Cruciferous Vegetable, the Antioxidant Natural Whole Food

Intake of cruciferous vegetables has shown to express the chemopreventive and/or chemotherapeutic effect against abnormal cell growth in some cancer.

Sulforaphane and cisplatin, the major compound found in cruciferous vegetables, exhibited the interaction or cooperation growth‑inhibiting and apoptosis‑promoting activities, through their pro-oxidant activity, according to the Soonchunhyang University,


Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

The antioxidant is a type of chemical compound inhibited the free radicals to protect the body against oxidative damage.

In the study of phenolic compounds, kaempferol and quercetin, from the ethanol extract of Chinese cabbage (EtCC) revealed that the phytochemicals suppressed tumor necrosis factor (TNF)-α-(a cell-signaling protein (cytokine) involved in systemic inflammation) induced inflammatory response and activation of antioxidant response against free radical expression.


Furthermore, in support of the antioxidant effect of Cruciferous vegetables, isothiocyanates, another phytochemical compound found in the vegetable also inhibited the generation of reactive oxygen species (ROS) and protected against the induction of cytoprotective genes against oxidative stress.

Taking all together, Cruciferous vegetables no doubt consist of a strong antioxidant capacity in inhibited
free radical causes of cellular damage.


Dr. Joo HK, the lead researcher said, " regular consumption of vegetables containing dietary phytochemicals might be a potential therapeutic strategy to protect against various stresses, to prevent several pathological conditions, and to treat chronic vascular inflammation".


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Sources
(1) Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells by Lee YJ1, Lee SH1.(PubMed)
(2) Ethanol Extract of Brassica rapa ssp. pekinensis Suppresses Tumor Necrosis Factor-α-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells by Joo HK1, Choi S1, Lee YR1, Lee EO1, Park MS2, Lim YP3, Park JT4, Jeon BH1.(PubMed)
(3) Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress by Yoda E1,2, Paszek M1, Konopnicki C1, Fujiwara R3, Chen S1, Tukey RH1.(PubMed)