Avocado may be the generation whole fruit medicine for the prevention and treatment of prostate cancer with no side effects, some scientists found
Prostate cancer is a medical condition in which the cells of the prostate has become cancerous, causing abnormal cell growth.
Most prostate cancers are slow-growing and can be detected during the physical (rectum) exams.
Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissues.
At the advanced stage, as the tumor continues to grow, it may suppress the nearly healthy tissue and nerve cells leading to severe symptoms and pain.
According to the statistic provided by the American Cancer Society, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases in 10 are diagnosed in men aged 65 or older.
The most common symptoms of prostate cancer include frequent urination, weak or interrupted urine flow or the need to strain to empty the bladder. and the urge to urine frequently at night due to the large size of the tumor that suppresses the bladder and the flow of urine.
Some patients may also experience symptoms of blood in the urine, blood in the seminal fluid and pain or burning during urination caused by the tumor that breaks the nearby small veins and nerve cells.
At this stage, cancerous cells from the prostate gland can also travel a distance away to infect other healthy tissue and organ, leading to the secondary metastasis.
There are many risk factors associated with the onset of prostate cancer. However, the increase in age, location and behavioral correlates are some prevalent risks of the disease onset.
According to the University of Zurich, factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat and increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy are possible preventative behavioral factors.
These results indicated that by following a healthy diet with moderate exercise, the risk of prostate cancer can be reduced substantially.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
With an aim to discover a natural ingredient or whole food for the prevention and treatment of prostate cancer with no side effects, researchers at the University of the West Indies investigate the intake of dietary MUFAs from the whole fruit of avocado in the risk of prostate cancer (PCa).
The case study included 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men, attending the same urology clinics.
Higher intakes of dietary MUFA were inversely related to prostate cancer. The principal source of dietary MUFA of the participants was the avocado intake. Dietary intakes of other fats were not associated with PCa.
Dr. Jackson MD, the lead author wrote in the report, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes".
Researchers at the University of California agreed that the avocado is known as a rich source of monounsaturated fatty acids, for treatment of prostate cancer, but suggested that other bioactive substances including carotenoids, which might contribute to cancer-preventive properties similar to those attributed to other fruits and vegetables.
In vitro, injection of acetone extract of avocado containing carotenoids and tocopherols inhibited the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines.
Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27 protein expression, a protein that regulates the cell cycle.
Lutein combined with other bioactive compounds also exerted a similar effect in inhibiting the prostate cancer cell spreading, but the chemical compound alone did not reproduce the effects of the avocado extract on cancer cell proliferation.
These results strongly indicated, the avocado anti-prostate cancer efficacy probably is associated with all bioactive compounds containing in the fruit such as monounsaturated fat, and carotenoids.
In order to illustrate the importance of the whole fruit in the inhibition of prostate cancer, researchers examined the 3 newly isolated compounds from unripe avocado and found that all 3 compounds exert significant activity against six human tumor cell lines in culture and show selectivity for human prostate adenocarcinoma (PC-3) cells with 3 being nearly as potent as adriamycin.
Dr. Lu QY, after taking into account other factors said, "Because the avocado also contains a significant amount of monounsaturated fat, these bioactive carotenoids are likely to be absorbed into the bloodstream, where in combination with other diet-derived phytochemicals they may contribute to the significant cancer risk reduction associated with a diet of fruits and vegetables".
Taken altogether, avocado with abundant bioactive active compounds and MUFAs may be considered a functional fruit for the prevention and treatment of prostate cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Leung's Encyclopedia of Natural Ingredients: Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL. (PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: the role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Tuesday, April 21, 2020
Monday, April 20, 2020
Healthy Honey Protects Our Skin Pigment Against the Onset of Melanoma Skin Cancer
Scientists may have found a natural whole food for the prevention and treatment of skin melanoma cancer, according to some studies.
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.
The 4 most common types of skin melanoma include
1. Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
2, Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
3. Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.
4. Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.
The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin. Why some people are susceptible to the onset of the disease while others do not even share similar health conditions, family history, and ethnicity.
However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV rays are the most common associated with the increased risk of melanoma skin cancer.
In fact, people who inherited the BRAF oncogene have a substantial risk to develop melanoma skin cancer and the most common genes which have been primarily linked to familial melanoma, are CDKN2A and CDK4.
Dr. Miriam Potrony, the lead author in the study "Update in genetic susceptibility in melanoma" suggested that 10% of melanoma skin cancer are genetically related and cyclin-dependent kinase inhibitor 2A (CDKN2A), identified as the first melanoma susceptibility gene more than 20 years ago, is the main high-risk gene for melanoma.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the finding a natural ingredient for the reduction of risk and treatment of melanoma skin cancer, researchers launched an investigation to determine the effect of chrysin, a flavonoid present in honey, propolis, against human uveal melanoma cell lines (M17 and SP6.5)
Injection of chrysin reduced the viability of cultured human melanoma cells in a dose-dependent manner (0, 10, 30 and 100 µM) with IC50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively.
Chrysin at 30-100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of nearby healthy cells.
Chrysin inhibited the melanoma skin cancer cells through the proteins associated with cancer cell death and degradation.
These results indicated chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway in the increased mitochondrial permeability
In the finding the scientist evidence for Manuka honey effect in the treatment of cancer, researchers at the UAE University conducted an investigation to examine the anti-cancer effect on three different cancer cell lines, murine melanoma (B16.F1) and colorectal carcinoma (CT26) as well as human breast cancer (MCF-7) cells in vitro.
Manuka honey has a potent anti-proliferative effect on all three cancer cell lines in a time- and dose-dependent manner, at the concentrations as low as 0.6% (w/v).
The efficacy of Manuka honey in the inhibitory melanoma skin cancer was attributed to the increased expression of pro-apoptotic and cell death programming activity.
Treatment with manuka honey alone resulted in about 33% inhibition of tumor growth, which correlated with a histologically observable increase in tumor apoptosis without inducing any side effects.
Dr. Fernandez-Cabezudo MJ, the lead author said, "Although better control of tumor growth was observed in animals treated with paclitaxel alone or in combination with manuka honey (61% inhibition), a dramatic improvement in host survival was seen in the co-treatment group".
In support of the above differentiation, a joint study led by Nazarbayev University also suggested that honey processed the anti-carcinogenic effects in vitro and in a murine model of melanoma.
Taken altogether, honey may be considered a functional food for the prevention of melanoma skin cancer and a secondary therapy combined with primary medicine for the treatment of melanoma skin cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis by Xue C1, Chen Y2, Hu DN3, Iacob C4, Lu C5, Huang Z. (PubMed)
(2) Honey: A Therapeutic Agent for Disorders of the Skin by McLoone P1, Oluwadun A2, Warnock M3, Fyfe L. (PubMed)
(3) Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model by Fernandez-Cabezudo MJ1, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK. (PubMed)
(4) Update in genetic susceptibility in melanoma by Miriam Potrony,1 Celia Badenas,2,3 Paula Aguilera,1,2 Joan Anton Puig-Butille,2,3Cristina Carrera,1,2 Josep Malvehy,1,2 and Susana Puig. (PMC)
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.
The 4 most common types of skin melanoma include
1. Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
2, Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
3. Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.
4. Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.
The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin. Why some people are susceptible to the onset of the disease while others do not even share similar health conditions, family history, and ethnicity.
However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV rays are the most common associated with the increased risk of melanoma skin cancer.
In fact, people who inherited the BRAF oncogene have a substantial risk to develop melanoma skin cancer and the most common genes which have been primarily linked to familial melanoma, are CDKN2A and CDK4.
Dr. Miriam Potrony, the lead author in the study "Update in genetic susceptibility in melanoma" suggested that 10% of melanoma skin cancer are genetically related and cyclin-dependent kinase inhibitor 2A (CDKN2A), identified as the first melanoma susceptibility gene more than 20 years ago, is the main high-risk gene for melanoma.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the finding a natural ingredient for the reduction of risk and treatment of melanoma skin cancer, researchers launched an investigation to determine the effect of chrysin, a flavonoid present in honey, propolis, against human uveal melanoma cell lines (M17 and SP6.5)
Injection of chrysin reduced the viability of cultured human melanoma cells in a dose-dependent manner (0, 10, 30 and 100 µM) with IC50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively.
Chrysin at 30-100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of nearby healthy cells.
Chrysin inhibited the melanoma skin cancer cells through the proteins associated with cancer cell death and degradation.
These results indicated chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway in the increased mitochondrial permeability
In the finding the scientist evidence for Manuka honey effect in the treatment of cancer, researchers at the UAE University conducted an investigation to examine the anti-cancer effect on three different cancer cell lines, murine melanoma (B16.F1) and colorectal carcinoma (CT26) as well as human breast cancer (MCF-7) cells in vitro.
Manuka honey has a potent anti-proliferative effect on all three cancer cell lines in a time- and dose-dependent manner, at the concentrations as low as 0.6% (w/v).
The efficacy of Manuka honey in the inhibitory melanoma skin cancer was attributed to the increased expression of pro-apoptotic and cell death programming activity.
Treatment with manuka honey alone resulted in about 33% inhibition of tumor growth, which correlated with a histologically observable increase in tumor apoptosis without inducing any side effects.
Dr. Fernandez-Cabezudo MJ, the lead author said, "Although better control of tumor growth was observed in animals treated with paclitaxel alone or in combination with manuka honey (61% inhibition), a dramatic improvement in host survival was seen in the co-treatment group".
In support of the above differentiation, a joint study led by Nazarbayev University also suggested that honey processed the anti-carcinogenic effects in vitro and in a murine model of melanoma.
Taken altogether, honey may be considered a functional food for the prevention of melanoma skin cancer and a secondary therapy combined with primary medicine for the treatment of melanoma skin cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis by Xue C1, Chen Y2, Hu DN3, Iacob C4, Lu C5, Huang Z. (PubMed)
(2) Honey: A Therapeutic Agent for Disorders of the Skin by McLoone P1, Oluwadun A2, Warnock M3, Fyfe L. (PubMed)
(3) Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model by Fernandez-Cabezudo MJ1, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK. (PubMed)
(4) Update in genetic susceptibility in melanoma by Miriam Potrony,1 Celia Badenas,2,3 Paula Aguilera,1,2 Joan Anton Puig-Butille,2,3Cristina Carrera,1,2 Josep Malvehy,1,2 and Susana Puig. (PMC)
Sunday, April 19, 2020
Banana, the Natural Antibiotic and Anti Oxidative Stress Functional Food
Banana may have a potential and substantial effect on balancing the levels of free radicals and antioxidants in the body, according to the studies.
Oxidative stress is a condition of imbalance of the ration of free radicals and antioxidant enzymes produced by the body, leading to the damage of cell, protein, and alternation of cell DNA.
The causes of oxidative are either associated with overexpression of free radicals and depressed the host antioxidant enzymes.
Free radicals are highly reactive molecules with the unpaired electron on the outer ring of the atom. In order for them to become balanced, they must donate or steal an electron from the stable molecules, leading to the chain of reaction which can not be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
This chain of domino's effect is known as oxidation.
Antioxidants are stable molecules that inhibit oxidation.
There are 2 types of antioxidants in the human body. The antioxidants are produced by the host and antioxidants come from dietary sources.
Every day, our body is bombarded by the invasion of free radical. Believe it not, substances include fried foods, alcohol, tobacco smoke, pesticides, air pollutants, which produce harmful free radicals to our body.
Epidemiological studies agreed that oxidative stress is involved in several age-related conditions, including cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer.
Dr. Seungyoun Jung,, the lead scientists in the evaluation of a healthy diet pattern and the risk of oxidative stress suggested, "Foods rich in healthy diets—characterized by a high intake of fruit, vegetables, and whole grains as well as a low intake of saturated fat—are aggregate sources of bioactive compounds. These compounds work as components in antioxidant systems, such as superoxide dismutases or glutathione peroxidase, and may break free radical chain reactions."
These results strongly indicated a healthy diet can form a significant part in reducing the risk of diseases associated with oxidative stress.
Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.
On finding a natural antioxidant ingredient or whole food for the prevention and treatment of the diseases associated with overexpression of free radical, researchers compared the antioxidant properties of banana (Musa paradisiaca) and Sapodilla/Chikoo (Manilkara zapota) peel extracts in chicken patties.
The chicken patties were assigned to 4 treatments viz., I. Control (meat + 2% salt), II.BHT (meat + 2% salt + 0.1% BHT), III. BPE (meat + 2% salt + 2% banana peel extract) and IV. SPE (meat + 2% salt + 2% sapodilla/chikoo peel extract).
By comparing the changes in color and lipid oxidation during 8 days refrigerated storage (4 ± °C) in 4 groups, researchers showed that
* The average phenolic content was 550.2 and 550.8 mg gallic acid equivalent per 10 g peel in BPE and SPE respectively.
* Free radical scavenging activity was 66.9 and 67.8% in BPE and SPE respectively.
* Banana peel extract had significantly (P < 0.05) higher reducing activity (1.6) as compared to sapodilla peel extract (0.91).
* Observation on lipid oxidation showed significantly (P < 0.05) higher TBARS values used for the determination of oxidative stress in control than the three treatments.
* The increase in TBARS from the initial day of storage to last day of storage was highest in control (514.3%)compared to BHT (387.7%), BPE (370.6%) and SPE (383.7%). Both synthetic antioxidants and natural extracts significantly decreased TBARS.
These results clearly suggested that the water extracts obtained from banana and sapodilla peel process natural antioxidants in poultry meat and meat products.
Furthermore, in examining the antioxidant activity of different Musa sp. leave extracts of hexane, ethyl acetate, and methanol, researchers found that
* All the Musa sp. extracts showed moderate antibacterial activities expect Musa paradisiaca with the inhibition zone ranging from 8.0 to 18.6 mm.
* Among four species ethyl acetate extracts of Musa paradisiaca showed the highest activity against tested pathogens particularly E. coli, P. aeruginosa, and Citrobacter sp.
* The minimum inhibitory concentrations were within the value of 15.63- 250 µg/mL and minimum bactericidal concentrations were ranging from 31.25- 250 µg/mL.
* Antioxidant activity of Musa acuminate exhibited maximum activity among the r three Musa species.
Taken all together, a banana may be considered functional food for the prevention and treatment of bacterial infections and diseases associated with oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Comparative antioxidant effect of BHT and water extracts of banana and sapodilla peels in raw poultry meat by Devatkal SK, Kumboj R, Paul D.(PubMed)
(2) Antibacterial and antioxidant activities of Musa sp. leaf extracts against multidrug resistant clinical pathogens causing nosocomial infection by Karuppiah P1, Mustaffa M.(PubMed)
(3) Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study by Seungyoun Jung,1,2,3,* Stephanie A. Smith-Warner,1,2 Walter C. Willett,1,2,4 Molin Wang,2Tianying Wu,5 Majken Jensen,2,4 Susan E. Hankinson,4,6 and A. Heather Eliassen. (PMC)
Saturday, April 18, 2020
Honey, the Potential Chemo Replacement for the Treatment Cancers, Scientists Say
Honey may process certain chemical compounds which have a potential effect in the reducing risk and treatment of cancers with no side effects, some scientists suggested.
Cancer cells are the type of cells which can grow indefinitely compared to normal cycle which can only survive after certain cycle division.
According to cellular biology, in a fully grown adult cell, the rate of cell proliferation is much less, and under normal circumstances and cell division in an adult can only occur when there is the need to replace cells that have been lost, damaged, or worn out.
Most cancers start in the cells on the surface of the inner lining of the tissue of the specific organ.
At the early stage, most cancer tumors do not induce any symptoms. However, after colonizing most tissue, the disorderly proliferative tumor can suppress the nearby tissue including nerve cells and blood vessels, causing localized pain and severe symptoms depending on the types of cancer.
Also, at this stage, malignant cells can also travel through lymph and blood to infect other healthy tissue, a distance away from the original site.
Although there are many risk factors associated with the onset of cancer, people with a genetic preposition are at the highest risk.
Men who carry genetic mutation BRCA1, BRCA2, and HOXB13, inherited from the parents are at 70% risk of prostate cancer, and women who carry the mutated genes BRCA1 and 2 have an increased risk breast cancer of over 55%.
Sadly, more than 12 percent of men with prostate cancer tested positive for hereditary mutations of cancer-causing genes, 87% of women reported BRCA testing by one-year post-diagnosis of breast cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient for the prevention and treatment of cancer with no side effects, a joint study led by the Universiti Sains Malaysia was conducted to examine the role of honey in modulating the development and progression of tumors or cancers.
By searching the available data online literature, researchers found that there is available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer.
Honey was highly cytotoxic against tumor or cancer cells, while it was non-cytotoxic to normal cells.
Honey inhibited growth and proliferation of tumors or cancers.
Application of honey inhibited carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages.
Furthermore, in the study to examine the honey and royal jelly effects against cisplatin-induced nephrotoxicity in patients with cancer, researchers examined the results of patients with cancer assigned for cisplatin chemotherapy randomly divided into bee honey and royal jelly groups pretreated before the initiation and during cisplatin chemotherapeutic regimen and control group on cisplatin only and showed that* Patients on crude bee honey and royal jelly capsules showed lower serum levels of renal injury products (creatinine and urea) compared to those in the control group.
* The changes in kidney parameters were significantly (p < 0.05) lower when compared within the bee honey group before and after cisplatin treatment.
These results indicated bee honey and royal jelly as natural compounds are effective in reducing cisplatin nephrotoxicity and may offer a promising chance for clinically meaningful prevention with no side effects.
Interestingly, Dr. the lead author in the examine the overwhelming evidence of the role of diet and lifestyle in cancer risk and prevention, suggested that there is a growing interest in the search for chemopreventative or chemotherapeutic agents derived from natural products.
And, honey is an important source of bioactive compounds derived from plants and recent years have been under the intensified study for its anticancer properties.
Recently, the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signaling, invasion, and inflammation has been presented. in numbers of conventional research.
Taken altogether, honey may be used as a functional food for the prevention of cancers and a secondary therapy combined with conventional medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of honey and its mechanisms of action on the development and progression of cancer by Erejuwa OO1, Sulaiman SA2, Wahab MS. (PubMed)
(2) Effect of Honey and Royal Jelly against Cisplatin-Induced Nephrotoxicity in Patients with Cancer by Osama H1, Abdullah A1, Gamal B1, Emad D1, Sayed D1, Hussein E1, Mahfouz E1, Tharwat J1, Sayed S1, Medhat S1, Bahaa T1, Abdelrahim MEA. (PubMed)
(3) Honey and Cancer: Current Status and Future Directions by Porcza LM1, Simms C2, Chopra M. (PubMed)
Cancer cells are the type of cells which can grow indefinitely compared to normal cycle which can only survive after certain cycle division.
According to cellular biology, in a fully grown adult cell, the rate of cell proliferation is much less, and under normal circumstances and cell division in an adult can only occur when there is the need to replace cells that have been lost, damaged, or worn out.
Most cancers start in the cells on the surface of the inner lining of the tissue of the specific organ.
At the early stage, most cancer tumors do not induce any symptoms. However, after colonizing most tissue, the disorderly proliferative tumor can suppress the nearby tissue including nerve cells and blood vessels, causing localized pain and severe symptoms depending on the types of cancer.
Also, at this stage, malignant cells can also travel through lymph and blood to infect other healthy tissue, a distance away from the original site.
Although there are many risk factors associated with the onset of cancer, people with a genetic preposition are at the highest risk.
Men who carry genetic mutation BRCA1, BRCA2, and HOXB13, inherited from the parents are at 70% risk of prostate cancer, and women who carry the mutated genes BRCA1 and 2 have an increased risk breast cancer of over 55%.
Sadly, more than 12 percent of men with prostate cancer tested positive for hereditary mutations of cancer-causing genes, 87% of women reported BRCA testing by one-year post-diagnosis of breast cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient for the prevention and treatment of cancer with no side effects, a joint study led by the Universiti Sains Malaysia was conducted to examine the role of honey in modulating the development and progression of tumors or cancers.
By searching the available data online literature, researchers found that there is available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer.
Honey was highly cytotoxic against tumor or cancer cells, while it was non-cytotoxic to normal cells.
Honey inhibited growth and proliferation of tumors or cancers.
Application of honey inhibited carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages.
Furthermore, in the study to examine the honey and royal jelly effects against cisplatin-induced nephrotoxicity in patients with cancer, researchers examined the results of patients with cancer assigned for cisplatin chemotherapy randomly divided into bee honey and royal jelly groups pretreated before the initiation and during cisplatin chemotherapeutic regimen and control group on cisplatin only and showed that* Patients on crude bee honey and royal jelly capsules showed lower serum levels of renal injury products (creatinine and urea) compared to those in the control group.
* The changes in kidney parameters were significantly (p < 0.05) lower when compared within the bee honey group before and after cisplatin treatment.
These results indicated bee honey and royal jelly as natural compounds are effective in reducing cisplatin nephrotoxicity and may offer a promising chance for clinically meaningful prevention with no side effects.
Interestingly, Dr. the lead author in the examine the overwhelming evidence of the role of diet and lifestyle in cancer risk and prevention, suggested that there is a growing interest in the search for chemopreventative or chemotherapeutic agents derived from natural products.
And, honey is an important source of bioactive compounds derived from plants and recent years have been under the intensified study for its anticancer properties.
Recently, the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signaling, invasion, and inflammation has been presented. in numbers of conventional research.
Taken altogether, honey may be used as a functional food for the prevention of cancers and a secondary therapy combined with conventional medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of honey and its mechanisms of action on the development and progression of cancer by Erejuwa OO1, Sulaiman SA2, Wahab MS. (PubMed)
(2) Effect of Honey and Royal Jelly against Cisplatin-Induced Nephrotoxicity in Patients with Cancer by Osama H1, Abdullah A1, Gamal B1, Emad D1, Sayed D1, Hussein E1, Mahfouz E1, Tharwat J1, Sayed S1, Medhat S1, Bahaa T1, Abdelrahim MEA. (PubMed)
(3) Honey and Cancer: Current Status and Future Directions by Porcza LM1, Simms C2, Chopra M. (PubMed)
Friday, April 17, 2020
Papaya, the Potential Functional Food for the Treatment of Anemia
Scientists may have found a whole fruit for the treatment of anemia with no side effects, according to studies.
Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.
There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.
People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.
Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. the Duliajan College study suggested that certain gene such as βE-Globin Gene is associated with the onset of anemia.
Dr. SK Sharma, the lead scientists in examine the anemia in India population surprisingly found that there is a high prevalence of anemia among children (78.9%), ever-married women (56.2%), pregnant women (57.9%) and never-married men (24.3%) in India.
The doctor continued after observing the levels of hemoglobin in the tested subjects, " Association of the lower level of hemoglobin,...., was observed in subjects carrying the βE-globin gene. The mean (± SD) hemoglobin levels of the subject with heterozygous and homozygous state of HbE was 10.9 ± 0.95 and 9.7 ± 0.64 g/dL, respectively, against 11.28 ± 1.42 g/dL observed in normal hemoglobin pattern (Hb AA)".
These results clearly stated that amenia may be a genetic preposition related disease that can be reversed in some people.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries.
With an aim to find a natural ingredient or whole food for the treatment of anemia, with no side effect, researchers at the Covenant University, examined the papaya anti-anemia effect in subjects with sickle cell disease (SCD)
Sickle cell disease (SCD)is a genetic disease caused by an individual inheriting an allele for sickle cell hemoglobin from both parents. The disease is associated with the unusual production of a large number of immature blood cells.
Application of Carica papaya seed oil (Cari-oil) showed significant effects in reducing the levels of sickle blood cells compared with that of untreated SCD patients.
RBCs in Cari-oil treated samples were significantly higher (P < 0.05) compared with VerMyg, antisickling plant-treated samples.
The Cari-oil extract significantly reduced (P < 0.05) lactate dehydrogenase activity, in both male (HbSSM) and female (HbSSF) human sickle cell blood.
Lactate dehydrogenase activity, LDH consistently increased in patients with anemia.
Furthermore, Cari-oil treated HbSSM and HbSSF blood had significantly increased (P < 0.05) peroxidase activity which was a significant decrease in patients with anemia, compared with controls.
Dr. the lead scientist suggested at the end of the experiment, "Methanolic extracts from... C. papaya seed oil exhibited antisickling properties coupled with the potential to reduce stress in sickle cell patients".
Moreover, in patients with beta-thalassemia major and intermedia and E-beta-thalassemia, researchers found that by ameliorating oxidative stress in red blood cells, the disease may be treatable.
In vitro and in vivo, oral administration of FPP to beta-thalassemic mice (50 mg/mouse/day for 3 months) and to patients (3 g x 3 times/day for 3 months), reduced all the above-mentioned parameters of oxidative stress (p < 0.001 in mice and p < 0.005 in patients).
The results suggested that FPP, as a potent antioxidant, might alleviate symptoms associated with oxidative stress in severe forms of thalassemia.
In human studies, injection of fermented papaya preparation (FPP) on two groups of beta-thal patients: beta-thal, major and intermedia, (in Israel) and E-beta-thal (in Singapore) increased the production of antioxidant enzymes produced by the host and significantly decreased the levels of ROS.
In other words, fermented papaya preparation (FPP) increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased their reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), indicating amelioration of their oxidative status, without a significant change in the hematological parameters.
The finding in human studies indicated it is possible that a longer duration of treatment, probably with the addition of an iron chelator, is required in order to achieve a significant change in the hematological parameters.
Taken altogether, Papaya, particularly in fermentation, may be considered a functional for the prevention and treatment of anemia with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Solenostemon monostachyus, Ipomoea involucrata and Carica papayaseed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT. (PubMed)
(2) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation by Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. (PubMed)
(3) Fermented papayapreparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E(PubMed)
(4) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)
Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.
There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.
People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.
Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. the Duliajan College study suggested that certain gene such as βE-Globin Gene is associated with the onset of anemia.
Dr. SK Sharma, the lead scientists in examine the anemia in India population surprisingly found that there is a high prevalence of anemia among children (78.9%), ever-married women (56.2%), pregnant women (57.9%) and never-married men (24.3%) in India.
The doctor continued after observing the levels of hemoglobin in the tested subjects, " Association of the lower level of hemoglobin,...., was observed in subjects carrying the βE-globin gene. The mean (± SD) hemoglobin levels of the subject with heterozygous and homozygous state of HbE was 10.9 ± 0.95 and 9.7 ± 0.64 g/dL, respectively, against 11.28 ± 1.42 g/dL observed in normal hemoglobin pattern (Hb AA)".
These results clearly stated that amenia may be a genetic preposition related disease that can be reversed in some people.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries.
With an aim to find a natural ingredient or whole food for the treatment of anemia, with no side effect, researchers at the Covenant University, examined the papaya anti-anemia effect in subjects with sickle cell disease (SCD)
Sickle cell disease (SCD)is a genetic disease caused by an individual inheriting an allele for sickle cell hemoglobin from both parents. The disease is associated with the unusual production of a large number of immature blood cells.
Application of Carica papaya seed oil (Cari-oil) showed significant effects in reducing the levels of sickle blood cells compared with that of untreated SCD patients.
RBCs in Cari-oil treated samples were significantly higher (P < 0.05) compared with VerMyg, antisickling plant-treated samples.
The Cari-oil extract significantly reduced (P < 0.05) lactate dehydrogenase activity, in both male (HbSSM) and female (HbSSF) human sickle cell blood.
Lactate dehydrogenase activity, LDH consistently increased in patients with anemia.
Furthermore, Cari-oil treated HbSSM and HbSSF blood had significantly increased (P < 0.05) peroxidase activity which was a significant decrease in patients with anemia, compared with controls.
Dr. the lead scientist suggested at the end of the experiment, "Methanolic extracts from... C. papaya seed oil exhibited antisickling properties coupled with the potential to reduce stress in sickle cell patients".
Moreover, in patients with beta-thalassemia major and intermedia and E-beta-thalassemia, researchers found that by ameliorating oxidative stress in red blood cells, the disease may be treatable.
In vitro and in vivo, oral administration of FPP to beta-thalassemic mice (50 mg/mouse/day for 3 months) and to patients (3 g x 3 times/day for 3 months), reduced all the above-mentioned parameters of oxidative stress (p < 0.001 in mice and p < 0.005 in patients).
The results suggested that FPP, as a potent antioxidant, might alleviate symptoms associated with oxidative stress in severe forms of thalassemia.
In human studies, injection of fermented papaya preparation (FPP) on two groups of beta-thal patients: beta-thal, major and intermedia, (in Israel) and E-beta-thal (in Singapore) increased the production of antioxidant enzymes produced by the host and significantly decreased the levels of ROS.
In other words, fermented papaya preparation (FPP) increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased their reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), indicating amelioration of their oxidative status, without a significant change in the hematological parameters.
The finding in human studies indicated it is possible that a longer duration of treatment, probably with the addition of an iron chelator, is required in order to achieve a significant change in the hematological parameters.
Taken altogether, Papaya, particularly in fermentation, may be considered a functional for the prevention and treatment of anemia with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Solenostemon monostachyus, Ipomoea involucrata and Carica papayaseed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT. (PubMed)
(2) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation by Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. (PubMed)
(3) Fermented papayapreparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E(PubMed)
(4) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)
Thursday, April 16, 2020
Fennel, The Functional Herb Which Processes Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
Fennel may have a therapeutic effect in reducing the risk and treatment of anxiety, some scientists suggested.
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of the present and future events.
In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.
Other causes of anxiety include the longterm use of illicit drugs, medication intake and medical condition and diseases associated with reduced lung functioning
Although medication may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.
In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.
If you are taking the above medicine, please make sure that you understand all the side effects.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the investigate the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus-maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing and head dipping.
* Fennel extract-treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents who were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of the above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of the analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through the expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, the application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease of anxiety through an increased percent number of entries and time spent in open arms.
Compared to other doses of treatment group, administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed a statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, the intake of fennel supplement should be taken with extreme care in the prevention of toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of the present and future events.
In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.
Other causes of anxiety include the longterm use of illicit drugs, medication intake and medical condition and diseases associated with reduced lung functioning
Although medication may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.
In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.
If you are taking the above medicine, please make sure that you understand all the side effects.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the investigate the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus-maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing and head dipping.
* Fennel extract-treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents who were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of the above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of the analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through the expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, the application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease of anxiety through an increased percent number of entries and time spent in open arms.
Compared to other doses of treatment group, administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed a statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, the intake of fennel supplement should be taken with extreme care in the prevention of toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Wednesday, April 15, 2020
Whole Food Onion Anti-Parasitic, Bacterial and Fungal Activity
Microbial infection is a disease caused by microorganisms, including viruses, bacteria, fungi, or parasites.
Most healthy adults can be recovered quickly without using antibiotics.
However, if the immune system or antibiotics used cannot wipe off all the micro invaders in a specific time, approximately 3 to 8 weeks, it will lead to the compromise, leading to chronic infection, such as asthma, airway inflammation, pneumonia, and other respiratory diseases.
Viruses are made up of a piece of genetic material, such as DNA or RNA enclosed in a coat of protein. Virtual infection is a result of a viral invasion that uses components of invaded cells to multiply, leading to the damages or alternation of the DNA or RNA of the host cells.
Bacterias are single-cell organisms that cause infectious diseases by multiplying after finding the specific tissue or organ. Pathogenic bacteria also challenges the immune system for survival.
Fungi are a class of living organisms, including yeasts, molds, and mushrooms. fungal infections in most cases start in the lungs or on the skin. The disease has been found mostly in people with a weakened immune system and long-term use of antibiotics.
Parasites are living organisms that live and extract food in a host. Parasites are also completely dependent on the host for survivors, including lice, ringworms, pinworms, and scabies.
Believe it or not, over 70 percent of parasites are not visible to the human eye, such as the malarial parasite, However, some parasites such as worms can reach many meters in length.
According to the statistics provided by the CDC, infectious diseases cause over 15 million visits to physician offices and 3.7 million visits to the emergency department in the US every year.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of infectious diseases, researchers examined the anti-parasitic activity of garlic and onion.
In parasitic Activity
According to the tested analysis, the abundance of a number of sulfur secondary metabolites in garlic and one (zwiebelane) in the onion extract killed both types of parasites (On Trypanosoma brucei brucei and Leishmania tarentolae) efficiently.
Furthermore, both extracts also inhibited the Trypanosoma brucei trypanothione reductase irreversibly.
The combinations of garlic and onion with common trypanocidal and leishmanicidal drugs exerted a synergistic effect in 50% of all tested cases.
Moreover, by additional differentiation of the chemical compound in both extracts, researchers found that the efficacy of garlic and onion against the tested parasites may be related to the amount and the profile of sulfur-containing compounds through inhibiting certain materials in the parasitic cells.
In Bacterial and Fungal Activity
Additionally, in the comparison of the antimicrobial activities of onion (Allium cepa), garlic (Allium sativum), mint (Mentha spicata), thyme (Thymus vulgaris), oak (Quercus), aloe vera (Aloe barbadensis Miller), and ginger (Zingiber officinale).
All extracts of these medicinal herbs in 80% methanol, 80% ethanol, 80% acetone, and 100% water demonstrated a significant effect against selected microbial strains, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pasteurella multocida, and fungal strains, Aspergillus niger, Aspergillus flavus, Rhizopus solani, and Alternaria alternata.
However, The extracts show better antimicrobial activity against bacterial strains as compared to fungal strains.
Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases caused by parasitic and microbial infection pending to the confirmation of the larger sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Phenolic Compounds and Antioxidant and Antimicrobial Activities of Some Common Herbs by Abdul Qadir M1, Shahzadi SK1, Bashir A2, Munir A2, Shahzad S. (PubMed)
(2) Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities by Krstin S1, Sobeh M2, Braun MS3, Wink M. (PubMed)
Most healthy adults can be recovered quickly without using antibiotics.
However, if the immune system or antibiotics used cannot wipe off all the micro invaders in a specific time, approximately 3 to 8 weeks, it will lead to the compromise, leading to chronic infection, such as asthma, airway inflammation, pneumonia, and other respiratory diseases.
Viruses are made up of a piece of genetic material, such as DNA or RNA enclosed in a coat of protein. Virtual infection is a result of a viral invasion that uses components of invaded cells to multiply, leading to the damages or alternation of the DNA or RNA of the host cells.
Bacterias are single-cell organisms that cause infectious diseases by multiplying after finding the specific tissue or organ. Pathogenic bacteria also challenges the immune system for survival.
Fungi are a class of living organisms, including yeasts, molds, and mushrooms. fungal infections in most cases start in the lungs or on the skin. The disease has been found mostly in people with a weakened immune system and long-term use of antibiotics.
Parasites are living organisms that live and extract food in a host. Parasites are also completely dependent on the host for survivors, including lice, ringworms, pinworms, and scabies.
Believe it or not, over 70 percent of parasites are not visible to the human eye, such as the malarial parasite, However, some parasites such as worms can reach many meters in length.
According to the statistics provided by the CDC, infectious diseases cause over 15 million visits to physician offices and 3.7 million visits to the emergency department in the US every year.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of infectious diseases, researchers examined the anti-parasitic activity of garlic and onion.
In parasitic Activity
According to the tested analysis, the abundance of a number of sulfur secondary metabolites in garlic and one (zwiebelane) in the onion extract killed both types of parasites (On Trypanosoma brucei brucei and Leishmania tarentolae) efficiently.
Furthermore, both extracts also inhibited the Trypanosoma brucei trypanothione reductase irreversibly.
The combinations of garlic and onion with common trypanocidal and leishmanicidal drugs exerted a synergistic effect in 50% of all tested cases.
Moreover, by additional differentiation of the chemical compound in both extracts, researchers found that the efficacy of garlic and onion against the tested parasites may be related to the amount and the profile of sulfur-containing compounds through inhibiting certain materials in the parasitic cells.
In Bacterial and Fungal Activity
Additionally, in the comparison of the antimicrobial activities of onion (Allium cepa), garlic (Allium sativum), mint (Mentha spicata), thyme (Thymus vulgaris), oak (Quercus), aloe vera (Aloe barbadensis Miller), and ginger (Zingiber officinale).
All extracts of these medicinal herbs in 80% methanol, 80% ethanol, 80% acetone, and 100% water demonstrated a significant effect against selected microbial strains, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pasteurella multocida, and fungal strains, Aspergillus niger, Aspergillus flavus, Rhizopus solani, and Alternaria alternata.
However, The extracts show better antimicrobial activity against bacterial strains as compared to fungal strains.
Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases caused by parasitic and microbial infection pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
-
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Phenolic Compounds and Antioxidant and Antimicrobial Activities of Some Common Herbs by Abdul Qadir M1, Shahzadi SK1, Bashir A2, Munir A2, Shahzad S. (PubMed)
(2) Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities by Krstin S1, Sobeh M2, Braun MS3, Wink M. (PubMed)
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