Asparagus is a flowering plant belongs to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
Diarrhea is a condition of frequent discharge of feces in liquid form.
According to the K.P. College of Pharmacy, Asparagus racemosus wild root extract used traditional herbal medicine exerted the antidiarrhoeal potency against several experimental models of diarrhea in model animals, similar to those of conventional medicine such as loperamide.
This efficacy is attributed to the root extracts in the mediation of Prostaglandin E2 (PGE2), a principal hormone in the expression of inflammatory diseases.
Dr. Venkatesan N., the lead researcher said, "The plant extracts showed significant (P < 0.05) inhibitory activity against castor oil-induced diarrhea and PGE2 induced enter polling in rats when tested at 200 mg/kg. Both extracts also showed significant (P < 0.001) reduction in gastrointestinal motility ".
In support of the above study, the test of animal model on Alpha-2 blocker (see alpha(2)-adrenoceptor) experimentally-induced diarrhea and ulceration, showed a positive effect of methanolic extract of Asparagus pubescens root in reducing significantly intestinal propulsive movement and intestinal fluid accumulation in (500-1500 mg/kg) in a dose-dependent manner.
In fact, the antidiarrhoeal effect of asparagus may be a result of modulating the expression of alpha(2)-adrenoceptor in regulated vascular smooth muscle contraction and vasoconstriction through Prostaglandin E2 (PGE2) modification. But further studies may be necessary to validate this potency.
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Sources
(1) Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals by Venkatesan N1, Thiyagarajan V, Narayanan S, Arul A, Raja S, Vijaya Kumar SG, Rajarajan T, Perianayagam JB.(PubMed)
(2) Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats by Nwafor PA1, Okwuasaba FK, Binda LG.(PubMed)
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
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