Cruciferous Vegetables - The Best Whole Food Medicine for Reduced Risk and Treatment of Colon Cancer

Cruciferous Vegetables containing various phytochemical compounds may be the best vegetables for reduced risk and treatment of colon cancer.
According to the joint study lead by the China Medical University, sulforaphane (SFN), an isothiocyanate, existed only in cruciferous vegetables, interfered with the cancer cell cycle division in the induction of apoptosis in HCT 116 cells.


Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Colon cancer is a condition of the abnormal proliferation of cells in the colon.



Dr. Martin SL the lead author in the study of the effect of sulforaphane (SFN) against colon cancer cells, said, " sulforaphane (SFN), found in cruciferous vegetables such as kale, cabbage, and broccoli sprouts, has been present as one of the most potent (histone deacetylase) HDAC inhibitors to date. " and " HDAC inhibition is a promising approach for delaying and/or preventing CRC and may be accomplished via consumption of SFN in cruciferous vegetables".

Furthermore, sulforaphane (SF) also expressed its chemoprotective properties in immortalized human colonic epithelial cell lines with no harm to normal tissues and levels of steroidogenic enzymes which play an important role in the pathogenesis of allergic diseases.


In multiple genetic and signaling pathway alterations underline the development of colon cancer study, 3,3'-diindolylmethane (DIM), a natural compound derived from cruciferous vegetables also significantly suppressed colon cancer effect through targeting Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation.

According to Dr. Tse G and Dr. Eslick GD. in the address of phytochemicals of Cruciferous Vegetables against colon cancer said, " Evidence shows cruciferous vegetables exhibit chemoprotective properties, commonly attributed to their rich source of isothiocyanates......, cruciferous vegetable intake protects against cancer of the colon" and " (cruciferous vegetable )demonstrates the significance of gene-diet interactions".

Although cruciferous Vegetable has shown to process a potency in the treatment of colon cancer, further human trials are necessary to confirm its validity.


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Sources
(1) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10.(PubMed)
(2) Mechanisms for inhibition of colon cancer cells by sulforaphane through epigenetic modulation of microRNA-21 and human telomerase reverse transcriptase (hTERT) down-regulation by Martin SL, Kala R, Tollefsbol TO1.(PubMed)
(3) Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A by Erzinger MM1, Bovet C1, Hecht KM1, Senger S1, Winiker P1, Sobotzki N2, Cristea S3,4, Beerenwinkel N3,4, Shay JW5, Marra G6, Wollscheid B1,2,7, Sturla SJ1.(PubMed)
(4) Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3'-diindolylmethane inhibiting proliferation of colon cancer cells by Leem SH1, Li XJ2, Park MH3, Park BH4, Kim SM2.(PubMed)
(5) Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis by Tse G1, Eslick GD.(PubMed)