontrollably in liver tissues.
Beet, best known as the beetroot or garden beet, belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Howard University, in liver tumor induced by injection of tumor initiation with N-nitrosodiethylamine (DEN, 30 mg/kg) in mice model, mice group treated with oral administration of 0.0025% betanin isolated from beet or beetroot, exerted a very significant effect on both the incidence and multiplicity of the liver tumors.
Dr. Kapadia GJ, the lead author suggested, betanin, the major chemical compound found in beetroot is an effective cancer chemopreventive agent in mice.
Regular consumption of the vegetable may ameliorate against the incidence of cancers, including liver cancer.
In the findings of natural food in compared to conventional anticancer drugs in high resistance HepG2 liver cancer cells, researchers at the University of Urbino "Carlo Bo" found that natural compound Vitexin-2-O-xyloside (XVX) and avenanthramides (AVNs) isolated from beet, exhibited antiproliferative and pro-apoptotic effects by sulforhodamine B method, and caspase activity assays, respectively
The study also showed the inhibition of the liver cell line may be a result of the phytochemicals activities in the activation of proteins in the regulated progression of apoptosis and prevented gene in overexpression of pro-cancer cell survival.
More importantly, the efficacy of beetroot in reduced incidence of early onset of liver cancer may also attribute to the antioxidant property in the prevention of overproduction of free radical which was known as an independent risk factor in inducing liver cancer, measured by Cellular antioxidant activity (CAA) assay.
Other in the examine of the effect of betaxanthins and betacyanins efficacy in the treatment of various cancers, postulated that the isolated phytochemicals may be a potential natural agent in inhibited cancer cell lines intrinsically and extrinsically in induced apoptosis.
More importantly, using Vitexin-2- O-xyloside, betaxanthins and betacyanins combination with conventional anticancer drugs may be a future treatment in reduce conventional anticancer drugs toxicity and overcome the expression of multidrug resistance of cancer cells.
Collectively, these findings may suggest that intake of functional food - beetroot regularly may reduce the risk and treatment of liver cancer, but further study may be necessary for validity.
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Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H.(PubMed)
(2) Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms by Scarpa ES1, Antonini E1, Palma F1, Mari M1, Ninfali P2.(PubMed)
(3) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
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