Carrot, The Functional Food Which Reduces Gastric/Stomach Cancer Risk By 26%

Carrots may have a profound and positive effect on reduced risk, progression and treatment of gastric cancer, some scientists suggested.

Gastric cancer is a slowly developed condition characterized by cell growth uncontrollably and disorderly in the stomach tissue. At the later stage, the cancerous cells may travel a distance away to infect other healthy cells of the tissue and organs.

According to the US cancer society, approximately 26000 new cases of gastric cancer are diagnosed in 2018 inducing the death of over 10,000 patients.

The risk that a man and woman will develop gastric cancer in their lifetime is 1 in 95 and 1 in 154 respectively.

The exact causes of gastric cancer are unknown, some researchers suggested that older people, male, heavy smokers, people with a family history of gastric cancer and certain ethnic groups such as
Asian (especially Korean or Japanese), South American, or Belarusian descent are at increased prevalent risk of gastric cancer.


Interestingly, during the past several decades, the numbers of common gastric cancer are showing a tendency of receding, however, at the same time, cancer in the area where the top part of the stomach meets the lower end of the swallowing tube (esophagus) has increased rapidly.

Also, some medical conditions such as lymphoma, H. pylori bacterial infections, tumors in the digestive system and stomach polyps are associated with risk of the disease.

If you experiment with persistent feeling floated after eating, and small meal after eating, heartburn, indigestion,... and stomach pain accompanied by general symptoms of cancer such as unexplained weight loss, please check with your doctor to rule out the possibility of gastric cancer..

Carrot, a root vegetable with orange color is a sub spiecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation the hypothesis of "eating carrots may play a major role in the prevention of gastric cancer", researchers at the joint study lead by the J Shahid Sadoughi University of Medical Sciences conducted a medical literature review selected from the databases of including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx, those studies satisfied the guidelines and criteria showed that risk of gastric cancer reduced by 26% with the consumption of carrots.

After taking into account other co-factors, researchers warranted that the result does not show the possibility of publication bias, according to the funnel graph by comprehensive meta analysis/2.0 software.


Although without mentioning the amount intake daily, these results showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.



Furthermore, in the analysis of the effect of Helicobacter pylori (H. pylori) overgrowth in the risk of gastric cancer, scientists found that injection of the gene of UreB into carrot by Agrobacterium-mediated transformation expressed a significant effect in regenerated carrot plants the expressed UreB protein accounted for 25mug/g roots in reduced expression of H. pylori.

The same application also showed a similar effect in immune response in inhibition of infection of bacterial Helicobacter pylori in mice.

These results suggested that certain chemical compounds in carrot may consist of a strong anti microorganism activity by protecting the plant against bacterial infection.
Therefore, UreB transgenic carrot can be potentially used as an edible vaccine for controlling H. pylori but also ameliorated risk of the bacteria in the induction of gastric cancer.

The illustration of the above differentiation was supported by the study conducted by the Graduate School of Fudan University.

According to the evaluation of the Wuxing soup containing Daikon Radish Leaves (Green element) Daikon Radish (White element) Carrots (Red color element) Burdock Root (Yellow element) Shittake Mushroom (Black element), application of the soup to the human gastric adenocarcinoma cell line (SGC-7901) expressed a huge inhibitory activity in reduced tumor cells proliferation in a time and dose-dependent manner.
More importantly, Wuxing soup induced tumor cell death through apoptotic morphological changes and DNA ladder of the tested SGC-7901 cells.


Additionally, used combination with calcium inhibitor Bapta AM, an intracellular calcium chelator not only exerted a strong effect in reduced the cancer apoptotic rate but also protected SGC-7901 cells in a dose-dependent manner.
Dr. Mo F, the lead author said, "Wuxing soup has an effective inhibition on cancer cells, and can induce SGC-7901 cells to apoptosis by calcium".



Taken together, carrot may be considered as a functional food in ameliorated risk and used combination with conventional standard treatment for gastric cancer.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of gastric cancer will be necessary to complete the picture of carrot's anti-cancer possibilities.




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Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3.(PubMed)
(2) Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccine candidate expressing UreB subunit against Helicobacter pylori by Zhang H1, Liu M, Li Y, Zhao Y, He H, Yang G, Zheng C.(PubMed)
(3) [The anti-tumour effect of Wuxing soup and its mechanism in inducing apoptosis of tumour cells mediated by calcium].[Article in Chinese] by Mo F1, Hu JY, Gan Y, Zhao YX, Zhao XT.(PubMed)