Black Bean, A Potent Functional Food In Reduced Risk of Cancers

Intake of black(common) bean and another common bean may associate to reduced risk and treatment of various types of cancers, a study of renowned institute study suggested.

Cancer is a class of chronic condition characterized by irregular cell growth in the body organs. Sometimes, the cancer cells can spread to other tissues or organs depending on the stages of cancer.


Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.



Fermentation products of soybean, black bean, and green bean mixture (BN999), showed a significant effect in inhibiting the growth of human breast cancer AU565 cells and prostate adenocarcinoma PC-3 cells without harming the normal human cells.

The study also found that in syngenic BALB/c mice, the mixture(BN999) inhibited the growth of mouse CT-26 colon cancer xenografts, without causing adverse effects.

Furthermore, BN999, also induced cancer cell death in other mechanisms, such as activating the protein gene involved pro-cancer cell apoptosis via cell mediatory activities, including a network of membranous anatomical structure and double membrane-bound organelle.in energy conversion.


Additionally, according to the joint study lead by the Universidad Autónoma de Querétaro, the efficacy of common bean in attenuated cancer risk factors as shown in animal models and in cell cultures. may also be attributed to other parameters of non-digested compounds like fiber, phenolics, peptides, and phytochemicals.


In fact, black (common) bean whole and non-digestible fraction also exhibited anti-proliferative activity and induced apoptosis in vitro and in vivo against colon cancer.


Dr. Rocio Campos-Vega lead author in the joint study also raised the important role of bean fiber and protein of the bean in ameliorated cancer risks, said, " the potential health benefits and bioactivity of beans on tumor inhibition, highlighting studies involving functional compounds, mainly non-digestible fractions that modulate genes and proteins, thereby, unraveling their preventive role against the development of cancer".

Other researchers in the evaluation of phytochemicals of black bean against various types of cancers showed that flavonoids and saponins isolated from black bean exerted a strong antioxidant capacity and antiproliferative activity against numbers of cancer cell lines in a concentration-dependent manner.

The study also insisted that depending on days of germination, total phenolic content extracted from seed coats at the 3 days exhibited the strongest effect in inhibited all cancer cell lines proliferation with no cytotoxicity against control cells.

Specifically, chemical compound genistein showed most effective against mammary cancer cells in compared to more related to hepatic and colon cancers in flavonols and saponins.

The findings suggested that black bean may be considered as a functional food as well as an integrated form of injection for reduced risk and treatment of various types of malignant tumors



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Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Common Beans and Their Non-Digestible Fraction: Cancer Inhibitory Activity—An Overview by Rocio Campos-Vega,1,* B Dave Oomah,2,† Guadalupe Loarca-Piña,1,† and Haydé Azeneth Vergara-Castañeda3(PMC)
(2) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(3) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.) by Guajardo-Flores D1, Serna-Saldívar SO, Gutiérrez-Uribe JA.(PubMed)