Healthy Legume: Green Bean Kills Breast Cancer Cells

The woman breast is made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman's breast is totally determined by the amount of fat.

Breast cancer is a medical and chronic condition characterized by the abnormal cell growth either in the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Most cases of breast cancer start in the cells on the surface of the inner lining tissues of the breast before growing into a tumor by invading the deeper layers of the organ.

According to the statistics, the lifetime risk of invasive breast cancer developing is 12%.

In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer diagnosed at the early stage is closed to 100%.

Epidemiologically, there are several factors that can reduce the risk of breast cancer including breastfeeding, early age at first full-term pregnancy, an increasing number of births, preeclampsia, longer duration of breastfeeding.

Believe it or not, in a new study, published in the journal Breast Cancer Research, women who drink five cups of coffee a day or more can reduce the risk of getting certain types of breast cancer. (How many women can do that without developing nervous tension).

Dr. Davaasambuu Ganmaa, the lead scientist said, "This was a prospective cohort study with 85,987 female participants in the Nurses’ Health Study".

And, "The multivariate relative risks (RRs) of breast cancer across categories of caffeinated coffee consumption were: 1.0 for <1cup/mo (reference category), 1.01 (95% confidence interval: 0.92–1.12) for 1/mo-4.9/wk, 0.92 (0.84–1.01) for 5/wk-1.9/d, 0.93 (0.85–1.02) for 2–3.9/d, 0.92 (0.82–1.03) for ≥4 cups per day (p for trend= 0.14)".


Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent compound that processes anti-cancer activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition of the growth of human breast cancer AU565 cell.

The application of the mixed product showed a significant effect on the induction of breast cancer cells apoptosis without affecting the health of normal human cells.

Furthermore, BN999 treatment also activated the protein calpain significantly associated with adverse breast cancer-specific survival of the inflammatory breast cancer at low levels.


Moreover, BN999 also promoted caspases proteins such as caspase-8, -9, and -3 in the induction of cancer cell apoptosis through several extrinsic pathways.

Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".


Taken altogether, green beans used combined with fermentation products of soybean, the black bean may be used as an adjunct therapy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Coffee, tea, caffeine, and risk of breast cancer: a twenty two-year follow-up by Davaasambuu Ganmaa,1 Walter C. Willett,1,3 Tricia Y. Li,1 Diane Feskanich,3Rob M. van Dam,1 Esther Lopez-Garcia,1 David J. Hunter,1,2 and Michelle D. Holmes. (PMC)