Healthy Food Cabbage Inhibits Human Cancer Cells in Vitro

Cancers are a class of chronic diseases associated with irregular cell growth in the tissue and organs caused by the alternation of cell DNA.


At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.

There are many types of cancer, depending on the location where cancer begins.

As of today, researchers do not know what are the exact cause of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.

Healthy cells become cancerous if they grow uncontrollably and disorderly out of range of a normal healthy cell population which can only divide between 40 and 60 times.

According to the Hayflick limit theory, most cell survival is totally dependent on the telomeres on the ends of each chromosome.

Every time, healthy cells undergo division, the telomeres are shortened. Once the telomeres shorten to a critical length, the cells will die off. However, cancer cells can divide indefinitely.


According to the statistic provided by the UK Cancers research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.

Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of the Human Development Index (HDI).

The Human Development Index (HDI) is a statistic composite index of life expectancy, education, and per capita income indicators, according to the definition.

In 2018, over 1,7 million new cases of cancer are diagnosed in the US, and approximately over 600,000 patients will die from the diseases.

The four most common types of cancer, occurring worldwide are lung, female breast, bowel, and prostate cancer.


Early diagnosis as always is the best way to improve the survival rate. Depending on types of cancer, most cancers have a 100% 5 years survival rate, if they are diagnosed at the stage of 0 and 1.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On finding a natural wholefood for the prevention of malignant tumors, researchers examined the effects of pierisin, a protein purified from pupae of the cabbage butterfly, Pieris rapae on the human gastric cancer TMK-1 cell line and human umbilical vein endothelial cells (HUVECs).

According to the results of differentiation,* Pierisin showed cytotoxic effects in all the human cells tested, with IC50 values ranging from 0.043 ng/ml to 150 ng/ml.
* Compared to other cancer cell lines, the cervical carcinoma cell line, HeLa, was the most sensitive to pierisin, showing a 1000-fold less IC50 value than that of HUVECs.

* Furthermore, pierisin clearly induced apoptotic cell death in most cancer cell lines and HUVECs through multiple different pathways including the proinflammatory, tumor-suppressive and immunomodulatory pathways.

Based on the results, researchers wrote, "Pierisin may thus be a promising new candidate for cancer therapy".

Taken altogether, cabbage may process anti-cancer activity, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines by Kono T1, Watanabe M, Koyama K, Kishimoto T, Fukushima S, Sugimura T, Wakabayashi K. (PubMed)

Honey, the Best Remedy for the treatment of Asthma with No Side Effects

Scientists may have found a natural alternative for the treatment of asthma, according to studies.
Asthma is a chronic inflammation of the airway of the lung with recurring symptoms. Asthma, attacks triggered by the stimuli can induce airway swollen and inflamed, leading to muscle constriction.

During asthma attacks, patients may experience symptoms of difficult breathing, and severe wheezing in the breath, and coughs that won't stop.

According to the statistic provided by the Centers for Disease Control and Prevention (CDC), 1 in 13 people in the US has asthma.

In other words, more than 26 million Americans have asthma, with half of the patients are children.

If you experience symptoms of a cough which is often worse at night or early in the morning, wheezing in your breath, accompanied by chest tightness and shortness of breath, you may be at the early stage of asthma. Please check with your doctor to rule out the possibility.

Genetic and environmental factors are the most common risk factors associated with the onset of asthma. Some researchers suggested that the widespread obesity over the past few decades may also have a strong implication on the onset of the disease.

Dr. David A. Beuthe r, the lead scientist in the concern of the association of asthma and obesity said, "Cross-sectional and prospective cohort studies of humans have shown a modest overall increase in asthma incidence and prevalence in the obese, although body mass index does not appear to be a significant modifier of asthma severity".

And, "Studying the obesity-asthma relationship in large cohorts, in which self-reports are frequently used to ascertain the diagnosis of asthma, has been complicated by alterations in pulmonary physiology caused by obesity, which may lead to dyspnea or other respiratory symptoms but do not fulfill accepted physiologic criteria for asthma".

These results strongly suggested that if you are obese, your risk of asthma is increased substantially.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on finding a natural remedy for the treatment of asthma investigated the effect of aerosolized honey on airway tissues in a rabbit model of ovalbumin (OVA)-induced asthma.

The study included 40 New Zealand white rabbits sensitized twice with a mixture of OVA and aluminum hydroxide on days 1 and 14.


Honey treatments were given from day 23 to day 25 at two different doses (25% (v/v) and 50% (v/v) of honey diluted in sterile phosphate buffer saline.


During the study, the aerosolized honey treatment group restored the epithelium, mucosa, and submucosal regions of the airway infected by the application of OVA.

Furthermore, the aerosolized honey treatment was also found to reduce the number of airway inflammatory cells present in bronchoalveolar lavage fluid and inhibit goblet cell hyperplasia, an indication of airway remodeling in asthma.

The findings strongly suggested that aerosolized honey has a significant effect on the treatment and management of asthma in animal models.

Additional differentiation of the modulatory effect of honey, royal jelly, and propolis extract on peripheral blood leukocytes and lung inflammation in a mouse conalbumin-induced asthma model in mice model divided into* The mice in group I that were not sensitized or treated; they were kept as controls.

* The mice in group II that were sensitized and challenged with conalbumin. Twenty-four hours after the first challenge with antigen.

* The mice in group III received 0.5 mg/kg of dexamethasone intraperitoneally per day for 18 consecutive days and were kept as positive controls.

* The mice in groups IV, V, and VI received 650, 1000, and 30 mg/kg of honey, royal jelly, and propolis (aqueous and ethanolic extract), respectively, once per day for 18 consecutive days.

At the end of the experiment, by comparing the blood sample before and after treatment, researchers showed
* The groups treated with propolis extract exhibited considerable ameliorative effects against asthma, probably due to the expression of flavonoids and phenolics that exert antioxidative effects

* Honey- or royal jelly-treated groups exhibited an increased incidence of asthma cascade events due to increased inflammatory cells, probably due to the antagonist to bronchial asthma cases.


The results clearly indicated that not all honey is the same. Some can be used for asthma while others can not, probably due to types of chemicals compounds found in the pollen

Taken altogether, honey and other bee products may be considered functional remedies for the prevention and treatment of asthma, pending the confirmation of the types of honey in a large and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma by Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B1.(PubMed)
(2) Evaluation of propolis, honey, and royal jelly in amelioration of peripheral blood leukocytes and lung inflammation in mouse conalbumin-induced asthma model by El-Aidy WK1, Ebeid AA1, Sallam Ael-R1, Muhammad IE2, Abbas AT3, Kamal MA4, Sohrab SS. (PubMed)
(3) Obesity and Asthma by David A. Beuther, Scott T. Weiss, and E. Rand Sutherland. (PMC)

Healthy Food Black bean Inhibits Osteocarcinoma Cells in Vitro

Intake of black bean regular may reduce risk and delay progression and treatment of osteosarcoma, an invasive form of bone cancer.
Osteosarcoma is a condition of bone cancer caused by irregular cell growth in bone, affecting mostly adolescents and young adults.

Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was first domesticated growth in South America.


According to the Chinese University of Hong Kong, hemagglutinin isolated from an edible legume, namely black bean, showed an anti-proliferative activity against tumor cell lines MG-63 and HepG2 but not the normal cell line.

Malignant osteosarcoma cells treated with the phytochemical also exerted a significant effect in shrinking of tumor cells as well as inducing apoptosis.

The study also stated that hemagglutinin also induced cell death by interfering with the first stage of tumor cell division in the expression of protein, RNA, and DNA and inducing mitochondrial membrane depolarization in controlling the plasma membrane of a muscle or nerve cell

Furthermore, the study also suggested that the efficacy of hemagglutinin in causing cell death may be attributed to the function of protein in increased regulation of pro-inflammatory expressions.
Dr. Dan X, the lead author said, " a novel hemagglutinin from an edible legume (showed) a growth-inhibitory effect on osteosarcoma and liver cancer cells" and " The hemagglutinating activity of this hemagglutinin was demonstrated to be ion-dependent and stable over a wide range of temperature and pH values".

The findings suggested that black beans may be considered as a functional food in improved bone health as well as reducing risk and treatment of osteosarcoma, but further studies are necessary to confirm its potency.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans by Dan X1, Wong JH1, Fang EF2, Chan FC3, Ng TB1(PubMed).

Cruciferous Vegetables Reduce the Risk of Ischemic Stroke

 Stroke is a medical condition caused by reduced blood flow to the brain resulting in cell death due to blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

Sadly, stroke is one of the most common causes of death worldwide.

In the US, according to statistics, approximately 800,000 people suffer a stroke of which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

There is a general belief that stroke is an accumulation over a long period of an unhealthy diet with red meat and processed meats in the induction of artery-clogging.

Atherosclerosisassociated with the hardening of the arteries caused by the buildup of fatty substances in the arteries can lead to stroke.


In other words, if the blood vessel that feeds the brain is blocked, a stroke occurs.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow, and decreased the chance of blood clots.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential remedy for reducing the mortality rate of cardiovascular diseases, researchers examined the therapeutic potential and protective effect of D3T found in cruciferous vegetables for the treatment of ischemic stroke.

The study included selected mice subjected to transient middle cerebral artery occlusion/reperfusion (tMCAO/R) who were administered with vehicle or D3T to evaluate the effect of D3T in cerebral brain injury.

Based on the results of the experiment,
* D3T reduced infarct size, decreased brain edema, lessened blood-brain barrier disruption, and ameliorated neurological deficits.

* D3T suppressed microglia (MG) activation induced by stroke and inhibited peripheral inflammatory immune cell infiltration of CNS in the ischemic brain.

* D3T also exerted a protective effect on ischemic stroke against the induction of oxidative stress by mediating the improved expression of antioxidant enzyme Nrf2.

Based on the results, researchers said, "D3T confers protection against ischemic stroke, which is mediated through suppression of MG activation and inhibition of CNS peripheral cell infiltration, and that the protective effect of D3T in ischemic stroke is dependent on the activation of Nrf2".

Taken altogether, cruciferous vegetables may be considered functional remedies for the protection in ischemic strokes, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway by Kuo PC1, Yu IC2, Scofield BA1, Brown DA3, Curfman ET2, Paraiso HC4, Chang FL5, Yen JH. (PubMed)

Cucumbers (Cucumis sativus), the Potential Anti-Gastric/Stomach Cancer Antioxidant

Gastric or mouth cancer is a chronic and medical condition characterized by abnormal cells growing in the tissues of the stomach.

The stomach-formed part of the digestive system is located between the esophagus and the small intestine and is a muscular, hollow of the digestive tract.

Most cases of gastric or mouth cancer start in the mucus-producing cells of the inside lining of the stomach due to the alternation of DNA. Adenocarcinoma is the most common type of gastric cancer.

At the early stage, due to the small size of the tumor, most patients with gastric cancer are asymptomatic.

However, as cancer continues to grow, it may induce general symptoms shared by all cancer and specific symptoms such as mild ache in the upper part of the body, difficulty of swallowing, feeling full or bloated after a small meal, vomiting blood or having blood in the stool.

At this stage, gastric cancer also induces secondary metastasis, by infecting other healthy tissues and organ far away from the original site.

Out of many risk factor associated with the onset of gastric cancer including diet, long-term inflammation of the stomach, smoking, and obesity, some researchers suggested low levels gastric acid production by the stomach may have a strong implication in facilitating the onset of the condition.


Dr. Helge L. Waldum, the lead scientist in the analysis of the correlation between Helicobacter pylori and gastric acid, wrote, "Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease, and gastric cancer. There are still unanswered questions related to the interaction between Hp and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect".

And, "The initial infection seems to require a temporal gastric hypoacidity. For Hp to survive in the gastric mucous layer, some acidity is necessary. Hp itself is probably not directly carcinogenic. Only when inducing oxyntic mucosal inflammation and atrophy with hypoacidity, Hp predisposes for gastric cancer. Gastrin most likely plays a central role in the Hp pathogenesis of duodenal ulcer and gastric cancer".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is also a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a potential compound for the treatment of gastric cancer, researchers examined the effect of Ecballium elaterium (L.) A. Rich (Cucurbitaceae) (squirting cucumber) on cell lines of gastric and esophageal origin namely called AGS (human gastric carcinoma) and KYSE30 (human esophageal squamous cell carcinoma).

The study included AGS and KYSE30 cancer cell lines incubated for 24, 48, and 72 h with an aqueous extract of the fruits of E. elaterium prepared and freeze-dried.

In AGS, at the IC(50) values of 2.5, 0.7, and 0.7 μg/ml, the aqueous extract for cell line after 24, 48, and 72 h, respectively showed significant induction of cell apoptosis.

Similarly, KYSE30 cell line induced apoptosis was found at IC(50) values for KYSE30 cell line in doses of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.


Furthermore, the injection of the extract also showed a significant increase in cell density at the G2/M phase, according to cell cycle analysis.

Moreover, the efficacy of the extract against gastric cancer cell lines was attributed to several compounds in the induction of cytotoxicity.

Based on the findings, researchers said, "The results of the current study showed that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on gastric and esophageal cancer cell lines by means of apoptosis".

In order to reveal more information of cucumber anti-gastric cancer activity, researchers investigated the effects of Cucurbitacin B (CuB), a natural compound found in Cucurbitaceae in cisplatin (DDP)-resistant human GC cell line SGC7901/DDP.


According to the tested assays, CuB treatment significantly suppressed SGC7901/DDP cell proliferation, induced caspase-dependent apoptosis, and autophagy.

Interestingly, the activation of autophagy was mediated through CuB- inhibition of the protein (TORC1) involved the regulation of cancer cell growth and survival.

In order to reveal more information of CuB anti-gastric cancer potency, scientists examined the CuB activity as a cancerous inhibitor of protein phosphatase 2A (CIP2A), a human oncoprotein that is overexpressed in multiple kinds of tumors including gastric cancer (GC).

In cisplatin (DDP)-resistant human GC cell line SGC7901/DDP, CuB treatment exerted a similar effect as of that of the aforementioned study in the inhibition of SGC7901/DDP cell proliferation, induced caspase-dependent apoptosis, and autophagy.


Moreover, CuB inhibited mTORC1 as showed in the previous study via the inhibition of CIP2A which activates the protein phosphatase 2A (PP2A) in the induction of cancer cell proliferation.

Based on the results, researchers said, "CuB can inhibit the proliferation, induce caspase-dependent apoptosis, and autophagy of SGC7901/DDP cells by suppressing CIP2A/PP2A/mTORC1 signaling axis".

Taken altogether, cucumber processed a high amount of Cucurbitacin B (CuB) as the main ingredient may be considered supplements for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Cucurbitacin B (CuB) in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastricadenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancercells by Liu X1, Duan C1, Ji J1, Zhang T1, Yuan X1, Zhang Y1, Ma W1, Yang J2, Yang L2, Jiang Z2, Yu H2, Liu Y1. (PubMed)
(3) Helicobacter pylori and gastric acid: an intimate and reciprocal relationship by Helge L. Waldum, Per M. Kleveland, and Øystein F. Sørdal. (PMC)