Cruciferous Vegetable- The Best Whole Food Medicine in Anti Inflammatory Effects

Intake of cruciferous vegetables may be inversely correlated with the circulating of proinflammatory levels of women.

In a total of 1,005 middle-aged Chinese women study, the consumption of cruciferous vegetables regularly is associated to lower circulating concentrations of proinflammatory cytokines.

Proinflammatory cytokines, also known as Interleukin (IL) and tumor necrosis factor (TNF), secreted by immune system to protect our body in inducing fever, inflammation, tissue destruction, etc.


Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Further to the study, Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells exhibited the induction of apoptosis in the cancer cell line, through the involvement of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin.


Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through an induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.



Other phytochemicals found the vegetables, such as 3,3'-diindolylmethane (DIM), a derivative of indole-3-carbinol, also expressed anti proinflammatory effect through interleukin (IL)-1beta, IL-6 and tumor necrosis factor.


In fact, chemical compounds found in the vegetable, not only inhibited the pro-inflammatory cytokines in the expression of chronic diseases and cancers but also involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.



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Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH.(PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)